CLCB_HUMAN
Evidence for PS localization
Functions
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CLCB_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 32.9787 | 4 | no |
| GO:0000166 | nucleotide binding | 28.7234 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.6596 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 27.6596 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 27.6596 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.6596 | 5 | no |
| GO:0005524 | ATP binding | 26.5957 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.5957 | 4 | no |
| GO:0043169 | cation binding | 24.4681 | 4 | no |
| GO:0046872 | metal ion binding | 24.4681 | 5 | no |
| GO:0003779 | actin binding | 22.3404 | 4 | no |
| GO:0045296 | cadherin binding | 20.2128 | 4 | no |
| GO:0032050 | clathrin heavy chain binding | 3.1915 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CLCB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.4468 | 4 | no |
| GO:0008104 | protein localization | 51.0638 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 51.0638 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.8723 | 4 | no |
| GO:0006996 | organelle organization | 46.8085 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.7447 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.5532 | 4 | no |
| GO:0071702 | organic substance transport | 39.3617 | 4 | yes |
| GO:0022607 | cellular component assembly | 39.3617 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.3617 | 4 | no |
| GO:0071705 | nitrogen compound transport | 37.2340 | 4 | yes |
| GO:0015031 | protein transport | 35.1064 | 4 | yes |
| GO:0010646 | regulation of cell communication | 35.1064 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.9787 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.9787 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.9787 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.9787 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 31.9149 | 4 | no |
| GO:0098657 | import into cell | 30.8511 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.8511 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.8511 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.8511 | 5 | no |
| GO:0051049 | regulation of transport | 30.8511 | 4 | no |
| GO:0043933 | protein-containing complex organization | 29.7872 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.7234 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.6596 | 4 | no |
| GO:0006886 | intracellular protein transport | 26.5957 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 26.5957 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.5319 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.5319 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.4681 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 24.4681 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.4681 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.4043 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.4043 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.4043 | 4 | no |
| GO:0061024 | membrane organization | 23.4043 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.3404 | 5 | no |
| GO:0033043 | regulation of organelle organization | 22.3404 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.2766 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.2766 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 21.2766 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.2766 | 6 | no |
| GO:0060341 | regulation of cellular localization | 21.2766 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.2128 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.2128 | 6 | no |
| GO:0032880 | regulation of protein localization | 20.2128 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.2128 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 18.0851 | 4 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 13.8298 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| ADA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CLCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MYO6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RN5A_HUMAN | [view interactions] | Low throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THOC4_HUMAN | [view interactions] | High throughput | no | no |
| KIT_HUMAN | [view interactions] | High throughput | no | no |
| KS6A5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ULK1_HUMAN | [view interactions] | High throughput | no | no |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK16_HUMAN | [view interactions] | High throughput | no | no |
| SIK1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K9_HUMAN | [view interactions] | High throughput | no | yes |
| STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OBSCN_HUMAN | [view interactions] | High throughput | no | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| PRPK_HUMAN | [view interactions] | High throughput | no | yes |
| WNK3_HUMAN | [view interactions] | High throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| PQBP1_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT4R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIFCL_HUMAN | [view interactions] | High throughput | no | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCF20_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEMI_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| MDEAS_HUMAN | [view interactions] | High throughput | no | yes |
| ARX_HUMAN | [view interactions] | High throughput | no | no |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| VPS41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| AP1AR_HUMAN | [view interactions] | High throughput | no | yes |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| DCP1B_HUMAN | [view interactions] | High throughput | no | yes |
| DCP2_HUMAN | [view interactions] | High throughput | no | yes |
| AFTIN_HUMAN | [view interactions] | High throughput | no | yes |
| LSM6_HUMAN | [view interactions] | High throughput | no | yes |
| IST1_HUMAN | [view interactions] | High throughput | no | yes |
| P5CS_HUMAN | [view interactions] | High throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHMP5_HUMAN | [view interactions] | High throughput | no | yes |
| DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
| MARF1_HUMAN | [view interactions] | High throughput | no | yes |
| LSM2_HUMAN | [view interactions] | High throughput | no | yes |
| LSM4_HUMAN | [view interactions] | High throughput | no | yes |
| LSM7_HUMAN | [view interactions] | High throughput | no | yes |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| NU133_HUMAN | [view interactions] | High throughput | no | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM1_HUMAN | [view interactions] | High throughput | no | no |
| CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RN207_HUMAN | [view interactions] | High throughput | no | no |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| CNDG2_HUMAN | [view interactions] | High throughput | no | yes |
| P4K2A_HUMAN | [view interactions] | High throughput | no | yes |
| PNPT1_HUMAN | [view interactions] | High throughput | no | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| HAP28_HUMAN | [view interactions] | High throughput | no | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP1_HUMAN | [view interactions] | High throughput | no | yes |
| AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| CA226_HUMAN | [view interactions] | High throughput | no | yes |
| DNMBP_HUMAN | [view interactions] | High throughput | no | no |
| EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGA1_HUMAN | [view interactions] | High throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
| SH319_HUMAN | [view interactions] | High throughput | no | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNRG_HUMAN | [view interactions] | High throughput | no | yes |
| TTI1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELP6_HUMAN | [view interactions] | High throughput | no | no |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| KIF15_HUMAN | [view interactions] | High throughput | no | no |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3C3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNPY3_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STON2_HUMAN | [view interactions] | High throughput | no | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| TPC_HUMAN | [view interactions] | High throughput | no | no |
| FA83B_HUMAN | [view interactions] | High throughput | no | no |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |