GNAZ_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000311 | MOD_SPalmitoyl_4 | MOD | 1 | 7 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GNAZ_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 39.6552 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 39.6552 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 39.6552 | 4 | yes |
| GO:0003924 | GTPase activity | 34.4828 | 7 | yes |
| GO:0016462 | pyrophosphatase activity | 34.4828 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 34.4828 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 34.4828 | 6 | yes |
| GO:0046872 | metal ion binding | 27.5862 | 4 | yes |
| GO:0019900 | kinase binding | 25.8621 | 4 | no |
| GO:0005525 | GTP binding | 24.1379 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 24.1379 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 24.1379 | 5 | yes |
| GO:0019901 | protein kinase binding | 22.4138 | 5 | no |
| GO:0001664 | G protein-coupled receptor binding | 18.9655 | 4 | yes |
| GO:0031821 | G protein-coupled serotonin receptor binding | 8.6207 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GNAZ_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 53.4483 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 53.4483 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 46.5517 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.5517 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.8276 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.8276 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.8276 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 43.1034 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 37.9310 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 37.9310 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 37.9310 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 36.2069 | 4 | no |
| GO:0071310 | cellular response to organic substance | 36.2069 | 4 | no |
| GO:0051049 | regulation of transport | 34.4828 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.4828 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 34.4828 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.7586 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 32.7586 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 32.7586 | 6 | no |
| GO:0023056 | positive regulation of signaling | 32.7586 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 32.7586 | 5 | no |
| GO:0031399 | regulation of protein modification process | 31.0345 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 31.0345 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.0345 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.0345 | 5 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 29.3103 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 29.3103 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.5862 | 6 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 27.5862 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.5862 | 5 | no |
| GO:0010941 | regulation of cell death | 27.5862 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 27.5862 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 27.5862 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 27.5862 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 27.5862 | 4 | no |
| GO:0051338 | regulation of transferase activity | 27.5862 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.8621 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.8621 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.8621 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.8621 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 25.8621 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.8621 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.8621 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.8621 | 7 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.8621 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.1379 | 6 | no |
| GO:2000145 | regulation of cell motility | 24.1379 | 4 | no |
| GO:0006996 | organelle organization | 24.1379 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 24.1379 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.1379 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.1379 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.1379 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.1379 | 4 | no |
| GO:0030334 | regulation of cell migration | 24.1379 | 5 | no |
| GO:0043549 | regulation of kinase activity | 24.1379 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 24.1379 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.1379 | 5 | no |
| GO:0051345 | positive regulation of hydrolase activity | 24.1379 | 5 | no |
| GO:0051347 | positive regulation of transferase activity | 24.1379 | 5 | no |
| GO:0080134 | regulation of response to stress | 22.4138 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 22.4138 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 22.4138 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.4138 | 5 | no |
| GO:0051050 | positive regulation of transport | 22.4138 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.4138 | 4 | no |
| GO:0022607 | cellular component assembly | 22.4138 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.4138 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 22.4138 | 8 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.4138 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.4138 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 22.4138 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 22.4138 | 7 | no |
| GO:0040017 | positive regulation of locomotion | 22.4138 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 20.6897 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 20.6897 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.6897 | 5 | no |
| GO:0060548 | negative regulation of cell death | 20.6897 | 5 | no |
| GO:0050890 | cognition | 20.6897 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 20.6897 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.6897 | 4 | no |
| GO:0030030 | cell projection organization | 20.6897 | 4 | no |
| GO:0033674 | positive regulation of kinase activity | 20.6897 | 6 | no |
| GO:0043408 | regulation of MAPK cascade | 20.6897 | 6 | no |
| GO:0045859 | regulation of protein kinase activity | 20.6897 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.6897 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 20.6897 | 4 | no |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 13.7931 | 5 | yes |
| GO:0098664 | G protein-coupled serotonin receptor signaling pathway | 3.4483 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AGRB2_HUMAN | [view interactions] | Low throughput | no | no |
| RGS19_HUMAN | [view interactions] | Low throughput | no | yes |
| EYA2_HUMAN | [view interactions] | Low throughput | no | yes |
| EYA1_HUMAN | [view interactions] | Low throughput | no | no |
| RGS10_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS20_HUMAN | [view interactions] | Low throughput | no | no |
| DRD5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTHR_HUMAN | [view interactions] | High throughput | no | yes |
| F1712_HUMAN | [view interactions] | High throughput | no | no |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| SDC1_HUMAN | [view interactions] | High throughput | no | no |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| ECP_HUMAN | [view interactions] | High throughput | no | no |
| PCDGK_HUMAN | [view interactions] | High throughput | no | yes |
| GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACBD7_HUMAN | [view interactions] | High throughput | no | no |
| GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
| RD3_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBPL_HUMAN | [view interactions] | High throughput | no | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| DAAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THOC7_HUMAN | [view interactions] | High throughput | no | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| APOL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA10_HUMAN | [view interactions] | High throughput | no | no |
| ISG20_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| GBG1_HUMAN | [view interactions] | High throughput | no | no |
| GBG10_HUMAN | [view interactions] | High throughput | no | no |
| GBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXCL6_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HBG2_HUMAN | [view interactions] | High throughput | no | no |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM6S2_HUMAN | [view interactions] | High throughput | no | no |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| RPC9_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| FBXW5_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| MED21_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| DRA_HUMAN | [view interactions] | Computational | no | no |
| CD3E_HUMAN | [view interactions] | Computational | no | no |
| GBB3_HUMAN | [view interactions] | Computational | no | yes |
| GBB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CXCR3_HUMAN | [view interactions] | Computational | no | no |
| ESR1_HUMAN | [view interactions] | Computational | no | no |
| ADCY8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADCY7_HUMAN | [view interactions] | Computational | no | yes |
| ADCY6_HUMAN | [view interactions] | Computational | no | yes |
| PAR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLF4_HUMAN | [view interactions] | Computational | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| EDNRB_HUMAN | [view interactions] | Computational | no | no |
| CD4_HUMAN | [view interactions] | Computational | no | no |
| AKT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DRB1_HUMAN | [view interactions] | Computational | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CD3D_HUMAN | [view interactions] | Computational | no | no |
| SDF1_HUMAN | [view interactions] | Computational | no | no |
| ADCY5_HUMAN | [view interactions] | Computational | no | no |
| GNB5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PAXI_HUMAN | [view interactions] | Computational | no | yes |
| GNAT3_HUMAN | [view interactions] | Computational | no | no |
| GNAT2_HUMAN | [view interactions] | Computational | no | no |
| EDN1_HUMAN | [view interactions] | Computational | no | no |
| SMO_HUMAN | [view interactions] | Computational | no | yes |
| RGS4_HUMAN | [view interactions] | Computational | no | no |
| ADCY9_HUMAN | [view interactions] | Computational | no | yes |
| GNAO_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADCY3_HUMAN | [view interactions] | Computational | no | yes |
| GBGT2_HUMAN | [view interactions] | Computational | no | no |
| GNA15_HUMAN | [view interactions] | Computational | no | yes |
| BCAR1_HUMAN | [view interactions] | Computational | no | yes |
| GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK14_HUMAN | [view interactions] | Computational | no | yes |
| S1PR1_HUMAN | [view interactions] | Computational | no | no |
| GNAI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| S1PR5_HUMAN | [view interactions] | Computational | no | no |
| GLI1_HUMAN | [view interactions] | Computational | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNA11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RGS1_HUMAN | [view interactions] | Computational | no | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NOS3_HUMAN | [view interactions] | Computational | no | no |
| ADCY2_HUMAN | [view interactions] | Computational | no | yes |
| ADCY4_HUMAN | [view interactions] | Computational | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CD3G_HUMAN | [view interactions] | Computational | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RGSL_HUMAN | [view interactions] | Computational | no | no |
| CD3Z_HUMAN | [view interactions] | Computational | no | no |
| S1PR4_HUMAN | [view interactions] | Computational | no | no |
| ANDR_HUMAN | [view interactions] | Computational | no | no |
| GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK08_HUMAN | [view interactions] | Computational | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CRFR1_HUMAN | [view interactions] | Computational | no | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG4_HUMAN | [view interactions] | Computational | no | no |
| GNAT1_HUMAN | [view interactions] | Computational | no | no |
| ADCY1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| S1PR3_HUMAN | [view interactions] | Computational | no | no |
| RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CXCR4_HUMAN | [view interactions] | Computational | no | no |