Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADA2A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ADA2A_HUMAN
GO:0001664 G protein-coupled receptor binding 46.6667 4 yes
GO:0031690 adrenergic receptor binding 26.6667 5 yes
GO:0004930 G protein-coupled receptor activity 20.0000 4 yes
GO:0004935 adrenergic receptor activity 20.0000 6 yes
GO:0004936 alpha-adrenergic receptor activity 20.0000 7 yes
GO:0004938 alpha2-adrenergic receptor activity 20.0000 8 yes
GO:0008227 G protein-coupled amine receptor activity 20.0000 5 yes
GO:0019900 kinase binding 20.0000 4 yes
GO:0042803 protein homodimerization activity 20.0000 4 yes
GO:0046982 protein heterodimerization activity 20.0000 4 yes
GO:0051379 epinephrine binding 20.0000 4 yes
GO:0019901 protein kinase binding 13.3333 5 yes
GO:0031692 alpha-1B adrenergic receptor binding 13.3333 6 yes
GO:0031696 alpha-2C adrenergic receptor binding 13.3333 6 yes
GO:0031996 thioesterase binding 13.3333 4 yes
GO:0051380 norepinephrine binding 13.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADA2A_HUMAN
GO:0051171 regulation of nitrogen compound metabolic process 66.6667 4 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 yes
GO:0009892 negative regulation of metabolic process 53.3333 4 yes
GO:0031323 regulation of cellular metabolic process 53.3333 4 yes
GO:0031399 regulation of protein modification process 53.3333 6 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 46.6667 4 yes
GO:0019220 regulation of phosphate metabolic process 46.6667 6 yes
GO:0051174 regulation of phosphorus metabolic process 46.6667 5 yes
GO:0001932 regulation of protein phosphorylation 40.0000 7 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 40.0000 5 yes
GO:0009966 regulation of signal transduction 40.0000 4 yes
GO:0010646 regulation of cell communication 40.0000 4 yes
GO:0042325 regulation of phosphorylation 40.0000 7 yes
GO:0048522 positive regulation of cellular process 40.0000 4 yes
GO:0051049 regulation of transport 40.0000 4 yes
GO:0071310 cellular response to organic substance 40.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 40.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 40.0000 5 no
GO:0051248 negative regulation of protein metabolic process 40.0000 6 no
GO:0003018 vascular process in circulatory system 33.3333 4 yes
GO:0009893 positive regulation of metabolic process 33.3333 4 yes
GO:0009894 regulation of catabolic process 33.3333 4 yes
GO:0043269 regulation of ion transport 33.3333 5 yes
GO:0043408 regulation of MAPK cascade 33.3333 6 yes
GO:0044057 regulation of system process 33.3333 4 yes
GO:0051051 negative regulation of transport 33.3333 4 yes
GO:1902531 regulation of intracellular signal transduction 33.3333 5 yes
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0007600 sensory perception 26.6667 4 yes
GO:0009967 positive regulation of signal transduction 26.6667 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 26.6667 5 yes
GO:0010647 positive regulation of cell communication 26.6667 5 yes
GO:0010648 negative regulation of cell communication 26.6667 5 yes
GO:0010959 regulation of metal ion transport 26.6667 6 yes
GO:0019229 regulation of vasoconstriction 26.6667 6 yes
GO:0023056 positive regulation of signaling 26.6667 4 yes
GO:0023057 negative regulation of signaling 26.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 26.6667 5 yes
GO:0032870 cellular response to hormone stimulus 26.6667 4 yes
GO:0035150 regulation of tube size 26.6667 4 yes
GO:0035296 regulation of tube diameter 26.6667 5 yes
GO:0042127 regulation of cell population proliferation 26.6667 4 yes
GO:0042176 regulation of protein catabolic process 26.6667 5 yes
GO:0043085 positive regulation of catalytic activity 26.6667 4 yes
GO:0043410 positive regulation of MAPK cascade 26.6667 7 yes
GO:0043549 regulation of kinase activity 26.6667 5 yes
GO:0045859 regulation of protein kinase activity 26.6667 6 yes
GO:0048584 positive regulation of response to stimulus 26.6667 4 yes
GO:0048585 negative regulation of response to stimulus 26.6667 4 yes
GO:0050804 modulation of chemical synaptic transmission 26.6667 5 yes
GO:0051046 regulation of secretion 26.6667 5 yes
GO:0051048 negative regulation of secretion 26.6667 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 26.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 26.6667 6 yes
GO:0051338 regulation of transferase activity 26.6667 4 yes
GO:0060627 regulation of vesicle-mediated transport 26.6667 4 yes
GO:0097746 blood vessel diameter maintenance 26.6667 5 yes
GO:0099177 regulation of trans-synaptic signaling 26.6667 4 yes
GO:1902533 positive regulation of intracellular signal transduction 26.6667 6 yes
GO:1903522 regulation of blood circulation 26.6667 5 yes
GO:1903530 regulation of secretion by cell 26.6667 4 yes
GO:1903531 negative regulation of secretion by cell 26.6667 5 yes
GO:0022411 cellular component disassembly 26.6667 4 no
GO:0032984 protein-containing complex disassembly 26.6667 5 no
GO:0043933 protein-containing complex organization 26.6667 4 no
GO:0051261 protein depolymerization 26.6667 6 no
GO:0010563 negative regulation of phosphorus metabolic process 26.6667 6 no
GO:0045936 negative regulation of phosphate metabolic process 26.6667 7 no
GO:0001934 positive regulation of protein phosphorylation 20.0000 8 yes
GO:0006937 regulation of muscle contraction 20.0000 6 yes
GO:0006940 regulation of smooth muscle contraction 20.0000 7 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 20.0000 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 20.0000 4 yes
GO:0007264 small GTPase mediated signal transduction 20.0000 4 yes
GO:0007265 Ras protein signal transduction 20.0000 5 yes
GO:0008284 positive regulation of cell population proliferation 20.0000 5 yes
GO:0009896 positive regulation of catabolic process 20.0000 5 yes
GO:0010468 regulation of gene expression 20.0000 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 20.0000 6 yes
GO:0010700 negative regulation of norepinephrine secretion 20.0000 6 yes
GO:0014060 regulation of epinephrine secretion 20.0000 6 yes
GO:0014061 regulation of norepinephrine secretion 20.0000 6 yes
GO:0017157 regulation of exocytosis 20.0000 5 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 20.0000 7 yes
GO:0030334 regulation of cell migration 20.0000 5 yes
GO:0030335 positive regulation of cell migration 20.0000 6 yes
GO:0031329 regulation of cellular catabolic process 20.0000 5 yes
GO:0031401 positive regulation of protein modification process 20.0000 7 yes
GO:0032147 activation of protein kinase activity 20.0000 8 yes
GO:0032148 activation of protein kinase B activity 20.0000 9 yes
GO:0032811 negative regulation of epinephrine secretion 20.0000 7 yes
GO:0032880 regulation of protein localization 20.0000 5 yes
GO:0033604 negative regulation of catecholamine secretion 20.0000 6 yes
GO:0033674 positive regulation of kinase activity 20.0000 6 yes
GO:0034762 regulation of transmembrane transport 20.0000 4 yes
GO:0034765 regulation of ion transmembrane transport 20.0000 5 yes
GO:0035624 receptor transactivation 20.0000 5 yes
GO:0040017 positive regulation of locomotion 20.0000 4 yes
GO:0042327 positive regulation of phosphorylation 20.0000 8 yes
GO:0043271 negative regulation of ion transport 20.0000 5 yes
GO:0043405 regulation of MAP kinase activity 20.0000 8 yes
GO:0045732 positive regulation of protein catabolic process 20.0000 6 yes
GO:0045860 positive regulation of protein kinase activity 20.0000 7 yes
GO:0045920 negative regulation of exocytosis 20.0000 6 yes
GO:0045937 positive regulation of phosphate metabolic process 20.0000 7 yes
GO:0045955 negative regulation of calcium ion-dependent exocytosis 20.0000 8 yes
GO:0050433 regulation of catecholamine secretion 20.0000 5 yes
GO:0051050 positive regulation of transport 20.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 20.0000 4 yes
GO:0051241 negative regulation of multicellular organismal process 20.0000 4 yes
GO:0051347 positive regulation of transferase activity 20.0000 5 yes
GO:0051924 regulation of calcium ion transport 20.0000 7 yes
GO:0051952 regulation of amine transport 20.0000 5 yes
GO:0051953 negative regulation of amine transport 20.0000 5 yes
GO:0060341 regulation of cellular localization 20.0000 4 yes
GO:0071875 adrenergic receptor signaling pathway 20.0000 4 yes
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 20.0000 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 20.0000 7 yes
GO:0090257 regulation of muscle system process 20.0000 5 yes
GO:0090304 nucleic acid metabolic process 20.0000 4 yes
GO:1903305 regulation of regulated secretory pathway 20.0000 6 yes
GO:1903306 negative regulation of regulated secretory pathway 20.0000 7 yes
GO:1904062 regulation of cation transmembrane transport 20.0000 6 yes
GO:2000145 regulation of cell motility 20.0000 4 yes
GO:2000147 positive regulation of cell motility 20.0000 5 yes
GO:2000273 positive regulation of signaling receptor activity 20.0000 4 yes
GO:0001817 regulation of cytokine production 13.3333 4 yes
GO:0001819 positive regulation of cytokine production 13.3333 5 yes
GO:0002526 acute inflammatory response 13.3333 5 yes
GO:0002791 regulation of peptide secretion 13.3333 6 yes
GO:0002792 negative regulation of peptide secretion 13.3333 6 yes
GO:0006259 DNA metabolic process 13.3333 4 yes
GO:0006260 DNA replication 13.3333 5 yes
GO:0006954 inflammatory response 13.3333 4 yes
GO:0006996 organelle organization 13.3333 4 yes
GO:0007010 cytoskeleton organization 13.3333 5 yes
GO:0007176 regulation of epidermal growth factor-activated receptor activity 13.3333 4 yes
GO:0007266 Rho protein signal transduction 13.3333 6 yes
GO:0009895 negative regulation of catabolic process 13.3333 5 yes
GO:0010628 positive regulation of gene expression 13.3333 6 yes
GO:0019216 regulation of lipid metabolic process 13.3333 5 yes
GO:0022898 regulation of transmembrane transporter activity 13.3333 4 yes
GO:0030162 regulation of proteolysis 13.3333 6 yes
GO:0031331 positive regulation of cellular catabolic process 13.3333 6 yes
GO:0032410 negative regulation of transporter activity 13.3333 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 13.3333 5 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 13.3333 5 yes
GO:0033500 carbohydrate homeostasis 13.3333 5 yes
GO:0034763 negative regulation of transmembrane transport 13.3333 5 yes
GO:0034766 negative regulation of ion transmembrane transport 13.3333 6 yes
GO:0042058 regulation of epidermal growth factor receptor signaling pathway 13.3333 6 yes
GO:0042311 vasodilation 13.3333 6 yes
GO:0042593 glucose homeostasis 13.3333 6 yes
GO:0043266 regulation of potassium ion transport 13.3333 7 yes
GO:0043268 positive regulation of potassium ion transport 13.3333 6 yes
GO:0043270 positive regulation of ion transport 13.3333 5 yes
GO:0043406 positive regulation of MAP kinase activity 13.3333 8 yes
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 13.3333 5 yes
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 13.3333 7 yes
GO:0045833 negative regulation of lipid metabolic process 13.3333 5 yes
GO:0045862 positive regulation of proteolysis 13.3333 7 yes
GO:0045932 negative regulation of muscle contraction 13.3333 5 yes
GO:0045986 negative regulation of smooth muscle contraction 13.3333 6 yes
GO:0046676 negative regulation of insulin secretion 13.3333 7 yes
GO:0046883 regulation of hormone secretion 13.3333 4 yes
GO:0046888 negative regulation of hormone secretion 13.3333 5 yes
GO:0046928 regulation of neurotransmitter secretion 13.3333 4 yes
GO:0048878 chemical homeostasis 13.3333 4 yes
GO:0050708 regulation of protein secretion 13.3333 5 yes
GO:0050709 negative regulation of protein secretion 13.3333 6 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 13.3333 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 13.3333 9 yes
GO:0050796 regulation of insulin secretion 13.3333 6 yes
GO:0050892 intestinal absorption 13.3333 4 yes
GO:0050951 sensory perception of temperature stimulus 13.3333 5 yes
GO:0050955 thermoception 13.3333 6 yes
GO:0050994 regulation of lipid catabolic process 13.3333 5 yes
GO:0050995 negative regulation of lipid catabolic process 13.3333 6 yes
GO:0051043 regulation of membrane protein ectodomain proteolysis 13.3333 6 yes
GO:0051044 positive regulation of membrane protein ectodomain proteolysis 13.3333 7 yes
GO:0051223 regulation of protein transport 13.3333 5 yes
GO:0051224 negative regulation of protein transport 13.3333 5 yes
GO:0051588 regulation of neurotransmitter transport 13.3333 5 yes
GO:0051926 negative regulation of calcium ion transport 13.3333 6 yes
GO:0061041 regulation of wound healing 13.3333 6 yes
GO:0061097 regulation of protein tyrosine kinase activity 13.3333 7 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 13.3333 8 yes
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 13.3333 7 yes
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus 13.3333 5 yes
GO:0070201 regulation of establishment of protein localization 13.3333 6 yes
GO:0070472 regulation of uterine smooth muscle contraction 13.3333 8 yes
GO:0070473 negative regulation of uterine smooth muscle contraction 13.3333 7 yes
GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway 13.3333 5 yes
GO:0071882 phospholipase C-activating adrenergic receptor signaling pathway 13.3333 5 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 13.3333 8 yes
GO:0080134 regulation of response to stress 13.3333 4 yes
GO:0090087 regulation of peptide transport 13.3333 5 yes
GO:0090276 regulation of peptide hormone secretion 13.3333 5 yes
GO:0090278 negative regulation of peptide hormone secretion 13.3333 6 yes
GO:0090303 positive regulation of wound healing 13.3333 6 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 13.3333 6 yes
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 13.3333 6 yes
GO:1901184 regulation of ERBB signaling pathway 13.3333 5 yes
GO:1901186 positive regulation of ERBB signaling pathway 13.3333 6 yes
GO:1903034 regulation of response to wounding 13.3333 5 yes
GO:1903036 positive regulation of response to wounding 13.3333 5 yes
GO:1903169 regulation of calcium ion transmembrane transport 13.3333 7 yes
GO:1903170 negative regulation of calcium ion transmembrane transport 13.3333 7 yes
GO:1903828 negative regulation of protein localization 13.3333 5 yes
GO:1904063 negative regulation of cation transmembrane transport 13.3333 7 yes
GO:1904950 negative regulation of establishment of protein localization 13.3333 6 yes
GO:2000300 regulation of synaptic vesicle exocytosis 13.3333 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EI2BA_HUMAN [view interactions] Low throughput no yes
ADA2C_HUMAN [view entry] [view interactions] Low throughput yes no
ADA2A_HUMAN [view entry] [view interactions] Low throughput yes no
UCHL1_HUMAN [view entry] [view interactions] Low throughput yes yes
NEB2_HUMAN [view entry] [view interactions] Low throughput yes yes
GGA3_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
HACD3_HUMAN [view interactions] High throughput no yes
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
PSPC_HUMAN [view interactions] Computational no no
ADCY5_HUMAN [view interactions] Computational no no
PSPB_HUMAN [view interactions] Computational no no