Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GNAQ_HUMAN

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) . Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
183 Arg Gln Sturge-Webersyndrome(SWS) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GNAQ_HUMAN
GO:0017076 purine nucleotide binding 34.1176 4 yes
GO:0032555 purine ribonucleotide binding 34.1176 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 32.9412 4 yes
GO:0046872 metal ion binding 28.2353 4 yes
GO:0003924 GTPase activity 27.0588 7 yes
GO:0016462 pyrophosphatase activity 27.0588 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 27.0588 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 27.0588 6 yes
GO:0030695 GTPase regulator activity 20.0000 4 yes
GO:0001664 G protein-coupled receptor binding 18.8235 4 yes
GO:0005525 GTP binding 18.8235 5 yes
GO:0019001 guanyl nucleotide binding 18.8235 5 yes
GO:0032561 guanyl ribonucleotide binding 18.8235 5 yes
GO:0005096 GTPase activator activity 10.5882 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GNAQ_HUMAN
GO:0010646 regulation of cell communication 58.8235 4 yes
GO:0048522 positive regulation of cellular process 56.4706 4 no
GO:0009966 regulation of signal transduction 52.9412 4 yes
GO:0048523 negative regulation of cellular process 49.4118 4 yes
GO:0051049 regulation of transport 43.5294 4 no
GO:1902531 regulation of intracellular signal transduction 41.1765 5 no
GO:0031323 regulation of cellular metabolic process 35.2941 4 yes
GO:0060255 regulation of macromolecule metabolic process 34.1176 4 yes
GO:0080090 regulation of primary metabolic process 34.1176 4 yes
GO:0048584 positive regulation of response to stimulus 32.9412 4 no
GO:0051171 regulation of nitrogen compound metabolic process 31.7647 4 yes
GO:0010647 positive regulation of cell communication 31.7647 5 no
GO:0023056 positive regulation of signaling 31.7647 4 no
GO:0051128 regulation of cellular component organization 30.5882 4 no
GO:0009967 positive regulation of signal transduction 30.5882 5 no
GO:0009893 positive regulation of metabolic process 30.5882 4 no
GO:0051246 regulation of protein metabolic process 29.4118 5 yes
GO:0043085 positive regulation of catalytic activity 28.2353 4 yes
GO:0051050 positive regulation of transport 28.2353 4 no
GO:0051240 positive regulation of multicellular organismal process 28.2353 4 no
GO:0031325 positive regulation of cellular metabolic process 28.2353 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 27.0588 4 yes
GO:0010648 negative regulation of cell communication 27.0588 5 no
GO:0023057 negative regulation of signaling 27.0588 4 no
GO:0043269 regulation of ion transport 27.0588 5 no
GO:0048585 negative regulation of response to stimulus 27.0588 4 no
GO:0050804 modulation of chemical synaptic transmission 27.0588 5 no
GO:0099177 regulation of trans-synaptic signaling 27.0588 4 no
GO:0006996 organelle organization 27.0588 4 no
GO:1902533 positive regulation of intracellular signal transduction 27.0588 6 no
GO:0019220 regulation of phosphate metabolic process 25.8824 6 yes
GO:0051174 regulation of phosphorus metabolic process 25.8824 5 yes
GO:0010468 regulation of gene expression 25.8824 5 no
GO:0010604 positive regulation of macromolecule metabolic process 25.8824 5 no
GO:0031399 regulation of protein modification process 24.7059 6 yes
GO:0051336 regulation of hydrolase activity 24.7059 4 yes
GO:0071310 cellular response to organic substance 24.7059 4 no
GO:0042127 regulation of cell population proliferation 24.7059 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 24.7059 5 no
GO:0042325 regulation of phosphorylation 23.5294 7 yes
GO:0051247 positive regulation of protein metabolic process 23.5294 6 no
GO:0010941 regulation of cell death 23.5294 4 no
GO:0001932 regulation of protein phosphorylation 22.3529 7 yes
GO:0009892 negative regulation of metabolic process 22.3529 4 yes
GO:0009968 negative regulation of signal transduction 22.3529 5 no
GO:0044057 regulation of system process 22.3529 4 no
GO:0033043 regulation of organelle organization 22.3529 5 no
GO:0043408 regulation of MAPK cascade 22.3529 6 no
GO:0043410 positive regulation of MAPK cascade 22.3529 7 no
GO:0042981 regulation of apoptotic process 22.3529 6 no
GO:0043067 regulation of programmed cell death 22.3529 5 no
GO:0010243 response to organonitrogen compound 21.1765 4 no
GO:0008104 protein localization 21.1765 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.1765 5 no
GO:0045595 regulation of cell differentiation 21.1765 4 no
GO:0051130 positive regulation of cellular component organization 21.1765 5 no
GO:0010562 positive regulation of phosphorus metabolic process 21.1765 6 no
GO:0042327 positive regulation of phosphorylation 21.1765 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.1765 7 no
GO:0051046 regulation of secretion 21.1765 5 no
GO:1903530 regulation of secretion by cell 21.1765 4 no
GO:0010605 negative regulation of macromolecule metabolic process 20.0000 5 yes
GO:0051345 positive regulation of hydrolase activity 20.0000 5 yes
GO:0031324 negative regulation of cellular metabolic process 14.1176 5 yes
GO:0043086 negative regulation of catalytic activity 14.1176 4 yes
GO:0043549 regulation of kinase activity 14.1176 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 14.1176 5 yes
GO:0051338 regulation of transferase activity 14.1176 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 12.9412 5 yes
GO:0045859 regulation of protein kinase activity 12.9412 6 yes
GO:0051248 negative regulation of protein metabolic process 12.9412 6 yes
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 11.7647 4 yes
GO:0095500 acetylcholine receptor signaling pathway 11.7647 4 yes
GO:0031400 negative regulation of protein modification process 9.4118 7 yes
GO:0060191 regulation of lipase activity 9.4118 5 yes
GO:0060193 positive regulation of lipase activity 9.4118 6 yes
GO:0001508 action potential 8.2353 4 yes
GO:0009416 response to light stimulus 8.2353 4 yes
GO:0010517 regulation of phospholipase activity 8.2353 6 yes
GO:0010518 positive regulation of phospholipase activity 8.2353 7 yes
GO:0010563 negative regulation of phosphorus metabolic process 8.2353 6 yes
GO:0045936 negative regulation of phosphate metabolic process 8.2353 7 yes
GO:0042326 negative regulation of phosphorylation 7.0588 8 yes
GO:0001933 negative regulation of protein phosphorylation 5.8824 8 yes
GO:0007215 glutamate receptor signaling pathway 5.8824 4 yes
GO:0010863 positive regulation of phospholipase C activity 5.8824 8 yes
GO:0051348 negative regulation of transferase activity 5.8824 5 yes
GO:1900274 regulation of phospholipase C activity 5.8824 7 yes
GO:0007202 activation of phospholipase C activity 4.7059 9 yes
GO:0033673 negative regulation of kinase activity 4.7059 6 yes
GO:0006469 negative regulation of protein kinase activity 3.5294 7 yes
GO:0007599 hemostasis 3.5294 4 yes
GO:0050821 protein stabilization 3.5294 4 yes
GO:0007603 phototransduction, visible light 2.3529 4 yes
GO:0009583 detection of light stimulus 2.3529 4 yes
GO:0009584 detection of visible light 2.3529 5 yes
GO:0030111 regulation of Wnt signaling pathway 2.3529 5 yes
GO:0060828 regulation of canonical Wnt signaling pathway 2.3529 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in GNAQ_HUMAN
DOID:331 central nervous system disease 2.3529 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AGTR1_HUMAN [view interactions] Low throughput no no
AIP_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PECA1_HUMAN [view interactions] Low throughput no no
KCNK3_HUMAN [view interactions] Low throughput no no
KCNK9_HUMAN [view interactions] Low throughput no no
TRPM8_HUMAN [view interactions] Low throughput no no
CXCR5_HUMAN [view interactions] Low throughput no yes
RARA_HUMAN [view interactions] Low throughput no no
RGS2_HUMAN [view interactions] Low throughput no no
KISSR_HUMAN [view interactions] Low throughput no yes
IQEC1_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCB3_HUMAN [view entry] [view interactions] Low throughput yes no
FLOT2_HUMAN [view entry] [view interactions] Low throughput yes yes
RIC8A_HUMAN [view entry] [view interactions] Low throughput yes no
RIC8B_HUMAN [view interactions] Low throughput no yes
RGS4_HUMAN [view interactions] Low throughput no no
RGS16_HUMAN [view interactions] Low throughput no no
ARBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
TTC1_HUMAN [view interactions] Low throughput no yes
PK3CA_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
AKP13_HUMAN [view interactions] Low throughput no yes
CRFR1_HUMAN [view interactions] Low throughput no yes
RGS5_HUMAN [view interactions] Low throughput no no
BTK_HUMAN [view interactions] Low throughput no no
VIPR1_HUMAN [view interactions] Low throughput no yes
PAR1_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS18_HUMAN [view interactions] Low throughput no yes
WDR36_HUMAN [view interactions] Low throughput no yes
TA2R_HUMAN [view interactions] Low throughput no no
PLCB2_HUMAN [view interactions] Low throughput no no
PI2R_HUMAN [view interactions] Low throughput no no
CYH2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
CYH1_HUMAN [view interactions] Low throughput no no
CYH3_HUMAN [view entry] [view interactions] Low throughput yes yes
PSD1_HUMAN [view entry] [view interactions] Low throughput yes no
GBB3_HUMAN [view interactions] Low throughput no yes
PLCB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CD47_HUMAN [view interactions] Low throughput no no
ARHGB_HUMAN [view interactions] Low throughput no yes
ARHG1_HUMAN [view interactions] Low throughput no no
ARHGC_HUMAN [view interactions] Low throughput no yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM7_HUMAN [view entry] [view interactions] Low throughput yes no
RGS7_HUMAN [view entry] [view interactions] Low throughput yes yes
GASR_HUMAN [view interactions] Low throughput no no
RGS8_HUMAN [view entry] [view interactions] Low throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
UIF_HUMAN [view interactions] High throughput no yes
MED21_HUMAN [view interactions] High throughput no yes
TIGD5_HUMAN [view interactions] High throughput no no
S1PR1_HUMAN [view interactions] High throughput no no
HXB5_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
S1PR2_HUMAN [view interactions] High throughput no no
CXB7_HUMAN [view interactions] High throughput no no
S2541_HUMAN [view interactions] High throughput no no
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
EXOC6_HUMAN [view entry] [view interactions] High throughput yes yes
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
CCNL2_HUMAN [view interactions] High throughput no yes
T185A_HUMAN [view interactions] High throughput no no
P2RY8_HUMAN [view interactions] High throughput no no
C1QL4_HUMAN [view interactions] High throughput no no
PCDGK_HUMAN [view interactions] High throughput no yes
GBG3_HUMAN [view entry] [view interactions] High throughput yes no
GBG4_HUMAN [view interactions] High throughput no no
TA2R7_HUMAN [view interactions] High throughput no no
SPRE2_HUMAN [view interactions] High throughput no yes
PIFO_HUMAN [view interactions] High throughput no no
ZN843_HUMAN [view interactions] High throughput no yes
MOT14_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PKHA7_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
LUM_HUMAN [view interactions] High throughput no no
PPT1_HUMAN [view interactions] High throughput no yes
5NT3A_HUMAN [view interactions] High throughput no yes
HOT_HUMAN [view interactions] High throughput no no
PARP2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
ABCE1_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no
OXDA_HUMAN [view interactions] High throughput no no
DUS22_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
ISG20_HUMAN [view interactions] High throughput no no
RN111_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
UBQL2_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
KI20A_HUMAN [view interactions] High throughput no yes
GBG1_HUMAN [view interactions] High throughput no no
LHPL5_HUMAN [view interactions] High throughput no no
GBG8_HUMAN [view interactions] High throughput no no
TACC3_HUMAN [view entry] [view interactions] High throughput yes yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
GBG5_HUMAN [view interactions] High throughput no no
CERS2_HUMAN [view interactions] High throughput no no
GBG10_HUMAN [view interactions] High throughput no no
PLCC_HUMAN [view interactions] High throughput no no
CMIP_HUMAN [view interactions] High throughput no yes
ZDH23_HUMAN [view interactions] High throughput no no
CKS1_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
MRGX1_HUMAN [view interactions] High throughput no no
CDK19_HUMAN [view interactions] High throughput no yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
GBB4_HUMAN [view entry] [view interactions] High throughput yes yes
CPLX1_HUMAN [view entry] [view interactions] High throughput yes yes
CPLX2_HUMAN [view entry] [view interactions] High throughput yes yes
GNA13_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
GNA11_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
TUB_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
EDN1_HUMAN [view interactions] Computational no no
PA24A_HUMAN [view entry] [view interactions] Computational yes yes
OPSD_HUMAN [view interactions] Computational no no
GLP1R_HUMAN [view interactions] Computational no no
ECHA_HUMAN [view entry] [view interactions] Computational yes yes
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
SDF1_HUMAN [view interactions] Computational no no
FZD6_HUMAN [view interactions] Computational no yes
CCR5_HUMAN [view interactions] Computational no no
PLCB4_HUMAN [view entry] [view interactions] Computational yes yes
DVL3_HUMAN [view interactions] Computational no yes
PLCG1_HUMAN [view entry] [view interactions] Computational yes yes
ADA1A_HUMAN [view entry] [view interactions] Computational yes no
CCR3_HUMAN [view interactions] Computational no yes
FFAR2_HUMAN [view interactions] Computational no yes
CAV1_HUMAN [view interactions] Computational no no
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes
ACM3_HUMAN [view entry] [view interactions] Computational yes yes
BKRB2_HUMAN [view interactions] Computational no yes
CCL4_HUMAN [view interactions] Computational no no
GNB5_HUMAN [view entry] [view interactions] Computational yes yes
RGS13_HUMAN [view interactions] Computational no no
ADA1D_HUMAN [view interactions] Computational no no
5HT2C_HUMAN [view interactions] Computational no no
OXYR_HUMAN [view interactions] Computational no no
PA24D_HUMAN [view interactions] Computational no no
GRM5_HUMAN [view entry] [view interactions] Computational yes no
RGS17_HUMAN [view entry] [view interactions] Computational yes yes
RGSL_HUMAN [view interactions] Computational no no
THRB_HUMAN [view interactions] Computational no no
ADA1B_HUMAN [view interactions] Computational no no
5HT2A_HUMAN [view entry] [view interactions] Computational yes yes
LPAR1_HUMAN [view entry] [view interactions] Computational yes no
AGTR2_HUMAN [view interactions] Computational no no
CAC1A_HUMAN [view interactions] Computational no no
RGS19_HUMAN [view interactions] Computational no yes
GRM1_HUMAN [view entry] [view interactions] Computational yes yes
GNA15_HUMAN [view interactions] Computational no yes
CCL11_HUMAN [view interactions] Computational no no
PA24B_HUMAN [view interactions] Computational no no
ARHG5_HUMAN [view interactions] Computational no yes
RASN_HUMAN [view entry] [view interactions] Computational yes no
V1AR_HUMAN [view interactions] Computational no no
GHSR_HUMAN [view entry] [view interactions] Computational yes no
SUCB2_HUMAN [view interactions] Computational no no
RGS1_HUMAN [view interactions] Computational no yes
PAR4_HUMAN [view entry] [view interactions] Computational yes no
CASR_HUMAN [view interactions] Computational no no
LSHR_HUMAN [view interactions] Computational no no
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
5HT2B_HUMAN [view interactions] Computational no no
FFAR4_HUMAN [view interactions] Computational no no
KCJ12_HUMAN [view interactions] Computational no no
PTH1R_HUMAN [view interactions] Computational no no
MK14_HUMAN [view interactions] Computational no yes
PA24C_HUMAN [view interactions] Computational no yes
PA24E_HUMAN [view interactions] Computational no no
ACM5_HUMAN [view entry] [view interactions] Computational yes no
ARRC_HUMAN [view interactions] Computational no no
ARG28_HUMAN [view interactions] Computational no yes
DVL1_HUMAN [view entry] [view interactions] Computational yes yes
GNRHR_HUMAN [view interactions] Computational no no
CXCR4_HUMAN [view interactions] Computational no no
LPAR3_HUMAN [view interactions] Computational no no
S1PR3_HUMAN [view interactions] Computational no no
GNA14_HUMAN [view entry] [view interactions] Computational yes yes
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
GNA12_HUMAN [view interactions] Computational no no
P2RY1_HUMAN [view entry] [view interactions] Computational yes yes
TRIO_HUMAN [view entry] [view interactions] Computational yes yes
BKRB1_HUMAN [view interactions] Computational no yes
GNAZ_HUMAN [view entry] [view interactions] Computational yes yes
GLR_HUMAN [view interactions] Computational no no
TRPC6_HUMAN [view interactions] Computational no no
AGRG1_HUMAN [view interactions] Computational no yes
MK08_HUMAN [view interactions] Computational no yes
KPCZ_HUMAN [view entry] [view interactions] Computational yes yes
V1BR_HUMAN [view interactions] Computational no no
KCNJ4_HUMAN [view entry] [view interactions] Computational yes no
ARHGP_HUMAN [view interactions] Computational no yes
NHRF1_HUMAN [view interactions] Computational no no
EDNRA_HUMAN [view interactions] Computational no yes
DRD1_HUMAN [view entry] [view interactions] Computational yes no
DVL2_HUMAN [view interactions] Computational no yes
ANGT_HUMAN [view interactions] Computational no no
CNR1_HUMAN [view interactions] Computational no yes
ACHA_HUMAN [view entry] [view interactions] Computational yes no
KCJ18_HUMAN [view interactions] Computational no no
RGS3_HUMAN [view interactions] Computational no no
AKT1_HUMAN [view entry] [view interactions] Computational yes yes
EDNRB_HUMAN [view interactions] Computational no no
KCNJ2_HUMAN [view entry] [view interactions] Computational yes yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
HRH1_HUMAN [view interactions] Computational no no
AA2BR_HUMAN [view interactions] Computational no no
GPER1_HUMAN [view entry] [view interactions] Computational yes yes
PLPL9_HUMAN [view interactions] Computational no yes
CCKAR_HUMAN [view interactions] Computational no no
ARRB2_HUMAN [view entry] [view interactions] Computational yes no
GPBAR_HUMAN [view interactions] Computational no no
RASK_HUMAN [view entry] [view interactions] Computational yes no
NK1R_HUMAN [view interactions] Computational no no
PE2R3_HUMAN [view interactions] Computational no no
PA24F_HUMAN [view interactions] Computational no no
ESR1_HUMAN [view interactions] Computational no no
P2RY2_HUMAN [view interactions] Computational no no
VAV_HUMAN [view interactions] Computational no no
LPAR2_HUMAN [view interactions] Computational no yes
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
DRD5_HUMAN [view entry] [view interactions] Computational yes no
FFAR1_HUMAN [view interactions] Computational no no
NTR1_HUMAN [view interactions] Computational no no
PAR2_HUMAN [view entry] [view interactions] Computational yes yes
GRPR_HUMAN [view interactions] Computational no no
KALRN_HUMAN [view entry] [view interactions] Computational yes yes
CLTR2_HUMAN [view interactions] Computational no no
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
PLCG2_HUMAN [view interactions] Computational no yes
PE2R1_HUMAN [view interactions] Computational no no
KCJ14_HUMAN [view interactions] Computational no no