Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACM1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACM1_HUMAN
GO:0001664 G protein-coupled receptor binding 57.1429 4 no
GO:0031625 ubiquitin protein ligase binding 42.8571 5 no
GO:0044389 ubiquitin-like protein ligase binding 42.8571 4 no
GO:0019900 kinase binding 28.5714 4 no
GO:0031748 D1 dopamine receptor binding 28.5714 6 no
GO:0050780 dopamine receptor binding 28.5714 5 no
GO:0005096 GTPase activator activity 28.5714 4 no
GO:0030695 GTPase regulator activity 28.5714 4 no
GO:0031701 angiotensin receptor binding 28.5714 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in ACM1_HUMAN
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0048522 positive regulation of cellular process 71.4286 4 yes
GO:0051049 regulation of transport 71.4286 4 yes
GO:0009966 regulation of signal transduction 57.1429 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0051050 positive regulation of transport 57.1429 4 yes
GO:0001932 regulation of protein phosphorylation 42.8571 7 no
GO:0001934 positive regulation of protein phosphorylation 42.8571 8 no
GO:0002090 regulation of receptor internalization 42.8571 7 no
GO:0008104 protein localization 42.8571 4 no
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0009967 positive regulation of signal transduction 42.8571 5 no
GO:0010562 positive regulation of phosphorus metabolic process 42.8571 6 no
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0010647 positive regulation of cell communication 42.8571 5 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0030100 regulation of endocytosis 42.8571 5 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0031401 positive regulation of protein modification process 42.8571 7 no
GO:0042325 regulation of phosphorylation 42.8571 7 no
GO:0042327 positive regulation of phosphorylation 42.8571 8 no
GO:0045937 positive regulation of phosphate metabolic process 42.8571 7 no
GO:0048259 regulation of receptor-mediated endocytosis 42.8571 6 no
GO:0048584 positive regulation of response to stimulus 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0051130 positive regulation of cellular component organization 42.8571 5 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0051247 positive regulation of protein metabolic process 42.8571 6 no
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:0060627 regulation of vesicle-mediated transport 42.8571 4 no
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:0006508 proteolysis 42.8571 4 no
GO:0009057 macromolecule catabolic process 42.8571 4 no
GO:0016567 protein ubiquitination 42.8571 8 no
GO:0019941 modification-dependent protein catabolic process 42.8571 6 no
GO:0032446 protein modification by small protein conjugation 42.8571 7 no
GO:0036211 protein modification process 42.8571 4 no
GO:0043412 macromolecule modification 42.8571 4 no
GO:0043632 modification-dependent macromolecule catabolic process 42.8571 5 no
GO:0043687 post-translational protein modification 42.8571 5 no
GO:0051603 proteolysis involved in protein catabolic process 42.8571 5 no
GO:0070647 protein modification by small protein conjugation or removal 42.8571 6 no
GO:0009968 negative regulation of signal transduction 42.8571 5 no
GO:0010648 negative regulation of cell communication 42.8571 5 no
GO:0023057 negative regulation of signaling 42.8571 4 no
GO:0048585 negative regulation of response to stimulus 42.8571 4 no
GO:0050804 modulation of chemical synaptic transmission 42.8571 5 yes
GO:0099177 regulation of trans-synaptic signaling 42.8571 4 yes
GO:0006996 organelle organization 28.5714 4 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0034762 regulation of transmembrane transport 28.5714 4 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0050806 positive regulation of synaptic transmission 28.5714 5 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0001817 regulation of cytokine production 28.5714 4 no
GO:0001818 negative regulation of cytokine production 28.5714 5 no
GO:0002031 G protein-coupled receptor internalization 28.5714 6 no
GO:0002092 positive regulation of receptor internalization 28.5714 7 no
GO:0006355 regulation of DNA-templated transcription 28.5714 7 no
GO:0006511 ubiquitin-dependent protein catabolic process 28.5714 7 no
GO:0006898 receptor-mediated endocytosis 28.5714 4 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0009890 negative regulation of biosynthetic process 28.5714 5 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010498 proteasomal protein catabolic process 28.5714 5 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0010629 negative regulation of gene expression 28.5714 7 no
GO:0015031 protein transport 28.5714 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0030163 protein catabolic process 28.5714 4 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0031396 regulation of protein ubiquitination 28.5714 9 no
GO:0031397 negative regulation of protein ubiquitination 28.5714 10 no
GO:0031400 negative regulation of protein modification process 28.5714 7 no
GO:0031623 receptor internalization 28.5714 5 no
GO:0032088 negative regulation of NF-kappaB transcription factor activity 28.5714 5 no
GO:0032675 regulation of interleukin-6 production 28.5714 5 no
GO:0032715 negative regulation of interleukin-6 production 28.5714 6 no
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 28.5714 6 no
GO:0043408 regulation of MAPK cascade 28.5714 6 no
GO:0043410 positive regulation of MAPK cascade 28.5714 7 no
GO:0043433 negative regulation of DNA-binding transcription factor activity 28.5714 4 no
GO:0045807 positive regulation of endocytosis 28.5714 5 no
GO:0048260 positive regulation of receptor-mediated endocytosis 28.5714 6 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:0051248 negative regulation of protein metabolic process 28.5714 6 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 28.5714 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 28.5714 8 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0098657 import into cell 28.5714 4 no
GO:1901565 organonitrogen compound catabolic process 28.5714 4 no
GO:1901873 regulation of post-translational protein modification 28.5714 7 no
GO:1901874 negative regulation of post-translational protein modification 28.5714 8 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:1902533 positive regulation of intracellular signal transduction 28.5714 6 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 28.5714 8 no
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 28.5714 9 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 28.5714 5 no
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 28.5714 6 no
GO:0007268 chemical synaptic transmission 28.5714 7 yes
GO:0007399 nervous system development 28.5714 4 yes
GO:0043269 regulation of monoatomic ion transport 28.5714 5 yes
GO:0043270 positive regulation of monoatomic ion transport 28.5714 5 yes
GO:0050890 cognition 28.5714 4 yes
GO:0060078 regulation of postsynaptic membrane potential 28.5714 4 yes
GO:0098916 anterograde trans-synaptic signaling 28.5714 6 yes
GO:0099536 synaptic signaling 28.5714 4 yes
GO:0099537 trans-synaptic signaling 28.5714 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RGS7_HUMAN [view entry] [view interactions] Low throughput yes yes
CC14A_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
GASP1_HUMAN [view interactions] High throughput no yes
GASP2_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes