GGA3_HUMAN
Evidence for PS localization
Functions
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed, PubMed, PubMed). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000504 | TRG_LysEnd_GGAAcLL_2 | TRG | 388 | 395 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GGA3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 29.1667 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.0833 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0051020 | GTPase binding | 14.5833 | 4 | yes |
| GO:0043130 | ubiquitin binding | 12.5000 | 4 | yes |
| GO:0031267 | small GTPase binding | 10.4167 | 5 | yes |
| GO:0035091 | phosphatidylinositol binding | 10.4167 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GGA3_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 66.6667 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 56.2500 | 4 | yes |
| GO:0071702 | organic substance transport | 54.1667 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 54.1667 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.1667 | 4 | no |
| GO:0015031 | protein transport | 52.0833 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 47.9167 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.8333 | 4 | yes |
| GO:0051049 | regulation of transport | 45.8333 | 4 | no |
| GO:0010646 | regulation of cell communication | 45.8333 | 4 | no |
| GO:0006886 | intracellular protein transport | 43.7500 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 43.7500 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.7500 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.6667 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 39.5833 | 4 | no |
| GO:0006996 | organelle organization | 37.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.4167 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.2500 | 5 | yes |
| GO:0022607 | cellular component assembly | 31.2500 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.2500 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.1667 | 5 | yes |
| GO:0010468 | regulation of gene expression | 29.1667 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.1667 | 4 | no |
| GO:0051050 | positive regulation of transport | 29.1667 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.0833 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 27.0833 | 4 | no |
| GO:0060341 | regulation of cellular localization | 27.0833 | 4 | no |
| GO:0006897 | endocytosis | 25.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | no |
| GO:0009894 | regulation of catabolic process | 22.9167 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.9167 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.9167 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.9167 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 20.8333 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 20.8333 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 20.8333 | 4 | no |
| GO:0051046 | regulation of secretion | 20.8333 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.8333 | 5 | no |
| GO:0007010 | cytoskeleton organization | 20.8333 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 20.8333 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.8333 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.8333 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 20.8333 | 4 | no |
| GO:0007034 | vacuolar transport | 18.7500 | 4 | yes |
| GO:0007041 | lysosomal transport | 18.7500 | 5 | yes |
| GO:0033365 | protein localization to organelle | 18.7500 | 5 | yes |
| GO:0042176 | regulation of protein catabolic process | 18.7500 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 16.6667 | 5 | yes |
| GO:0016197 | endosomal transport | 16.6667 | 4 | yes |
| GO:0072657 | protein localization to membrane | 16.6667 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 14.5833 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 14.5833 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 12.5000 | 5 | yes |
| GO:0034394 | protein localization to cell surface | 12.5000 | 5 | yes |
| GO:0048193 | Golgi vesicle transport | 12.5000 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 12.5000 | 5 | yes |
| GO:0009896 | positive regulation of catabolic process | 10.4167 | 5 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 10.4167 | 6 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 10.4167 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 10.4167 | 4 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 10.4167 | 4 | yes |
| GO:0006605 | protein targeting | 8.3333 | 5 | yes |
| GO:0006622 | protein targeting to lysosome | 8.3333 | 6 | yes |
| GO:0006623 | protein targeting to vacuole | 8.3333 | 5 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 8.3333 | 6 | yes |
| GO:0032456 | endocytic recycling | 8.3333 | 5 | yes |
| GO:0061462 | protein localization to lysosome | 8.3333 | 7 | yes |
| GO:0072665 | protein localization to vacuole | 8.3333 | 6 | yes |
| GO:0072666 | establishment of protein localization to vacuole | 8.3333 | 5 | yes |
| GO:0006893 | Golgi to plasma membrane transport | 6.2500 | 5 | yes |
| GO:0061951 | establishment of protein localization to plasma membrane | 6.2500 | 5 | yes |
| GO:0090150 | establishment of protein localization to membrane | 6.2500 | 4 | yes |
| GO:0031648 | protein destabilization | 4.1667 | 4 | yes |
| GO:0034248 | regulation of cellular amide metabolic process | 4.1667 | 5 | yes |
| GO:0034249 | negative regulation of cellular amide metabolic process | 4.1667 | 6 | yes |
| GO:0043001 | Golgi to plasma membrane protein transport | 4.1667 | 5 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 4.1667 | 6 | yes |
| GO:1902430 | negative regulation of amyloid-beta formation | 4.1667 | 7 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 4.1667 | 6 | yes |
| GO:1902992 | negative regulation of amyloid precursor protein catabolic process | 4.1667 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GGA3_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 4.1667 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TS101_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MPRI_HUMAN | [view interactions] | Low throughput | no | yes |
| MPRD_HUMAN | [view interactions] | Low throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | Low throughput | no | yes |
| PACS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MON2_HUMAN | [view interactions] | Low throughput | no | no |
| BACE1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA2_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARAP3_HUMAN | [view interactions] | Low throughput | no | no |
| LAPM5_HUMAN | [view interactions] | Low throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS18_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MET_HUMAN | [view interactions] | Low throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNX17_HUMAN | [view interactions] | Low throughput | no | yes |
| ADA2B_HUMAN | [view interactions] | Low throughput | no | no |
| NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
| PD2R_HUMAN | [view interactions] | Low throughput | no | no |
| PTGDS_HUMAN | [view interactions] | Low throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADA2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRP10_HUMAN | [view interactions] | Low throughput | no | no |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYNRG_HUMAN | [view interactions] | Low throughput | no | yes |
| EPN4_HUMAN | [view interactions] | Low throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA3_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| TPC6A_HUMAN | [view interactions] | High throughput | no | yes |
| UPP_HUMAN | [view interactions] | High throughput | no | no |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| PKHB2_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA3_HUMAN | [view interactions] | High throughput | no | no |
| RN214_HUMAN | [view interactions] | High throughput | no | yes |
| ZN497_HUMAN | [view interactions] | High throughput | no | no |
| DAZP2_HUMAN | [view interactions] | High throughput | no | no |
| LITAF_HUMAN | [view interactions] | High throughput | no | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HAUS4_HUMAN | [view interactions] | High throughput | no | yes |
| CARME_HUMAN | [view interactions] | High throughput | no | yes |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
| TBC17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ3_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ARFG1_HUMAN | [view interactions] | Computational | no | no |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| COPA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EREG_HUMAN | [view interactions] | Computational | no | no |