RIC8A_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex . Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RIC8A_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 50.0000 | 4 | no |
| GO:0043169 | cation binding | 47.6190 | 4 | no |
| GO:0046872 | metal ion binding | 47.6190 | 5 | no |
| GO:0000166 | nucleotide binding | 42.8571 | 4 | no |
| GO:0017076 | purine nucleotide binding | 42.8571 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 40.4762 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 38.0952 | 4 | no |
| GO:0001664 | G protein-coupled receptor binding | 28.5714 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 28.5714 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.5714 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.5714 | 6 | no |
| GO:0003924 | GTPase activity | 23.8095 | 7 | no |
| GO:0005525 | GTP binding | 23.8095 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 23.8095 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 23.8095 | 5 | no |
| GO:0019900 | kinase binding | 21.4286 | 4 | no |
| GO:0030695 | GTPase regulator activity | 9.5238 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 7.1429 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RIC8A_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 52.3810 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.4762 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.4762 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.7143 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0051049 | regulation of transport | 30.9524 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.9524 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 30.9524 | 4 | no |
| GO:0006996 | organelle organization | 30.9524 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
| GO:0032880 | regulation of protein localization | 28.5714 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.5714 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.1905 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.1905 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.1905 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.1905 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.1905 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 23.8095 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.8095 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.8095 | 4 | no |
| GO:0008104 | protein localization | 23.8095 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.8095 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.8095 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 23.8095 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.8095 | 5 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 21.4286 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 21.4286 | 5 | no |
| GO:0010468 | regulation of gene expression | 21.4286 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.4286 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 21.4286 | 5 | no |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 11.9048 | 5 | yes |
| GO:0009416 | response to light stimulus | 9.5238 | 4 | yes |
| GO:0001701 | in utero embryonic development | 7.1429 | 6 | yes |
| GO:0009792 | embryo development ending in birth or egg hatching | 7.1429 | 4 | yes |
| GO:0043009 | chordate embryonic development | 7.1429 | 5 | yes |
| GO:0050890 | cognition | 7.1429 | 4 | yes |
| GO:0007612 | learning | 4.7619 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PDE4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI18_HUMAN | [view interactions] | Low throughput | no | no |
| NCS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNA13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HBA_HUMAN | [view interactions] | High throughput | no | no |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| P63_HUMAN | [view interactions] | High throughput | no | no |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSHR_HUMAN | [view interactions] | High throughput | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPP2_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAPS2_HUMAN | [view interactions] | High throughput | no | yes |
| RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SARNP_HUMAN | [view interactions] | High throughput | no | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKI8_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| SIM26_HUMAN | [view interactions] | High throughput | no | no |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| FBLN3_HUMAN | [view interactions] | High throughput | no | no |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| NUTM1_HUMAN | [view interactions] | High throughput | no | no |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| Z585B_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NECA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDH17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| PACN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYCT_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG5_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN6_HUMAN | [view interactions] | High throughput | no | no |
| DCTN5_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA12_HUMAN | [view interactions] | High throughput | no | no |