Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGS7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed, PubMed). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed). May play a role in synaptic vesicle exocytosis (PubMed). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RGS7_HUMAN
GO:0016462 pyrophosphatase activity 52.6316 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 52.6316 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 52.6316 6 yes
GO:0003924 GTPase activity 36.8421 7 yes
GO:0000166 nucleotide binding 36.8421 4 no
GO:0017076 purine nucleotide binding 36.8421 5 no
GO:0032555 purine ribonucleotide binding 36.8421 4 no
GO:0035639 purine ribonucleoside triphosphate binding 36.8421 4 no
GO:0043168 anion binding 36.8421 4 no
GO:0043169 cation binding 31.5789 4 no
GO:0030695 GTPase regulator activity 26.3158 4 yes
GO:0005525 GTP binding 26.3158 5 no
GO:0019001 guanyl nucleotide binding 26.3158 6 no
GO:0032561 guanyl ribonucleotide binding 26.3158 5 no
GO:0046872 metal ion binding 26.3158 5 no
GO:0004930 G protein-coupled receptor activity 26.3158 4 no
GO:0099528 G protein-coupled neurotransmitter receptor activity 26.3158 4 no
GO:0005096 GTPase activator activity 21.0526 4 yes
GO:0019900 kinase binding 21.0526 4 no
GO:0019901 protein kinase binding 21.0526 5 no
GO:0031625 ubiquitin protein ligase binding 21.0526 5 no
GO:0044389 ubiquitin-like protein ligase binding 21.0526 4 no
GO:0001664 G protein-coupled receptor binding 21.0526 4 no
GO:0003723 RNA binding 21.0526 4 no
GO:0004435 phosphatidylinositol phospholipase C activity 21.0526 7 no
GO:0004620 phospholipase activity 21.0526 5 no
GO:0004629 phospholipase C activity 21.0526 6 no
GO:0004993 G protein-coupled serotonin receptor activity 21.0526 6 no
GO:0008081 phosphoric diester hydrolase activity 21.0526 5 no
GO:0008227 G protein-coupled amine receptor activity 21.0526 5 no
GO:0015464 acetylcholine receptor activity 21.0526 4 no
GO:0016298 lipase activity 21.0526 4 no
GO:0016907 G protein-coupled acetylcholine receptor activity 21.0526 5 no
GO:0042578 phosphoric ester hydrolase activity 21.0526 4 no
GO:0098960 postsynaptic neurotransmitter receptor activity 21.0526 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RGS7_HUMAN
GO:0010646 regulation of cell communication 63.1579 4 yes
GO:0048522 positive regulation of cellular process 57.8947 4 yes
GO:0048523 negative regulation of cellular process 47.3684 4 yes
GO:0051049 regulation of transport 47.3684 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 42.1053 4 no
GO:0009966 regulation of signal transduction 36.8421 4 yes
GO:0051050 positive regulation of transport 36.8421 4 yes
GO:0031323 regulation of cellular metabolic process 36.8421 4 no
GO:0032880 regulation of protein localization 36.8421 5 no
GO:0060341 regulation of cellular localization 36.8421 4 no
GO:0043085 positive regulation of catalytic activity 31.5789 4 yes
GO:0051336 regulation of hydrolase activity 31.5789 4 yes
GO:0060255 regulation of macromolecule metabolic process 31.5789 4 no
GO:0080090 regulation of primary metabolic process 31.5789 4 no
GO:1903829 positive regulation of protein localization 31.5789 5 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 31.5789 5 no
GO:0034762 regulation of transmembrane transport 26.3158 4 yes
GO:0043269 regulation of monoatomic ion transport 26.3158 5 yes
GO:0048585 negative regulation of response to stimulus 26.3158 4 yes
GO:0051345 positive regulation of hydrolase activity 26.3158 5 yes
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 26.3158 4 no
GO:0095500 acetylcholine receptor signaling pathway 26.3158 4 no
GO:0070201 regulation of establishment of protein localization 26.3158 6 no
GO:0010243 response to organonitrogen compound 21.0526 4 yes
GO:0010648 negative regulation of cell communication 21.0526 5 yes
GO:0010959 regulation of metal ion transport 21.0526 6 yes
