PSDE_HUMAN
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving Lys-63-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PSDE_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 38.7755 | 4 | no |
GO:0000166 | nucleotide binding | 38.0952 | 4 | no |
GO:0017076 | purine nucleotide binding | 37.4150 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 36.7347 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 36.0544 | 4 | no |
GO:0003723 | RNA binding | 34.0136 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 29.9320 | 6 | no |
GO:0032559 | adenyl ribonucleotide binding | 29.2517 | 5 | no |
GO:0005524 | ATP binding | 28.5714 | 5 | no |
GO:0016462 | pyrophosphatase activity | 23.1293 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.1293 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.1293 | 6 | no |
GO:0043169 | cation binding | 17.6871 | 4 | yes |
GO:0046872 | metal ion binding | 17.6871 | 5 | yes |
GO:0019783 | ubiquitin-like protein peptidase activity | 3.4014 | 4 | yes |
GO:0101005 | deubiquitinase activity | 3.4014 | 5 | yes |
GO:0061135 | endopeptidase regulator activity | 2.7211 | 4 | yes |
GO:0061578 | K63-linked deubiquitinase activity | 2.7211 | 6 | yes |
GO:0016504 | peptidase activator activity | 2.0408 | 4 | yes |
GO:0008237 | metallopeptidase activity | 1.3605 | 4 | yes |
GO:0061133 | endopeptidase activator activity | 1.3605 | 5 | yes |
GO:0140492 | metal-dependent deubiquitinase activity | 1.3605 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PSDE_HUMAN |
---|---|---|---|---|
GO:0060255 | regulation of macromolecule metabolic process | 54.4218 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 53.0612 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 50.3401 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 48.9796 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 41.4966 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 40.8163 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 40.1361 | 5 | no |
GO:0048523 | negative regulation of cellular process | 40.1361 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 36.7347 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 36.7347 | 4 | no |
GO:0051128 | regulation of cellular component organization | 36.7347 | 4 | no |
GO:0010646 | regulation of cell communication | 36.0544 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 34.0136 | 5 | no |
GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
GO:0031325 | positive regulation of cellular metabolic process | 32.6531 | 5 | no |
GO:0006996 | organelle organization | 31.9728 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.9728 | 5 | no |
GO:0009966 | regulation of signal transduction | 31.2925 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 29.2517 | 5 | no |
GO:0008104 | protein localization | 28.5714 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.5714 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 28.5714 | 6 | no |
GO:0043412 | macromolecule modification | 26.5306 | 4 | yes |
GO:0022607 | cellular component assembly | 26.5306 | 4 | no |
GO:0036211 | protein modification process | 25.8503 | 4 | yes |
GO:0043067 | regulation of programmed cell death | 23.8095 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 23.8095 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 23.8095 | 4 | no |
GO:0042981 | regulation of apoptotic process | 23.1293 | 5 | no |
GO:0060341 | regulation of cellular localization | 23.1293 | 4 | no |
GO:0031399 | regulation of protein modification process | 23.1293 | 6 | no |
GO:0048584 | positive regulation of response to stimulus | 23.1293 | 4 | no |
GO:0009894 | regulation of catabolic process | 22.4490 | 4 | yes |
GO:0071702 | organic substance transport | 22.4490 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 22.4490 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 22.4490 | 5 | no |
GO:0033043 | regulation of organelle organization | 22.4490 | 5 | no |
GO:0009057 | macromolecule catabolic process | 21.7687 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 21.7687 | 6 | no |
GO:0080134 | regulation of response to stress | 21.7687 | 4 | no |
GO:0032880 | regulation of protein localization | 21.7687 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 21.7687 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 20.4082 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 20.4082 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 20.4082 | 6 | no |
GO:0006508 | proteolysis | 19.0476 | 4 | yes |
GO:0019941 | modification-dependent protein catabolic process | 16.3265 | 6 | yes |
GO:0043632 | modification-dependent macromolecule catabolic process | 16.3265 | 5 | yes |
GO:0051603 | proteolysis involved in protein catabolic process | 16.3265 | 5 | yes |
GO:1901565 | organonitrogen compound catabolic process | 16.3265 | 4 | yes |
GO:0042176 | regulation of protein catabolic process | 15.6463 | 5 | yes |
GO:0090304 | nucleic acid metabolic process | 15.6463 | 4 | yes |
GO:0030162 | regulation of proteolysis | 14.2857 | 6 | yes |
GO:0006511 | ubiquitin-dependent protein catabolic process | 13.6054 | 7 | yes |
GO:0043687 | post-translational protein modification | 13.6054 | 5 | yes |
GO:0070647 | protein modification by small protein conjugation or removal | 13.6054 | 6 | yes |
GO:0030163 | protein catabolic process | 12.9252 | 4 | yes |
GO:1903050 | regulation of proteolysis involved in protein catabolic process | 11.5646 | 7 | yes |
GO:0061136 | regulation of proteasomal protein catabolic process | 10.8844 | 6 | yes |
GO:0010498 | proteasomal protein catabolic process | 10.2041 | 5 | yes |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 9.5238 | 6 | yes |
GO:0006974 | DNA damage response | 8.1633 | 4 | yes |
GO:0006259 | DNA metabolic process | 6.1224 | 5 | yes |
GO:0006281 | DNA repair | 4.0816 | 5 | yes |
GO:0070646 | protein modification by small protein removal | 4.0816 | 7 | yes |
GO:0097305 | response to alcohol | 4.0816 | 4 | yes |
GO:0016579 | protein deubiquitination | 3.4014 | 8 | yes |
GO:0045471 | response to ethanol | 3.4014 | 5 | yes |
GO:0006302 | double-strand break repair | 2.7211 | 6 | yes |
GO:0006303 | double-strand break repair via nonhomologous end joining | 2.0408 | 7 | yes |
GO:0006310 | DNA recombination | 2.0408 | 6 | yes |
GO:0000724 | double-strand break repair via homologous recombination | 1.3605 | 7 | yes |
GO:0000725 | recombinational repair | 1.3605 | 6 | yes |
GO:0070536 | protein K63-linked deubiquitination | 1.3605 | 9 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
DDI2_HUMAN | [view interactions] | Low throughput | no | no |
UB2V1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ID1_HUMAN | [view interactions] | Low throughput | no | yes |
LPPRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ADRM1_HUMAN | [view interactions] | Low throughput | no | yes |
PSMD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PSB5_HUMAN | [view interactions] | Low throughput | no | yes |
PRS6B_HUMAN | [view interactions] | Low throughput | no | yes |
TXNL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRS8_HUMAN | [view interactions] | Low throughput | no | yes |
PSA1_HUMAN | [view interactions] | Low throughput | no | yes |
PSMD4_HUMAN | [view interactions] | Low throughput | no | yes |
PSB4_HUMAN | [view interactions] | Low throughput | no | yes |
PSA6_HUMAN | [view interactions] | Low throughput | no | yes |
PSA2_HUMAN | [view interactions] | Low throughput | no | yes |
IKKE_HUMAN | [view interactions] | Low throughput | no | yes |
MITF_HUMAN | [view interactions] | Low throughput | no | no |
UBE3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PSME1_HUMAN | [view interactions] | Low throughput | no | yes |
UBE3C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
E2F1_HUMAN | [view interactions] | Low throughput | no | yes |
SGTA_HUMAN | [view interactions] | Low throughput | no | yes |
BAG6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SNAI1_HUMAN | [view interactions] | Low throughput | no | yes |
TGFR2_HUMAN | [view interactions] | Low throughput | no | no |
TGFR1_HUMAN | [view interactions] | Low throughput | no | no |
ACVR1_HUMAN | [view interactions] | Low throughput | no | yes |
BMR1A_HUMAN | [view interactions] | Low throughput | no | no |
AVR2B_HUMAN | [view interactions] | Low throughput | no | no |
IRF3_HUMAN | [view interactions] | Low throughput | no | yes |
MAVS_HUMAN | [view interactions] | Low throughput | no | yes |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FZR1_HUMAN | [view interactions] | High throughput | no | no |
RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WDR5_HUMAN | [view interactions] | High throughput | no | no |
F262_HUMAN | [view interactions] | High throughput | no | no |
TMM31_HUMAN | [view interactions] | High throughput | no | no |
MVP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CC74A_HUMAN | [view interactions] | High throughput | no | no |
PTBP1_HUMAN | [view interactions] | High throughput | no | no |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
5NTC_HUMAN | [view interactions] | High throughput | no | yes |
MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ISG15_HUMAN | [view interactions] | High throughput | no | no |
