CLCB_HUMAN
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CLCB_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 30.2083 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 30.2083 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 30.2083 | 4 | no |
GO:0005524 | ATP binding | 26.0417 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 26.0417 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 26.0417 | 5 | no |
GO:0046872 | metal ion binding | 25.0000 | 4 | no |
GO:0019900 | kinase binding | 21.8750 | 4 | no |
GO:0019901 | protein kinase binding | 21.8750 | 5 | no |
GO:0032050 | clathrin heavy chain binding | 3.1250 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CLCB_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 60.4167 | 4 | no |
GO:0016192 | vesicle-mediated transport | 56.2500 | 4 | yes |
GO:0008104 | protein localization | 48.9583 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 48.9583 | 4 | no |
GO:0051128 | regulation of cellular component organization | 48.9583 | 4 | no |
GO:0071702 | organic substance transport | 44.7917 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 44.7917 | 4 | no |
GO:0071705 | nitrogen compound transport | 43.7500 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 43.7500 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 42.7083 | 4 | no |
GO:0006996 | organelle organization | 42.7083 | 4 | no |
GO:0015031 | protein transport | 40.6250 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 40.6250 | 4 | no |
GO:0051049 | regulation of transport | 38.5417 | 4 | no |
GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
GO:0006897 | endocytosis | 33.3333 | 5 | yes |
GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 32.2917 | 4 | no |
GO:0006886 | intracellular protein transport | 31.2500 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 31.2500 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.2500 | 5 | no |
GO:0022607 | cellular component assembly | 30.2083 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 29.1667 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 28.1250 | 5 | no |
GO:0010468 | regulation of gene expression | 28.1250 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 27.0833 | 4 | no |
GO:0033043 | regulation of organelle organization | 27.0833 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 27.0833 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 26.0417 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.0417 | 5 | no |
GO:0051050 | positive regulation of transport | 26.0417 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 26.0417 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
GO:0043933 | protein-containing complex organization | 23.9583 | 4 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 23.9583 | 4 | no |
GO:0061024 | membrane organization | 23.9583 | 4 | no |
GO:0006898 | receptor-mediated endocytosis | 22.9167 | 6 | yes |
GO:1902531 | regulation of intracellular signal transduction | 22.9167 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 22.9167 | 4 | no |
GO:0060341 | regulation of cellular localization | 21.8750 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 21.8750 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 21.8750 | 4 | no |
GO:0030030 | cell projection organization | 20.8333 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 20.8333 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 20.8333 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 20.8333 | 6 | no |
GO:0010647 | positive regulation of cell communication | 20.8333 | 5 | no |
GO:0023056 | positive regulation of signaling | 20.8333 | 4 | no |
GO:0065003 | protein-containing complex assembly | 18.7500 | 5 | yes |
GO:0072583 | clathrin-dependent endocytosis | 14.5833 | 7 | yes |
GO:0048268 | clathrin coat assembly | 9.3750 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in CLCB_HUMAN |
---|---|---|---|---|
DOID:114 | heart disease | 4.1667 | 3 | no |
DOID:0050700 | cardiomyopathy | 3.1250 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 3.1250 | 5 | no |
DOID:2843 | long QT syndrome | 2.0833 | 6 | no |
DOID:0050155 | sensory system disease | 2.0833 | 3 | no |
DOID:0050563 | nonsyndromic deafness | 2.0833 | 5 | no |
DOID:0050564 | autosomal dominant nonsyndromic deafness | 2.0833 | 6 | no |
DOID:2742 | auditory system disease | 2.0833 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MYO6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RN5A_HUMAN | [view interactions] | Low throughput | no | yes |
HIP1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
ADA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CLCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
P53_HUMAN | [view interactions] | High throughput | no | no |
AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCF20_HUMAN | [view interactions] | High throughput | no | yes |
PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEST_HUMAN | [view interactions] | High throughput | no | no |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GEMI_HUMAN | [view interactions] | High throughput | no | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO19_HUMAN | [view interactions] | High throughput | no | yes |
MDEAS_HUMAN | [view interactions] | High throughput | no | yes |
ARX_HUMAN | [view interactions] | High throughput | no | no |
MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CD2AP_HUMAN | [view interactions] | High throughput | no | no |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALL3_HUMAN | [view interactions] | High throughput | no | yes |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMAP1_HUMAN | [view interactions] | High throughput | no | yes |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VP33B_HUMAN | [view interactions] | High throughput | no | yes |
VPS41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TES_HUMAN | [view interactions] | High throughput | no | yes |
UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LARP7_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI26_HUMAN | [view interactions] | High throughput | no | yes |
SIK2_HUMAN | [view interactions] | High throughput | no | yes |
RHG18_HUMAN | [view interactions] | High throughput | no | yes |
EDC4_HUMAN | [view interactions] | High throughput | no | yes |
AP1AR_HUMAN | [view interactions] | High throughput | no | yes |
TGO1_HUMAN | [view interactions] | High throughput | no | yes |
DCP1B_HUMAN | [view interactions] | High throughput | no | yes |
DCP2_HUMAN | [view interactions] | High throughput | no | yes |
AFTIN_HUMAN | [view interactions] | High throughput | no | yes |
LSM6_HUMAN | [view interactions] | High throughput | no | yes |
IST1_HUMAN | [view interactions] | High throughput | no | yes |
P5CS_HUMAN | [view interactions] | High throughput | no | yes |
AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHMP5_HUMAN | [view interactions] | High throughput | no | yes |
DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
MARF1_HUMAN | [view interactions] | High throughput | no | yes |
LSM2_HUMAN | [view interactions] | High throughput | no | yes |
LSM4_HUMAN | [view interactions] | High throughput | no | yes |
LSM7_HUMAN | [view interactions] | High throughput | no | yes |
EDC3_HUMAN | [view interactions] | High throughput | no | yes |
NU133_HUMAN | [view interactions] | High throughput | no | yes |
AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHM1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPRI_HUMAN | [view interactions] | High throughput | no | yes |
HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LSM1_HUMAN | [view interactions] | High throughput | no | no |
CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNDD3_HUMAN | [view interactions] | High throughput | no | no |
CNDG2_HUMAN | [view interactions] | High throughput | no | yes |
P4K2A_HUMAN | [view interactions] | High throughput | no | yes |
PNPT1_HUMAN | [view interactions] | High throughput | no | yes |
CH10_HUMAN | [view interactions] | High throughput | no | yes |
HAP28_HUMAN | [view interactions] | High throughput | no | yes |
CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NECP1_HUMAN | [view interactions] | High throughput | no | no |
AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
BICD2_HUMAN | [view interactions] | High throughput | no | yes |
CA226_HUMAN | [view interactions] | High throughput | no | yes |
DNMBP_HUMAN | [view interactions] | High throughput | no | no |
EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GGA1_HUMAN | [view interactions] | High throughput | no | yes |
GGA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HOOK1_HUMAN | [view interactions] | High throughput | no | no |
ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
SH319_HUMAN | [view interactions] | High throughput | no | no |
SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNRG_HUMAN | [view interactions] | High throughput | no | yes |
TTI1_HUMAN | [view interactions] | High throughput | no | yes |
AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ELP6_HUMAN | [view interactions] | High throughput | no | no |
GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECM29_HUMAN | [view interactions] | High throughput | no | no |
KIF15_HUMAN | [view interactions] | High throughput | no | no |
MARK3_HUMAN | [view interactions] | High throughput | no | yes |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PK3C3_HUMAN | [view interactions] | High throughput | no | yes |
TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DAB2_HUMAN | [view interactions] | High throughput | no | yes |
CLH2_HUMAN | [view interactions] | High throughput | no | no |
GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DEN1A_HUMAN | [view interactions] | High throughput | no | no |
GTSE1_HUMAN | [view interactions] | High throughput | no | no |
SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPN4_HUMAN | [view interactions] | High throughput | no | yes |
P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
SC16A_HUMAN | [view interactions] | High throughput | no | yes |
FA83B_HUMAN | [view interactions] | High throughput | no | no |
TPC_HUMAN | [view interactions] | High throughput | no | no |
FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
STON2_HUMAN | [view interactions] | High throughput | no | yes |
AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OCRL_HUMAN | [view interactions] | High throughput | no | yes |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THOC4_HUMAN | [view interactions] | High throughput | no | no |
KIT_HUMAN | [view interactions] | High throughput | no | no |
KS6A5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ULK1_HUMAN | [view interactions] | High throughput | no | no |
ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STK16_HUMAN | [view interactions] | High throughput | no | no |
SIK1_HUMAN | [view interactions] | High throughput | no | yes |
M3K9_HUMAN | [view interactions] | High throughput | no | yes |
STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
M3K21_HUMAN | [view interactions] | High throughput | no | yes |
OBSCN_HUMAN | [view interactions] | High throughput | no | yes |
PRPK_HUMAN | [view interactions] | High throughput | no | yes |
WNK3_HUMAN | [view interactions] | High throughput | no | no |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
PQBP1_HUMAN | [view interactions] | High throughput | no | yes |
5HT4R_HUMAN | [view interactions] | High throughput | no | yes |
EIFCL_HUMAN | [view interactions] | High throughput | no | yes |
DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAN2_HUMAN | [view interactions] | High throughput | no | no |
NCF2_HUMAN | [view interactions] | Computational | no | no |
GIT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ERD22_HUMAN | [view interactions] | Computational | no | yes |
UBQL2_HUMAN | [view interactions] | Computational | no | yes |
ASAP2_HUMAN | [view interactions] | Computational | no | yes |
GOSR2_HUMAN | [view interactions] | Computational | no | yes |
ARFG1_HUMAN | [view interactions] | Computational | no | no |
COPA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ERD23_HUMAN | [view interactions] | Computational | no | yes |
EHD2_HUMAN | [view interactions] | Computational | no | no |
ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AP1S1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FZD5_HUMAN | [view interactions] | Computational | no | yes |
DYN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PHLD_HUMAN | [view interactions] | Computational | no | no |
CD4_HUMAN | [view interactions] | Computational | no | no |
NECP2_HUMAN | [view interactions] | Computational | no | yes |
ARAP1_HUMAN | [view interactions] | Computational | no | yes |
EPN3_HUMAN | [view interactions] | Computational | no | no |
RHG05_HUMAN | [view interactions] | Computational | no | yes |
RHG06_HUMAN | [view interactions] | Computational | no | yes |
ROR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DYN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EREG_HUMAN | [view interactions] | Computational | no | no |
ARAP2_HUMAN | [view interactions] | Computational | no | no |
YKT6_HUMAN | [view interactions] | Computational | no | yes |
ARFG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RHG04_HUMAN | [view interactions] | Computational | no | no |
ASAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RBP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CHIN_HUMAN | [view interactions] | Computational | no | no |
ROR1_HUMAN | [view interactions] | Computational | no | no |
RHG01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FZD2_HUMAN | [view interactions] | Computational | no | no |
ERD21_HUMAN | [view interactions] | Computational | no | yes |