EHMT2_HUMAN
Evidence for PS localization
Functions
Histone methyltransferase that specifically mono- and dimethylates Lys-9 of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of Lys-56 of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates Lys-27 of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of Lys-373 of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EHMT2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 32.3529 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 32.3529 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.3529 | 4 | no |
| GO:0003723 | RNA binding | 29.4118 | 4 | no |
| GO:0046872 | metal ion binding | 26.4706 | 4 | yes |
| GO:0005524 | ATP binding | 26.4706 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 26.4706 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.4706 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 20.5882 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.5882 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.5882 | 6 | no |
| GO:0003677 | DNA binding | 14.7059 | 4 | yes |
| GO:0001221 | transcription coregulator binding | 11.7647 | 4 | yes |
| GO:0003690 | double-stranded DNA binding | 11.7647 | 5 | yes |
| GO:0000976 | transcription cis-regulatory region binding | 8.8235 | 5 | yes |
| GO:0001067 | transcription regulatory region nucleic acid binding | 8.8235 | 4 | yes |
| GO:0001222 | transcription corepressor binding | 8.8235 | 5 | yes |
| GO:0043565 | sequence-specific DNA binding | 8.8235 | 5 | yes |
| GO:1990837 | sequence-specific double-stranded DNA binding | 8.8235 | 6 | yes |
| GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 5.8824 | 6 | yes |
| GO:0008168 | methyltransferase activity | 5.8824 | 4 | yes |
| GO:0008170 | N-methyltransferase activity | 5.8824 | 5 | yes |
| GO:0008270 | zinc ion binding | 5.8824 | 6 | yes |
| GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity | 5.8824 | 5 | yes |
| GO:0016278 | lysine N-methyltransferase activity | 5.8824 | 6 | yes |
| GO:0016279 | protein-lysine N-methyltransferase activity | 5.8824 | 4 | yes |
| GO:0018024 | histone-lysine N-methyltransferase activity | 5.8824 | 5 | yes |
| GO:0042054 | histone methyltransferase activity | 5.8824 | 4 | yes |
| GO:0046914 | transition metal ion binding | 5.8824 | 5 | yes |
| GO:0046974 | histone methyltransferase activity (H3-K9 specific) | 5.8824 | 6 | yes |
| GO:0046976 | histone methyltransferase activity (H3-K27 specific) | 5.8824 | 6 | yes |
| GO:0070742 | C2H2 zinc finger domain binding | 5.8824 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EHMT2_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 70.5882 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 67.6471 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 67.6471 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 67.6471 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 64.7059 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 52.9412 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 47.0588 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 47.0588 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.0588 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 44.1176 | 5 | no |
| GO:0010468 | regulation of gene expression | 44.1176 | 5 | yes |
| GO:0010646 | regulation of cell communication | 41.1765 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.1765 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 41.1765 | 5 | yes |
| GO:0043412 | macromolecule modification | 41.1765 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 38.2353 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 38.2353 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.2353 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 38.2353 | 5 | yes |
| GO:0036211 | protein modification process | 38.2353 | 4 | yes |
| GO:0006996 | organelle organization | 35.2941 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 35.2941 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 35.2941 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.2941 | 5 | yes |
| GO:0022607 | cellular component assembly | 35.2941 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 32.3529 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.4118 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 29.4118 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.4118 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.4706 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 26.4706 | 4 | yes |
| GO:0008104 | protein localization | 26.4706 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.4706 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 26.4706 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 23.5294 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 23.5294 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.5294 | 6 | no |
| GO:0010941 | regulation of cell death | 23.5294 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.5294 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 23.5294 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.5294 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.5294 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.5294 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.5294 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 23.5294 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.5882 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 20.5882 | 6 | yes |
| GO:0006468 | protein phosphorylation | 20.5882 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.5882 | 4 | no |
| GO:0016310 | phosphorylation | 20.5882 | 5 | no |
| GO:0071702 | organic substance transport | 20.5882 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.5882 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 20.5882 | 5 | no |
| GO:0042176 | regulation of protein catabolic process | 20.5882 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.5882 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.5882 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.5882 | 6 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 20.5882 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.5882 | 6 | yes |
| GO:0018193 | peptidyl-amino acid modification | 20.5882 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.5882 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 20.5882 | 4 | yes |
| GO:0051052 | regulation of DNA metabolic process | 20.5882 | 5 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 17.6471 | 6 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 17.6471 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 14.7059 | 5 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 14.7059 | 7 | yes |
| GO:1903507 | negative regulation of nucleic acid-templated transcription | 14.7059 | 8 | yes |
| GO:0006259 | DNA metabolic process | 14.7059 | 4 | yes |
| GO:0009895 | negative regulation of catabolic process | 14.7059 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 14.7059 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 14.7059 | 4 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 14.7059 | 7 | yes |
| GO:0051276 | chromosome organization | 11.7647 | 5 | yes |
| GO:0097305 | response to alcohol | 11.7647 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 11.7647 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 11.7647 | 4 | yes |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 11.7647 | 8 | yes |
| GO:0006325 | chromatin organization | 11.7647 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 11.7647 | 7 | yes |
| GO:0010639 | negative regulation of organelle organization | 11.7647 | 6 | yes |
| GO:0031056 | regulation of histone modification | 11.7647 | 7 | yes |
| GO:0031330 | negative regulation of cellular catabolic process | 11.7647 | 6 | yes |
| GO:0031667 | response to nutrient levels | 11.7647 | 4 | yes |
| GO:0051570 | regulation of histone H3-K9 methylation | 8.8235 | 6 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 8.8235 | 5 | yes |
| GO:0006304 | DNA modification | 8.8235 | 5 | yes |
| GO:0006305 | DNA alkylation | 8.8235 | 6 | yes |
| GO:0006306 | DNA methylation | 8.8235 | 4 | yes |
| GO:0010506 | regulation of autophagy | 8.8235 | 6 | yes |
| GO:0016241 | regulation of macroautophagy | 8.8235 | 7 | yes |
| GO:0031060 | regulation of histone methylation | 8.8235 | 5 | yes |
| GO:0031669 | cellular response to nutrient levels | 8.8235 | 4 | yes |
| GO:0044728 | DNA methylation or demethylation | 8.8235 | 6 | yes |
| GO:0045471 | response to ethanol | 8.8235 | 5 | yes |
| GO:0050890 | cognition | 8.8235 | 4 | yes |
| GO:0051569 | regulation of histone H3-K4 methylation | 5.8824 | 6 | yes |
| GO:0060992 | response to fungicide | 5.8824 | 4 | yes |
| GO:0070193 | synaptonemal complex organization | 5.8824 | 6 | yes |
| GO:0071312 | cellular response to alkaloid | 5.8824 | 5 | yes |
| GO:0071314 | cellular response to cocaine | 5.8824 | 5 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 5.8824 | 4 | yes |
| GO:0071466 | cellular response to xenobiotic stimulus | 5.8824 | 4 | yes |
| GO:1902115 | regulation of organelle assembly | 5.8824 | 5 | yes |
| GO:1902116 | negative regulation of organelle assembly | 5.8824 | 6 | yes |
| GO:1902902 | negative regulation of autophagosome assembly | 5.8824 | 7 | yes |
| GO:2000785 | regulation of autophagosome assembly | 5.8824 | 6 | yes |
| GO:0006275 | regulation of DNA replication | 5.8824 | 6 | yes |
| GO:0006479 | protein methylation | 5.8824 | 4 | yes |
| GO:0007130 | synaptonemal complex assembly | 5.8824 | 4 | yes |
| GO:0007286 | spermatid development | 5.8824 | 4 | yes |
| GO:0007613 | memory | 5.8824 | 4 | yes |
| GO:0007616 | long-term memory | 5.8824 | 5 | yes |
| GO:0008213 | protein alkylation | 5.8824 | 5 | yes |
| GO:0009267 | cellular response to starvation | 5.8824 | 4 | yes |
| GO:0010424 | DNA methylation on cytosine within a CG sequence | 5.8824 | 6 | yes |
| GO:0010507 | negative regulation of autophagy | 5.8824 | 7 | yes |
| GO:0016242 | negative regulation of macroautophagy | 5.8824 | 8 | yes |
| GO:0016570 | histone modification | 5.8824 | 5 | yes |
| GO:0016571 | histone methylation | 5.8824 | 5 | yes |
| GO:0018022 | peptidyl-lysine methylation | 5.8824 | 5 | yes |
| GO:0018027 | peptidyl-lysine dimethylation | 5.8824 | 6 | yes |
| GO:0018205 | peptidyl-lysine modification | 5.8824 | 6 | yes |
| GO:0032776 | DNA methylation on cytosine | 5.8824 | 5 | yes |
| GO:0034968 | histone lysine methylation | 5.8824 | 6 | yes |
| GO:0042220 | response to cocaine | 5.8824 | 4 | yes |
| GO:0043279 | response to alkaloid | 5.8824 | 5 | yes |
| GO:0044030 | regulation of DNA methylation | 5.8824 | 6 | yes |
| GO:0044088 | regulation of vacuole organization | 5.8824 | 6 | yes |
| GO:0048148 | behavioral response to cocaine | 5.8824 | 4 | yes |
| GO:0048665 | neuron fate specification | 5.8824 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in EHMT2_HUMAN |
|---|---|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | 5.8824 | 6 | no |
| DOID:114 | heart disease | 5.8824 | 3 | no |
| DOID:440 | neuromuscular disease | 5.8824 | 5 | no |
| DOID:574 | peripheral nervous system disease | 5.8824 | 3 | no |
| DOID:65 | connective tissue disease | 5.8824 | 3 | no |
| DOID:870 | neuropathy | 5.8824 | 4 | no |
| DOID:700 | mitochondrial metabolism disease | 5.8824 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PRDM1_HUMAN | [view interactions] | Low throughput | no | yes |
| JARD2_HUMAN | [view interactions] | Low throughput | no | yes |
| ZN217_HUMAN | [view interactions] | Low throughput | no | yes |
| UHRF1_HUMAN | [view interactions] | Low throughput | no | yes |
| BAF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTBP2_HUMAN | [view interactions] | Low throughput | no | no |
| DNMT1_HUMAN | [view interactions] | Low throughput | no | no |
| MED12_HUMAN | [view interactions] | Low throughput | no | yes |
| CEBPB_HUMAN | [view interactions] | Low throughput | no | no |
| MECOM_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ESCO2_HUMAN | [view interactions] | Low throughput | no | no |
| RUVB2_HUMAN | [view interactions] | Low throughput | no | yes |
| ESCO1_HUMAN | [view interactions] | Low throughput | no | yes |
| NR0B2_HUMAN | [view interactions] | Low throughput | no | no |
| UHRF2_HUMAN | [view interactions] | Low throughput | no | no |
| PML_HUMAN | [view interactions] | Low throughput | no | yes |
| LASP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EHMT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | Low throughput | no | yes |
| RFA2_HUMAN | [view interactions] | Low throughput | no | yes |
| FOXO1_HUMAN | [view interactions] | Low throughput | no | yes |
| BRE1A_HUMAN | [view interactions] | Low throughput | no | yes |
| RERE_HUMAN | [view interactions] | Low throughput | no | yes |
| GFI1_HUMAN | [view interactions] | Low throughput | no | yes |
| PRDM5_HUMAN | [view interactions] | Low throughput | no | yes |
| CBX5_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | Low throughput | no | no |
| KAT2B_HUMAN | [view interactions] | Low throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | Low throughput | no | yes |
| EHMT1_HUMAN | [view interactions] | Low throughput | no | yes |
| WIZ_HUMAN | [view interactions] | Low throughput | no | yes |
| CHD4_HUMAN | [view interactions] | Low throughput | no | yes |
| RELB_HUMAN | [view interactions] | Low throughput | no | yes |
| DNM3L_HUMAN | [view interactions] | Low throughput | no | yes |
| H14_HUMAN | [view interactions] | Low throughput | no | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| NCOA2_HUMAN | [view interactions] | Low throughput | no | no |
| H32_HUMAN | [view interactions] | Low throughput | no | yes |
| DNM3A_HUMAN | [view interactions] | Low throughput | no | yes |
| H11_HUMAN | [view interactions] | Low throughput | no | no |
| SETB1_HUMAN | [view interactions] | Low throughput | no | yes |
| DNLI1_HUMAN | [view interactions] | Low throughput | no | yes |
| SUV91_HUMAN | [view interactions] | Low throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NKX31_HUMAN | [view interactions] | Low throughput | no | no |
| ACSM3_HUMAN | [view interactions] | Low throughput | no | yes |
| HXA9_HUMAN | [view interactions] | Low throughput | no | yes |
| RAD51_HUMAN | [view interactions] | Low throughput | no | yes |
| CDC73_HUMAN | [view interactions] | Low throughput | no | yes |
| DNM3B_HUMAN | [view interactions] | Low throughput | no | yes |
| GFI1B_HUMAN | [view interactions] | Low throughput | no | no |
| CDYL_HUMAN | [view interactions] | Low throughput | no | yes |
| REST_HUMAN | [view interactions] | Low throughput | no | yes |
| CHD1_HUMAN | [view interactions] | Low throughput | no | yes |
| H33_HUMAN | [view interactions] | Low throughput | no | yes |
| CBX1_HUMAN | [view interactions] | Low throughput | no | yes |
| CBX3_HUMAN | [view interactions] | Low throughput | no | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| LHX3_HUMAN | [view interactions] | High throughput | no | no |
| LHX4_HUMAN | [view interactions] | High throughput | no | no |
| MYB_HUMAN | [view interactions] | High throughput | no | yes |
| MYOD1_HUMAN | [view interactions] | High throughput | no | no |
| NFIC_HUMAN | [view interactions] | High throughput | no | yes |
| NFIX_HUMAN | [view interactions] | High throughput | no | yes |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| PAX9_HUMAN | [view interactions] | High throughput | no | no |
| SOX15_HUMAN | [view interactions] | High throughput | no | no |
| SOX17_HUMAN | [view interactions] | High throughput | no | no |
| SP7_HUMAN | [view interactions] | High throughput | no | no |
| TEAD1_HUMAN | [view interactions] | High throughput | no | no |
| TLX1_HUMAN | [view interactions] | High throughput | no | no |
| TLX2_HUMAN | [view interactions] | High throughput | no | no |
| TLX3_HUMAN | [view interactions] | High throughput | no | no |
| TYY1_HUMAN | [view interactions] | High throughput | no | yes |
| VSX1_HUMAN | [view interactions] | High throughput | no | no |
| E4F1_HUMAN | [view interactions] | High throughput | no | yes |
| Z512B_HUMAN | [view interactions] | High throughput | no | yes |
| ITB5_HUMAN | [view interactions] | High throughput | no | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| F161A_HUMAN | [view interactions] | High throughput | no | no |
| PNCB_HUMAN | [view interactions] | High throughput | no | no |
| ZN785_HUMAN | [view interactions] | High throughput | no | no |
| ZBT38_HUMAN | [view interactions] | High throughput | no | no |
| ZN688_HUMAN | [view interactions] | High throughput | no | yes |
| ZN446_HUMAN | [view interactions] | High throughput | no | yes |
| MCAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| MAZ_HUMAN | [view interactions] | High throughput | no | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS7_HUMAN | [view interactions] | High throughput | no | yes |
| ESS2_HUMAN | [view interactions] | High throughput | no | yes |
| MED30_HUMAN | [view interactions] | High throughput | no | no |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| CDK8_HUMAN | [view interactions] | High throughput | no | no |
| MED6_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1B_HUMAN | [view interactions] | High throughput | no | yes |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| SMRCD_HUMAN | [view interactions] | High throughput | no | yes |
| TFAP4_HUMAN | [view interactions] | High throughput | no | yes |
| LMBL2_HUMAN | [view interactions] | High throughput | no | no |
| CTNA3_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| SUV92_HUMAN | [view interactions] | High throughput | no | no |
| LHX6_HUMAN | [view interactions] | High throughput | no | yes |
| MIER2_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1A_HUMAN | [view interactions] | High throughput | no | no |
| ZBT46_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XAGE3_HUMAN | [view interactions] | High throughput | no | no |
| LMBL1_HUMAN | [view interactions] | High throughput | no | no |
| ZN223_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| ZN211_HUMAN | [view interactions] | High throughput | no | yes |
| CWC15_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| Z518A_HUMAN | [view interactions] | High throughput | no | no |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| MTF2_HUMAN | [view interactions] | High throughput | no | no |
| RTF2_HUMAN | [view interactions] | High throughput | no | yes |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| EZH1_HUMAN | [view interactions] | High throughput | no | yes |
| MK67I_HUMAN | [view interactions] | High throughput | no | yes |
| CDYL2_HUMAN | [view interactions] | High throughput | no | yes |
| CHAP1_HUMAN | [view interactions] | High throughput | no | yes |
| MPP8_HUMAN | [view interactions] | High throughput | no | yes |
| MBTD1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMF1_HUMAN | [view interactions] | High throughput | no | yes |
| I2BPL_HUMAN | [view interactions] | High throughput | no | yes |
| HIRP3_HUMAN | [view interactions] | High throughput | no | no |
| PALLD_HUMAN | [view interactions] | High throughput | no | yes |
| DENR_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| ZBT7A_HUMAN | [view interactions] | High throughput | no | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| H2AZ_HUMAN | [view interactions] | High throughput | no | yes |
| H2AY_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| LRWD1_HUMAN | [view interactions] | High throughput | no | no |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| NSL1_HUMAN | [view interactions] | High throughput | no | no |
| CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
| DSN1_HUMAN | [view interactions] | High throughput | no | yes |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| PMF1_HUMAN | [view interactions] | High throughput | no | no |
| CAF1B_HUMAN | [view interactions] | High throughput | no | no |
| AHDC1_HUMAN | [view interactions] | High throughput | no | yes |
| SCAI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGO1_HUMAN | [view interactions] | High throughput | no | no |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| ADNP2_HUMAN | [view interactions] | High throughput | no | yes |
| GAG2E_HUMAN | [view interactions] | High throughput | no | no |
| H2A1_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPRS_HUMAN | [view interactions] | High throughput | no | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| RGS12_HUMAN | [view interactions] | High throughput | no | no |
| CAC1A_HUMAN | [view interactions] | High throughput | no | no |
| CDY2_HUMAN | [view interactions] | High throughput | no | no |
| AB17A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGE2D_HUMAN | [view interactions] | High throughput | no | no |
| MTA2_HUMAN | [view interactions] | High throughput | no | yes |
| TIG1_HUMAN | [view interactions] | High throughput | no | yes |
| H2B3B_HUMAN | [view interactions] | High throughput | no | yes |
| MIER1_HUMAN | [view interactions] | High throughput | no | no |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TWST2_HUMAN | [view interactions] | High throughput | no | no |
| RFXK_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN764_HUMAN | [view interactions] | High throughput | no | no |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| PPARD_HUMAN | [view interactions] | High throughput | no | yes |
| NANP8_HUMAN | [view interactions] | High throughput | no | no |
| ZN414_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| GATA3_HUMAN | [view interactions] | High throughput | no | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| NOS2_HUMAN | [view interactions] | High throughput | no | yes |
| MTA3_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP1_HUMAN | [view interactions] | High throughput | no | no |
| GT251_HUMAN | [view interactions] | High throughput | no | no |
| NAGK_HUMAN | [view interactions] | High throughput | no | no |
| MTA1_HUMAN | [view interactions] | High throughput | no | yes |
| GPX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLOD3_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT3_HUMAN | [view interactions] | High throughput | no | no |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MBD3_HUMAN | [view interactions] | High throughput | no | yes |
| ZEB2_HUMAN | [view interactions] | High throughput | no | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| CBX4_HUMAN | [view interactions] | High throughput | no | yes |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| FBX38_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC8_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2B_HUMAN | [view interactions] | High throughput | no | no |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| RPA49_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| NFE2_HUMAN | [view interactions] | High throughput | no | no |
| RPB1_HUMAN | [view interactions] | High throughput | no | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VEZF1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN462_HUMAN | [view interactions] | High throughput | no | no |
| KLF3_HUMAN | [view interactions] | High throughput | no | yes |
| NAA11_HUMAN | [view interactions] | High throughput | no | no |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN837_HUMAN | [view interactions] | High throughput | no | no |
| HIC2_HUMAN | [view interactions] | High throughput | no | yes |
| KLF12_HUMAN | [view interactions] | High throughput | no | yes |
| MX2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN775_HUMAN | [view interactions] | High throughput | no | no |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD3_HUMAN | [view interactions] | High throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| LIMS1_HUMAN | [view interactions] | High throughput | no | yes |
| KLF6_HUMAN | [view interactions] | High throughput | no | yes |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| XAGE2_HUMAN | [view interactions] | High throughput | no | no |
| THAP7_HUMAN | [view interactions] | High throughput | no | no |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD33_HUMAN | [view interactions] | High throughput | no | no |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| PE2R4_HUMAN | [view interactions] | High throughput | no | yes |
| ZN644_HUMAN | [view interactions] | High throughput | no | no |
| LACRT_HUMAN | [view interactions] | High throughput | no | no |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYTA_HUMAN | [view interactions] | High throughput | no | no |
| PSB3_HUMAN | [view interactions] | High throughput | no | yes |
| PIP_HUMAN | [view interactions] | High throughput | no | no |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM5C_HUMAN | [view interactions] | High throughput | no | no |
| POGZ_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRPC_HUMAN | [view interactions] | High throughput | no | no |
| MYOM2_HUMAN | [view interactions] | High throughput | no | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| TBXT_HUMAN | [view interactions] | High throughput | no | no |
| ELF2_HUMAN | [view interactions] | High throughput | no | yes |
| ELF4_HUMAN | [view interactions] | High throughput | no | no |
| ELK3_HUMAN | [view interactions] | High throughput | no | yes |
| ETV3_HUMAN | [view interactions] | High throughput | no | yes |
| ETV7_HUMAN | [view interactions] | High throughput | no | no |
| FEV_HUMAN | [view interactions] | High throughput | no | no |
| GATA2_HUMAN | [view interactions] | High throughput | no | yes |
| HEN1_HUMAN | [view interactions] | High throughput | no | no |
| HNF4A_HUMAN | [view interactions] | High throughput | no | no |
| IRF8_HUMAN | [view interactions] | High throughput | no | no |
| KLF15_HUMAN | [view interactions] | High throughput | no | yes |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| KLF5_HUMAN | [view interactions] | High throughput | no | yes |
| KLF8_HUMAN | [view interactions] | High throughput | no | no |
| KLF9_HUMAN | [view interactions] | High throughput | no | no |
| LHX1_HUMAN | [view interactions] | High throughput | no | no |
| LHX2_HUMAN | [view interactions] | High throughput | no | no |