GNAQ_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) . Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 183 | Arg | Gln | Sturge-Webersyndrome(SWS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GNAQ_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.6154 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 30.7692 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 30.7692 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 30.7692 | 6 | yes |
| GO:0003924 | GTPase activity | 28.8462 | 7 | yes |
| GO:0030695 | GTPase regulator activity | 28.8462 | 4 | yes |
| GO:0000166 | nucleotide binding | 26.9231 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 26.9231 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 26.9231 | 4 | yes |
| GO:0043169 | cation binding | 26.9231 | 4 | yes |
| GO:0046872 | metal ion binding | 26.9231 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | yes |
| GO:0001664 | G protein-coupled receptor binding | 17.3077 | 4 | yes |
| GO:0005096 | GTPase activator activity | 17.3077 | 4 | yes |
| GO:0005525 | GTP binding | 17.3077 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 17.3077 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 17.3077 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GNAQ_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 59.6154 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 48.0769 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.1538 | 4 | yes |
| GO:0051049 | regulation of transport | 40.3846 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.6154 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 30.7692 | 4 | no |
| GO:0006996 | organelle organization | 28.8462 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 26.9231 | 4 | yes |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 23.0769 | 4 | yes |
| GO:0051046 | regulation of secretion | 23.0769 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 23.0769 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.0769 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.0769 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.0769 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.0769 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.0769 | 4 | no |
| GO:0022607 | cellular component assembly | 23.0769 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 23.0769 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 21.1538 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 21.1538 | 4 | yes |
| GO:0051050 | positive regulation of transport | 21.1538 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 21.1538 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.1538 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.1538 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.1538 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.1538 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 17.3077 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 15.3846 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 15.3846 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 15.3846 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 15.3846 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 15.3846 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 15.3846 | 7 | yes |
| GO:0095500 | acetylcholine receptor signaling pathway | 13.4615 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 13.4615 | 7 | yes |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 13.4615 | 5 | yes |
| GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 13.4615 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 13.4615 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 11.5385 | 4 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 11.5385 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 9.6154 | 6 | yes |
| GO:0001508 | action potential | 9.6154 | 4 | yes |
| GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 9.6154 | 4 | yes |
| GO:0043086 | negative regulation of catalytic activity | 9.6154 | 4 | yes |
| GO:0051338 | regulation of transferase activity | 7.6923 | 4 | yes |
| GO:0009416 | response to light stimulus | 7.6923 | 4 | yes |
| GO:0043549 | regulation of kinase activity | 7.6923 | 5 | yes |
| GO:0050821 | protein stabilization | 5.7692 | 4 | yes |
| GO:0050865 | regulation of cell activation | 5.7692 | 4 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 5.7692 | 4 | yes |
| GO:0031400 | negative regulation of protein modification process | 5.7692 | 7 | yes |
| GO:0045859 | regulation of protein kinase activity | 5.7692 | 6 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 3.8462 | 7 | yes |
| GO:0051348 | negative regulation of transferase activity | 3.8462 | 5 | yes |
| GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway | 3.8462 | 4 | yes |
| GO:0060191 | regulation of lipase activity | 3.8462 | 5 | yes |
| GO:0060193 | positive regulation of lipase activity | 3.8462 | 6 | yes |
| GO:1900274 | regulation of phospholipase C activity | 3.8462 | 7 | yes |
| GO:0007603 | phototransduction, visible light | 3.8462 | 4 | yes |
| GO:0009583 | detection of light stimulus | 3.8462 | 4 | yes |
| GO:0009584 | detection of visible light | 3.8462 | 5 | yes |
| GO:0010517 | regulation of phospholipase activity | 3.8462 | 6 | yes |
| GO:0010518 | positive regulation of phospholipase activity | 3.8462 | 7 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 3.8462 | 6 | yes |
| GO:0010863 | positive regulation of phospholipase C activity | 3.8462 | 8 | yes |
| GO:0033673 | negative regulation of kinase activity | 3.8462 | 6 | yes |
| GO:0042326 | negative regulation of phosphorylation | 3.8462 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VIPR1_HUMAN | [view interactions] | Low throughput | no | yes |
| PAR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS18_HUMAN | [view interactions] | Low throughput | no | yes |
| WDR36_HUMAN | [view interactions] | Low throughput | no | no |
| TA2R_HUMAN | [view interactions] | Low throughput | no | no |
| PLCB2_HUMAN | [view interactions] | Low throughput | no | no |
| PI2R_HUMAN | [view interactions] | Low throughput | no | no |
| CYH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYH1_HUMAN | [view interactions] | Low throughput | no | no |
| CYH3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBB3_HUMAN | [view interactions] | Low throughput | no | yes |
| PLCB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CD47_HUMAN | [view interactions] | Low throughput | no | no |
| ARHGB_HUMAN | [view interactions] | Low throughput | no | yes |
| ARHG1_HUMAN | [view interactions] | Low throughput | no | no |
| ARHGC_HUMAN | [view interactions] | Low throughput | no | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GASR_HUMAN | [view interactions] | Low throughput | no | no |
| KNG1_HUMAN | [view interactions] | Low throughput | no | no |
| BKRB2_HUMAN | [view interactions] | Low throughput | no | yes |
| GAST_HUMAN | [view interactions] | Low throughput | no | no |
| CCKN_HUMAN | [view interactions] | Low throughput | no | yes |
| FFAR4_HUMAN | [view interactions] | Low throughput | no | no |
| NTR1_HUMAN | [view interactions] | Low throughput | no | no |
| CASR_HUMAN | [view interactions] | Low throughput | no | no |
| AGTR1_HUMAN | [view interactions] | Low throughput | no | no |
| AIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PECA1_HUMAN | [view interactions] | Low throughput | no | no |
| KCNK3_HUMAN | [view interactions] | Low throughput | no | no |
| KCNK9_HUMAN | [view interactions] | Low throughput | no | no |
| TRPM8_HUMAN | [view interactions] | Low throughput | no | no |
| CXCR5_HUMAN | [view interactions] | Low throughput | no | yes |
| RARA_HUMAN | [view interactions] | Low throughput | no | no |
| RGS2_HUMAN | [view interactions] | Low throughput | no | no |
| KISSR_HUMAN | [view interactions] | Low throughput | no | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGRF1_HUMAN | [view interactions] | Low throughput | no | no |
| PLCB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FLOT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIC8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RIC8B_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RGS16_HUMAN | [view interactions] | Low throughput | no | no |
| ARBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TTC1_HUMAN | [view interactions] | Low throughput | no | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| AKP13_HUMAN | [view interactions] | Low throughput | no | yes |
| CRFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS5_HUMAN | [view interactions] | Low throughput | no | no |
| BTK_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| ISG20_HUMAN | [view interactions] | High throughput | no | no |
| RN111_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| GBG1_HUMAN | [view interactions] | High throughput | no | no |
| LHPL5_HUMAN | [view interactions] | High throughput | no | no |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG5_HUMAN | [view interactions] | High throughput | no | no |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| GBG10_HUMAN | [view interactions] | High throughput | no | no |
| PLCC_HUMAN | [view interactions] | High throughput | no | no |
| CMIP_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| CKS1_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MRGX1_HUMAN | [view interactions] | High throughput | no | no |
| CDK19_HUMAN | [view interactions] | High throughput | no | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPLX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TUB_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| MED21_HUMAN | [view interactions] | High throughput | no | yes |
| TIGD5_HUMAN | [view interactions] | High throughput | no | no |
| S1PR1_HUMAN | [view interactions] | High throughput | no | no |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| C1QL4_HUMAN | [view interactions] | High throughput | no | no |
| PCDGK_HUMAN | [view interactions] | High throughput | no | yes |
| GBG4_HUMAN | [view interactions] | High throughput | no | no |
| GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TA2R7_HUMAN | [view interactions] | High throughput | no | no |
| SPRE2_HUMAN | [view interactions] | High throughput | no | yes |
| CMAP3_HUMAN | [view interactions] | High throughput | no | no |
| MOT14_HUMAN | [view interactions] | High throughput | no | yes |
| ZN843_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LUM_HUMAN | [view interactions] | High throughput | no | no |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| 5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
| HOT_HUMAN | [view interactions] | High throughput | no | no |
| PARP2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |