RGS7_HUMAN
Evidence for PS localization
Functions
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed, PubMed). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed). May play a role in synaptic vesicle exocytosis (PubMed). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RGS7_HUMAN |
|---|---|---|---|---|
| GO:0016462 | pyrophosphatase activity | 64.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 64.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 64.0000 | 6 | yes |
| GO:0003924 | GTPase activity | 52.0000 | 7 | yes |
| GO:0005096 | GTPase activator activity | 36.0000 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 36.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 32.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 32.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.0000 | 4 | no |
| GO:0046872 | metal ion binding | 24.0000 | 4 | no |
| GO:0005525 | GTP binding | 24.0000 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 24.0000 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 24.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RGS7_HUMAN |
|---|---|---|---|---|
| GO:0009966 | regulation of signal transduction | 56.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 56.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.0000 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 44.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.0000 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 44.0000 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 40.0000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 40.0000 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 36.0000 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 36.0000 | 4 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 36.0000 | 5 | yes |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 36.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.0000 | 4 | no |
| GO:0043087 | regulation of GTPase activity | 28.0000 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 28.0000 | 6 | yes |
| GO:0051049 | regulation of transport | 28.0000 | 4 | yes |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 28.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 28.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 28.0000 | 4 | no |
| GO:0043269 | regulation of ion transport | 24.0000 | 5 | yes |
| GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 24.0000 | 4 | no |
| GO:0095500 | acetylcholine receptor signaling pathway | 24.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 24.0000 | 4 | no |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 20.0000 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 20.0000 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 20.0000 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 20.0000 | 5 | yes |
| GO:0051050 | positive regulation of transport | 20.0000 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 16.0000 | 6 | yes |
| GO:0043270 | positive regulation of ion transport | 16.0000 | 5 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 16.0000 | 6 | yes |
| GO:0007420 | brain development | 12.0000 | 4 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 12.0000 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 12.0000 | 6 | yes |
| GO:0097305 | response to alcohol | 12.0000 | 4 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 12.0000 | 7 | yes |
| GO:0001975 | response to amphetamine | 8.0000 | 6 | yes |
| GO:0014075 | response to amine | 8.0000 | 5 | yes |
| GO:0043266 | regulation of potassium ion transport | 8.0000 | 7 | yes |
| GO:0043268 | positive regulation of potassium ion transport | 8.0000 | 6 | yes |
| GO:0045471 | response to ethanol | 8.0000 | 5 | yes |
| GO:1901379 | regulation of potassium ion transmembrane transport | 8.0000 | 7 | yes |
| GO:1901381 | positive regulation of potassium ion transmembrane transport | 8.0000 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKD1_HUMAN | [view interactions] | Low throughput | no | yes |
| SNAPN_HUMAN | [view interactions] | Low throughput | no | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNB5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| R7BP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GP158_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| RGS3_HUMAN | [view interactions] | Computational | no | no |
| RGS6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RGS9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| R9BP_HUMAN | [view interactions] | Computational | no | no |
| RGS21_HUMAN | [view interactions] | Computational | no | no |
| RGS4_HUMAN | [view interactions] | Computational | no | no |
| RGS8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RGS5_HUMAN | [view interactions] | Computational | no | no |
| RGS13_HUMAN | [view interactions] | Computational | no | no |
| RGS11_HUMAN | [view interactions] | Computational | no | yes |
| RGS16_HUMAN | [view interactions] | Computational | no | no |
| RGS18_HUMAN | [view interactions] | Computational | no | yes |
| RGS19_HUMAN | [view interactions] | Computational | no | yes |
| RGS17_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RGS1_HUMAN | [view interactions] | Computational | no | yes |
| SUCB2_HUMAN | [view interactions] | Computational | no | no |
| RGS20_HUMAN | [view interactions] | Computational | no | no |
| RGS10_HUMAN | [view interactions] | Computational | no | yes |
| RGS12_HUMAN | [view interactions] | Computational | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |