CLCB_HUMAN
Evidence for PS localization
Functions
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CLCB_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.2083 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.2083 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.2083 | 4 | no |
| GO:0005524 | ATP binding | 26.0417 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 26.0417 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.0417 | 5 | no |
| GO:0046872 | metal ion binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 21.8750 | 4 | no |
| GO:0019901 | protein kinase binding | 21.8750 | 5 | no |
| GO:0032050 | clathrin heavy chain binding | 3.1250 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CLCB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.4167 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 56.2500 | 4 | yes |
| GO:0008104 | protein localization | 48.9583 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.9583 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.9583 | 4 | no |
| GO:0071702 | organic substance transport | 44.7917 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 44.7917 | 4 | no |
| GO:0071705 | nitrogen compound transport | 43.7500 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 43.7500 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.7083 | 4 | no |
| GO:0006996 | organelle organization | 42.7083 | 4 | no |
| GO:0015031 | protein transport | 40.6250 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.6250 | 4 | no |
| GO:0051049 | regulation of transport | 38.5417 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
| GO:0006897 | endocytosis | 33.3333 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.2917 | 4 | no |
| GO:0006886 | intracellular protein transport | 31.2500 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.2500 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.2500 | 5 | no |
| GO:0022607 | cellular component assembly | 30.2083 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.1667 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.1250 | 5 | no |
| GO:0010468 | regulation of gene expression | 28.1250 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 27.0833 | 4 | no |
| GO:0033043 | regulation of organelle organization | 27.0833 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.0833 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.0417 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.0417 | 5 | no |
| GO:0051050 | positive regulation of transport | 26.0417 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.0417 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.9583 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 23.9583 | 4 | no |
| GO:0061024 | membrane organization | 23.9583 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 22.9167 | 6 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 22.9167 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.9167 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.8750 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.8750 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.8750 | 4 | no |
| GO:0030030 | cell projection organization | 20.8333 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.8333 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.8333 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.8333 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 20.8333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.8333 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 18.7500 | 5 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 14.5833 | 7 | yes |
| GO:0048268 | clathrin coat assembly | 9.3750 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in CLCB_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 4.1667 | 3 | no |
| DOID:0050700 | cardiomyopathy | 3.1250 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.1250 | 5 | no |
| DOID:2843 | long QT syndrome | 2.0833 | 6 | no |
| DOID:0050155 | sensory system disease | 2.0833 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 2.0833 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 2.0833 | 6 | no |
| DOID:2742 | auditory system disease | 2.0833 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MYO6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RN5A_HUMAN | [view interactions] | Low throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| ADA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CLCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCF20_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEMI_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| MDEAS_HUMAN | [view interactions] | High throughput | no | yes |
| ARX_HUMAN | [view interactions] | High throughput | no | no |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| VPS41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| AP1AR_HUMAN | [view interactions] | High throughput | no | yes |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| DCP1B_HUMAN | [view interactions] | High throughput | no | yes |
| DCP2_HUMAN | [view interactions] | High throughput | no | yes |
| AFTIN_HUMAN | [view interactions] | High throughput | no | yes |
| LSM6_HUMAN | [view interactions] | High throughput | no | yes |
| IST1_HUMAN | [view interactions] | High throughput | no | yes |
| P5CS_HUMAN | [view interactions] | High throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHMP5_HUMAN | [view interactions] | High throughput | no | yes |
| DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
| MARF1_HUMAN | [view interactions] | High throughput | no | yes |
| LSM2_HUMAN | [view interactions] | High throughput | no | yes |
| LSM4_HUMAN | [view interactions] | High throughput | no | yes |
| LSM7_HUMAN | [view interactions] | High throughput | no | yes |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| NU133_HUMAN | [view interactions] | High throughput | no | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM1_HUMAN | [view interactions] | High throughput | no | no |
| CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| CNDG2_HUMAN | [view interactions] | High throughput | no | yes |
| P4K2A_HUMAN | [view interactions] | High throughput | no | yes |
| PNPT1_HUMAN | [view interactions] | High throughput | no | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| HAP28_HUMAN | [view interactions] | High throughput | no | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| CA226_HUMAN | [view interactions] | High throughput | no | yes |
| DNMBP_HUMAN | [view interactions] | High throughput | no | no |
| EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGA1_HUMAN | [view interactions] | High throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
| SH319_HUMAN | [view interactions] | High throughput | no | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNRG_HUMAN | [view interactions] | High throughput | no | yes |
| TTI1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELP6_HUMAN | [view interactions] | High throughput | no | no |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| KIF15_HUMAN | [view interactions] | High throughput | no | no |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3C3_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| FA83B_HUMAN | [view interactions] | High throughput | no | no |
| TPC_HUMAN | [view interactions] | High throughput | no | no |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| STON2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THOC4_HUMAN | [view interactions] | High throughput | no | no |
| KIT_HUMAN | [view interactions] | High throughput | no | no |
| KS6A5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ULK1_HUMAN | [view interactions] | High throughput | no | no |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK16_HUMAN | [view interactions] | High throughput | no | no |
| SIK1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K9_HUMAN | [view interactions] | High throughput | no | yes |
| STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| OBSCN_HUMAN | [view interactions] | High throughput | no | yes |
| PRPK_HUMAN | [view interactions] | High throughput | no | yes |
| WNK3_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| PQBP1_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT4R_HUMAN | [view interactions] | High throughput | no | yes |
| EIFCL_HUMAN | [view interactions] | High throughput | no | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| NCF2_HUMAN | [view interactions] | Computational | no | no |
| GIT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ERD22_HUMAN | [view interactions] | Computational | no | yes |
| UBQL2_HUMAN | [view interactions] | Computational | no | yes |
| ASAP2_HUMAN | [view interactions] | Computational | no | yes |
| GOSR2_HUMAN | [view interactions] | Computational | no | yes |
| ARFG1_HUMAN | [view interactions] | Computational | no | no |
| COPA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ERD23_HUMAN | [view interactions] | Computational | no | yes |
| EHD2_HUMAN | [view interactions] | Computational | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP1S1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FZD5_HUMAN | [view interactions] | Computational | no | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PHLD_HUMAN | [view interactions] | Computational | no | no |
| CD4_HUMAN | [view interactions] | Computational | no | no |
| NECP2_HUMAN | [view interactions] | Computational | no | yes |
| ARAP1_HUMAN | [view interactions] | Computational | no | yes |
| EPN3_HUMAN | [view interactions] | Computational | no | no |
| RHG05_HUMAN | [view interactions] | Computational | no | yes |
| RHG06_HUMAN | [view interactions] | Computational | no | yes |
| ROR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EREG_HUMAN | [view interactions] | Computational | no | no |
| ARAP2_HUMAN | [view interactions] | Computational | no | no |
| YKT6_HUMAN | [view interactions] | Computational | no | yes |
| ARFG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RHG04_HUMAN | [view interactions] | Computational | no | no |
| ASAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RBP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CHIN_HUMAN | [view interactions] | Computational | no | no |
| ROR1_HUMAN | [view interactions] | Computational | no | no |
| RHG01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FZD2_HUMAN | [view interactions] | Computational | no | no |
| ERD21_HUMAN | [view interactions] | Computational | no | yes |