GNAI3_HUMAN
Evidence for PS localization
Functions
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed, PubMed, PubMed). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed). Stimulates the activity of receptor-regulated K(+) channels (PubMed). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 40 | Gly | Arg | Auriculocondylarsyndrome1(ARCND1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GNAI3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 39.1753 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 38.1443 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.0825 | 4 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 29.8969 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 29.8969 | 6 | yes |
| GO:0003924 | GTPase activity | 29.8969 | 7 | yes |
| GO:0016462 | pyrophosphatase activity | 29.8969 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 19.5876 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 19.5876 | 5 | yes |
| GO:0046872 | metal ion binding | 19.5876 | 4 | yes |
| GO:0005525 | GTP binding | 19.5876 | 5 | yes |
| GO:0001664 | G protein-coupled receptor binding | 12.3711 | 4 | yes |
| GO:0019003 | GDP binding | 8.2474 | 4 | yes |
| GO:0031821 | G protein-coupled serotonin receptor binding | 4.1237 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GNAI3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.5773 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.5155 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.5155 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.3299 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.2371 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.1753 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.1443 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.1443 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.1134 | 4 | yes |
| GO:0051049 | regulation of transport | 35.0515 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.0206 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.0206 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.9588 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 31.9588 | 5 | no |
| GO:0023056 | positive regulation of signaling | 31.9588 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.9588 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 30.9278 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.8969 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.8969 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.8969 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.8041 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.8041 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.8041 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 26.8041 | 5 | no |
| GO:0006996 | organelle organization | 26.8041 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 25.7732 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.7732 | 7 | no |
| GO:0010468 | regulation of gene expression | 25.7732 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.7423 | 7 | no |
| GO:0051336 | regulation of hydrolase activity | 24.7423 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 24.7423 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 24.7423 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 24.7423 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.7113 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 23.7113 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.6804 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.6804 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.6804 | 7 | no |
| GO:0060341 | regulation of cellular localization | 22.6804 | 4 | no |
| GO:0022607 | cellular component assembly | 22.6804 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 22.6804 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 21.6495 | 8 | no |
| GO:0031401 | positive regulation of protein modification process | 21.6495 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.6495 | 4 | yes |
| GO:0010941 | regulation of cell death | 21.6495 | 4 | yes |
| GO:0008104 | protein localization | 21.6495 | 4 | no |
| GO:0071702 | organic substance transport | 20.6186 | 4 | no |
| GO:0032880 | regulation of protein localization | 20.6186 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.6186 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 20.6186 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.6186 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 20.6186 | 4 | no |
| GO:0030334 | regulation of cell migration | 20.6186 | 5 | no |
| GO:2000145 | regulation of cell motility | 20.6186 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 20.6186 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.6186 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.6186 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 19.5876 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 19.5876 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 19.5876 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 18.5567 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 18.5567 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 18.5567 | 4 | yes |
| GO:0060548 | negative regulation of cell death | 18.5567 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 16.4948 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 16.4948 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 15.4639 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 15.4639 | 5 | yes |
| GO:0043086 | negative regulation of catalytic activity | 15.4639 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 14.4330 | 5 | yes |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 12.3711 | 5 | yes |
| GO:0009896 | positive regulation of catabolic process | 11.3402 | 5 | yes |
| GO:0031279 | regulation of cyclase activity | 10.3093 | 4 | yes |
| GO:0010506 | regulation of autophagy | 9.2784 | 6 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 9.2784 | 6 | yes |
| GO:0045761 | regulation of adenylate cyclase activity | 9.2784 | 5 | yes |
| GO:0051339 | regulation of lyase activity | 9.2784 | 4 | yes |
| GO:0016241 | regulation of macroautophagy | 8.2474 | 7 | yes |
| GO:0007194 | negative regulation of adenylate cyclase activity | 7.2165 | 6 | yes |
| GO:0031280 | negative regulation of cyclase activity | 7.2165 | 5 | yes |
| GO:0051350 | negative regulation of lyase activity | 7.2165 | 5 | yes |
| GO:0061024 | membrane organization | 7.2165 | 4 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 6.1856 | 4 | yes |
| GO:0007420 | brain development | 6.1856 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 6.1856 | 5 | yes |
| GO:0010508 | positive regulation of autophagy | 6.1856 | 7 | yes |
| GO:0048660 | regulation of smooth muscle cell proliferation | 6.1856 | 5 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 6.1856 | 5 | yes |
| GO:0006163 | purine nucleotide metabolic process | 5.1546 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 5.1546 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 5.1546 | 5 | yes |
| GO:0016239 | positive regulation of macroautophagy | 5.1546 | 8 | yes |
| GO:0019693 | ribose phosphate metabolic process | 5.1546 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 5.1546 | 4 | yes |
| GO:2001234 | negative regulation of apoptotic signaling pathway | 5.1546 | 6 | yes |
| GO:0048661 | positive regulation of smooth muscle cell proliferation | 4.1237 | 6 | yes |
| GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 4.1237 | 6 | yes |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 4.1237 | 5 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 3.0928 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 3.0928 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 3.0928 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 3.0928 | 7 | yes |
| GO:0016050 | vesicle organization | 3.0928 | 5 | yes |
| GO:0051341 | regulation of oxidoreductase activity | 3.0928 | 4 | yes |
| GO:0051353 | positive regulation of oxidoreductase activity | 3.0928 | 5 | yes |
| GO:0032928 | regulation of superoxide anion generation | 2.0619 | 7 | yes |
| GO:0032930 | positive regulation of superoxide anion generation | 2.0619 | 7 | yes |
| GO:0033860 | regulation of NAD(P)H oxidase activity | 2.0619 | 5 | yes |
| GO:0033864 | positive regulation of NAD(P)H oxidase activity | 2.0619 | 6 | yes |
| GO:0046039 | GTP metabolic process | 2.0619 | 7 | yes |
| GO:0090322 | regulation of superoxide metabolic process | 2.0619 | 6 | yes |
| GO:1904707 | positive regulation of vascular associated smooth muscle cell proliferation | 2.0619 | 7 | yes |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process | 2.0619 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GNAI3_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 2.0619 | 3 | no |
| DOID:0050155 | sensory system disease | 2.0619 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FZD7_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS2_HUMAN | [view interactions] | Low throughput | no | no |
| STK11_HUMAN | [view interactions] | Low throughput | no | yes |
| DVL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| C5AR1_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS19_HUMAN | [view interactions] | Low throughput | no | yes |
| NUCB1_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS12_HUMAN | [view interactions] | Low throughput | no | no |
| GBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GPSM2_HUMAN | [view interactions] | Low throughput | no | yes |
| GRM4_HUMAN | [view interactions] | Low throughput | no | no |
| MTR1A_HUMAN | [view interactions] | Low throughput | no | no |
| RIC8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| S1PR1_HUMAN | [view interactions] | Low throughput | no | no |
| DAPLE_HUMAN | [view interactions] | Low throughput | no | yes |
| RASA3_HUMAN | [view interactions] | Low throughput | no | yes |
| CNR1_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS10_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS3_HUMAN | [view interactions] | Low throughput | no | no |
| RGS16_HUMAN | [view interactions] | Low throughput | no | no |
| RGS5_HUMAN | [view interactions] | Low throughput | no | no |
| RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS18_HUMAN | [view interactions] | Low throughput | no | yes |
| GBB3_HUMAN | [view interactions] | Low throughput | no | yes |
| GPSM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRDN_HUMAN | [view interactions] | Low throughput | no | no |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| DUS9_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| PKHH3_HUMAN | [view interactions] | High throughput | no | no |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| MA1B1_HUMAN | [view interactions] | High throughput | no | yes |
| AVR2A_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| CDV3_HUMAN | [view interactions] | High throughput | no | no |
| CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| DAF_HUMAN | [view interactions] | High throughput | no | no |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| IF5_HUMAN | [view interactions] | High throughput | no | yes |
| 5MP2_HUMAN | [view interactions] | High throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI3R4_HUMAN | [view interactions] | High throughput | no | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG35_HUMAN | [view interactions] | High throughput | no | yes |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STRP2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| RPA34_HUMAN | [view interactions] | High throughput | no | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUCB2_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM222_HUMAN | [view interactions] | High throughput | no | no |
| DCNL5_HUMAN | [view interactions] | High throughput | no | yes |
| AN13B_HUMAN | [view interactions] | High throughput | no | no |
| GBG5_HUMAN | [view interactions] | High throughput | no | no |
| GBG11_HUMAN | [view interactions] | High throughput | no | no |
| GBG10_HUMAN | [view interactions] | High throughput | no | no |
| GNAT2_HUMAN | [view interactions] | High throughput | no | no |
| GBG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG4_HUMAN | [view interactions] | High throughput | no | no |
| PCP2_HUMAN | [view interactions] | High throughput | no | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK3_HUMAN | [view interactions] | High throughput | no | yes |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| KC1G1_HUMAN | [view interactions] | High throughput | no | no |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| AT12A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX30_HUMAN | [view interactions] | High throughput | no | no |
| RGS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPSM3_HUMAN | [view interactions] | High throughput | no | no |
| PHF24_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| RIPK3_HUMAN | [view interactions] | High throughput | no | no |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| MICA3_HUMAN | [view interactions] | High throughput | no | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS4_HUMAN | [view interactions] | High throughput | no | yes |
| SCC4_HUMAN | [view interactions] | High throughput | no | no |
| TRI69_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| STT3B_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCF2_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| RPGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| RDH13_HUMAN | [view interactions] | High throughput | no | no |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| AAAS_HUMAN | [view interactions] | High throughput | no | yes |
| ALG6_HUMAN | [view interactions] | High throughput | no | no |
| UBP33_HUMAN | [view interactions] | High throughput | no | yes |
| NDC1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| BRAF_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| API5_HUMAN | [view interactions] | High throughput | no | no |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF6_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| GAB1_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| S1PR3_HUMAN | [view interactions] | Computational | no | no |
| CXCR4_HUMAN | [view interactions] | Computational | no | no |
| RPGF3_HUMAN | [view interactions] | Computational | no | yes |
| RGS20_HUMAN | [view interactions] | Computational | no | no |
| AA1R_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBG12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADCY1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNAT1_HUMAN | [view interactions] | Computational | no | no |
| DRD2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRM3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GABR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK08_HUMAN | [view interactions] | Computational | no | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EGF_HUMAN | [view interactions] | Computational | no | no |
| CRFR1_HUMAN | [view interactions] | Computational | no | yes |
| S1PR4_HUMAN | [view interactions] | Computational | no | no |
| PK3CG_HUMAN | [view interactions] | Computational | no | yes |
| GNA14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADCY4_HUMAN | [view interactions] | Computational | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CD3G_HUMAN | [view interactions] | Computational | no | no |
| LPAR1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PI3R6_HUMAN | [view interactions] | Computational | no | yes |
| RGSL_HUMAN | [view interactions] | Computational | no | no |
| CD3Z_HUMAN | [view interactions] | Computational | no | no |
| OXYR_HUMAN | [view interactions] | Computational | no | no |
| RL3R1_HUMAN | [view interactions] | Computational | no | no |
| RIC8B_HUMAN | [view interactions] | Computational | no | yes |
| NOS3_HUMAN | [view interactions] | Computational | no | no |
| PHLP_HUMAN | [view interactions] | Computational | no | yes |
| RGS22_HUMAN | [view interactions] | Computational | no | no |
| ADCY2_HUMAN | [view interactions] | Computational | no | yes |
| OPRM_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MK14_HUMAN | [view interactions] | Computational | no | yes |
| PTH1R_HUMAN | [view interactions] | Computational | no | no |
| NPY1R_HUMAN | [view interactions] | Computational | no | no |
| S1PR5_HUMAN | [view interactions] | Computational | no | no |
| GLI1_HUMAN | [view interactions] | Computational | no | no |
| CASR_HUMAN | [view interactions] | Computational | no | no |
| RGS1_HUMAN | [view interactions] | Computational | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRM2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADCY3_HUMAN | [view interactions] | Computational | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PTN11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BCAR1_HUMAN | [view interactions] | Computational | no | yes |
| GNA15_HUMAN | [view interactions] | Computational | no | yes |
| EDN1_HUMAN | [view interactions] | Computational | no | no |
| SMO_HUMAN | [view interactions] | Computational | no | yes |
| ADCY9_HUMAN | [view interactions] | Computational | no | yes |
| RPGF4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNAT3_HUMAN | [view interactions] | Computational | no | no |
| ADRB3_HUMAN | [view interactions] | Computational | no | no |
| ADCY5_HUMAN | [view interactions] | Computational | no | no |
| BKRB2_HUMAN | [view interactions] | Computational | no | yes |
| PI3R5_HUMAN | [view interactions] | Computational | no | no |
| PAXI_HUMAN | [view interactions] | Computational | no | yes |
| RL3R2_HUMAN | [view interactions] | Computational | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DRB1_HUMAN | [view interactions] | Computational | no | no |
| RASD1_HUMAN | [view interactions] | Computational | no | yes |
| P2Y12_HUMAN | [view interactions] | Computational | no | no |
| CCR5_HUMAN | [view interactions] | Computational | no | no |
| LCK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SDF1_HUMAN | [view interactions] | Computational | no | no |
| CD3D_HUMAN | [view interactions] | Computational | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PAR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLF4_HUMAN | [view interactions] | Computational | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| EDNRB_HUMAN | [view interactions] | Computational | no | no |
| AKT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CD4_HUMAN | [view interactions] | Computational | no | no |
| ADCY6_HUMAN | [view interactions] | Computational | no | yes |
| ADCY7_HUMAN | [view interactions] | Computational | no | yes |
| OPRD_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ADRB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADCY8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CXCR3_HUMAN | [view interactions] | Computational | no | no |
| RGS9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DRA_HUMAN | [view interactions] | Computational | no | no |
| GABR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PE2R3_HUMAN | [view interactions] | Computational | no | no |
| CD3E_HUMAN | [view interactions] | Computational | no | no |
| SSR2_HUMAN | [view interactions] | Computational | no | yes |