Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGS12_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RGS12_HUMAN
GO:0000166 nucleotide binding 37.5000 4 no
GO:0017076 purine nucleotide binding 37.5000 5 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0043168 anion binding 37.5000 4 no
GO:0003924 GTPase activity 33.3333 7 yes
GO:0016462 pyrophosphatase activity 33.3333 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 33.3333 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 33.3333 6 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0005525 GTP binding 25.0000 5 no
GO:0019001 guanyl nucleotide binding 25.0000 6 no
GO:0032561 guanyl ribonucleotide binding 25.0000 5 no
GO:0030695 GTPase regulator activity 16.6667 4 yes
GO:0005096 GTPase activator activity 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RGS12_HUMAN
GO:0031323 regulation of cellular metabolic process 75.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0080090 regulation of primary metabolic process 62.5000 4 no
GO:0048523 negative regulation of cellular process 62.5000 4 yes
GO:0010646 regulation of cell communication 58.3333 4 yes
GO:0048522 positive regulation of cellular process 54.1667 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 yes
GO:0031399 regulation of protein modification process 45.8333 6 no
GO:0051128 regulation of cellular component organization 45.8333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 45.8333 5 no
GO:0031324 negative regulation of cellular metabolic process 45.8333 5 no
GO:0009889 regulation of biosynthetic process 41.6667 4 no
GO:0010468 regulation of gene expression 41.6667 6 no
GO:0010556 regulation of macromolecule biosynthetic process 41.6667 5 no
GO:0031326 regulation of cellular biosynthetic process 41.6667 5 no
GO:1902531 regulation of intracellular signal transduction 41.6667 5 no
GO:0019220 regulation of phosphate metabolic process 41.6667 6 no
GO:0051174 regulation of phosphorus metabolic process 41.6667 5 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0008104 protein localization 37.5000 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0051338 regulation of transferase activity 29.1667 4 no
GO:0001932 regulation of protein phosphorylation 29.1667 7 no
GO:0006355 regulation of DNA-templated transcription 29.1667 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.1667 5 no
GO:0031325 positive regulation of cellular metabolic process 29.1667 5 no
GO:0033043 regulation of organelle organization 29.1667 5 no
GO:0043408 regulation of MAPK cascade 29.1667 6 no
GO:0045595 regulation of cell differentiation 29.1667 4 no
GO:0051252 regulation of RNA metabolic process 29.1667 5 no
GO:0141124 intracellular signaling cassette 29.1667 4 no
GO:2001141 regulation of RNA biosynthetic process 29.1667 6 no
GO:0006996 organelle organization 29.1667 4 no
GO:0051248 negative regulation of protein metabolic process 29.1667 6 no
GO:0032880 regulation of protein localization 29.1667 5 no
GO:0048585 negative regulation of response to stimulus 29.1667 4 yes
GO:0043549 regulation of kinase activity 29.1667 5 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0051051 negative regulation of transport 25.0000 4 no
GO:0043086 negative regulation of catalytic activity 25.0000 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 25.0000 7 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043066 negative regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0043069 negative regulation of programmed cell death 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 yes
GO:0010648 negative regulation of cell communication 25.0000 5 yes
GO:0023057 negative regulation of signaling 25.0000 4 yes
GO:0000165 MAPK cascade 20.8333 5 no
GO:0006796 phosphate-containing compound metabolic process 20.8333 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 20.8333 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 20.8333 5 no
GO:0009891 positive regulation of biosynthetic process 20.8333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0022603 regulation of anatomical structure morphogenesis 20.8333 4 no
GO:0031328 positive regulation of cellular biosynthetic process 20.8333 6 no
GO:0031344 regulation of cell projection organization 20.8333 5 no
GO:0031401 positive regulation of protein modification process 20.8333 7 no
GO:0043085 positive regulation of catalytic activity 20.8333 4 no
GO:0051094 positive regulation of developmental process 20.8333 4 no
GO:0051240 positive regulation of multicellular organismal process 20.8333 4 no
GO:0051247 positive regulation of protein metabolic process 20.8333 6 no
GO:0060627 regulation of vesicle-mediated transport 20.8333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.8333 6 no
GO:0009890 negative regulation of biosynthetic process 20.8333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0031327 negative regulation of cellular biosynthetic process 20.8333 6 no
GO:0034762 regulation of transmembrane transport 20.8333 4 no
GO:0043269 regulation of monoatomic ion transport 20.8333 5 no
GO:0042127 regulation of cell population proliferation 20.8333 4 no
GO:0010563 negative regulation of phosphorus metabolic process 20.8333 6 no
GO:0010647 positive regulation of cell communication 20.8333 5 no
GO:0023056 positive regulation of signaling 20.8333 4 no
GO:0031400 negative regulation of protein modification process 20.8333 7 no
GO:0045936 negative regulation of phosphate metabolic process 20.8333 7 no
GO:0030334 regulation of cell migration 20.8333 5 no
GO:0048584 positive regulation of response to stimulus 20.8333 4 no
GO:0050776 regulation of immune response 20.8333 4 no
GO:0051493 regulation of cytoskeleton organization 20.8333 6 no
GO:0051726 regulation of cell cycle 20.8333 4 no
GO:0010243 response to organonitrogen compound 20.8333 4 no
GO:0071310 cellular response to organic substance 20.8333 4 no
GO:1901701 cellular response to oxygen-containing compound 20.8333 4 no
GO:0022607 cellular component assembly 20.8333 4 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 20.8333 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLGP3_HUMAN [view entry] [view interactions] Low throughput yes yes
MP2K2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARAF_HUMAN [view interactions] Low throughput no yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
RASN_HUMAN [view entry] [view interactions] Low throughput yes no
BRAF_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1B_HUMAN [view interactions] Low throughput no yes
BCR_HUMAN [view entry] [view interactions] Low throughput yes yes
CXCR2_HUMAN [view interactions] Low throughput no no
GNAI2_HUMAN [view entry] [view interactions] Low throughput yes yes
EF1A1_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK1_HUMAN [view interactions] Low throughput no yes
MYCB2_HUMAN [view entry] [view interactions] Low throughput yes no
RING1_HUMAN [view interactions] Low throughput no yes
RBBP6_HUMAN [view interactions] Low throughput no yes
HERC2_HUMAN [view interactions] Low throughput no yes
LTN1_HUMAN [view interactions] Low throughput no no
MTR1A_HUMAN [view interactions] High throughput no no
ARL4C_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
P20D2_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
KPCD2_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
WIZ_HUMAN [view interactions] High throughput no yes
EHMT2_HUMAN [view entry] [view interactions] High throughput yes yes
EHMT1_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes