GGA3_HUMAN
Evidence for PS localization
Functions
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed, PubMed, PubMed). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000504 | TRG_LysEnd_GGAAcLL_2 | TRG | 388 | 395 | - |
| ELMI000504 | TRG_LysEnd_GGAAcLL_2 | TRG | 388 | 395 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GGA3_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.0426 | 4 | no |
| GO:0000166 | nucleotide binding | 29.7872 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.6596 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.6596 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.5319 | 4 | no |
| GO:0051020 | GTPase binding | 14.8936 | 4 | yes |
| GO:0043130 | ubiquitin binding | 12.7660 | 4 | yes |
| GO:0031267 | small GTPase binding | 10.6383 | 5 | yes |
| GO:0035091 | phosphatidylinositol binding | 10.6383 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GGA3_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 70.2128 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 53.1915 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 53.1915 | 4 | no |
| GO:0071702 | organic substance transport | 53.1915 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 53.1915 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.1915 | 4 | no |
| GO:0015031 | protein transport | 51.0638 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.8085 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.8085 | 4 | yes |
| GO:0006996 | organelle organization | 44.6809 | 4 | no |
| GO:0006886 | intracellular protein transport | 44.6809 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.6809 | 4 | no |
| GO:0051049 | regulation of transport | 42.5532 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.5532 | 4 | yes |
| GO:0022607 | cellular component assembly | 36.1702 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.0426 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.0426 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.0426 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 34.0426 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.9149 | 5 | no |
| GO:0060341 | regulation of cellular localization | 31.9149 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.9149 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.9149 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 31.9149 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 29.7872 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.7872 | 6 | no |
| GO:0032880 | regulation of protein localization | 29.7872 | 5 | no |
| GO:0098657 | import into cell | 29.7872 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 27.6596 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.6596 | 6 | no |
| GO:2000145 | regulation of cell motility | 27.6596 | 4 | no |
| GO:0051050 | positive regulation of transport | 27.6596 | 4 | no |
| GO:0030030 | cell projection organization | 27.6596 | 4 | no |
| GO:0030334 | regulation of cell migration | 27.6596 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 25.5319 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.5319 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.5319 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.5319 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.5319 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 25.5319 | 4 | yes |
| GO:0072657 | protein localization to membrane | 25.5319 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 25.5319 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.5319 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.5319 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 23.4043 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.4043 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.4043 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 23.4043 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.4043 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 21.2766 | 6 | no |
| GO:0036211 | protein modification process | 21.2766 | 4 | no |
| GO:0040017 | positive regulation of locomotion | 21.2766 | 4 | no |
| GO:0043412 | macromolecule modification | 21.2766 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.2766 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 21.2766 | 5 | no |
| GO:0051046 | regulation of secretion | 21.2766 | 5 | no |
| GO:0007010 | cytoskeleton organization | 21.2766 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.2766 | 5 | yes |
| GO:0033365 | protein localization to organelle | 21.2766 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 21.2766 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.2766 | 5 | no |
| GO:0007034 | vacuolar transport | 19.1489 | 4 | yes |
| GO:0007041 | lysosomal transport | 19.1489 | 5 | yes |
| GO:0042176 | regulation of protein catabolic process | 19.1489 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 17.0213 | 5 | yes |
| GO:0009057 | macromolecule catabolic process | 14.8936 | 4 | yes |
| GO:0072659 | protein localization to plasma membrane | 14.8936 | 5 | yes |
| GO:0034394 | protein localization to cell surface | 12.7660 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 12.7660 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 12.7660 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 10.6383 | 5 | yes |
| GO:0032456 | endocytic recycling | 10.6383 | 4 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 10.6383 | 6 | yes |
| GO:0072665 | protein localization to vacuole | 10.6383 | 6 | yes |
| GO:0072666 | establishment of protein localization to vacuole | 10.6383 | 5 | yes |
| GO:0006605 | protein targeting | 8.5106 | 4 | yes |
| GO:0006622 | protein targeting to lysosome | 8.5106 | 6 | yes |
| GO:0006623 | protein targeting to vacuole | 8.5106 | 5 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 8.5106 | 4 | yes |
| GO:0061462 | protein localization to lysosome | 8.5106 | 7 | yes |
| GO:0006893 | Golgi to plasma membrane transport | 6.3830 | 4 | yes |
| GO:0061951 | establishment of protein localization to plasma membrane | 6.3830 | 5 | yes |
| GO:0090150 | establishment of protein localization to membrane | 6.3830 | 4 | yes |
| GO:0030163 | protein catabolic process | 4.2553 | 4 | yes |
| GO:0031648 | protein destabilization | 4.2553 | 4 | yes |
| GO:0034248 | regulation of amide metabolic process | 4.2553 | 4 | yes |
| GO:0034249 | negative regulation of amide metabolic process | 4.2553 | 5 | yes |
| GO:0043001 | Golgi to plasma membrane protein transport | 4.2553 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 4.2553 | 4 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 4.2553 | 5 | yes |
| GO:1902430 | negative regulation of amyloid-beta formation | 4.2553 | 6 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 4.2553 | 6 | yes |
| GO:1902992 | negative regulation of amyloid precursor protein catabolic process | 4.2553 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MPRI_HUMAN | [view interactions] | Low throughput | no | yes |
| MPRD_HUMAN | [view interactions] | Low throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TS101_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | Low throughput | no | yes |
| PACS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MON2_HUMAN | [view interactions] | Low throughput | no | no |
| BACE1_HUMAN | [view interactions] | Low throughput | no | yes |
| PD2R_HUMAN | [view interactions] | Low throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA2_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTGDS_HUMAN | [view interactions] | Low throughput | no | yes |
| EPN4_HUMAN | [view interactions] | Low throughput | no | yes |
| SYNRG_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARAP3_HUMAN | [view interactions] | Low throughput | no | no |
| LAPM5_HUMAN | [view interactions] | Low throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS18_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MET_HUMAN | [view interactions] | Low throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNX17_HUMAN | [view interactions] | Low throughput | no | yes |
| ADA2B_HUMAN | [view interactions] | Low throughput | no | no |
| NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADA2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRP10_HUMAN | [view interactions] | Low throughput | no | no |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS11_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| ETS1_HUMAN | [view interactions] | High throughput | no | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA3_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPC6A_HUMAN | [view interactions] | High throughput | no | yes |
| UPP_HUMAN | [view interactions] | High throughput | no | no |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| PKHB2_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA3_HUMAN | [view interactions] | High throughput | no | no |
| RN214_HUMAN | [view interactions] | High throughput | no | yes |
| ZN497_HUMAN | [view interactions] | High throughput | no | no |
| DAZP2_HUMAN | [view interactions] | High throughput | no | no |
| LITAF_HUMAN | [view interactions] | High throughput | no | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GTPB4_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAUS4_HUMAN | [view interactions] | High throughput | no | yes |
| CARME_HUMAN | [view interactions] | High throughput | no | yes |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
| TBC17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ3_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| CMTR2_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |