GNAZ_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000311 | MOD_SPalmitoyl_4 | MOD | 1 | 7 | - |
| ELMI000311 | MOD_SPalmitoyl_4 | MOD | 1 | 7 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GNAZ_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 22.2222 | 4 | yes |
| GO:0019900 | kinase binding | 22.2222 | 4 | no |
| GO:0003924 | GTPase activity | 19.4444 | 7 | yes |
| GO:0016462 | pyrophosphatase activity | 19.4444 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 19.4444 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 19.4444 | 6 | yes |
| GO:0046872 | metal ion binding | 19.4444 | 5 | yes |
| GO:0000166 | nucleotide binding | 13.8889 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 13.8889 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 13.8889 | 4 | yes |
| GO:0043168 | anion binding | 13.8889 | 4 | yes |
| GO:0001664 | G protein-coupled receptor binding | 11.1111 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 11.1111 | 4 | yes |
| GO:0005525 | GTP binding | 8.3333 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 8.3333 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 8.3333 | 5 | yes |
| GO:0010852 | cyclase inhibitor activity | 5.5556 | 4 | yes |
| GO:0010854 | adenylate cyclase regulator activity | 5.5556 | 4 | yes |
| GO:0010855 | adenylate cyclase inhibitor activity | 5.5556 | 5 | yes |
| GO:0031821 | G protein-coupled serotonin receptor binding | 5.5556 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GNAZ_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 52.7778 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 38.8889 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.1111 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.1111 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.1111 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.1111 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
| GO:0051049 | regulation of transport | 30.5556 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 30.5556 | 4 | no |
| GO:0050890 | cognition | 30.5556 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 30.5556 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 27.7778 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 27.7778 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.7778 | 5 | no |
| GO:0006996 | organelle organization | 27.7778 | 4 | no |
| GO:0007612 | learning | 25.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 25.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.2222 | 4 | no |
| GO:0010468 | regulation of gene expression | 22.2222 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.2222 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.2222 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.2222 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 22.2222 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.2222 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.2222 | 6 | no |
| GO:0008104 | protein localization | 22.2222 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.2222 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 19.4444 | 4 | yes |
| GO:0032880 | regulation of protein localization | 16.6667 | 5 | yes |
| GO:0051046 | regulation of secretion | 16.6667 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 16.6667 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 16.6667 | 4 | yes |
| GO:0051051 | negative regulation of transport | 13.8889 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 13.8889 | 6 | yes |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 11.1111 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 11.1111 | 4 | yes |
| GO:0046888 | negative regulation of hormone secretion | 11.1111 | 5 | yes |
| GO:0050708 | regulation of protein secretion | 11.1111 | 5 | yes |
| GO:0051048 | negative regulation of secretion | 11.1111 | 5 | yes |
| GO:0051223 | regulation of protein transport | 11.1111 | 5 | yes |
| GO:1903531 | negative regulation of secretion by cell | 11.1111 | 5 | yes |
| GO:1903828 | negative regulation of protein localization | 11.1111 | 5 | yes |
| GO:1904950 | negative regulation of establishment of protein localization | 11.1111 | 6 | yes |
| GO:0002791 | regulation of peptide secretion | 8.3333 | 6 | yes |
| GO:0002792 | negative regulation of peptide secretion | 8.3333 | 6 | yes |
| GO:0046676 | negative regulation of insulin secretion | 8.3333 | 7 | yes |
| GO:0050709 | negative regulation of protein secretion | 8.3333 | 6 | yes |
| GO:0050796 | regulation of insulin secretion | 8.3333 | 6 | yes |
| GO:0051224 | negative regulation of protein transport | 8.3333 | 5 | yes |
| GO:0090087 | regulation of peptide transport | 8.3333 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 8.3333 | 5 | yes |
| GO:0090278 | negative regulation of peptide hormone secretion | 8.3333 | 6 | yes |
| GO:0098664 | G protein-coupled serotonin receptor signaling pathway | 5.5556 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AGRB2_HUMAN | [view interactions] | Low throughput | no | no |
| RGS19_HUMAN | [view interactions] | Low throughput | no | yes |
| EYA2_HUMAN | [view interactions] | Low throughput | no | yes |
| EYA1_HUMAN | [view interactions] | Low throughput | no | no |
| RGS10_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS20_HUMAN | [view interactions] | Low throughput | no | no |
| DRD5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| OPRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| MED21_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| F1712_HUMAN | [view interactions] | High throughput | no | no |
| MTHR_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| SDC1_HUMAN | [view interactions] | High throughput | no | no |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| ECP_HUMAN | [view interactions] | High throughput | no | no |
| PCDGK_HUMAN | [view interactions] | High throughput | no | yes |
| GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACBD7_HUMAN | [view interactions] | High throughput | no | no |
| GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
| RD3_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBPL_HUMAN | [view interactions] | High throughput | no | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| DAAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THOC7_HUMAN | [view interactions] | High throughput | no | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| APOL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA10_HUMAN | [view interactions] | High throughput | no | no |
| ISG20_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| GBG1_HUMAN | [view interactions] | High throughput | no | no |
| GBG10_HUMAN | [view interactions] | High throughput | no | no |
| CXCL6_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HBG2_HUMAN | [view interactions] | High throughput | no | no |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM6S2_HUMAN | [view interactions] | High throughput | no | no |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| RPC9_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| FBXW5_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |