PSDE_HUMAN
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving Lys-63-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PSDE_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 33.5938 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 33.5938 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 32.8125 | 4 | no |
GO:0003723 | RNA binding | 32.0313 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 25.7813 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 25.7813 | 5 | no |
GO:0005524 | ATP binding | 25.0000 | 5 | no |
GO:0016462 | pyrophosphatase activity | 23.4375 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.4375 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.4375 | 6 | no |
GO:0046872 | metal ion binding | 13.2813 | 4 | yes |
GO:0004843 | cysteine-type deubiquitinase activity | 4.6875 | 5 | yes |
GO:0008234 | cysteine-type peptidase activity | 4.6875 | 4 | yes |
GO:0019783 | ubiquitin-like protein peptidase activity | 4.6875 | 4 | yes |
GO:0101005 | deubiquitinase activity | 4.6875 | 5 | yes |
GO:0016504 | peptidase activator activity | 3.1250 | 4 | yes |
GO:0061135 | endopeptidase regulator activity | 3.1250 | 4 | yes |
GO:0061578 | Lys63-specific deubiquitinase activity | 2.3438 | 6 | yes |
GO:0008237 | metallopeptidase activity | 1.5625 | 4 | yes |
GO:0061133 | endopeptidase activator activity | 1.5625 | 5 | yes |
GO:0140492 | metal-dependent deubiquitinase activity | 1.5625 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PSDE_HUMAN |
---|---|---|---|---|
GO:0060255 | regulation of macromolecule metabolic process | 57.8125 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 57.0313 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 56.2500 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 52.3438 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 51.5625 | 4 | no |
GO:0048523 | negative regulation of cellular process | 42.1875 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 39.8438 | 5 | yes |
GO:0051128 | regulation of cellular component organization | 38.2813 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 38.2813 | 4 | no |
GO:0010468 | regulation of gene expression | 35.9375 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.9375 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 35.9375 | 5 | no |
GO:0010646 | regulation of cell communication | 35.1563 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 34.3750 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 34.3750 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.3750 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 33.5938 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 33.5938 | 5 | no |
GO:0009966 | regulation of signal transduction | 33.5938 | 4 | no |
GO:0043412 | macromolecule modification | 32.8125 | 4 | yes |
GO:0036211 | protein modification process | 32.0313 | 4 | yes |
GO:0006996 | organelle organization | 32.0313 | 4 | no |
GO:0022607 | cellular component assembly | 27.3438 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 27.3438 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 26.5625 | 4 | no |
GO:0009057 | macromolecule catabolic process | 25.7813 | 4 | yes |
GO:0010941 | regulation of cell death | 25.7813 | 4 | no |
GO:0043067 | regulation of programmed cell death | 25.0000 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
GO:0042981 | regulation of apoptotic process | 24.2188 | 6 | no |
GO:0006355 | regulation of DNA-templated transcription | 24.2188 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 24.2188 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 24.2188 | 6 | no |
GO:0033043 | regulation of organelle organization | 24.2188 | 5 | no |
GO:0031399 | regulation of protein modification process | 24.2188 | 6 | no |
GO:0008104 | protein localization | 24.2188 | 4 | no |
GO:0044265 | cellular macromolecule catabolic process | 23.4375 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 23.4375 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 23.4375 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.4375 | 6 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.4375 | 5 | no |
GO:0009894 | regulation of catabolic process | 22.6563 | 4 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.6563 | 6 | no |
GO:0048584 | positive regulation of response to stimulus | 22.6563 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 22.6563 | 4 | no |
GO:0006508 | proteolysis | 21.8750 | 4 | yes |
GO:0051603 | proteolysis involved in protein catabolic process | 21.0938 | 5 | yes |
GO:0060341 | regulation of cellular localization | 21.0938 | 4 | no |
GO:0080134 | regulation of response to stress | 21.0938 | 4 | no |
GO:0019941 | modification-dependent protein catabolic process | 20.3125 | 6 | yes |
GO:0043632 | modification-dependent macromolecule catabolic process | 20.3125 | 5 | yes |
GO:0051049 | regulation of transport | 20.3125 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 20.3125 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 20.3125 | 6 | no |
GO:0090304 | nucleic acid metabolic process | 17.9688 | 4 | yes |
GO:0006511 | ubiquitin-dependent protein catabolic process | 17.1875 | 7 | yes |
GO:0030162 | regulation of proteolysis | 17.1875 | 6 | yes |
GO:0042176 | regulation of protein catabolic process | 17.1875 | 5 | yes |
GO:0070647 | protein modification by small protein conjugation or removal | 14.0625 | 5 | yes |
GO:1901565 | organonitrogen compound catabolic process | 14.0625 | 4 | yes |
GO:0030163 | protein catabolic process | 12.5000 | 4 | yes |
GO:1903050 | regulation of proteolysis involved in protein catabolic process | 12.5000 | 7 | yes |
GO:0061136 | regulation of proteasomal protein catabolic process | 11.7188 | 6 | yes |
GO:0010498 | proteasomal protein catabolic process | 10.9375 | 5 | yes |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 9.3750 | 6 | yes |
GO:0006974 | cellular response to DNA damage stimulus | 7.8125 | 4 | yes |
GO:0006259 | DNA metabolic process | 7.0313 | 4 | yes |
GO:0070646 | protein modification by small protein removal | 6.2500 | 5 | yes |
GO:0016579 | protein deubiquitination | 5.4688 | 6 | yes |
GO:0006281 | DNA repair | 4.6875 | 5 | yes |
GO:0097305 | response to alcohol | 3.9063 | 4 | yes |
GO:0006302 | double-strand break repair | 3.1250 | 6 | yes |
GO:0006303 | double-strand break repair via nonhomologous end joining | 2.3438 | 7 | yes |
GO:0006310 | DNA recombination | 2.3438 | 5 | yes |
GO:0045471 | response to ethanol | 2.3438 | 5 | yes |
GO:0070536 | protein K63-linked deubiquitination | 2.3438 | 7 | yes |
GO:0000724 | double-strand break repair via homologous recombination | 1.5625 | 7 | yes |
GO:0000725 | recombinational repair | 1.5625 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in PSDE_HUMAN |
---|---|---|---|---|
DOID:1289 | neurodegenerative disease | 2.3438 | 4 | no |
DOID:331 | central nervous system disease | 2.3438 | 3 | no |
DOID:12377 | spinal muscular atrophy | 1.5625 | 6 | no |
DOID:231 | motor neuron disease | 1.5625 | 5 | no |
DOID:37 | skin disease | 1.5625 | 3 | no |
DOID:0080000 | muscular disease | 1.5625 | 3 | no |
DOID:423 | myopathy | 1.5625 | 5 | no |
DOID:66 | muscle tissue disease | 1.5625 | 4 | no |
DOID:9884 | muscular dystrophy | 1.5625 | 6 | no |
DOID:114 | heart disease | 1.5625 | 3 | no |
DOID:65 | connective tissue disease | 1.5625 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MITF_HUMAN | [view interactions] | Low throughput | no | no |
UBE3A_HUMAN | [view interactions] | Low throughput | no | yes |
PSME1_HUMAN | [view interactions] | Low throughput | no | yes |
UBE3C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
E2F1_HUMAN | [view interactions] | Low throughput | no | yes |
SGTA_HUMAN | [view interactions] | Low throughput | no | yes |
BAG6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SNAI1_HUMAN | [view interactions] | Low throughput | no | yes |
TGFR2_HUMAN | [view interactions] | Low throughput | no | no |
TGFR1_HUMAN | [view interactions] | Low throughput | no | no |
ACVR1_HUMAN | [view interactions] | Low throughput | no | yes |
BMR1A_HUMAN | [view interactions] | Low throughput | no | no |
AVR2B_HUMAN | [view interactions] | Low throughput | no | no |
IRF3_HUMAN | [view interactions] | Low throughput | no | yes |
MAVS_HUMAN | [view interactions] | Low throughput | no | yes |
UB2V1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ADRM1_HUMAN | [view interactions] | Low throughput | no | yes |
PSMD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PSB5_HUMAN | [view interactions] | Low throughput | no | yes |
PSMD4_HUMAN | [view interactions] | Low throughput | no | yes |
PSA1_HUMAN | [view interactions] | Low throughput | no | yes |
PRS8_HUMAN | [view interactions] | Low throughput | no | yes |
TXNL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRS6B_HUMAN | [view interactions] | Low throughput | no | yes |
PSB4_HUMAN | [view interactions] | Low throughput | no | yes |
PSA2_HUMAN | [view interactions] | Low throughput | no | yes |
PSA6_HUMAN | [view interactions] | Low throughput | no | yes |
IKKE_HUMAN | [view interactions] | Low throughput | no | yes |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PKHB2_HUMAN | [view interactions] | High throughput | no | yes |
EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB15B_HUMAN | [view interactions] | High throughput | no | yes |
PRP31_HUMAN | [view interactions] | High throughput | no | yes |
BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
SYRC_HUMAN | [view interactions] | High throughput | no | yes |
ABRX2_HUMAN | [view interactions] | High throughput | no | yes |
ARG39_HUMAN | [view interactions] | High throughput | no | yes |
EHMT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRM2A_HUMAN | [view interactions] | High throughput | no | no |
LMBL1_HUMAN | [view interactions] | High throughput | no | no |
PPARD_HUMAN | [view interactions] | High throughput | no | yes |
CERS2_HUMAN | [view interactions] | High throughput | no | no |
DOXA1_HUMAN | [view interactions] | High throughput | no | yes |
NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
DEP1A_HUMAN | [view interactions] | High throughput | no | yes |
OFD1_HUMAN | [view interactions] | High throughput | no | yes |
TAB1_HUMAN | [view interactions] | High throughput | no | yes |
DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCBP4_HUMAN | [view interactions] | High throughput | no | no |
MKS3_HUMAN | [view interactions] | High throughput | no | no |
LRIG3_HUMAN | [view interactions] | High throughput | no | yes |
CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
POC5_HUMAN | [view interactions] | High throughput | no | yes |
TLR9_HUMAN | [view interactions] | High throughput | no | no |
TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DEN5B_HUMAN | [view interactions] | High throughput | no | yes |
PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNE2_HUMAN | [view interactions] | High throughput | no | no |
INSI2_HUMAN | [view interactions] | High throughput | no | yes |
CENPE_HUMAN | [view interactions] | High throughput | no | no |
PCKGC_HUMAN | [view interactions] | High throughput | no | no |
DYH5_HUMAN | [view interactions] | High throughput | no | no |
CEP85_HUMAN | [view interactions] | High throughput | no | no |
ZFN2A_HUMAN | [view interactions] | High throughput | no | yes |
NOSTN_HUMAN | [view interactions] | High throughput | no | yes |
RD23A_HUMAN | [view interactions] | High throughput | no | yes |
SPT6H_HUMAN | [view interactions] | High throughput | no | yes |
FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZC12B_HUMAN | [view interactions] | High throughput | no | no |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NOS2_HUMAN | [view interactions] | High throughput | no | yes |
AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIZ_HUMAN | [view interactions] | High throughput | no | no |
RNF11_HUMAN | [view interactions] | High throughput | no | yes |
PDZD7_HUMAN | [view interactions] | High throughput | no | no |
CASPA_HUMAN | [view interactions] | High throughput | no | yes |
PSME3_HUMAN | [view interactions] | High throughput | no | yes |
SH321_HUMAN | [view interactions] | High throughput | no | yes |
PSME2_HUMAN | [view interactions] | High throughput | no | no |
LIPB2_HUMAN | [view interactions] | High throughput | no | yes |
KNL1_HUMAN | [view interactions] | High throughput | no | no |
UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
MFF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
SPAG5_HUMAN | [view interactions] | High throughput | no | yes |
UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
BBOF1_HUMAN | [view interactions] | High throughput | no | no |
UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DGKQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
VP13D_HUMAN | [view interactions] | High throughput | no | no |
CC74B_HUMAN | [view interactions] | High throughput | no | no |
GUF1_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHD3_HUMAN | [view interactions] | High throughput | no | yes |
HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IPP_HUMAN | [view interactions] | High throughput | no | yes |
DRC8_HUMAN | [view interactions] | High throughput | no | yes |
PTN2_HUMAN | [view interactions] | High throughput | no | yes |
TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FILA_HUMAN | [view interactions] | High throughput | no | no |
TRI18_HUMAN | [view interactions] | High throughput | no | no |
ELOB_HUMAN | [view interactions] | High throughput | no | no |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
SPAG7_HUMAN | [view interactions] | High throughput | no | yes |
LMBL4_HUMAN | [view interactions] | High throughput | no | no |
RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
NAR4_HUMAN | [view interactions] | High throughput | no | no |
PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
DHC24_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
V1AR_HUMAN | [view interactions] | High throughput | no | no |
ZN598_HUMAN | [view interactions] | High throughput | no | no |
DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPGF4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDX24_HUMAN | [view interactions] | High throughput | no | yes |
GET3_HUMAN | [view interactions] | High throughput | no | yes |
KIF11_HUMAN | [view interactions] | High throughput | no | yes |
UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
ECM29_HUMAN | [view interactions] | High throughput | no | no |
SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GET4_HUMAN | [view interactions] | High throughput | no | yes |
PCNT_HUMAN | [view interactions] | High throughput | no | yes |
FGF11_HUMAN | [view interactions] | High throughput | no | no |
ICE2_HUMAN | [view interactions] | High throughput | no | no |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
I12R1_HUMAN | [view interactions] | High throughput | no | no |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
MANEA_HUMAN | [view interactions] | High throughput | no | yes |
AL1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
EYA3_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
NFX1_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
ATX3_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
NUCL_HUMAN | [view interactions] | High throughput | no | yes |
ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANDR_HUMAN | [view interactions] | High throughput | no | no |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
MAF_HUMAN | [view interactions] | High throughput | no | yes |
TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
SYDC_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALBU_HUMAN | [view interactions] | High throughput | no | no |
TOP1_HUMAN | [view interactions] | High throughput | no | yes |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOP2A_HUMAN | [view interactions] | High throughput | no | no |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FZR1_HUMAN | [view interactions] | High throughput | no | no |
RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WDR5_HUMAN | [view interactions] | High throughput | no | no |
F262_HUMAN | [view interactions] | High throughput | no | no |
TMM31_HUMAN | [view interactions] | High throughput | no | no |
MVP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CC74A_HUMAN | [view interactions] | High throughput | no | no |
PTBP1_HUMAN | [view interactions] | High throughput | no | no |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
5NTC_HUMAN | [view interactions] | High throughput | no | yes |
MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DCD_HUMAN | [view interactions] | High throughput | no | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
DHX15_HUMAN | [view interactions] | High throughput | no | yes |
RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAFB2_HUMAN | [view interactions] | High throughput | no | yes |
PSMA8_HUMAN | [view interactions] | High throughput | no | no |
HPS3_HUMAN | [view interactions] | High throughput | no | yes |
NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AHNK2_HUMAN | [view interactions] | High throughput | no | yes |
TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSN6_HUMAN | [view interactions] | High throughput | no | yes |
PPM1B_HUMAN | [view interactions] | High throughput | no | yes |
MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NLRP9_HUMAN | [view interactions] | High throughput | no | no |
RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRP8_HUMAN | [view interactions] | High throughput | no | yes |
RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSB8_HUMAN | [view interactions] | High throughput | no | yes |
UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APOB_HUMAN | [view interactions] | High throughput | no | no |
EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDIA5_HUMAN | [view interactions] | High throughput | no | yes |
EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THIO_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
SYCC_HUMAN | [view interactions] | High throughput | no | yes |
TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPH3L_HUMAN | [view interactions] | High throughput | no | no |
NAA20_HUMAN | [view interactions] | High throughput | no | no |
MAGI1_HUMAN | [view interactions] | High throughput | no | no |
PPCE_HUMAN | [view interactions] | High throughput | no | yes |
INY2B_HUMAN | [view interactions] | High throughput | no | no |
BABA1_HUMAN | [view interactions] | High throughput | no | yes |
STXB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYPT2_HUMAN | [view interactions] | High throughput | no | no |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IGSF3_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
RMP_HUMAN | [view interactions] | High throughput | no | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SOGA1_HUMAN | [view interactions] | High throughput | no | yes |
CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
H2B1J_HUMAN | [view interactions] | High throughput | no | yes |
H2B1L_HUMAN | [view interactions] | High throughput | no | yes |
H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
H2B1O_HUMAN | [view interactions] | High throughput | no | yes |
H2B2F_HUMAN | [view interactions] | High throughput | no | yes |
H2B1A_HUMAN | [view interactions] | High throughput | no | no |
H2B1K_HUMAN | [view interactions] | High throughput | no | yes |
H2B1N_HUMAN | [view interactions] | High throughput | no | yes |
H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
H2B1M_HUMAN | [view interactions] | High throughput | no | yes |
KIT_HUMAN | [view interactions] | High throughput | no | no |
GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XCR1_HUMAN | [view interactions] | High throughput | no | no |
CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LSS_HUMAN | [view interactions] | High throughput | no | yes |
TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H11_HUMAN | [view interactions] | High throughput | no | no |
H12_HUMAN | [view interactions] | High throughput | no | yes |
H14_HUMAN | [view interactions] | High throughput | no | yes |
H15_HUMAN | [view interactions] | High throughput | no | no |
H13_HUMAN | [view interactions] | High throughput | no | no |
SOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHX9_HUMAN | [view interactions] | High throughput | no | yes |
GOGA3_HUMAN | [view interactions] | High throughput | no | yes |
NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
ALKB1_HUMAN | [view interactions] | High throughput | no | yes |
SF3B4_HUMAN | [view interactions] | High throughput | no | yes |
DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF2G_HUMAN | [view interactions] | High throughput | no | yes |
TRI60_HUMAN | [view interactions] | High throughput | no | no |
ARI4B_HUMAN | [view interactions] | High throughput | no | yes |
ODR4_HUMAN | [view interactions] | High throughput | no | yes |
KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
FMN1_HUMAN | [view interactions] | High throughput | no | no |
PSMD5_HUMAN | [view interactions] | High throughput | no | yes |
VASN_HUMAN | [view interactions] | High throughput | no | yes |
PSMD8_HUMAN | [view interactions] | High throughput | no | yes |
IQCE_HUMAN | [view interactions] | High throughput | no | yes |
PSD10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INT5_HUMAN | [view interactions] | High throughput | no | no |
PRS7_HUMAN | [view interactions] | High throughput | no | yes |
RSBNL_HUMAN | [view interactions] | High throughput | no | yes |
PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
CC174_HUMAN | [view interactions] | High throughput | no | yes |
PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
LCTL_HUMAN | [view interactions] | High throughput | no | no |
DJC14_HUMAN | [view interactions] | High throughput | no | yes |
PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
REX1B_HUMAN | [view interactions] | High throughput | no | no |
KIF27_HUMAN | [view interactions] | High throughput | no | no |
PSD12_HUMAN | [view interactions] | High throughput | no | yes |
PLDX1_HUMAN | [view interactions] | High throughput | no | no |
SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PASD1_HUMAN | [view interactions] | High throughput | no | no |
PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
MILK2_HUMAN | [view interactions] | High throughput | no | no |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ULK2_HUMAN | [view interactions] | High throughput | no | yes |
HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
PUSL1_HUMAN | [view interactions] | High throughput | no | yes |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHG18_HUMAN | [view interactions] | High throughput | no | yes |
YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
CMYA5_HUMAN | [view interactions] | High throughput | no | no |
AFG2H_HUMAN | [view interactions] | High throughput | no | yes |
SVOP_HUMAN | [view interactions] | High throughput | no | no |
PSD13_HUMAN | [view interactions] | High throughput | no | yes |
YJEN3_HUMAN | [view interactions] | High throughput | no | yes |
PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
PSA5_HUMAN | [view interactions] | High throughput | no | yes |
RAI3_HUMAN | [view interactions] | High throughput | no | yes |
O2T29_HUMAN | [view interactions] | High throughput | no | no |
OR2T5_HUMAN | [view interactions] | High throughput | no | no |
CHD6_HUMAN | [view interactions] | High throughput | no | no |
NCOA4_HUMAN | [view interactions] | High throughput | no | no |
GIPC2_HUMAN | [view interactions] | High throughput | no | yes |
BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
TGFA1_HUMAN | [view interactions] | High throughput | no | no |
GSLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UTP4_HUMAN | [view interactions] | High throughput | no | yes |
EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
COA7_HUMAN | [view interactions] | High throughput | no | yes |
PRS10_HUMAN | [view interactions] | High throughput | no | yes |
MEP50_HUMAN | [view interactions] | High throughput | no | yes |
SPNDC_HUMAN | [view interactions] | High throughput | no | yes |
SPAT9_HUMAN | [view interactions] | High throughput | no | yes |
PSB9_HUMAN | [view interactions] | High throughput | no | no |
PC11X_HUMAN | [view interactions] | High throughput | no | yes |
PSB3_HUMAN | [view interactions] | High throughput | no | yes |
PC11Y_HUMAN | [view interactions] | High throughput | no | no |
CCD92_HUMAN | [view interactions] | High throughput | no | yes |
CRNL1_HUMAN | [view interactions] | High throughput | no | no |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
GPTC2_HUMAN | [view interactions] | High throughput | no | yes |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
ZMYM2_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
BMS1_HUMAN | [view interactions] | High throughput | no | yes |
PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR1H4_HUMAN | [view interactions] | High throughput | no | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VSIG4_HUMAN | [view interactions] | High throughput | no | no |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMC2_HUMAN | [view interactions] | High throughput | no | no |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHD1_HUMAN | [view interactions] | High throughput | no | no |
MCM9_HUMAN | [view interactions] | High throughput | no | yes |
PCLO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MOT11_HUMAN | [view interactions] | High throughput | no | no |
FANCJ_HUMAN | [view interactions] | High throughput | no | yes |
UBCP1_HUMAN | [view interactions] | High throughput | no | yes |
HERC1_HUMAN | [view interactions] | High throughput | no | no |
HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KRI1_HUMAN | [view interactions] | High throughput | no | yes |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
SETX_HUMAN | [view interactions] | High throughput | no | yes |
RD23B_HUMAN | [view interactions] | High throughput | no | yes |
CARD9_HUMAN | [view interactions] | High throughput | no | no |
P2RY6_HUMAN | [view interactions] | High throughput | no | no |
WASC4_HUMAN | [view interactions] | High throughput | no | yes |
AMFR_HUMAN | [view interactions] | High throughput | no | yes |
FSIP1_HUMAN | [view interactions] | High throughput | no | no |
BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
B2L14_HUMAN | [view interactions] | High throughput | no | yes |
LIMK2_HUMAN | [view interactions] | High throughput | no | yes |
DDX47_HUMAN | [view interactions] | High throughput | no | yes |
KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COG6_HUMAN | [view interactions] | High throughput | no | yes |
SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
RGS22_HUMAN | [view interactions] | High throughput | no | no |
NEK7_HUMAN | [view interactions] | High throughput | no | yes |
M3K14_HUMAN | [view interactions] | High throughput | no | yes |
AURKB_HUMAN | [view interactions] | High throughput | no | yes |
TTF1_HUMAN | [view interactions] | High throughput | no | yes |
NRBP2_HUMAN | [view interactions] | High throughput | no | yes |
CCD47_HUMAN | [view interactions] | High throughput | no | yes |
SG196_HUMAN | [view interactions] | High throughput | no | yes |
RMC1_HUMAN | [view interactions] | High throughput | no | no |
PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASAP3_HUMAN | [view interactions] | High throughput | no | yes |
HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DYH10_HUMAN | [view interactions] | High throughput | no | no |
PSB7_HUMAN | [view interactions] | High throughput | no | yes |
NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSA7_HUMAN | [view interactions] | High throughput | no | yes |
P63_HUMAN | [view interactions] | High throughput | no | no |
PSB2_HUMAN | [view interactions] | High throughput | no | yes |
TTHY_HUMAN | [view interactions] | High throughput | no | no |
PSB1_HUMAN | [view interactions] | High throughput | no | yes |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
DX39B_HUMAN | [view interactions] | High throughput | no | no |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RP1_HUMAN | [view interactions] | High throughput | no | no |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRY1_HUMAN | [view interactions] | High throughput | no | no |
PSME4_HUMAN | [view interactions] | High throughput | no | yes |
TMPSD_HUMAN | [view interactions] | High throughput | no | no |
PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INADL_HUMAN | [view interactions] | High throughput | no | no |
TBB1_HUMAN | [view interactions] | High throughput | no | yes |
MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LIFR_HUMAN | [view interactions] | High throughput | no | no |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZNF26_HUMAN | [view interactions] | High throughput | no | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYTL1_HUMAN | [view interactions] | High throughput | no | yes |
PSA3_HUMAN | [view interactions] | High throughput | no | no |
TP4AP_HUMAN | [view interactions] | High throughput | no | yes |
KLF16_HUMAN | [view interactions] | High throughput | no | yes |
RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KLF8_HUMAN | [view interactions] | High throughput | no | no |
EIF3L_HUMAN | [view interactions] | High throughput | no | yes |
CRCM_HUMAN | [view interactions] | High throughput | no | no |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
SHRM3_HUMAN | [view interactions] | High throughput | no | yes |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
KHDR3_HUMAN | [view interactions] | High throughput | no | yes |
PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
PAAF1_HUMAN | [view interactions] | High throughput | no | yes |
KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
RO52_HUMAN | [view interactions] | High throughput | no | yes |
KHDR2_HUMAN | [view interactions] | High throughput | no | yes |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
RPP30_HUMAN | [view interactions] | High throughput | no | yes |
LITD1_HUMAN | [view interactions] | High throughput | no | no |
RTCB_HUMAN | [view interactions] | High throughput | no | yes |
OLIG1_HUMAN | [view interactions] | High throughput | no | no |
CAVN1_HUMAN | [view interactions] | High throughput | no | no |
DPY30_HUMAN | [view interactions] | High throughput | no | yes |
SESQ1_HUMAN | [view interactions] | High throughput | no | no |
FAM9B_HUMAN | [view interactions] | High throughput | no | no |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
GLI1_HUMAN | [view interactions] | Computational | no | no |
OAZ2_HUMAN | [view interactions] | Computational | no | no |
GEMI_HUMAN | [view interactions] | Computational | no | no |
PSB11_HUMAN | [view interactions] | Computational | no | no |
PTEN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IKBA_HUMAN | [view interactions] | Computational | no | yes |
FBXL7_HUMAN | [view interactions] | Computational | no | no |
SUFU_HUMAN | [view interactions] | Computational | no | yes |
COP1_HUMAN | [view interactions] | Computational | no | no |
CCND1_HUMAN | [view interactions] | Computational | no | yes |
UBP5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HNRPD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CDC6_HUMAN | [view interactions] | Computational | no | yes |
NUMB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
P73_HUMAN | [view interactions] | Computational | no | no |
OAZ1_HUMAN | [view interactions] | Computational | no | yes |
RUNX3_HUMAN | [view interactions] | Computational | no | no |
TF65_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NFKB1_HUMAN | [view interactions] | Computational | no | yes |
NACAM_HUMAN | [view interactions] | Computational | no | no |
ORC1_HUMAN | [view interactions] | Computational | no | yes |
NEDD8_HUMAN | [view interactions] | Computational | no | yes |
SPRE2_HUMAN | [view interactions] | Computational | no | yes |
PSB10_HUMAN | [view interactions] | Computational | no | no |
MPIP1_HUMAN | [view interactions] | Computational | no | no |
RUNX2_HUMAN | [view interactions] | Computational | no | no |
DDI1_HUMAN | [view interactions] | Computational | no | no |
SPRE1_HUMAN | [view interactions] | Computational | no | yes |
IF2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSMF1_HUMAN | [view interactions] | Computational | no | yes |
SPRE3_HUMAN | [view interactions] | Computational | no | no |
PAK2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GLI2_HUMAN | [view interactions] | Computational | no | yes |
UCHL3_HUMAN | [view interactions] | Computational | no | yes |
GLI3_HUMAN | [view interactions] | Computational | no | yes |
SHH_HUMAN | [view interactions] | Computational | no | no |
EIF3M_HUMAN | [view interactions] | Computational | no | yes |
RAN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NOTC4_HUMAN | [view interactions] | Computational | no | no |
PRIC1_HUMAN | [view interactions] | Computational | no | yes |
UBE2K_HUMAN | [view interactions] | Computational | no | yes |
DCOR_HUMAN | [view interactions] | Computational | no | yes |