GBG3_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBG3_HUMAN |
|---|---|---|---|---|
| GO:0003924 | GTPase activity | 57.1429 | 7 | yes |
| GO:0016462 | pyrophosphatase activity | 57.1429 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 57.1429 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 57.1429 | 6 | yes |
| GO:0000166 | nucleotide binding | 42.8571 | 4 | no |
| GO:0017076 | purine nucleotide binding | 42.8571 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 42.8571 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 42.8571 | 4 | no |
| GO:0032561 | guanyl ribonucleotide binding | 42.8571 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 42.8571 | 4 | no |
| GO:0043168 | anion binding | 42.8571 | 4 | no |
| GO:0043169 | cation binding | 42.8571 | 4 | no |
| GO:0046872 | metal ion binding | 42.8571 | 5 | no |
| GO:0001664 | G protein-coupled receptor binding | 38.0952 | 4 | no |
| GO:0005525 | GTP binding | 38.0952 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBG3_HUMAN |
|---|---|---|---|---|
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 52.3810 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 33.3333 | 4 | no |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 28.5714 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 28.5714 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.8095 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 23.8095 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 23.8095 | 4 | no |
| GO:0051049 | regulation of transport | 23.8095 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KCNK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GNB5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNP23_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAT2_HUMAN | [view interactions] | High throughput | no | no |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLP_HUMAN | [view interactions] | High throughput | no | yes |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| S18L2_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI73_HUMAN | [view interactions] | High throughput | no | no |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |