RIC8A_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex . Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RIC8A_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 51.4286 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 51.4286 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 48.5714 | 4 | no |
| GO:0046872 | metal ion binding | 40.0000 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 34.2857 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 34.2857 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 34.2857 | 6 | no |
| GO:0003924 | GTPase activity | 31.4286 | 7 | no |
| GO:0005525 | GTP binding | 31.4286 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 31.4286 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 31.4286 | 5 | no |
| GO:0001664 | G protein-coupled receptor binding | 28.5714 | 4 | no |
| GO:0030695 | GTPase regulator activity | 8.5714 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 5.7143 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RIC8A_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 37.1429 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.2857 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.4286 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 28.5714 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 28.5714 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 28.5714 | 4 | no |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.7143 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.7143 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.7143 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.7143 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 22.8571 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.8571 | 5 | no |
| GO:0007010 | cytoskeleton organization | 22.8571 | 5 | no |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 14.2857 | 5 | yes |
| GO:0009416 | response to light stimulus | 8.5714 | 4 | yes |
| GO:0001701 | in utero embryonic development | 5.7143 | 6 | yes |
| GO:0009792 | embryo development ending in birth or egg hatching | 5.7143 | 4 | yes |
| GO:0043009 | chordate embryonic development | 5.7143 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RIC8A_HUMAN |
|---|---|---|---|---|
| DOID:12377 | spinal muscular atrophy | 8.5714 | 6 | no |
| DOID:1289 | neurodegenerative disease | 8.5714 | 4 | no |
| DOID:231 | motor neuron disease | 8.5714 | 5 | no |
| DOID:331 | central nervous system disease | 8.5714 | 3 | no |
| DOID:332 | amyotrophic lateral sclerosis | 5.7143 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GNAI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDE4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI18_HUMAN | [view interactions] | Low throughput | no | no |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNA13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NECA2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH17_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| PACN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYCT_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG5_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN6_HUMAN | [view interactions] | High throughput | no | no |
| DCTN5_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA12_HUMAN | [view interactions] | High throughput | no | no |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| HBA_HUMAN | [view interactions] | High throughput | no | no |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| P63_HUMAN | [view interactions] | High throughput | no | no |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSHR_HUMAN | [view interactions] | High throughput | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPP2_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAPS2_HUMAN | [view interactions] | High throughput | no | yes |
| RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SARNP_HUMAN | [view interactions] | High throughput | no | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR61_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| FBLN3_HUMAN | [view interactions] | High throughput | no | no |
| NUTM1_HUMAN | [view interactions] | High throughput | no | no |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| Z585B_HUMAN | [view interactions] | High throughput | no | no |
| NCS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNAS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |