Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACM1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACM1_HUMAN
GO:0046872 metal ion binding 24.3902 4 no
GO:0019900 kinase binding 24.3902 4 no
GO:0019901 protein kinase binding 24.3902 5 no
GO:0001664 G protein-coupled receptor binding 21.9512 4 no
GO:0017076 purine nucleotide binding 21.9512 4 no
GO:0032555 purine ribonucleotide binding 21.9512 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.9512 4 no
GO:0004930 G protein-coupled receptor activity 19.5122 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 14.6341 4 yes
GO:0008227 G protein-coupled amine receptor activity 12.1951 5 yes
GO:0015464 acetylcholine receptor activity 12.1951 4 yes
GO:0004435 phosphatidylinositol phospholipase C activity 9.7561 7 yes
GO:0004620 phospholipase activity 9.7561 5 yes
GO:0004629 phospholipase C activity 9.7561 6 yes
GO:0004993 G protein-coupled serotonin receptor activity 9.7561 5 yes
GO:0008081 phosphoric diester hydrolase activity 9.7561 5 yes
GO:0016298 lipase activity 9.7561 4 yes
GO:0016907 G protein-coupled acetylcholine receptor activity 9.7561 5 yes
GO:0042578 phosphoric ester hydrolase activity 9.7561 4 yes
GO:0099528 G protein-coupled neurotransmitter receptor activity 9.7561 4 yes
GO:0099589 serotonin receptor activity 9.7561 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 4.8780 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACM1_HUMAN
GO:0048522 positive regulation of cellular process 56.0976 4 yes
GO:0010646 regulation of cell communication 48.7805 4 no
GO:0009966 regulation of signal transduction 46.3415 4 no
GO:0048523 negative regulation of cellular process 46.3415 4 no
GO:0031323 regulation of cellular metabolic process 39.0244 4 no
GO:0051049 regulation of transport 36.5854 4 yes
GO:0060255 regulation of macromolecule metabolic process 36.5854 4 no
GO:0080090 regulation of primary metabolic process 36.5854 4 no
GO:0043085 positive regulation of catalytic activity 36.5854 4 no
GO:0051128 regulation of cellular component organization 36.5854 4 no
GO:0048584 positive regulation of response to stimulus 34.1463 4 no
GO:0009893 positive regulation of metabolic process 34.1463 4 no
GO:0051171 regulation of nitrogen compound metabolic process 34.1463 4 no
GO:0010647 positive regulation of cell communication 31.7073 5 no
GO:0023056 positive regulation of signaling 31.7073 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.7073 5 no
GO:0031325 positive regulation of cellular metabolic process 31.7073 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.7073 5 no
GO:0051240 positive regulation of multicellular organismal process 31.7073 4 no
GO:1902531 regulation of intracellular signal transduction 31.7073 5 no
GO:0051336 regulation of hydrolase activity 29.2683 4 no
GO:0009967 positive regulation of signal transduction 29.2683 5 no
GO:0043269 regulation of ion transport 29.2683 5 yes
GO:0019220 regulation of phosphate metabolic process 29.2683 6 no
GO:0051174 regulation of phosphorus metabolic process 29.2683 5 no
GO:0051130 positive regulation of cellular component organization 29.2683 5 no
GO:0051246 regulation of protein metabolic process 29.2683 5 no
GO:0036211 protein modification process 26.8293 4 no
GO:0043412 macromolecule modification 26.8293 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 26.8293 4 yes
GO:0001932 regulation of protein phosphorylation 26.8293 7 no
GO:0006996 organelle organization 26.8293 4 no
GO:0022603 regulation of anatomical structure morphogenesis 26.8293 4 no
GO:0031399 regulation of protein modification process 26.8293 6 no
GO:0042325 regulation of phosphorylation 26.8293 7 no
GO:0043408 regulation of MAPK cascade 26.8293 6 no
GO:0048585 negative regulation of response to stimulus 26.8293 4 no
GO:0051094 positive regulation of developmental process 26.8293 4 no
GO:0051247 positive regulation of protein metabolic process 26.8293 6 no
GO:0010941 regulation of cell death 26.8293 4 no
GO:0042981 regulation of apoptotic process 26.8293 6 no
GO:0043067 regulation of programmed cell death 26.8293 5 no
GO:0022607 cellular component assembly 24.3902 4 no
GO:0033043 regulation of organelle organization 24.3902 5 no
GO:1902533 positive regulation of intracellular signal transduction 24.3902 6 no
GO:0051050 positive regulation of transport 24.3902 4 yes
GO:0099537 trans-synaptic signaling 24.3902 4 yes
GO:0001934 positive regulation of protein phosphorylation 24.3902 8 no
GO:0009968 negative regulation of signal transduction 24.3902 5 no
GO:0010562 positive regulation of phosphorus metabolic process 24.3902 6 no
GO:0010648 negative regulation of cell communication 24.3902 5 no
GO:0023057 negative regulation of signaling 24.3902 4 no
GO:0030334 regulation of cell migration 24.3902 5 no
GO:0031401 positive regulation of protein modification process 24.3902 7 no
GO:0042327 positive regulation of phosphorylation 24.3902 8 no
GO:0044087 regulation of cellular component biogenesis 24.3902 4 no
GO:0045937 positive regulation of phosphate metabolic process 24.3902 7 no
GO:2000145 regulation of cell motility 24.3902 4 no
GO:0034762 regulation of transmembrane transport 24.3902 4 no
GO:0034765 regulation of ion transmembrane transport 24.3902 5 no
GO:0080134 regulation of response to stress 21.9512 4 no
GO:0034330 cell junction organization 21.9512 4 no
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 21.9512 4 yes
GO:0095500 acetylcholine receptor signaling pathway 21.9512 4 yes
GO:0071310 cellular response to organic substance 21.9512 4 no
GO:0030030 cell projection organization 21.9512 4 no
GO:0043549 regulation of kinase activity 21.9512 5 no
GO:0044057 regulation of system process 21.9512 4 no
GO:0045859 regulation of protein kinase activity 21.9512 6 no
GO:0051338 regulation of transferase activity 21.9512 4 no
GO:0007268 chemical synaptic transmission 19.5122 6 yes
GO:0098916 anterograde trans-synaptic signaling 19.5122 5 yes
GO:0042127 regulation of cell population proliferation 17.0732 4 yes
GO:0043270 positive regulation of ion transport 17.0732 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 14.6341 4 yes
GO:0032880 regulation of protein localization 14.6341 5 yes
GO:0060341 regulation of cellular localization 14.6341 4 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 12.1951 5 yes
GO:0007399 nervous system development 12.1951 4 yes
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 9.7561 4 yes
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway 9.7561 5 yes
GO:0046903 secretion 9.7561 4 yes
GO:0050890 cognition 9.7561 4 yes
GO:1903829 positive regulation of protein localization 9.7561 5 yes
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 7.3171 4 yes
GO:0051223 regulation of protein transport 7.3171 5 yes
GO:0070201 regulation of establishment of protein localization 7.3171 6 yes
GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 4.8780 5 yes
GO:0007274 neuromuscular synaptic transmission 4.8780 7 yes
GO:0007589 body fluid secretion 4.8780 4 yes
GO:0032386 regulation of intracellular transport 4.8780 5 yes
GO:0051222 positive regulation of protein transport 4.8780 5 yes
GO:1904951 positive regulation of establishment of protein localization 4.8780 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RGS7_HUMAN [view entry] [view interactions] Low throughput yes yes
CC14A_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
GASP1_HUMAN [view interactions] High throughput no yes
GASP2_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
LAMB1_HUMAN [view interactions] Computational no yes
CCR5_HUMAN [view interactions] Computational no no
PLCG1_HUMAN [view entry] [view interactions] Computational yes yes
JUN_HUMAN [view interactions] Computational no yes
CCR3_HUMAN [view interactions] Computational no yes
SRC8_HUMAN [view entry] [view interactions] Computational yes yes
GBG2_HUMAN [view entry] [view interactions] Computational yes yes
GBB1_HUMAN [view entry] [view interactions] Computational yes yes
SDF1_HUMAN [view interactions] Computational no no
GBG7_HUMAN [view entry] [view interactions] Computational yes yes
ACM3_HUMAN [view entry] [view interactions] Computational yes yes
CCL4_HUMAN [view interactions] Computational no no
GBB2_HUMAN [view entry] [view interactions] Computational yes yes
UTRN_HUMAN [view entry] [view interactions] Computational yes yes
ITB1_HUMAN [view entry] [view interactions] Computational yes no
GNB5_HUMAN [view entry] [view interactions] Computational yes yes
DAG1_HUMAN [view entry] [view interactions] Computational yes no
ITA1_HUMAN [view interactions] Computational no yes
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes
PAK3_HUMAN [view entry] [view interactions] Computational yes no
PAXI_HUMAN [view interactions] Computational no yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
PAK2_HUMAN [view entry] [view interactions] Computational yes no
GBG11_HUMAN [view interactions] Computational no no
ACTS_HUMAN [view interactions] Computational no no
PAK5_HUMAN [view interactions] Computational no yes
ACM5_HUMAN [view entry] [view interactions] Computational yes no
GBG4_HUMAN [view interactions] Computational no no
GBG12_HUMAN [view entry] [view interactions] Computational yes yes
LAMA5_HUMAN [view entry] [view interactions] Computational yes no
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
PAK1_HUMAN [view entry] [view interactions] Computational yes yes
GBG1_HUMAN [view interactions] Computational no no
LAMB2_HUMAN [view interactions] Computational no yes
CXCR4_HUMAN [view interactions] Computational no no
LPAR3_HUMAN [view interactions] Computational no no
EDN1_HUMAN [view interactions] Computational no no
SP1_HUMAN [view interactions] Computational no yes
LAMC2_HUMAN [view interactions] Computational no no
LPAR5_HUMAN [view interactions] Computational no yes
ARHG6_HUMAN [view interactions] Computational no no
PE2R1_HUMAN [view interactions] Computational no no
ARBK1_HUMAN [view entry] [view interactions] Computational yes yes
GBB3_HUMAN [view interactions] Computational no yes
GBGT2_HUMAN [view interactions] Computational no no
GBG5_HUMAN [view interactions] Computational no no
SUCB2_HUMAN [view interactions] Computational no no
PAK4_HUMAN [view interactions] Computational no yes
GIT2_HUMAN [view interactions] Computational no yes
GBG10_HUMAN [view interactions] Computational no no
CCL11_HUMAN [view interactions] Computational no no
LAMA2_HUMAN [view interactions] Computational no no
GBG3_HUMAN [view entry] [view interactions] Computational yes no
FPR1_HUMAN [view interactions] Computational no no
GBB4_HUMAN [view entry] [view interactions] Computational yes yes
P2RY2_HUMAN [view interactions] Computational no no
GNA11_HUMAN [view entry] [view interactions] Computational yes yes
GBG8_HUMAN [view interactions] Computational no no
LAMA1_HUMAN [view interactions] Computational no no
LAMC3_HUMAN [view interactions] Computational no no
LPAR2_HUMAN [view interactions] Computational no yes
LPAR6_HUMAN [view interactions] Computational no no
GBG13_HUMAN [view interactions] Computational no no
ANGT_HUMAN [view interactions] Computational no no
RAPSN_HUMAN [view entry] [view interactions] Computational yes no
LAMC1_HUMAN [view interactions] Computational no yes
5HT2C_HUMAN [view interactions] Computational no no
ACHA_HUMAN [view entry] [view interactions] Computational yes no
ADRB2_HUMAN [view entry] [view interactions] Computational yes no
ARHG7_HUMAN [view entry] [view interactions] Computational yes yes
THRB_HUMAN [view interactions] Computational no no
SRC_HUMAN [view entry] [view interactions] Computational yes no
ADA1B_HUMAN [view interactions] Computational no no
LPAR1_HUMAN [view entry] [view interactions] Computational yes no
AGTR2_HUMAN [view interactions] Computational no no
LPAR4_HUMAN [view interactions] Computational no no
LAMA3_HUMAN [view interactions] Computational no no
PAR1_HUMAN [view entry] [view interactions] Computational yes yes
LAMB3_HUMAN [view interactions] Computational no yes
GRM5_HUMAN [view entry] [view interactions] Computational yes no
ACM2_HUMAN [view entry] [view interactions] Computational yes yes