Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBG3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBG3_HUMAN
GO:0003924 GTPase activity 44.4444 7 yes
GO:0016462 pyrophosphatase activity 44.4444 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 44.4444 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 44.4444 6 yes
GO:0046872 metal ion binding 40.7407 4 no
GO:0017076 purine nucleotide binding 37.0370 4 no
GO:0032555 purine ribonucleotide binding 37.0370 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.0370 4 no
GO:0019001 guanyl nucleotide binding 33.3333 5 no
GO:0032561 guanyl ribonucleotide binding 33.3333 5 no
GO:0001664 G protein-coupled receptor binding 29.6296 4 no
GO:0005525 GTP binding 29.6296 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBG3_HUMAN
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 48.1481 4 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0048522 positive regulation of cellular process 33.3333 4 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0009966 regulation of signal transduction 29.6296 4 no
GO:0010646 regulation of cell communication 29.6296 4 no
GO:0051049 regulation of transport 29.6296 4 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 25.9259 5 no
GO:0031323 regulation of cellular metabolic process 25.9259 4 no
GO:0051336 regulation of hydrolase activity 25.9259 4 no
GO:0043269 regulation of ion transport 25.9259 5 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 22.2222 5 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 22.2222 4 no
GO:0095500 acetylcholine receptor signaling pathway 22.2222 4 no
GO:0051171 regulation of nitrogen compound metabolic process 22.2222 4 no
GO:0060255 regulation of macromolecule metabolic process 22.2222 4 no
GO:0080090 regulation of primary metabolic process 22.2222 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCNK2_HUMAN [view interactions] Low throughput no no
GNB5_HUMAN [view entry] [view interactions] Low throughput yes yes
SNP23_HUMAN [view entry] [view interactions] High throughput yes no
GNAI1_HUMAN [view entry] [view interactions] High throughput yes yes
PHLP_HUMAN [view interactions] High throughput no yes
GBB4_HUMAN [view entry] [view interactions] High throughput yes yes
GNA13_HUMAN [view entry] [view interactions] High throughput yes yes
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] High throughput yes yes
GNA11_HUMAN [view entry] [view interactions] High throughput yes yes
GNAT2_HUMAN [view interactions] High throughput no no
GNAZ_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
NTAQ1_HUMAN [view interactions] High throughput no yes
S18L2_HUMAN [view interactions] High throughput no no
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
GBB3_HUMAN [view interactions] High throughput no yes
TRI73_HUMAN [view interactions] High throughput no no
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
FLNC_HUMAN [view entry] [view interactions] High throughput yes no
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
GBG2_HUMAN [view entry] [view interactions] High throughput yes yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
LPAR2_HUMAN [view interactions] Computational no yes
CAC1D_HUMAN [view interactions] Computational no yes
GBG1_HUMAN [view interactions] Computational no no
LPAR5_HUMAN [view interactions] Computational no yes
LPAR3_HUMAN [view interactions] Computational no no
CAC1C_HUMAN [view entry] [view interactions] Computational yes no
CA2D2_HUMAN [view entry] [view interactions] Computational yes yes
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
CACB3_HUMAN [view entry] [view interactions] Computational yes no
CACB2_HUMAN [view interactions] Computational no yes
GBG13_HUMAN [view interactions] Computational no no
ACM2_HUMAN [view entry] [view interactions] Computational yes yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
LPAR1_HUMAN [view entry] [view interactions] Computational yes no
LPAR4_HUMAN [view interactions] Computational no no
PAR1_HUMAN [view entry] [view interactions] Computational yes yes
LPAR6_HUMAN [view interactions] Computational no no