ARRB2_HUMAN
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3. Acts as an adapter protein coupling FFAR4 receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed, PubMed). During the activation step of NLRP3 inflammasome, directly associates with NLRP3 leading to inhibition of proinflammatory cytokine release and inhibition of inflammation (PubMed). [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ARRB2_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 38.8626 | 4 | no |
GO:0043168 | anion binding | 27.4882 | 4 | no |
GO:0000166 | nucleotide binding | 25.5924 | 4 | no |
GO:0017076 | purine nucleotide binding | 25.1185 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 24.6445 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 24.1706 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 20.3791 | 6 | no |
GO:0043169 | cation binding | 20.3791 | 4 | no |
GO:0019900 | kinase binding | 18.4834 | 4 | yes |
GO:0019901 | protein kinase binding | 16.5877 | 5 | yes |
GO:0044389 | ubiquitin-like protein ligase binding | 13.7441 | 4 | yes |
GO:0031625 | ubiquitin protein ligase binding | 12.7962 | 5 | yes |
GO:0001664 | G protein-coupled receptor binding | 8.5308 | 4 | yes |
GO:0031748 | D1 dopamine receptor binding | 1.8957 | 6 | yes |
GO:0050780 | dopamine receptor binding | 1.8957 | 5 | yes |
GO:0031701 | angiotensin receptor binding | 1.4218 | 5 | yes |
GO:0043422 | protein kinase B binding | 1.4218 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ARRB2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 54.0284 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 53.0806 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 52.6066 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 51.6588 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 49.7630 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 44.5498 | 4 | yes |
GO:0010646 | regulation of cell communication | 43.1280 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 43.1280 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 42.1801 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 41.7062 | 4 | yes |
GO:0010468 | regulation of gene expression | 39.8104 | 6 | yes |
GO:0009966 | regulation of signal transduction | 38.3886 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 37.9147 | 5 | yes |
GO:0051128 | regulation of cellular component organization | 36.9668 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 36.4929 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 35.0711 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.6493 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 30.8057 | 4 | yes |
GO:0009891 | positive regulation of biosynthetic process | 30.3318 | 5 | yes |
GO:0051252 | regulation of RNA metabolic process | 29.8578 | 5 | yes |
GO:0006996 | organelle organization | 29.8578 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 29.3839 | 5 | yes |
GO:0022607 | cellular component assembly | 29.3839 | 4 | no |
GO:0008104 | protein localization | 28.9100 | 4 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 28.9100 | 6 | yes |
GO:0051049 | regulation of transport | 28.9100 | 4 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.9621 | 6 | yes |
GO:0009059 | macromolecule biosynthetic process | 27.4882 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 27.4882 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 27.4882 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 26.0664 | 5 | yes |
GO:0043412 | macromolecule modification | 26.0664 | 4 | yes |
GO:0036211 | protein modification process | 25.5924 | 4 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 25.5924 | 6 | yes |
GO:0006355 | regulation of DNA-templated transcription | 25.5924 | 7 | yes |
GO:0090304 | nucleic acid metabolic process | 25.1185 | 4 | yes |
GO:0023056 | positive regulation of signaling | 24.6445 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 24.1706 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 24.1706 | 6 | yes |
GO:0009967 | positive regulation of signal transduction | 23.6967 | 5 | yes |
GO:0031399 | regulation of protein modification process | 23.2227 | 6 | yes |
GO:0048585 | negative regulation of response to stimulus | 23.2227 | 4 | yes |
GO:0071702 | organic substance transport | 22.7488 | 4 | yes |
GO:0060341 | regulation of cellular localization | 22.7488 | 4 | no |
GO:0010648 | negative regulation of cell communication | 21.8009 | 5 | yes |
GO:0023057 | negative regulation of signaling | 21.8009 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 21.8009 | 5 | no |
GO:0043067 | regulation of programmed cell death | 21.8009 | 4 | no |
GO:0071705 | nitrogen compound transport | 21.3270 | 4 | yes |
GO:0009894 | regulation of catabolic process | 21.3270 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 20.8531 | 5 | yes |
GO:0051130 | positive regulation of cellular component organization | 20.8531 | 5 | yes |
GO:0016070 | RNA metabolic process | 20.3791 | 5 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 20.3791 | 4 | yes |
GO:0009890 | negative regulation of biosynthetic process | 19.9052 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 19.4313 | 6 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 19.4313 | 6 | yes |
GO:0019220 | regulation of phosphate metabolic process | 18.4834 | 6 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 18.4834 | 5 | yes |
GO:0051248 | negative regulation of protein metabolic process | 18.4834 | 6 | yes |
GO:0010628 | positive regulation of gene expression | 18.0095 | 7 | yes |
GO:0015031 | protein transport | 18.0095 | 4 | yes |
GO:0080134 | regulation of response to stress | 18.0095 | 4 | yes |
GO:0051050 | positive regulation of transport | 17.5355 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 17.5355 | 4 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 17.0616 | 6 | yes |
GO:0042325 | regulation of phosphorylation | 16.1137 | 7 | yes |
GO:0045595 | regulation of cell differentiation | 16.1137 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 15.1659 | 7 | yes |
GO:0031401 | positive regulation of protein modification process | 14.6919 | 7 | yes |
GO:0009057 | macromolecule catabolic process | 13.2701 | 4 | yes |
GO:0031400 | negative regulation of protein modification process | 13.2701 | 7 | yes |
GO:0098657 | import into cell | 12.7962 | 4 | yes |
GO:0010629 | negative regulation of gene expression | 12.3223 | 7 | yes |
GO:0043687 | post-translational protein modification | 12.3223 | 5 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 11.8483 | 6 | yes |
GO:0032101 | regulation of response to external stimulus | 11.8483 | 4 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 11.8483 | 7 | yes |
GO:1901873 | regulation of post-translational protein modification | 11.8483 | 7 | yes |
GO:1903320 | regulation of protein modification by small protein conjugation or removal | 11.8483 | 8 | yes |
GO:0032446 | protein modification by small protein conjugation | 11.3744 | 7 | yes |
GO:0043408 | regulation of MAPK cascade | 11.3744 | 6 | yes |
GO:0045597 | positive regulation of cell differentiation | 11.3744 | 5 | yes |
GO:0070647 | protein modification by small protein conjugation or removal | 11.3744 | 6 | yes |
GO:0031396 | regulation of protein ubiquitination | 10.9005 | 9 | yes |
GO:0042327 | positive regulation of phosphorylation | 10.9005 | 8 | yes |
GO:0050776 | regulation of immune response | 10.9005 | 4 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 10.9005 | 4 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 10.9005 | 4 | yes |
GO:0006508 | proteolysis | 10.9005 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 10.4265 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 10.4265 | 4 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 10.4265 | 8 | yes |
GO:1902532 | negative regulation of intracellular signal transduction | 9.9526 | 6 | yes |
GO:0031347 | regulation of defense response | 9.4787 | 5 | yes |
GO:0010563 | negative regulation of phosphorus metabolic process | 9.0047 | 6 | yes |
GO:0016567 | protein ubiquitination | 9.0047 | 8 | yes |
GO:0019941 | modification-dependent protein catabolic process | 9.0047 | 6 | yes |
GO:0043410 | positive regulation of MAPK cascade | 9.0047 | 7 | yes |
GO:0043632 | modification-dependent macromolecule catabolic process | 9.0047 | 5 | yes |
GO:0045936 | negative regulation of phosphate metabolic process | 9.0047 | 7 | yes |
GO:0051603 | proteolysis involved in protein catabolic process | 9.0047 | 5 | yes |
GO:1901565 | organonitrogen compound catabolic process | 9.0047 | 4 | yes |
GO:0001817 | regulation of cytokine production | 8.5308 | 4 | yes |
GO:0002831 | regulation of response to biotic stimulus | 8.5308 | 4 | yes |
GO:1901362 | organic cyclic compound biosynthetic process | 8.0569 | 4 | yes |
GO:0006898 | receptor-mediated endocytosis | 7.5829 | 4 | yes |
GO:0030100 | regulation of endocytosis | 7.5829 | 5 | yes |
GO:0034654 | nucleobase-containing compound biosynthetic process | 7.5829 | 4 | yes |
GO:0042326 | negative regulation of phosphorylation | 7.5829 | 8 | yes |
GO:0045088 | regulation of innate immune response | 7.5829 | 5 | yes |
GO:0001933 | negative regulation of protein phosphorylation | 7.5829 | 8 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 7.1090 | 4 | yes |
GO:0030163 | protein catabolic process | 7.1090 | 4 | yes |
GO:0141187 | nucleic acid biosynthetic process | 7.1090 | 5 | yes |
GO:0006511 | ubiquitin-dependent protein catabolic process | 7.1090 | 7 | yes |
GO:0010498 | proteasomal protein catabolic process | 6.1611 | 5 | yes |
GO:0031397 | negative regulation of protein ubiquitination | 6.1611 | 10 | yes |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 6.1611 | 6 | yes |
GO:1901874 | negative regulation of post-translational protein modification | 6.1611 | 8 | yes |
GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | 6.1611 | 9 | yes |
GO:0031623 | receptor internalization | 5.6872 | 5 | yes |
GO:0032774 | RNA biosynthetic process | 5.6872 | 5 | yes |
GO:0043393 | regulation of protein binding | 5.2133 | 4 | yes |
GO:0048259 | regulation of receptor-mediated endocytosis | 5.2133 | 6 | yes |
GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 4.7393 | 6 | yes |
GO:0070372 | regulation of ERK1 and ERK2 cascade | 4.7393 | 7 | yes |
GO:0032102 | negative regulation of response to external stimulus | 4.2654 | 5 | yes |
GO:0043122 | regulation of canonical NF-kappaB signal transduction | 4.2654 | 6 | yes |
GO:0045807 | positive regulation of endocytosis | 4.2654 | 5 | yes |
GO:0051100 | negative regulation of binding | 4.2654 | 4 | yes |
GO:0062207 | regulation of pattern recognition receptor signaling pathway | 4.2654 | 5 | yes |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 4.2654 | 8 | yes |
GO:0002683 | negative regulation of immune system process | 4.2654 | 4 | yes |
GO:0006351 | DNA-templated transcription | 4.2654 | 6 | yes |
GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 3.7915 | 5 | yes |
GO:0031348 | negative regulation of defense response | 3.7915 | 5 | yes |
GO:0048260 | positive regulation of receptor-mediated endocytosis | 3.7915 | 6 | yes |
GO:0002090 | regulation of receptor internalization | 3.7915 | 7 | yes |
GO:0008344 | adult locomotory behavior | 3.3175 | 4 | yes |
GO:0032091 | negative regulation of protein binding | 3.3175 | 5 | yes |
GO:0043433 | negative regulation of DNA-binding transcription factor activity | 3.3175 | 4 | yes |
GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 3.3175 | 7 | yes |
GO:0060078 | regulation of postsynaptic membrane potential | 3.3175 | 4 | yes |
GO:0002697 | regulation of immune effector process | 3.3175 | 4 | yes |
GO:0006366 | transcription by RNA polymerase II | 3.3175 | 7 | yes |
GO:0050777 | negative regulation of immune response | 2.8436 | 5 | yes |
GO:0001818 | negative regulation of cytokine production | 2.8436 | 5 | yes |
GO:0002832 | negative regulation of response to biotic stimulus | 2.8436 | 5 | yes |
GO:0007178 | cell surface receptor protein serine/threonine kinase signaling pathway | 2.3697 | 5 | yes |
GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway | 2.3697 | 6 | yes |
GO:0045824 | negative regulation of innate immune response | 2.3697 | 6 | yes |
GO:0050806 | positive regulation of synaptic transmission | 2.3697 | 5 | yes |
GO:0051898 | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 2.3697 | 7 | yes |
GO:0060079 | excitatory postsynaptic potential | 2.3697 | 5 | yes |
GO:0060326 | cell chemotaxis | 2.3697 | 4 | yes |
GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | 2.3697 | 6 | yes |
GO:0002092 | positive regulation of receptor internalization | 2.3697 | 7 | yes |
GO:0022401 | negative adaptation of signaling pathway | 1.8957 | 6 | yes |
GO:0023058 | adaptation of signaling pathway | 1.8957 | 5 | yes |
GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 1.8957 | 5 | yes |
GO:0032655 | regulation of interleukin-12 production | 1.8957 | 5 | yes |
GO:0032675 | regulation of interleukin-6 production | 1.8957 | 5 | yes |
GO:0002029 | desensitization of G protein-coupled receptor signaling pathway | 1.8957 | 7 | yes |
GO:0002031 | G protein-coupled receptor internalization | 1.8957 | 6 | yes |
GO:0002703 | regulation of leukocyte mediated immunity | 1.8957 | 5 | yes |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 1.4218 | 7 | yes |
GO:0007628 | adult walking behavior | 1.4218 | 5 | yes |
GO:0032695 | negative regulation of interleukin-12 production | 1.4218 | 6 | yes |
GO:0032715 | negative regulation of interleukin-6 production | 1.4218 | 6 | yes |
GO:0043124 | negative regulation of canonical NF-kappaB signal transduction | 1.4218 | 7 | yes |
GO:0051147 | regulation of muscle cell differentiation | 1.4218 | 5 | yes |
GO:0051149 | positive regulation of muscle cell differentiation | 1.4218 | 6 | yes |
GO:0090659 | walking behavior | 1.4218 | 4 | yes |
GO:0002032 | desensitization of G protein-coupled receptor signaling pathway by arrestin | 1.4218 | 6 | yes |
GO:0002698 | negative regulation of immune effector process | 1.4218 | 5 | yes |
GO:0002706 | regulation of lymphocyte mediated immunity | 1.4218 | 6 | yes |
GO:0031341 | regulation of cell killing | 0.9479 | 4 | yes |
GO:0031342 | negative regulation of cell killing | 0.9479 | 5 | yes |
GO:0032225 | regulation of synaptic transmission, dopaminergic | 0.9479 | 6 | yes |
GO:0032226 | positive regulation of synaptic transmission, dopaminergic | 0.9479 | 6 | yes |
GO:0032651 | regulation of interleukin-1 beta production | 0.9479 | 6 | yes |
GO:0032652 | regulation of interleukin-1 production | 0.9479 | 5 | yes |
GO:0032680 | regulation of tumor necrosis factor production | 0.9479 | 6 | yes |
GO:0032691 | negative regulation of interleukin-1 beta production | 0.9479 | 7 | yes |
GO:0032692 | negative regulation of interleukin-1 production | 0.9479 | 6 | yes |
GO:0032720 | negative regulation of tumor necrosis factor production | 0.9479 | 7 | yes |
GO:0034121 | regulation of toll-like receptor signaling pathway | 0.9479 | 6 | yes |
GO:0034122 | negative regulation of toll-like receptor signaling pathway | 0.9479 | 5 | yes |
GO:0042269 | regulation of natural killer cell mediated cytotoxicity | 0.9479 | 6 | yes |
GO:0045953 | negative regulation of natural killer cell mediated cytotoxicity | 0.9479 | 7 | yes |
GO:0051153 | regulation of striated muscle cell differentiation | 0.9479 | 6 | yes |
GO:0051155 | positive regulation of striated muscle cell differentiation | 0.9479 | 7 | yes |
GO:1903555 | regulation of tumor necrosis factor superfamily cytokine production | 0.9479 | 5 | yes |
GO:1903556 | negative regulation of tumor necrosis factor superfamily cytokine production | 0.9479 | 6 | yes |
GO:1905207 | regulation of cardiocyte differentiation | 0.9479 | 5 | yes |
GO:1905209 | positive regulation of cardiocyte differentiation | 0.9479 | 5 | yes |
GO:2000725 | regulation of cardiac muscle cell differentiation | 0.9479 | 6 | yes |
GO:2000727 | positive regulation of cardiac muscle cell differentiation | 0.9479 | 6 | yes |
GO:0001910 | regulation of leukocyte mediated cytotoxicity | 0.9479 | 5 | yes |
GO:0001911 | negative regulation of leukocyte mediated cytotoxicity | 0.9479 | 6 | yes |
GO:0002704 | negative regulation of leukocyte mediated immunity | 0.9479 | 6 | yes |
GO:0002707 | negative regulation of lymphocyte mediated immunity | 0.9479 | 7 | yes |
GO:0002715 | regulation of natural killer cell mediated immunity | 0.9479 | 6 | yes |
GO:0002716 | negative regulation of natural killer cell mediated immunity | 0.9479 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SENP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBP20_HUMAN | [view interactions] | Low throughput | no | yes |
KLH12_HUMAN | [view interactions] | Low throughput | no | no |
CUL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PE2R4_HUMAN | [view interactions] | Low throughput | no | yes |
TAB1_HUMAN | [view interactions] | Low throughput | no | yes |
AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MSHR_HUMAN | [view interactions] | Low throughput | no | no |
MGRN1_HUMAN | [view interactions] | Low throughput | no | yes |
SUFU_HUMAN | [view interactions] | Low throughput | no | yes |
GRM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAV1_HUMAN | [view interactions] | Low throughput | no | no |
CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TNIP1_HUMAN | [view interactions] | Low throughput | no | yes |
HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
RBP2_HUMAN | [view interactions] | Low throughput | no | yes |
ACE2_HUMAN | [view interactions] | Low throughput | no | no |
OPSD_HUMAN | [view interactions] | Low throughput | no | no |
OPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LSHR_HUMAN | [view interactions] | Low throughput | no | no |
PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PDE4D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GSK3A_HUMAN | [view interactions] | Low throughput | no | yes |
ARBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SUMO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SUMO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CSK22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
UBC9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
OX1R_HUMAN | [view interactions] | Low throughput | no | yes |
TRFR_HUMAN | [view interactions] | Low throughput | no | no |
OXER1_HUMAN | [view interactions] | Low throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CRFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IMB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACKR3_HUMAN | [view interactions] | Low throughput | no | no |
AP3B2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MK10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
FFAR4_HUMAN | [view interactions] | Low throughput | no | no |
MP2K4_HUMAN | [view interactions] | Low throughput | no | yes |
ADCY2_HUMAN | [view interactions] | Low throughput | no | yes |
MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LIMK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
OPRM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
5HT2C_HUMAN | [view interactions] | Low throughput | no | no |
EGLN_HUMAN | [view interactions] | Low throughput | no | no |
MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ADRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GPR3_HUMAN | [view interactions] | Low throughput | no | no |
ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NPHN_HUMAN | [view interactions] | Low throughput | no | no |
ADRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAR10_HUMAN | [view interactions] | Low throughput | no | yes |
TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
COF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
AGRB2_HUMAN | [view interactions] | Low throughput | no | no |
SSR2_HUMAN | [view interactions] | Low throughput | no | yes |
CCR7_HUMAN | [view interactions] | Low throughput | no | no |
AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PE2R2_HUMAN | [view interactions] | Low throughput | no | no |
AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
2ABB_HUMAN | [view interactions] | Low throughput | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RXFP1_HUMAN | [view interactions] | Low throughput | no | yes |
RGS9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EDNRA_HUMAN | [view interactions] | Low throughput | no | yes |
ACM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AGTR1_HUMAN | [view interactions] | Low throughput | no | no |
DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
APJ_HUMAN | [view interactions] | Low throughput | no | yes |
AP1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
5HT2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CXCR3_HUMAN | [view interactions] | Low throughput | no | no |
CXCR4_HUMAN | [view interactions] | Low throughput | no | no |
V2R_HUMAN | [view interactions] | Low throughput | no | no |
ILK_HUMAN | [view interactions] | Low throughput | no | no |
KIF3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SMO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GNDS_HUMAN | [view interactions] | Low throughput | no | yes |
SL9A5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PTGDS_HUMAN | [view interactions] | Low throughput | no | yes |
UBP33_HUMAN | [view interactions] | Low throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CYH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PTAFR_HUMAN | [view interactions] | Low throughput | no | yes |
ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DRD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
AGRG1_HUMAN | [view interactions] | Low throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IGF1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MP2K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PTPA_HUMAN | [view interactions] | Low throughput | no | yes |
TEBP_HUMAN | [view interactions] | Low throughput | no | yes |
C5AR1_HUMAN | [view interactions] | Low throughput | no | yes |
ARRD3_HUMAN | [view interactions] | Low throughput | no | no |
IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
GLUC_HUMAN | [view interactions] | Low throughput | no | no |
CSK_HUMAN | [view interactions] | Low throughput | no | yes |
AGRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CYH1_HUMAN | [view interactions] | Low throughput | no | no |
TA2R_HUMAN | [view interactions] | Low throughput | no | no |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
TM38A_HUMAN | [view interactions] | High throughput | no | yes |
PABP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMMR_HUMAN | [view interactions] | High throughput | no | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRPV4_HUMAN | [view interactions] | High throughput | no | yes |
RASF8_HUMAN | [view interactions] | High throughput | no | yes |
WDR26_HUMAN | [view interactions] | High throughput | no | yes |
STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANM1_HUMAN | [view interactions] | High throughput | no | yes |
ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NP1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
KBTB8_HUMAN | [view interactions] | High throughput | no | no |
SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
ACTH_HUMAN | [view interactions] | High throughput | no | no |
KANK1_HUMAN | [view interactions] | High throughput | no | yes |
STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRPF1_HUMAN | [view interactions] | High throughput | no | yes |
IF2B1_HUMAN | [view interactions] | High throughput | no | no |
UTP25_HUMAN | [view interactions] | High throughput | no | yes |
SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NAA15_HUMAN | [view interactions] | High throughput | no | yes |
SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
RTF1_HUMAN | [view interactions] | High throughput | no | yes |
SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFX1_HUMAN | [view interactions] | High throughput | no | yes |
RPA1_HUMAN | [view interactions] | High throughput | no | yes |
WDR70_HUMAN | [view interactions] | High throughput | no | no |
PABP3_HUMAN | [view interactions] | High throughput | no | yes |
ARK2N_HUMAN | [view interactions] | High throughput | no | yes |
RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAD18_HUMAN | [view interactions] | High throughput | no | yes |
CPNE1_HUMAN | [view interactions] | High throughput | no | no |
TPC2_HUMAN | [view interactions] | High throughput | no | no |
H11_HUMAN | [view interactions] | High throughput | no | no |
SAHH3_HUMAN | [view interactions] | High throughput | no | yes |
NKTR_HUMAN | [view interactions] | High throughput | no | no |
EMIL1_HUMAN | [view interactions] | High throughput | no | no |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
ILF3_HUMAN | [view interactions] | High throughput | no | yes |
AFF4_HUMAN | [view interactions] | High throughput | no | yes |
HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENL_HUMAN | [view interactions] | High throughput | no | yes |
RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AF9_HUMAN | [view interactions] | High throughput | no | yes |
RL21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IKBL1_HUMAN | [view interactions] | High throughput | no | no |
RL12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNFL8_HUMAN | [view interactions] | High throughput | no | no |
ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TFAP4_HUMAN | [view interactions] | High throughput | no | yes |
TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
GP156_HUMAN | [view interactions] | High throughput | no | no |
PPM1A_HUMAN | [view interactions] | High throughput | no | yes |
AASD1_HUMAN | [view interactions] | High throughput | no | yes |
MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CENPB_HUMAN | [view interactions] | High throughput | no | yes |
HTSF1_HUMAN | [view interactions] | High throughput | no | yes |
JPH1_HUMAN | [view interactions] | High throughput | no | no |
RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E41L5_HUMAN | [view interactions] | High throughput | no | no |
ICLN_HUMAN | [view interactions] | High throughput | no | yes |
C102B_HUMAN | [view interactions] | High throughput | no | yes |
H1X_HUMAN | [view interactions] | High throughput | no | yes |
DAAF8_HUMAN | [view interactions] | High throughput | no | no |
ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBRL_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPM1B_HUMAN | [view interactions] | High throughput | no | yes |
CDK7_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBM10_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
UBR5_HUMAN | [view interactions] | High throughput | no | no |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
RIGI_HUMAN | [view interactions] | High throughput | no | yes |
YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
NUCL_HUMAN | [view interactions] | High throughput | no | yes |
TULP3_HUMAN | [view interactions] | High throughput | no | yes |
RPA2_HUMAN | [view interactions] | High throughput | no | no |
TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
ARRC_HUMAN | [view interactions] | High throughput | no | no |
TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
LURA1_HUMAN | [view interactions] | High throughput | no | yes |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZN653_HUMAN | [view interactions] | High throughput | no | yes |
RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MIIP_HUMAN | [view interactions] | High throughput | no | yes |
NONO_HUMAN | [view interactions] | High throughput | no | yes |
EIF1A_HUMAN | [view interactions] | High throughput | no | no |
DHX15_HUMAN | [view interactions] | High throughput | no | yes |
CD6_HUMAN | [view interactions] | High throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PO2F1_HUMAN | [view interactions] | High throughput | no | yes |
TR150_HUMAN | [view interactions] | High throughput | no | yes |
TM169_HUMAN | [view interactions] | High throughput | no | yes |
COPT1_HUMAN | [view interactions] | High throughput | no | no |
TBA8_HUMAN | [view interactions] | High throughput | no | yes |
RHG22_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CRCM_HUMAN | [view interactions] | High throughput | no | no |
NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNR1B_HUMAN | [view interactions] | High throughput | no | no |
COPRS_HUMAN | [view interactions] | High throughput | no | yes |
GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GP182_HUMAN | [view interactions] | High throughput | no | no |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MANS1_HUMAN | [view interactions] | High throughput | no | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASA2_HUMAN | [view interactions] | High throughput | no | yes |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
ALPK2_HUMAN | [view interactions] | High throughput | no | no |
DGKE_HUMAN | [view interactions] | High throughput | no | yes |
MAS_HUMAN | [view interactions] | High throughput | no | no |
MCM3_HUMAN | [view interactions] | High throughput | no | no |
TMM74_HUMAN | [view interactions] | High throughput | no | no |
NOP10_HUMAN | [view interactions] | High throughput | no | yes |
SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPR37_HUMAN | [view interactions] | High throughput | no | no |
NHRF2_HUMAN | [view interactions] | High throughput | no | no |
KCAB1_HUMAN | [view interactions] | High throughput | no | no |
TPTE2_HUMAN | [view interactions] | High throughput | no | no |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BOLA2_HUMAN | [view interactions] | High throughput | no | yes |
SPNDC_HUMAN | [view interactions] | High throughput | no | yes |
ACTBM_HUMAN | [view interactions] | High throughput | no | no |
BRD2_HUMAN | [view interactions] | High throughput | no | yes |
ACTBL_HUMAN | [view interactions] | High throughput | no | no |
BRD3_HUMAN | [view interactions] | High throughput | no | yes |
BSN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
M3K1_HUMAN | [view interactions] | High throughput | no | yes |
DVL2_HUMAN | [view interactions] | High throughput | no | yes |
S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RL36_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
H2AX_HUMAN | [view interactions] | High throughput | no | yes |
RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CASB_HUMAN | [view interactions] | High throughput | no | no |
ARHGB_HUMAN | [view interactions] | High throughput | no | yes |
PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
ITA2B_HUMAN | [view interactions] | High throughput | no | no |
E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H12_HUMAN | [view interactions] | High throughput | no | yes |
RL26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPAB1_HUMAN | [view interactions] | High throughput | no | yes |
TAB2_HUMAN | [view interactions] | High throughput | no | yes |
MYCD_HUMAN | [view interactions] | High throughput | no | yes |
ALS_HUMAN | [view interactions] | High throughput | no | no |
M3K7_HUMAN | [view interactions] | High throughput | no | yes |
KC1A_HUMAN | [view interactions] | High throughput | no | yes |
CDK4_HUMAN | [view interactions] | High throughput | no | no |
SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPAC1_HUMAN | [view interactions] | High throughput | no | no |
COTL1_HUMAN | [view interactions] | High throughput | no | yes |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
RHG17_HUMAN | [view interactions] | High throughput | no | no |
HDAC1_HUMAN | [view interactions] | High throughput | no | no |
M3K14_HUMAN | [view interactions] | High throughput | no | yes |
PF21A_HUMAN | [view interactions] | High throughput | no | yes |
DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WEE1_HUMAN | [view interactions] | High throughput | no | yes |
RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAK5_HUMAN | [view interactions] | High throughput | no | yes |
NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KPB2_HUMAN | [view interactions] | High throughput | no | yes |
ARHGC_HUMAN | [view interactions] | High throughput | no | yes |
CENPF_HUMAN | [view interactions] | High throughput | no | no |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRP11_HUMAN | [view interactions] | High throughput | no | no |
5HT4R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HIPK3_HUMAN | [view interactions] | High throughput | no | yes |
ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPIN1_HUMAN | [view interactions] | High throughput | no | no |
JAK1_HUMAN | [view interactions] | High throughput | no | yes |
NAA10_HUMAN | [view interactions] | High throughput | no | yes |
VPS51_HUMAN | [view interactions] | High throughput | no | yes |
DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHOCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARRS_HUMAN | [view interactions] | High throughput | no | no |
CT2NL_HUMAN | [view interactions] | High throughput | no | yes |
RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LEO1_HUMAN | [view interactions] | High throughput | no | yes |
COBL_HUMAN | [view interactions] | High throughput | no | yes |
NOP56_HUMAN | [view interactions] | High throughput | no | yes |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBX46_HUMAN | [view interactions] | High throughput | no | no |
TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
TFE3_HUMAN | [view interactions] | High throughput | no | yes |
SPIN3_HUMAN | [view interactions] | High throughput | no | yes |
WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
MUC13_HUMAN | [view interactions] | High throughput | no | no |
XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
PKN3_HUMAN | [view interactions] | High throughput | no | yes |
SMD1_HUMAN | [view interactions] | High throughput | no | yes |
PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANR11_HUMAN | [view interactions] | High throughput | no | yes |
G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNE2_HUMAN | [view interactions] | High throughput | no | no |
SDC3_HUMAN | [view interactions] | High throughput | no | yes |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KC1AL_HUMAN | [view interactions] | High throughput | no | no |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
SF3B2_HUMAN | [view interactions] | High throughput | no | yes |
CDK13_HUMAN | [view interactions] | High throughput | no | no |
MEP50_HUMAN | [view interactions] | High throughput | no | yes |
DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MOB1A_HUMAN | [view interactions] | High throughput | no | yes |
SDHA_HUMAN | [view interactions] | High throughput | no | yes |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ROA0_HUMAN | [view interactions] | High throughput | no | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
MED4_HUMAN | [view interactions] | High throughput | no | yes |
ARHG6_HUMAN | [view interactions] | High throughput | no | no |
CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SERB1_HUMAN | [view interactions] | High throughput | no | yes |
E2AK1_HUMAN | [view interactions] | High throughput | no | yes |
F263_HUMAN | [view interactions] | High throughput | no | yes |
IMA4_HUMAN | [view interactions] | High throughput | no | yes |
H2B1O_HUMAN | [view interactions] | High throughput | no | yes |
DDX27_HUMAN | [view interactions] | High throughput | no | no |
GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PESC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL7L_HUMAN | [view interactions] | High throughput | no | no |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LBR_HUMAN | [view interactions] | High throughput | no | yes |
RM43_HUMAN | [view interactions] | High throughput | no | no |
2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
RM44_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
BOP1_HUMAN | [view interactions] | High throughput | no | yes |
PTBP1_HUMAN | [view interactions] | High throughput | no | no |
IMA3_HUMAN | [view interactions] | High throughput | no | yes |
RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
INSR_HUMAN | [view interactions] | High throughput | no | yes |
H2A2B_HUMAN | [view interactions] | High throughput | no | yes |
RS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CEP63_HUMAN | [view interactions] | High throughput | no | yes |
HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK09_HUMAN | [view interactions] | High throughput | no | yes |
SMD2_HUMAN | [view interactions] | High throughput | no | yes |
MED8_HUMAN | [view interactions] | High throughput | no | yes |
TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STC2_HUMAN | [view interactions] | High throughput | no | no |
NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
SMRC2_HUMAN | [view interactions] | High throughput | no | yes |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PYRG1_HUMAN | [view interactions] | High throughput | no | no |
CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBA3D_HUMAN | [view interactions] | High throughput | no | no |
HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NINL_HUMAN | [view interactions] | High throughput | no | yes |
RPA43_HUMAN | [view interactions] | High throughput | no | yes |
CE170_HUMAN | [view interactions] | High throughput | no | yes |
YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCOF_HUMAN | [view interactions] | High throughput | no | yes |
RL7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK3_HUMAN | [view interactions] | High throughput | no | no |
IKKA_HUMAN | [view interactions] | High throughput | no | yes |
HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA3C_HUMAN | [view interactions] | High throughput | no | no |
HNRPR_HUMAN | [view interactions] | High throughput | no | yes |
RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCD_HUMAN | [view interactions] | High throughput | no | no |
UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRP4_HUMAN | [view interactions] | High throughput | no | yes |
AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ERH_HUMAN | [view interactions] | High throughput | no | yes |
E2AK4_HUMAN | [view interactions] | High throughput | no | yes |
ARRD4_HUMAN | [view interactions] | High throughput | no | yes |
RL28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BCLF1_HUMAN | [view interactions] | High throughput | no | yes |
SIR1_HUMAN | [view interactions] | High throughput | no | yes |
EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLIC1_HUMAN | [view interactions] | High throughput | no | no |
G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DGKZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GPR55_HUMAN | [view interactions] | High throughput | no | no |
THOC4_HUMAN | [view interactions] | High throughput | no | no |
CENPM_HUMAN | [view interactions] | High throughput | no | yes |
DKC1_HUMAN | [view interactions] | High throughput | no | yes |
EVI2A_HUMAN | [view interactions] | High throughput | no | no |