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ARRB2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3. Acts as an adapter protein coupling FFAR4 receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed, PubMed). During the activation step of NLRP3 inflammasome, directly associates with NLRP3 leading to inhibition of proinflammatory cytokine release and inhibition of inflammation (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ARRB2_HUMAN
GO:0003723 RNA binding 37.3832 4 no
GO:0017076 purine nucleotide binding 28.9720 4 no
GO:0032555 purine ribonucleotide binding 28.9720 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5047 4 no
GO:0030554 adenyl nucleotide binding 21.0280 5 no
GO:0032559 adenyl ribonucleotide binding 21.0280 5 no
GO:0019900 kinase binding 20.5607 4 yes
GO:0005524 ATP binding 20.5607 5 no
GO:0019901 protein kinase binding 19.6262 5 yes
GO:0044389 ubiquitin-like protein ligase binding 13.0841 4 yes
GO:0001664 G protein-coupled receptor binding 12.6168 4 yes
GO:0031625 ubiquitin protein ligase binding 12.1495 5 yes
GO:0031690 adrenergic receptor binding 3.7383 5 yes
GO:0031748 D1 dopamine receptor binding 1.8692 6 yes
GO:0050780 dopamine receptor binding 1.8692 5 yes
GO:0031701 angiotensin receptor binding 1.4019 5 yes
GO:0031691 alpha-1A adrenergic receptor binding 0.9346 6 yes
GO:0031692 alpha-1B adrenergic receptor binding 0.9346 6 yes
GO:0031702 type 1 angiotensin receptor binding 0.9346 6 yes
GO:0031762 follicle-stimulating hormone receptor binding 0.9346 5 yes
GO:0031821 G protein-coupled serotonin receptor binding 0.9346 5 yes
GO:0031826 type 2A serotonin receptor binding 0.9346 6 yes
GO:0031859 platelet activating factor receptor binding 0.9346 5 yes
GO:0043422 protein kinase B binding 0.9346 6 yes
GO:0051019 mitogen-activated protein kinase binding 0.9346 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ARRB2_HUMAN
GO:0031323 regulation of cellular metabolic process 54.6729 4 yes
GO:0080090 regulation of primary metabolic process 54.6729 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.2056 4 yes
GO:0048522 positive regulation of cellular process 53.7383 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 53.7383 4 yes
GO:0048523 negative regulation of cellular process 50.9346 4 yes
GO:0010646 regulation of cell communication 45.3271 4 yes
GO:0009893 positive regulation of metabolic process 42.5234 4 yes
GO:0009966 regulation of signal transduction 41.1215 4 yes
GO:0010468 regulation of gene expression 41.1215 5 yes
GO:0051128 regulation of cellular component organization 40.1869 4 yes
GO:0051246 regulation of protein metabolic process 38.7850 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 38.3178 5 yes
GO:0009889 regulation of biosynthetic process 37.3832 4 yes
GO:0031326 regulation of cellular biosynthetic process 35.9813 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 35.0467 5 yes
GO:0031325 positive regulation of cellular metabolic process 34.1121 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 33.6449 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.7103 5 yes
GO:0051049 regulation of transport 30.8411 4 yes
GO:0006996 organelle organization 30.8411 4 no
GO:0009892 negative regulation of metabolic process 30.3738 4 yes
GO:1902531 regulation of intracellular signal transduction 29.9065 5 yes
GO:0051252 regulation of RNA metabolic process 28.9720 5 yes
GO:0008104 protein localization 28.5047 4 yes
GO:0022607 cellular component assembly 28.0374 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.0374 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 27.5701 5 yes
GO:0043412 macromolecule modification 27.1028 4 yes
GO:0051247 positive regulation of protein metabolic process 27.1028 6 yes
GO:0036211 protein modification process 26.6355 4 yes
GO:0048584 positive regulation of response to stimulus 26.6355 4 yes
GO:0031399 regulation of protein modification process 26.1682 6 yes
GO:0031324 negative regulation of cellular metabolic process 25.7009 5 yes
GO:0071702 organic substance transport 25.7009 4 yes
GO:0023056 positive regulation of signaling 25.7009 4 yes
GO:0010647 positive regulation of cell communication 25.2336 5 yes
GO:0009967 positive regulation of signal transduction 24.7664 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 24.2991 7 yes
GO:2001141 regulation of RNA biosynthetic process 24.2991 6 yes
GO:0006355 regulation of DNA-templated transcription 24.2991 6 yes
GO:0051174 regulation of phosphorus metabolic process 23.8318 5 yes
GO:0071705 nitrogen compound transport 23.8318 4 yes
GO:0010941 regulation of cell death 23.8318 4 yes
GO:0019220 regulation of phosphate metabolic process 23.8318 6 yes
GO:0048585 negative regulation of response to stimulus 23.3645 4 yes
GO:0051130 positive regulation of cellular component organization 23.3645 5 yes
GO:0009059 macromolecule biosynthetic process 23.3645 4 yes
GO:0016192 vesicle-mediated transport 23.3645 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 22.8972 4 yes
GO:0010648 negative regulation of cell communication 22.8972 5 yes
GO:0023057 negative regulation of signaling 22.8972 4 yes
GO:0033043 regulation of organelle organization 22.4299 5 yes
GO:0042981 regulation of apoptotic process 21.9626 6 yes
GO:0043067 regulation of programmed cell death 21.9626 5 yes
GO:0060341 regulation of cellular localization 21.9626 4 no
GO:0090304 nucleic acid metabolic process 21.4953 4 yes
GO:0009968 negative regulation of signal transduction 21.4953 5 yes
GO:0042325 regulation of phosphorylation 21.0280 7 yes
GO:0009891 positive regulation of biosynthetic process 21.0280 5 yes
GO:0015031 protein transport 21.0280 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 20.5607 6 yes
GO:1902533 positive regulation of intracellular signal transduction 20.5607 6 yes
GO:0043085 positive regulation of catalytic activity 20.5607 4 no
GO:0071310 cellular response to organic substance 20.5607 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.0935 6 yes
GO:0051240 positive regulation of multicellular organismal process 20.0935 4 yes
GO:0009894 regulation of catabolic process 20.0935 4 no
GO:0051050 positive regulation of transport 19.1589 4 yes
GO:0051248 negative regulation of protein metabolic process 18.6916 6 yes
GO:0010628 positive regulation of gene expression 18.6916 6 yes
GO:0016070 RNA metabolic process 18.6916 5 yes
GO:0001932 regulation of protein phosphorylation 18.2243 7 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 18.2243 6 yes
GO:0031401 positive regulation of protein modification process 17.7570 7 yes
GO:0051094 positive regulation of developmental process 17.7570 4 yes
GO:0045595 regulation of cell differentiation 17.2897 4 yes
GO:0045937 positive regulation of phosphate metabolic process 17.2897 7 yes
GO:0080134 regulation of response to stress 17.2897 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 17.2897 6 yes
GO:0042327 positive regulation of phosphorylation 15.8879 8 yes
GO:0051129 negative regulation of cellular component organization 15.4206 5 yes
GO:0051336 regulation of hydrolase activity 15.4206 4 yes
GO:0060548 negative regulation of cell death 14.9533 5 yes
GO:0060627 regulation of vesicle-mediated transport 14.4860 4 yes
GO:0043408 regulation of MAPK cascade 14.0187 6 yes
GO:0001934 positive regulation of protein phosphorylation 14.0187 8 yes
GO:0031400 negative regulation of protein modification process 13.5514 7 yes
GO:0030162 regulation of proteolysis 13.5514 6 yes
GO:0043066 negative regulation of apoptotic process 13.0841 7 yes
GO:0043069 negative regulation of programmed cell death 13.0841 6 yes
GO:0043269 regulation of ion transport 13.0841 5 yes
GO:0045597 positive regulation of cell differentiation 12.1495 5 yes
GO:0006897 endocytosis 12.1495 5 yes
GO:2001233 regulation of apoptotic signaling pathway 11.6822 5 yes
GO:0010942 positive regulation of cell death 11.6822 5 yes
GO:0032101 regulation of response to external stimulus 11.2150 4 yes
GO:0050776 regulation of immune response 11.2150 4 yes
GO:0050804 modulation of chemical synaptic transmission 11.2150 5 yes
GO:0051241 negative regulation of multicellular organismal process 11.2150 4 yes
GO:0099177 regulation of trans-synaptic signaling 11.2150 4 yes
GO:0009057 macromolecule catabolic process 11.2150 4 yes
GO:0043065 positive regulation of apoptotic process 10.7477 7 yes
GO:0043068 positive regulation of programmed cell death 10.7477 6 yes
GO:0043410 positive regulation of MAPK cascade 10.7477 7 yes
GO:0001817 regulation of cytokine production 10.7477 4 yes
GO:0010629 negative regulation of gene expression 10.7477 6 yes
GO:0045936 negative regulation of phosphate metabolic process 10.2804 7 yes
GO:1902532 negative regulation of intracellular signal transduction 10.2804 6 yes
GO:0010563 negative regulation of phosphorus metabolic process 10.2804 6 yes
GO:0043086 negative regulation of catalytic activity 9.8131 4 yes
GO:0044265 cellular macromolecule catabolic process 9.8131 4 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 9.8131 7 yes
GO:0010959 regulation of metal ion transport 9.8131 6 yes
GO:0031396 regulation of protein ubiquitination 8.8785 8 yes
GO:0051052 regulation of DNA metabolic process 8.8785 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 8.8785 4 yes
GO:0042326 negative regulation of phosphorylation 8.4112 8 yes
GO:0006508 proteolysis 8.4112 4 yes
GO:0006898 receptor-mediated endocytosis 8.4112 6 yes
GO:0030100 regulation of endocytosis 8.4112 5 yes
GO:0031347 regulation of defense response 7.9439 5 yes
GO:0032446 protein modification by small protein conjugation 7.9439 6 yes
GO:0043393 regulation of protein binding 7.9439 4 yes
GO:0070647 protein modification by small protein conjugation or removal 7.9439 5 yes
GO:0001933 negative regulation of protein phosphorylation 7.9439 8 yes
GO:2001234 negative regulation of apoptotic signaling pathway 7.4766 6 yes
GO:0016567 protein ubiquitination 7.4766 7 yes
GO:0043632 modification-dependent macromolecule catabolic process 7.0093 5 yes
GO:0051054 positive regulation of DNA metabolic process 7.0093 6 yes
GO:0051603 proteolysis involved in protein catabolic process 7.0093 5 yes
GO:0052547 regulation of peptidase activity 7.0093 5 yes
GO:0052548 regulation of endopeptidase activity 7.0093 6 yes
GO:0002831 regulation of response to biotic stimulus 7.0093 4 yes
GO:0010639 negative regulation of organelle organization 7.0093 6 yes
GO:0019941 modification-dependent protein catabolic process 7.0093 6 yes
GO:0043270 positive regulation of ion transport 6.5421 5 yes
GO:0051924 regulation of calcium ion transport 6.5421 7 yes
GO:1901214 regulation of neuron death 6.5421 5 yes
GO:1901565 organonitrogen compound catabolic process 6.5421 4 yes
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 6.0748 8 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 6.0748 7 yes
GO:0030163 protein catabolic process 6.0748 4 yes
GO:0031397 negative regulation of protein ubiquitination 5.6075 9 yes
GO:0031623 receptor internalization 5.6075 7 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 5.6075 8 yes
GO:0045861 negative regulation of proteolysis 5.6075 7 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 5.6075 7 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 5.1402 6 yes
GO:0048259 regulation of receptor-mediated endocytosis 5.1402 6 yes
GO:1901362 organic cyclic compound biosynthetic process 5.1402 4 yes
GO:0006511 ubiquitin-dependent protein catabolic process 5.1402 7 yes
GO:0010498 proteasomal protein catabolic process 5.1402 5 yes
GO:0018130 heterocycle biosynthetic process 5.1402 4 yes
GO:0019438 aromatic compound biosynthetic process 5.1402 4 yes
GO:0032102 negative regulation of response to external stimulus 4.6729 5 yes
GO:0034654 nucleobase-containing compound biosynthetic process 4.6729 4 yes
GO:0043087 regulation of GTPase activity 4.6729 5 yes
GO:0045088 regulation of innate immune response 4.6729 5 yes
GO:0045807 positive regulation of endocytosis 4.6729 5 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 4.6729 8 yes
GO:2000278 regulation of DNA biosynthetic process 4.6729 6 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 4.6729 5 yes
GO:0010821 regulation of mitochondrion organization 4.6729 6 yes
GO:0031348 negative regulation of defense response 4.2056 5 yes
GO:0032091 negative regulation of protein binding 4.2056 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 4.2056 8 yes
GO:0051100 negative regulation of binding 4.2056 4 yes
GO:0051346 negative regulation of hydrolase activity 4.2056 5 yes
GO:1901215 negative regulation of neuron death 4.2056 6 yes
GO:0002683 negative regulation of immune system process 4.2056 4 yes
GO:0032774 RNA biosynthetic process 3.7383 5 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 3.7383 8 yes
GO:0051896 regulation of protein kinase B signaling 3.7383 6 yes
GO:0062207 regulation of pattern recognition receptor signaling pathway 3.7383 5 yes
GO:2000573 positive regulation of DNA biosynthetic process 3.7383 7 yes
GO:0002090 regulation of receptor internalization 3.7383 7 yes
GO:0010466 negative regulation of peptidase activity 3.7383 6 yes
GO:0010951 negative regulation of endopeptidase activity 3.7383 7 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 3.2710 9 yes
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 3.2710 8 yes
GO:0043433 negative regulation of DNA-binding transcription factor activity 3.2710 4 yes
GO:0043523 regulation of neuron apoptotic process 3.2710 6 yes
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 3.2710 6 yes
GO:0048260 positive regulation of receptor-mediated endocytosis 3.2710 6 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 3.2710 9 yes
GO:0050777 negative regulation of immune response 3.2710 5 yes
GO:0060078 regulation of postsynaptic membrane potential 3.2710 4 yes
GO:0097659 nucleic acid-templated transcription 3.2710 6 yes
GO:2000117 negative regulation of cysteine-type endopeptidase activity 3.2710 8 yes
GO:0002697 regulation of immune effector process 3.2710 4 yes
GO:0006351 DNA-templated transcription 3.2710 7 yes
GO:0050806 positive regulation of synaptic transmission 2.8037 5 yes
GO:0051897 positive regulation of protein kinase B signaling 2.8037 7 yes
GO:0051928 positive regulation of calcium ion transport 2.8037 6 yes
GO:0060079 excitatory postsynaptic potential 2.8037 5 yes
GO:0001818 negative regulation of cytokine production 2.8037 5 yes
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 2.8037 5 yes
GO:0008344 adult locomotory behavior 2.8037 4 yes
GO:0032088 negative regulation of NF-kappaB transcription factor activity 2.3364 5 yes
GO:0032675 regulation of interleukin-6 production 2.3364 5 yes
GO:0034121 regulation of toll-like receptor signaling pathway 2.3364 6 yes
GO:0043524 negative regulation of neuron apoptotic process 2.3364 7 yes
GO:0060326 cell chemotaxis 2.3364 4 yes
GO:0002029 desensitization of G protein-coupled receptor signaling pathway 2.3364 7 yes
GO:0002092 positive regulation of receptor internalization 2.3364 7 yes
GO:0002832 negative regulation of response to biotic stimulus 2.3364 5 yes
GO:0010823 negative regulation of mitochondrion organization 2.3364 7 yes
GO:0022401 negative adaptation of signaling pathway 2.3364 6 yes
GO:0023058 adaptation of signaling pathway 2.3364 5 yes
GO:0032651 regulation of interleukin-1 beta production 1.8692 6 yes
GO:0032652 regulation of interleukin-1 production 1.8692 5 yes
GO:0032655 regulation of interleukin-12 production 1.8692 5 yes
GO:0032965 regulation of collagen biosynthetic process 1.8692 5 yes
GO:0032967 positive regulation of collagen biosynthetic process 1.8692 6 yes
GO:0045824 negative regulation of innate immune response 1.8692 6 yes
GO:0051898 negative regulation of protein kinase B signaling 1.8692 7 yes
GO:0062149 detection of stimulus involved in sensory perception of pain 1.8692 4 yes
GO:0090199 regulation of release of cytochrome c from mitochondria 1.8692 7 yes
GO:0090201 negative regulation of release of cytochrome c from mitochondria 1.8692 7 yes
GO:1904035 regulation of epithelial cell apoptotic process 1.8692 7 yes
GO:0002031 G protein-coupled receptor internalization 1.8692 8 yes
GO:0002703 regulation of leukocyte mediated immunity 1.8692 5 yes
GO:0006366 transcription by RNA polymerase II 1.8692 8 yes
GO:0007420 brain development 1.8692 4 yes
GO:0010660 regulation of muscle cell apoptotic process 1.8692 7 yes
GO:0010712 regulation of collagen metabolic process 1.8692 4 yes
GO:0010714 positive regulation of collagen metabolic process 1.8692 5 yes
GO:0031341 regulation of cell killing 1.4019 4 yes
GO:0031342 negative regulation of cell killing 1.4019 5 yes
GO:0032680 regulation of tumor necrosis factor production 1.4019 6 yes
GO:0032695 negative regulation of interleukin-12 production 1.4019 6 yes
GO:0032715 negative regulation of interleukin-6 production 1.4019 6 yes
GO:0034122 negative regulation of toll-like receptor signaling pathway 1.4019 6 yes
GO:0050961 detection of temperature stimulus involved in sensory perception 1.4019 4 yes
GO:0050965 detection of temperature stimulus involved in sensory perception of pain 1.4019 5 yes
GO:0090659 walking behavior 1.4019 4 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 1.4019 5 yes
GO:1904037 positive regulation of epithelial cell apoptotic process 1.4019 8 yes
GO:0002032 desensitization of G protein-coupled receptor signaling pathway by arrestin 1.4019 6 yes
GO:0002698 negative regulation of immune effector process 1.4019 5 yes
GO:0007179 transforming growth factor beta receptor signaling pathway 1.4019 6 yes
GO:0007628 adult walking behavior 1.4019 5 yes
GO:0010656 negative regulation of muscle cell apoptotic process 1.4019 8 yes
GO:0016048 detection of temperature stimulus 1.4019 4 yes
GO:0032225 regulation of synaptic transmission, dopaminergic 0.9346 6 yes
GO:0032226 positive regulation of synaptic transmission, dopaminergic 0.9346 6 yes
GO:0032691 negative regulation of interleukin-1 beta production 0.9346 7 yes
GO:0032692 negative regulation of interleukin-1 production 0.9346 6 yes
GO:0032720 negative regulation of tumor necrosis factor production 0.9346 7 yes
GO:0034260 negative regulation of GTPase activity 0.9346 4 yes
GO:0034391 regulation of smooth muscle cell apoptotic process 0.9346 8 yes
GO:0034392 negative regulation of smooth muscle cell apoptotic process 0.9346 9 yes
GO:0042269 regulation of natural killer cell mediated cytotoxicity 0.9346 6 yes
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 0.9346 7 yes
GO:0051147 regulation of muscle cell differentiation 0.9346 5 yes
GO:0051149 positive regulation of muscle cell differentiation 0.9346 6 yes
GO:0051153 regulation of striated muscle cell differentiation 0.9346 6 yes
GO:0051155 positive regulation of striated muscle cell differentiation 0.9346 7 yes
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 0.9346 6 yes
GO:1905207 regulation of cardiocyte differentiation 0.9346 5 yes
GO:1905209 positive regulation of cardiocyte differentiation 0.9346 5 yes
GO:0001910 regulation of leukocyte mediated cytotoxicity 0.9346 5 yes
GO:0001911 negative regulation of leukocyte mediated cytotoxicity 0.9346 6 yes
GO:2000725 regulation of cardiac muscle cell differentiation 0.9346 6 yes
GO:2000727 positive regulation of cardiac muscle cell differentiation 0.9346 6 yes
GO:0002704 negative regulation of leukocyte mediated immunity 0.9346 6 yes
GO:0002706 regulation of lymphocyte mediated immunity 0.9346 6 yes
GO:0002707 negative regulation of lymphocyte mediated immunity 0.9346 7 yes
GO:0002715 regulation of natural killer cell mediated immunity 0.9346 6 yes
GO:0002716 negative regulation of natural killer cell mediated immunity 0.9346 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in ARRB2_HUMAN
DOID:114 heart disease 1.8692 3 no
DOID:0050700 cardiomyopathy 1.4019 4 no
DOID:0060036 intrinsic cardiomyopathy 1.4019 5 no
DOID:1289 neurodegenerative disease 1.4019 4 no
DOID:331 central nervous system disease 1.4019 3 no
DOID:0050890 synucleinopathy 0.9346 5 no
DOID:0060892 late onset Parkinsons disease 0.9346 7 no
DOID:14330 Parkinsons disease 0.9346 6 no
DOID:440 neuromuscular disease 0.9346 5 no
DOID:574 peripheral nervous system disease 0.9346 3 no
DOID:870 neuropathy 0.9346 4 no
DOID:2843 long QT syndrome 0.9346 6 no
DOID:0080001 bone disease 0.9346 4 no
DOID:0080006 bone development disease 0.9346 5 no
DOID:65 connective tissue disease 0.9346 3 no
DOID:0050155 sensory system disease 0.9346 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
TNIP1_HUMAN [view interactions] Low throughput no yes
HIF1A_HUMAN [view interactions] Low throughput no no
RBP2_HUMAN [view interactions] Low throughput no yes
OPSD_HUMAN [view interactions] Low throughput no no
OPRD_HUMAN [view entry] [view interactions] Low throughput yes no
LSHR_HUMAN [view interactions] Low throughput no no
PP2AA_HUMAN [view entry] [view interactions] Low throughput yes yes
GSK3A_HUMAN [view interactions] Low throughput no yes
ARBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
SUMO1_HUMAN [view interactions] Low throughput no yes
SUMO2_HUMAN [view interactions] Low throughput no yes
CSK22_HUMAN [view entry] [view interactions] Low throughput yes no
UBC9_HUMAN [view interactions] Low throughput no yes
OX1R_HUMAN [view interactions] Low throughput no yes
TRFR_HUMAN [view interactions] Low throughput no no
OXER1_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
CRFR1_HUMAN [view interactions] Low throughput no yes
AP3B2_HUMAN [view entry] [view interactions] Low throughput yes yes
IMB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PDE4D_HUMAN [view entry] [view interactions] Low throughput yes yes
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
MK10_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K5_HUMAN [view interactions] Low throughput no yes
MP2K4_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view interactions] Low throughput no yes
FFAR4_HUMAN [view interactions] Low throughput no no
5HT2C_HUMAN [view interactions] Low throughput no no
ADCY2_HUMAN [view interactions] Low throughput no yes
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
LIMK1_HUMAN [view interactions] Low throughput no yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
OPRM_HUMAN [view entry] [view interactions] Low throughput yes no
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
EGLN_HUMAN [view interactions] Low throughput no no
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
GPR3_HUMAN [view interactions] Low throughput no no
ACKR3_HUMAN [view interactions] Low throughput no no
RAGP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NPHN_HUMAN [view interactions] Low throughput no no
ADRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAR10_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view interactions] Low throughput no yes
AGRB2_HUMAN [view interactions] Low throughput no no
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
SSR2_HUMAN [view interactions] Low throughput no yes
CCR7_HUMAN [view interactions] Low throughput no no
PE2R2_HUMAN [view interactions] Low throughput no no
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
2ABB_HUMAN [view interactions] Low throughput no yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
RXFP1_HUMAN [view interactions] Low throughput no yes
RGS9_HUMAN [view entry] [view interactions] Low throughput yes no
AP2B1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
EDNRA_HUMAN [view interactions] Low throughput no yes
TF65_HUMAN [view entry] [view interactions] Low throughput yes yes
ACM2_HUMAN [view entry] [view interactions] Low throughput yes yes
AGTR1_HUMAN [view interactions] Low throughput no no
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
TAB1_HUMAN [view interactions] Low throughput no yes
APJ_HUMAN [view interactions] Low throughput no yes
5HT2A_HUMAN [view entry] [view interactions] Low throughput yes yes
CXCR3_HUMAN [view interactions] Low throughput no no
CXCR4_HUMAN [view interactions] Low throughput no no
V2R_HUMAN [view interactions] Low throughput no no
KIF3A_HUMAN [view entry] [view interactions] Low throughput yes yes
ILK_HUMAN [view interactions] Low throughput no no
SMO_HUMAN [view interactions] Low throughput no yes
GNDS_HUMAN [view interactions] Low throughput no yes
SL9A5_HUMAN [view interactions] Low throughput no no
PTGDS_HUMAN [view interactions] Low throughput no yes
UBP33_HUMAN [view interactions] Low throughput no yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
CYH2_HUMAN [view entry] [view interactions] Low throughput yes yes
PTAFR_HUMAN [view interactions] Low throughput no yes
ITCH_HUMAN [view interactions] Low throughput no yes
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD4_HUMAN [view entry] [view interactions] Low throughput yes no
AGRG1_HUMAN [view interactions] Low throughput no yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] Low throughput yes yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPA_HUMAN [view interactions] Low throughput no yes
TEBP_HUMAN [view interactions] Low throughput no yes
C5AR1_HUMAN [view interactions] Low throughput no yes
ARRD3_HUMAN [view interactions] Low throughput no no
IKBA_HUMAN [view interactions] Low throughput no yes
GLUC_HUMAN [view interactions] Low throughput no no
CSK_HUMAN [view interactions] Low throughput no yes
AGRB1_HUMAN [view entry] [view interactions] Low throughput yes no
CYH1_HUMAN [view interactions] Low throughput no no
TA2R_HUMAN [view interactions] Low throughput no no
FLNA_HUMAN [view entry] [view interactions] Low throughput yes no
SENP1_HUMAN [view interactions] Low throughput no no
AP1B1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP20_HUMAN [view interactions] Low throughput no yes
KLH12_HUMAN [view interactions] Low throughput no no
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
PE2R4_HUMAN [view interactions] Low throughput no yes
MSHR_HUMAN [view interactions] Low throughput no no
MGRN1_HUMAN [view interactions] Low throughput no yes
SUFU_HUMAN [view interactions] Low throughput no yes
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAV1_HUMAN [view interactions] Low throughput no no
AP2A1_HUMAN [view entry] [view interactions] Low throughput yes yes
COF1_HUMAN [view entry] [view interactions] Low throughput yes no
XRCC5_HUMAN [view interactions] High throughput no yes
TMM74_HUMAN [view interactions] High throughput no no
SRRM2_HUMAN [view interactions] High throughput no yes
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
SPIN3_HUMAN [view interactions] High throughput no yes
GPR37_HUMAN [view interactions] High throughput no no
TBB4B_HUMAN [view interactions] High throughput no yes
NHRF2_HUMAN [view entry] [view interactions] High throughput yes no
TPTE2_HUMAN [view interactions] High throughput no no
NOP56_HUMAN [view interactions] High throughput no yes
LEO1_HUMAN [view interactions] High throughput no yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
ARRS_HUMAN [view interactions] High throughput no no
BRD2_HUMAN [view interactions] High throughput no yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
BRD3_HUMAN [view interactions] High throughput no yes
NAA10_HUMAN [view interactions] High throughput no yes
SPIN1_HUMAN [view interactions] High throughput no no
ZRAB2_HUMAN [view interactions] High throughput no yes
LRP11_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
H2AX_HUMAN [view interactions] High throughput no yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
ITA2B_HUMAN [view interactions] High throughput no no
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
CENPF_HUMAN [view interactions] High throughput no no
ARHGC_HUMAN [view interactions] High throughput no yes
KPB2_HUMAN [view interactions] High throughput no yes
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
NSUN2_HUMAN [view interactions] High throughput no yes
PAK5_HUMAN [view interactions] High throughput no yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
TAB2_HUMAN [view interactions] High throughput no yes
ALS_HUMAN [view interactions] High throughput no no
RL30_HUMAN [view entry] [view interactions] High throughput yes yes
KC1A_HUMAN [view interactions] High throughput no yes
WEE1_HUMAN [view interactions] High throughput no yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
COTL1_HUMAN [view interactions] High throughput no yes
RL19_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view interactions] High throughput no yes
LAP2A_HUMAN [view interactions] High throughput no yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
M3K14_HUMAN [view interactions] High throughput no yes
RHG17_HUMAN [view interactions] High throughput no no
ACTC_HUMAN [view interactions] High throughput no no
RPAC1_HUMAN [view interactions] High throughput no no
CDK4_HUMAN [view interactions] High throughput no no
M3K7_HUMAN [view interactions] High throughput no yes
MYCD_HUMAN [view interactions] High throughput no yes
RPAB1_HUMAN [view interactions] High throughput no yes
AFAD_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] High throughput yes yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
RL26_HUMAN [view entry] [view interactions] High throughput yes yes
H12_HUMAN [view interactions] High throughput no yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
P3C2A_HUMAN [view interactions] High throughput no yes
PRP4B_HUMAN [view interactions] High throughput no yes
ARHGB_HUMAN [view interactions] High throughput no yes
CASB_HUMAN [view interactions] High throughput no no
RL11_HUMAN [view entry] [view interactions] High throughput yes yes
RL36_HUMAN [view entry] [view interactions] High throughput yes yes
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
M3K1_HUMAN [view interactions] High throughput no yes
BSN_HUMAN [view entry] [view interactions] High throughput yes yes
5HT4R_HUMAN [view interactions] High throughput no yes
HIPK3_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
PPM1A_HUMAN [view interactions] High throughput no yes
H11_HUMAN [view interactions] High throughput no no
ACTBL_HUMAN [view interactions] High throughput no no
ACTBM_HUMAN [view interactions] High throughput no no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
SPNDC_HUMAN [view interactions] High throughput no yes
PKN3_HUMAN [view interactions] High throughput no yes
BOLA2_HUMAN [view interactions] High throughput no yes
MUC13_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
WDR6_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
TFE3_HUMAN [view interactions] High throughput no yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
FBX46_HUMAN [view interactions] High throughput no no
KCAB1_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
COBL_HUMAN [view interactions] High throughput no yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
NOP10_HUMAN [view interactions] High throughput no yes
CT2NL_HUMAN [view interactions] High throughput no yes
MCM3_HUMAN [view interactions] High throughput no no
PHOCN_HUMAN [view interactions] High throughput no yes
DGKE_HUMAN [view interactions] High throughput no yes
VPS51_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
JAK1_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
RS17_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE2_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
ANR11_HUMAN [view interactions] High throughput no yes
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
COPRS_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
TBA8_HUMAN [view interactions] High throughput no yes
TR150_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
DHX15_HUMAN [view interactions] High throughput no yes
ACM1_HUMAN [view entry] [view interactions] High throughput yes yes
NONO_HUMAN [view interactions] High throughput no yes
RL15_HUMAN [view entry] [view interactions] High throughput yes no
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4A_HUMAN [view interactions] High throughput no yes
ARRC_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
RPA2_HUMAN [view interactions] High throughput no no
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
NUCL_HUMAN [view interactions] High throughput no yes
E2AK1_HUMAN [view interactions] High throughput no yes
YBOX1_HUMAN [view interactions] High throughput no yes
IMA4_HUMAN [view interactions] High throughput no yes
SCYL2_HUMAN [view interactions] High throughput no yes
DDX27_HUMAN [view interactions] High throughput no no
UBR5_HUMAN [view interactions] High throughput no no
PESC_HUMAN [view entry] [view interactions] High throughput yes yes
RBM10_HUMAN [view interactions] High throughput no yes
RL7L_HUMAN [view interactions] High throughput no no
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
RM43_HUMAN [view interactions] High throughput no no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
AP3B1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK7_HUMAN [view interactions] High throughput no yes
RM44_HUMAN [view interactions] High throughput no yes
PPM1B_HUMAN [view interactions] High throughput no yes
BOP1_HUMAN [view interactions] High throughput no yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
IMA3_HUMAN [view interactions] High throughput no yes
EF1A2_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
FBRL_HUMAN [view interactions] High throughput no yes
AKT2_HUMAN [view entry] [view interactions] High throughput yes yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
H1X_HUMAN [view interactions] High throughput no yes
ICLN_HUMAN [view interactions] High throughput no yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
HTSF1_HUMAN [view interactions] High throughput no yes
MK09_HUMAN [view interactions] High throughput no yes
MYL6_HUMAN [view entry] [view interactions] High throughput yes no
MED8_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
STC2_HUMAN [view interactions] High throughput no no
ARP5L_HUMAN [view entry] [view interactions] High throughput yes yes
SMRC2_HUMAN [view interactions] High throughput no yes
RL12_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
RL21_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RFIP5_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
NKTR_HUMAN [view interactions] High throughput no no
CPNE1_HUMAN [view interactions] High throughput no no
RL22_HUMAN [view entry] [view interactions] High throughput yes no
PABP3_HUMAN [view interactions] High throughput no yes
RPA1_HUMAN [view interactions] High throughput no yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B3_HUMAN [view interactions] High throughput no yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
NINL_HUMAN [view interactions] High throughput no yes
IF2B1_HUMAN [view interactions] High throughput no no
CE170_HUMAN [view interactions] High throughput no yes
STK38_HUMAN [view entry] [view interactions] High throughput yes yes
ACTH_HUMAN [view interactions] High throughput no no
SF3B1_HUMAN [view interactions] High throughput no yes
TBA1C_HUMAN [view interactions] High throughput no yes
RL3_HUMAN [view entry] [view interactions] High throughput yes yes
NP1L1_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
ANM1_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
WDR26_HUMAN [view interactions] High throughput no yes
TRPV4_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
RLA0_HUMAN [view entry] [view interactions] High throughput yes yes
PABP4_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
DKC1_HUMAN [view interactions] High throughput no yes
THOC4_HUMAN [view interactions] High throughput no no
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
DGKZ_HUMAN [view entry] [view interactions] High throughput yes yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
CLIC1_HUMAN [view interactions] High throughput no no
UBB_HUMAN [view entry] [view interactions] High throughput yes yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
BCLF1_HUMAN [view interactions] High throughput no yes
PRP4_HUMAN [view interactions] High throughput no yes
RL28_HUMAN [view entry] [view interactions] High throughput yes yes
E2AK4_HUMAN [view interactions] High throughput no yes
ERH_HUMAN [view interactions] High throughput no yes
ARRD4_HUMAN [view interactions] High throughput no yes
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
SIR1_HUMAN [view interactions] High throughput no yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
DCD_HUMAN [view interactions] High throughput no no
HNRPR_HUMAN [view interactions] High throughput no yes
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
CAN1_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
GPR55_HUMAN [view interactions] High throughput no no
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
CENPM_HUMAN [view interactions] High throughput no yes
HNRPC_HUMAN [view interactions] High throughput no yes
EVI2A_HUMAN [view interactions] High throughput no no
IKKA_HUMAN [view interactions] High throughput no yes
TM38A_HUMAN [view interactions] High throughput no yes
CDK3_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
HMMR_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
PJA2_HUMAN [view entry] [view interactions] High throughput yes yes
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
RASF8_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
STRN3_HUMAN [view interactions] High throughput no yes
RL18_HUMAN [view entry] [view interactions] High throughput yes yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
RS3A_HUMAN [view entry] [view interactions] High throughput yes yes
RL7_HUMAN [view entry] [view interactions] High throughput yes yes
TCOF_HUMAN [view interactions] High throughput no yes
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
KBTB8_HUMAN [view interactions] High throughput no no
XRCC6_HUMAN [view interactions] High throughput no yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
KANK1_HUMAN [view interactions] High throughput no yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
BRPF1_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
UTP25_HUMAN [view interactions] High throughput no yes
YBOX3_HUMAN [view interactions] High throughput no yes
NAA15_HUMAN [view interactions] High throughput no yes
RPA43_HUMAN [view interactions] High throughput no yes
RTF1_HUMAN [view interactions] High throughput no yes
RL14_HUMAN [view entry] [view interactions] High throughput yes yes
RFX1_HUMAN [view interactions] High throughput no yes
HNRH2_HUMAN [view entry] [view interactions] High throughput yes yes
WDR70_HUMAN [view interactions] High throughput no no
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
CR025_HUMAN [view interactions] High throughput no yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
RAD18_HUMAN [view interactions] High throughput no yes
TBA3C_HUMAN [view interactions] High throughput no no
TPC2_HUMAN [view interactions] High throughput no no
TBA3D_HUMAN [view interactions] High throughput no no
SAHH3_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
EMIL1_HUMAN [view interactions] High throughput no no
PYRG1_HUMAN [view interactions] High throughput no no
FLNB_HUMAN [view interactions] High throughput no no
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
AFF4_HUMAN [view interactions] High throughput no yes
RLA2_HUMAN [view entry] [view interactions] High throughput yes yes
ENL_HUMAN [view interactions] High throughput no yes
PDIA1_HUMAN [view interactions] High throughput no yes
AF9_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
IKBL1_HUMAN [view interactions] High throughput no no
RS19_HUMAN [view entry] [view interactions] High throughput yes no
TNFL8_HUMAN [view interactions] High throughput no no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
TFAP4_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
GP156_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
AASD1_HUMAN [view interactions] High throughput no yes
NOLC1_HUMAN [view interactions] High throughput no yes
CENPB_HUMAN [view interactions] High throughput no yes
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
JPH1_HUMAN [view interactions] High throughput no no
SMD2_HUMAN [view interactions] High throughput no yes
E41L5_HUMAN [view interactions] High throughput no no
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
C102B_HUMAN [view interactions] High throughput no yes
HNRPF_HUMAN [view interactions] High throughput no yes
DAAF8_HUMAN [view interactions] High throughput no no
ANM5_HUMAN [view entry] [view interactions] High throughput yes yes
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
RS7_HUMAN [view entry] [view interactions] High throughput yes yes
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
H2A2B_HUMAN [view interactions] High throughput no yes
RS8_HUMAN [view entry] [view interactions] High throughput yes no
RL31_HUMAN [view entry] [view interactions] High throughput yes yes
PTBP1_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
HDGR2_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
LBR_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
NUPR1_HUMAN [view interactions] High throughput no no
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
DDX58_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
H2B1O_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
F263_HUMAN [view interactions] High throughput no yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
PAIRB_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ARHG6_HUMAN [view interactions] High throughput no no
HNRPU_HUMAN [view interactions] High throughput no yes
LURA1_HUMAN [view interactions] High throughput no yes
ROA0_HUMAN [view interactions] High throughput no yes
ZN653_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
MIIP_HUMAN [view interactions] High throughput no yes
SDHA_HUMAN [view interactions] High throughput no yes
EIF1A_HUMAN [view interactions] High throughput no no
MOB1A_HUMAN [view interactions] High throughput no yes
CD6_HUMAN [view interactions] High throughput no no
RLA1_HUMAN [view entry] [view interactions] High throughput yes no
PO2F1_HUMAN [view interactions] High throughput no yes
TM169_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
COPT1_HUMAN [view interactions] High throughput no no
MEP50_HUMAN [view interactions] High throughput no yes
RHG22_HUMAN [view entry] [view interactions] High throughput yes yes
CDK13_HUMAN [view interactions] High throughput no no
PI42A_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B2_HUMAN [view interactions] High throughput no yes
CRCM_HUMAN [view interactions] High throughput no no
TNR1B_HUMAN [view interactions] High throughput no no
KC1AL_HUMAN [view interactions] High throughput no no
GPBL1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
GP182_HUMAN [view interactions] High throughput no no
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
KCNE3_HUMAN [view interactions] High throughput no yes
SDC3_HUMAN [view interactions] High throughput no yes
MANS1_HUMAN [view interactions] High throughput no yes
G3BP2_HUMAN [view entry] [view interactions] High throughput yes yes
RASA2_HUMAN [view interactions] High throughput no yes
MYPT1_HUMAN [view entry] [view interactions] High throughput yes yes
ALPK2_HUMAN [view interactions] High throughput no no
SMD1_HUMAN [view interactions] High throughput no yes
MAS_HUMAN [view interactions] High throughput no no
PAR1_HUMAN [view entry] [view interactions] Computational yes yes
P2R3B_HUMAN [view interactions] Computational no no
HRH4_HUMAN [view interactions] Computational no no
RB11A_HUMAN [view entry] [view interactions] Computational yes yes
GRK5_HUMAN [view interactions] Computational no yes
CNR1_HUMAN [view interactions] Computational no yes
ROR2_HUMAN [view entry] [view interactions] Computational yes yes
2A5G_HUMAN [view interactions] Computational no yes
CADH5_HUMAN [view interactions] Computational no yes
TIGIT_HUMAN [view interactions] Computational no no
PEBP1_HUMAN [view entry] [view interactions] Computational yes yes
RL3R1_HUMAN [view interactions] Computational no no
NHRF1_HUMAN [view interactions] Computational no no
GPR35_HUMAN [view interactions] Computational no no
2A5E_HUMAN [view interactions] Computational no yes
P2R3A_HUMAN [view interactions] Computational no yes
NOS3_HUMAN [view interactions] Computational no no
DVL2_HUMAN [view interactions] Computational no yes
GRK6_HUMAN [view interactions] Computational no yes
PTH1R_HUMAN [view interactions] Computational no no
MK14_HUMAN [view interactions] Computational no yes
2ABG_HUMAN [view interactions] Computational no yes
LYN_HUMAN [view entry] [view interactions] Computational yes no
RAC1_HUMAN [view entry] [view interactions] Computational yes no
UBQL2_HUMAN [view interactions] Computational no yes
GNA11_HUMAN [view entry] [view interactions] Computational yes yes
GLI1_HUMAN [view interactions] Computational no no
DYN1_HUMAN [view entry] [view interactions] Computational yes yes
KIRR1_HUMAN [view interactions] Computational no no
TRAF3_HUMAN [view entry] [view interactions] Computational yes yes
APH1A_HUMAN [view interactions] Computational no yes
NK1R_HUMAN [view interactions] Computational no no
GNA15_HUMAN [view interactions] Computational no yes
TGBR3_HUMAN [view interactions] Computational no yes
CXCR2_HUMAN [view interactions] Computational no no
RAB5A_HUMAN [view entry] [view interactions] Computational yes yes
FZD4_HUMAN [view interactions] Computational no yes
2ABD_HUMAN [view interactions] Computational no yes
IL8_HUMAN [view interactions] Computational no no
P2R3C_HUMAN [view interactions] Computational no yes
GRK4_HUMAN [view interactions] Computational no yes
GRK7_HUMAN [view interactions] Computational no no
NFKB1_HUMAN [view interactions] Computational no yes
IQGA1_HUMAN [view entry] [view interactions] Computational yes no
2ABA_HUMAN [view interactions] Computational no yes
CLH2_HUMAN [view interactions] Computational no no
FZD2_HUMAN [view interactions] Computational no no
GRK1_HUMAN [view interactions] Computational no no
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
WNT5A_HUMAN [view entry] [view interactions] Computational yes no
KISSR_HUMAN [view interactions] Computational no yes
ARBK2_HUMAN [view entry] [view interactions] Computational yes yes
FGR_HUMAN [view interactions] Computational no no
2A5D_HUMAN [view entry] [view interactions] Computational yes yes
2A5A_HUMAN [view interactions] Computational no yes
GLI2_HUMAN [view interactions] Computational no yes
2AAB_HUMAN [view interactions] Computational no yes
MTG1_HUMAN [view interactions] Computational no yes
C5AR2_HUMAN [view interactions] Computational no yes
PP2AB_HUMAN [view interactions] Computational no yes
CCR1_HUMAN [view interactions] Computational no no
2A5B_HUMAN [view interactions] Computational no yes
FYN_HUMAN [view entry] [view interactions] Computational yes no
CCR5_HUMAN [view interactions] Computational no no
GP161_HUMAN [view interactions] Computational no yes
CP110_HUMAN [view interactions] Computational no yes
GNA14_HUMAN [view entry] [view interactions] Computational yes yes
GLI3_HUMAN [view interactions] Computational no yes
SDF1_HUMAN [view interactions] Computational no no
CXCR1_HUMAN [view interactions] Computational no yes