DCD_HUMAN | [view interactions] | High throughput | no | no |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHX15_HUMAN | [view interactions] | High throughput | no | yes |
SRSF6_HUMAN | [view interactions] | High throughput | no | yes |
RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
FAF2_HUMAN | [view interactions] | High throughput | no | yes |
SAFB2_HUMAN | [view interactions] | High throughput | no | yes |
SF3A2_HUMAN | [view interactions] | High throughput | no | yes |
HPS3_HUMAN | [view interactions] | High throughput | no | yes |
RS15A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RINI_HUMAN | [view interactions] | High throughput | no | yes |
TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPM1B_HUMAN | [view interactions] | High throughput | no | yes |
CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASPC1_HUMAN | [view interactions] | High throughput | no | yes |
TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BUB3_HUMAN | [view interactions] | High throughput | no | yes |
UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDB1_HUMAN | [view interactions] | High throughput | no | yes |
EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPB2_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPH3L_HUMAN | [view interactions] | High throughput | no | no |
UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
MAGI1_HUMAN | [view interactions] | High throughput | no | no |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INY2B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STXB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYPT2_HUMAN | [view interactions] | High throughput | no | no |
HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IGSF3_HUMAN | [view interactions] | High throughput | no | yes |
GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RMP_HUMAN | [view interactions] | High throughput | no | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MTCL2_HUMAN | [view interactions] | High throughput | no | yes |
CH10_HUMAN | [view interactions] | High throughput | no | yes |
CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H2B1J_HUMAN | [view interactions] | High throughput | no | yes |
BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
H2B1L_HUMAN | [view interactions] | High throughput | no | yes |
RITA1_HUMAN | [view interactions] | High throughput | no | yes |
H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
H2B1O_HUMAN | [view interactions] | High throughput | no | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
H2B2F_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
H2B1A_HUMAN | [view interactions] | High throughput | no | no |
STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H2B1K_HUMAN | [view interactions] | High throughput | no | yes |
H2B1N_HUMAN | [view interactions] | High throughput | no | yes |
DDI1_HUMAN | [view interactions] | High throughput | no | no |
H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
MOB3C_HUMAN | [view interactions] | High throughput | no | no |
H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
EZH2_HUMAN | [view interactions] | High throughput | no | no |
H2B1M_HUMAN | [view interactions] | High throughput | no | yes |
MIDN_HUMAN | [view interactions] | High throughput | no | no |
KIT_HUMAN | [view interactions] | High throughput | no | no |
GOLI_HUMAN | [view interactions] | High throughput | no | yes |
GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XCR1_HUMAN | [view interactions] | High throughput | no | no |
PML_HUMAN | [view interactions] | High throughput | no | yes |
CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
LSS_HUMAN | [view interactions] | High throughput | no | yes |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPPL3_HUMAN | [view interactions] | High throughput | no | no |
PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSMA8_HUMAN | [view interactions] | High throughput | no | no |
SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H11_HUMAN | [view interactions] | High throughput | no | no |
AHNK2_HUMAN | [view interactions] | High throughput | no | yes |
H12_HUMAN | [view interactions] | High throughput | no | yes |
CSN6_HUMAN | [view interactions] | High throughput | no | yes |
H14_HUMAN | [view interactions] | High throughput | no | yes |
MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
H15_HUMAN | [view interactions] | High throughput | no | no |
MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H13_HUMAN | [view interactions] | High throughput | no | no |
NLRP9_HUMAN | [view interactions] | High throughput | no | no |
SOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRP8_HUMAN | [view interactions] | High throughput | no | yes |
DHX9_HUMAN | [view interactions] | High throughput | no | yes |
PSB8_HUMAN | [view interactions] | High throughput | no | yes |
GOGA3_HUMAN | [view interactions] | High throughput | no | yes |
APOB_HUMAN | [view interactions] | High throughput | no | no |
NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
PDIA5_HUMAN | [view interactions] | High throughput | no | yes |
ALKB1_HUMAN | [view interactions] | High throughput | no | yes |
SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
SF3B4_HUMAN | [view interactions] | High throughput | no | yes |
THIO_HUMAN | [view interactions] | High throughput | no | yes |
DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYCC_HUMAN | [view interactions] | High throughput | no | yes |
IF2G_HUMAN | [view interactions] | High throughput | no | yes |
CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI60_HUMAN | [view interactions] | High throughput | no | no |
NAA20_HUMAN | [view interactions] | High throughput | no | no |
ARI4B_HUMAN | [view interactions] | High throughput | no | yes |
PPCE_HUMAN | [view interactions] | High throughput | no | yes |
ODR4_HUMAN | [view interactions] | High throughput | no | yes |
BABA1_HUMAN | [view interactions] | High throughput | no | yes |
KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
FMN1_HUMAN | [view interactions] | High throughput | no | no |
SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSMD5_HUMAN | [view interactions] | High throughput | no | yes |
VASN_HUMAN | [view interactions] | High throughput | no | yes |
IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
IQCE_HUMAN | [view interactions] | High throughput | no | yes |
PLST_HUMAN | [view interactions] | High throughput | no | yes |
SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INT5_HUMAN | [view interactions] | High throughput | no | no |
MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PSD12_HUMAN | [view interactions] | High throughput | no | yes |
RSBNL_HUMAN | [view interactions] | High throughput | no | yes |
KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
REX1B_HUMAN | [view interactions] | High throughput | no | no |
CC174_HUMAN | [view interactions] | High throughput | no | yes |
ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCTL_HUMAN | [view interactions] | High throughput | no | no |
RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DJC14_HUMAN | [view interactions] | High throughput | no | yes |
IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
ILF2_HUMAN | [view interactions] | High throughput | no | yes |
PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
GRASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ILF3_HUMAN | [view interactions] | High throughput | no | yes |
PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
KIF27_HUMAN | [view interactions] | High throughput | no | no |
STK4_HUMAN | [view interactions] | High throughput | no | yes |
PRS7_HUMAN | [view interactions] | High throughput | no | yes |
PLDX1_HUMAN | [view interactions] | High throughput | no | no |
CDC37_HUMAN | [view interactions] | High throughput | no | yes |
PSD10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PASD1_HUMAN | [view interactions] | High throughput | no | no |
LARP1_HUMAN | [view interactions] | High throughput | no | yes |
PSMD8_HUMAN | [view interactions] | High throughput | no | yes |
MILK2_HUMAN | [view interactions] | High throughput | no | no |
UB2Q1_HUMAN | [view interactions] | High throughput | no | no |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ULK2_HUMAN | [view interactions] | High throughput | no | yes |
PYRG2_HUMAN | [view interactions] | High throughput | no | yes |
HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
PUSL1_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG18_HUMAN | [view interactions] | High throughput | no | yes |
STING_HUMAN | [view interactions] | High throughput | no | yes |
CMYA5_HUMAN | [view interactions] | High throughput | no | no |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
SVOP_HUMAN | [view interactions] | High throughput | no | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PRS10_HUMAN | [view interactions] | High throughput | no | yes |
YJEN3_HUMAN | [view interactions] | High throughput | no | yes |
KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
SERB1_HUMAN | [view interactions] | High throughput | no | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAI3_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
O2T29_HUMAN | [view interactions] | High throughput | no | no |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
OR2T5_HUMAN | [view interactions] | High throughput | no | no |
NCOA4_HUMAN | [view interactions] | High throughput | no | no |
CHD6_HUMAN | [view interactions] | High throughput | no | no |
GIPC2_HUMAN | [view interactions] | High throughput | no | yes |
TGFA1_HUMAN | [view interactions] | High throughput | no | no |
GSLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSA5_HUMAN | [view interactions] | High throughput | no | yes |
UTP4_HUMAN | [view interactions] | High throughput | no | yes |
PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COA7_HUMAN | [view interactions] | High throughput | no | yes |
PSD13_HUMAN | [view interactions] | High throughput | no | yes |
MEP50_HUMAN | [view interactions] | High throughput | no | yes |
AFG2A_HUMAN | [view interactions] | High throughput | no | yes |
SPNDC_HUMAN | [view interactions] | High throughput | no | yes |
SPAT9_HUMAN | [view interactions] | High throughput | no | yes |
PSB9_HUMAN | [view interactions] | High throughput | no | no |
PC11X_HUMAN | [view interactions] | High throughput | no | yes |
PSB3_HUMAN | [view interactions] | High throughput | no | yes |
PC11Y_HUMAN | [view interactions] | High throughput | no | no |
CCD92_HUMAN | [view interactions] | High throughput | no | yes |
CRNL1_HUMAN | [view interactions] | High throughput | no | no |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
GPTC2_HUMAN | [view interactions] | High throughput | no | yes |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
ZMYM2_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
BMS1_HUMAN | [view interactions] | High throughput | no | yes |
PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR1H4_HUMAN | [view interactions] | High throughput | no | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VSIG4_HUMAN | [view interactions] | High throughput | no | no |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMC2_HUMAN | [view interactions] | High throughput | no | no |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHD1_HUMAN | [view interactions] | High throughput | no | no |
MCM9_HUMAN | [view interactions] | High throughput | no | yes |
PCLO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MOT11_HUMAN | [view interactions] | High throughput | no | no |
FANCJ_HUMAN | [view interactions] | High throughput | no | yes |
UBCP1_HUMAN | [view interactions] | High throughput | no | yes |
HERC1_HUMAN | [view interactions] | High throughput | no | no |
HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KRI1_HUMAN | [view interactions] | High throughput | no | yes |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
SETX_HUMAN | [view interactions] | High throughput | no | yes |
RD23B_HUMAN | [view interactions] | High throughput | no | yes |
CARD9_HUMAN | [view interactions] | High throughput | no | no |
P2RY6_HUMAN | [view interactions] | High throughput | no | no |
WASC4_HUMAN | [view interactions] | High throughput | no | yes |
AMFR_HUMAN | [view interactions] | High throughput | no | yes |
FSIP1_HUMAN | [view interactions] | High throughput | no | no |
BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
B2L14_HUMAN | [view interactions] | High throughput | no | yes |
LIMK2_HUMAN | [view interactions] | High throughput | no | yes |
DDX47_HUMAN | [view interactions] | High throughput | no | yes |
KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COG6_HUMAN | [view interactions] | High throughput | no | yes |
SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
RGS22_HUMAN | [view interactions] | High throughput | no | no |
NEK7_HUMAN | [view interactions] | High throughput | no | yes |
M3K14_HUMAN | [view interactions] | High throughput | no | yes |
AURKB_HUMAN | [view interactions] | High throughput | no | yes |
TTF1_HUMAN | [view interactions] | High throughput | no | yes |
NRBP2_HUMAN | [view interactions] | High throughput | no | yes |
CCD47_HUMAN | [view interactions] | High throughput | no | yes |
SG196_HUMAN | [view interactions] | High throughput | no | yes |
RMC1_HUMAN | [view interactions] | High throughput | no | no |
PSA3_HUMAN | [view interactions] | High throughput | no | no |
ASAP3_HUMAN | [view interactions] | High throughput | no | yes |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYH10_HUMAN | [view interactions] | High throughput | no | no |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P63_HUMAN | [view interactions] | High throughput | no | no |
TBB1_HUMAN | [view interactions] | High throughput | no | yes |
TTHY_HUMAN | [view interactions] | High throughput | no | no |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DX39B_HUMAN | [view interactions] | High throughput | no | no |
PSME4_HUMAN | [view interactions] | High throughput | no | yes |
RP1_HUMAN | [view interactions] | High throughput | no | no |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRY1_HUMAN | [view interactions] | High throughput | no | no |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMPSD_HUMAN | [view interactions] | High throughput | no | no |
ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSB1_HUMAN | [view interactions] | High throughput | no | yes |
INADL_HUMAN | [view interactions] | High throughput | no | no |
PSB2_HUMAN | [view interactions] | High throughput | no | yes |
MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSA7_HUMAN | [view interactions] | High throughput | no | yes |
LIFR_HUMAN | [view interactions] | High throughput | no | no |
PSB7_HUMAN | [view interactions] | High throughput | no | yes |
ZNF26_HUMAN | [view interactions] | High throughput | no | yes |
HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYTL1_HUMAN | [view interactions] | High throughput | no | yes |
PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TP4AP_HUMAN | [view interactions] | High throughput | no | yes |
KLF16_HUMAN | [view interactions] | High throughput | no | yes |
RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KLF8_HUMAN | [view interactions] | High throughput | no | no |
EIF3L_HUMAN | [view interactions] | High throughput | no | yes |
CRCM_HUMAN | [view interactions] | High throughput | no | no |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHRM3_HUMAN | [view interactions] | High throughput | no | yes |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
KHDR3_HUMAN | [view interactions] | High throughput | no | yes |
PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
PAAF1_HUMAN | [view interactions] | High throughput | no | yes |
KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
RO52_HUMAN | [view interactions] | High throughput | no | yes |
KHDR2_HUMAN | [view interactions] | High throughput | no | yes |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
RPP30_HUMAN | [view interactions] | High throughput | no | yes |
LITD1_HUMAN | [view interactions] | High throughput | no | no |
RTCB_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
CAVN1_HUMAN | [view interactions] | High throughput | no | no |
OLIG1_HUMAN | [view interactions] | High throughput | no | no |
SESQ1_HUMAN | [view interactions] | High throughput | no | no |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
FAM9B_HUMAN | [view interactions] | High throughput | no | no |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DPY30_HUMAN | [view interactions] | High throughput | no | yes |
EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHB2_HUMAN | [view interactions] | High throughput | no | yes |
PRP31_HUMAN | [view interactions] | High throughput | no | yes |
RB15B_HUMAN | [view interactions] | High throughput | no | yes |
SYRC_HUMAN | [view interactions] | High throughput | no | yes |
BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
ARG39_HUMAN | [view interactions] | High throughput | no | yes |
ABRX2_HUMAN | [view interactions] | High throughput | no | yes |
GRM2A_HUMAN | [view interactions] | High throughput | no | no |
EHMT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPARD_HUMAN | [view interactions] | High throughput | no | yes |
LMBL1_HUMAN | [view interactions] | High throughput | no | no |
DOXA1_HUMAN | [view interactions] | High throughput | no | yes |
CERS2_HUMAN | [view interactions] | High throughput | no | no |
DEP1A_HUMAN | [view interactions] | High throughput | no | yes |
NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
TAB1_HUMAN | [view interactions] | High throughput | no | yes |
OFD1_HUMAN | [view interactions] | High throughput | no | yes |
PCBP4_HUMAN | [view interactions] | High throughput | no | no |
DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRIG3_HUMAN | [view interactions] | High throughput | no | yes |
MKS3_HUMAN | [view interactions] | High throughput | no | no |
MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
TLR9_HUMAN | [view interactions] | High throughput | no | no |
POC5_HUMAN | [view interactions] | High throughput | no | yes |
DEN5B_HUMAN | [view interactions] | High throughput | no | yes |
TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNE2_HUMAN | [view interactions] | High throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CENPE_HUMAN | [view interactions] | High throughput | no | no |
INSI2_HUMAN | [view interactions] | High throughput | no | yes |
DYH5_HUMAN | [view interactions] | High throughput | no | no |
PCKGC_HUMAN | [view interactions] | High throughput | no | no |
CEP85_HUMAN | [view interactions] | High throughput | no | no |
NOSTN_HUMAN | [view interactions] | High throughput | no | yes |
ZFN2A_HUMAN | [view interactions] | High throughput | no | yes |
SPT6H_HUMAN | [view interactions] | High throughput | no | yes |
RD23A_HUMAN | [view interactions] | High throughput | no | yes |
ZC12B_HUMAN | [view interactions] | High throughput | no | no |
FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NOS2_HUMAN | [view interactions] | High throughput | no | yes |
KIZ_HUMAN | [view interactions] | High throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDZD7_HUMAN | [view interactions] | High throughput | no | no |
RNF11_HUMAN | [view interactions] | High throughput | no | yes |
CASPA_HUMAN | [view interactions] | High throughput | no | yes |
SH321_HUMAN | [view interactions] | High throughput | no | yes |
PSME3_HUMAN | [view interactions] | High throughput | no | yes |
LIPB2_HUMAN | [view interactions] | High throughput | no | yes |
PSME2_HUMAN | [view interactions] | High throughput | no | no |
KNL1_HUMAN | [view interactions] | High throughput | no | no |
MFF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
SPAG5_HUMAN | [view interactions] | High throughput | no | yes |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BBOF1_HUMAN | [view interactions] | High throughput | no | no |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
DGKQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VP13D_HUMAN | [view interactions] | High throughput | no | no |
ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
GUF1_HUMAN | [view interactions] | High throughput | no | yes |
CC74B_HUMAN | [view interactions] | High throughput | no | no |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHD3_HUMAN | [view interactions] | High throughput | no | yes |
DRC8_HUMAN | [view interactions] | High throughput | no | yes |
IPP_HUMAN | [view interactions] | High throughput | no | yes |
TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN2_HUMAN | [view interactions] | High throughput | no | yes |
FILA_HUMAN | [view interactions] | High throughput | no | no |
ELOB_HUMAN | [view interactions] | High throughput | no | no |
TRI18_HUMAN | [view interactions] | High throughput | no | no |
SPAG7_HUMAN | [view interactions] | High throughput | no | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
LMBL4_HUMAN | [view interactions] | High throughput | no | no |
RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
NAR4_HUMAN | [view interactions] | High throughput | no | no |
BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
DHC24_HUMAN | [view interactions] | High throughput | no | yes |
PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
V1AR_HUMAN | [view interactions] | High throughput | no | no |
ZN598_HUMAN | [view interactions] | High throughput | no | no |
DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPGF4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDX24_HUMAN | [view interactions] | High throughput | no | yes |
GET3_HUMAN | [view interactions] | High throughput | no | yes |
KIF11_HUMAN | [view interactions] | High throughput | no | yes |
UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
ECM29_HUMAN | [view interactions] | High throughput | no | no |
SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GET4_HUMAN | [view interactions] | High throughput | no | yes |
PCNT_HUMAN | [view interactions] | High throughput | no | yes |
FGF11_HUMAN | [view interactions] | High throughput | no | no |
ICE2_HUMAN | [view interactions] | High throughput | no | no |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
I12R1_HUMAN | [view interactions] | High throughput | no | no |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
MANEA_HUMAN | [view interactions] | High throughput | no | yes |
AL1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
EYA3_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
NFX1_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
ATX3_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
NUCL_HUMAN | [view interactions] | High throughput | no | yes |
ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANDR_HUMAN | [view interactions] | High throughput | no | no |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
MAF_HUMAN | [view interactions] | High throughput | no | yes |
TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
SYDC_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALBU_HUMAN | [view interactions] | High throughput | no | no |
TOP1_HUMAN | [view interactions] | High throughput | no | yes |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOP2A_HUMAN | [view interactions] | High throughput | no | no |