GO:0023057 negative regulation of signaling 21.0526 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 21.0526 5 yes
GO:0043087 regulation of GTPase activity 21.0526 5 yes
GO:0043270 positive regulation of monoatomic ion transport 21.0526 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 21.0526 6 yes
GO:0009889 regulation of biosynthetic process 21.0526 4 no
GO:0010556 regulation of macromolecule biosynthetic process 21.0526 5 no
GO:0010647 positive regulation of cell communication 21.0526 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.0526 5 no
GO:0023056 positive regulation of signaling 21.0526 4 no
GO:0031326 regulation of cellular biosynthetic process 21.0526 5 no
GO:0048584 positive regulation of response to stimulus 21.0526 4 no
GO:0051128 regulation of cellular component organization 21.0526 4 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 21.0526 4 no
GO:0019220 regulation of phosphate metabolic process 21.0526 6 no
GO:0050821 protein stabilization 21.0526 4 no
GO:0051174 regulation of phosphorus metabolic process 21.0526 5 no
GO:0050804 modulation of chemical synaptic transmission 21.0526 5 no
GO:0099177 regulation of trans-synaptic signaling 21.0526 4 no
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 21.0526 4 no
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway 21.0526 5 no
GO:0007268 chemical synaptic transmission 21.0526 7 no
GO:0051223 regulation of protein transport 21.0526 5 no
GO:0098916 anterograde trans-synaptic signaling 21.0526 6 no
GO:0099536 synaptic signaling 21.0526 4 no
GO:0099537 trans-synaptic signaling 21.0526 5 no
GO:1904951 positive regulation of establishment of protein localization 21.0526 6 no
GO:0009893 positive regulation of metabolic process 21.0526 4 no
GO:0031325 positive regulation of cellular metabolic process 21.0526 5 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 15.7895 5 yes
GO:0009968 negative regulation of signal transduction 15.7895 5 yes
GO:0034764 positive regulation of transmembrane transport 15.7895 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 15.7895 6 yes
GO:0043547 positive regulation of GTPase activity 15.7895 6 yes
GO:1904064 positive regulation of cation transmembrane transport 15.7895 7 yes
GO:0001975 response to amphetamine 10.5263 6 yes
GO:0014075 response to amine 10.5263 5 yes
GO:0043266 regulation of potassium ion transport 10.5263 7 yes
GO:0043268 positive regulation of potassium ion transport 10.5263 6 yes
GO:0045471 response to ethanol 10.5263 5 yes
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 10.5263 6 yes
GO:0097305 response to alcohol 10.5263 4 yes
GO:1901379 regulation of potassium ion transmembrane transport 10.5263 7 yes
GO:1901381 positive regulation of potassium ion transmembrane transport 10.5263 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
PKD1_HUMAN [view interactions] Low throughput no yes
SNAPN_HUMAN [view interactions] Low throughput no yes
GNAI3_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAZ_HUMAN [view entry] [view interactions] Low throughput yes yes
GNB5_HUMAN [view entry] [view interactions] Low throughput yes yes
R7BP_HUMAN [view entry] [view interactions] Low throughput yes yes
ACM3_HUMAN [view entry] [view interactions] Low throughput yes yes
ACM5_HUMAN [view entry] [view interactions] Low throughput yes no
ACM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACM2_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS7_HUMAN [view entry] [view interactions] Low throughput yes yes
MGLYR_HUMAN [view entry] [view interactions] Low throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
H12_HUMAN [view interactions] High throughput no yes
MCM7_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
FOS_HUMAN [view interactions] High throughput no yes
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CSK_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes