Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADA2C_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ADA2C_HUMAN
GO:0001664 G protein-coupled receptor binding 83.3333 4 yes
GO:0031690 adrenergic receptor binding 66.6667 5 yes
GO:0043169 cation binding 66.6667 4 yes
GO:0004930 G protein-coupled receptor activity 50.0000 4 yes
GO:0004935 adrenergic receptor activity 50.0000 6 yes
GO:0004936 alpha-adrenergic receptor activity 50.0000 7 yes
GO:0004938 alpha2-adrenergic receptor activity 50.0000 8 yes
GO:0008227 G protein-coupled amine receptor activity 50.0000 5 yes
GO:0031694 alpha-2A adrenergic receptor binding 50.0000 6 yes
GO:0042803 protein homodimerization activity 50.0000 4 yes
GO:0046982 protein heterodimerization activity 50.0000 4 yes
GO:0043130 ubiquitin binding 33.3333 4 no
GO:0044389 ubiquitin-like protein ligase binding 33.3333 4 no
GO:0019900 kinase binding 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ADA2C_HUMAN
GO:0001932 regulation of protein phosphorylation 100.0000 7 yes
GO:0009966 regulation of signal transduction 100.0000 4 yes
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:0019220 regulation of phosphate metabolic process 100.0000 6 yes
GO:0031323 regulation of cellular metabolic process 100.0000 4 yes
GO:0031399 regulation of protein modification process 100.0000 6 yes
GO:0042325 regulation of phosphorylation 100.0000 7 yes
GO:0048523 negative regulation of cellular process 100.0000 4 yes
GO:0051174 regulation of phosphorus metabolic process 100.0000 5 yes
GO:0051246 regulation of protein metabolic process 100.0000 5 yes
GO:0060255 regulation of macromolecule metabolic process 100.0000 4 yes
GO:0080090 regulation of primary metabolic process 100.0000 4 yes
GO:0043549 regulation of kinase activity 83.3333 5 yes
GO:0045859 regulation of protein kinase activity 83.3333 6 yes
GO:0048522 positive regulation of cellular process 83.3333 4 yes
GO:0051338 regulation of transferase activity 83.3333 4 yes
GO:0009893 positive regulation of metabolic process 66.6667 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 66.6667 5 yes
GO:0031325 positive regulation of cellular metabolic process 66.6667 5 yes
GO:0043408 regulation of MAPK cascade 66.6667 6 yes
GO:0051046 regulation of secretion 66.6667 5 yes
GO:0051049 regulation of transport 66.6667 4 yes
GO:1902531 regulation of intracellular signal transduction 66.6667 5 yes
GO:1903530 regulation of secretion by cell 66.6667 4 yes
GO:0001934 positive regulation of protein phosphorylation 50.0000 8 yes
GO:0003018 vascular process in circulatory system 50.0000 4 yes
GO:0006937 regulation of muscle contraction 50.0000 6 yes
GO:0006940 regulation of smooth muscle contraction 50.0000 7 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 50.0000 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 50.0000 5 yes
GO:0009967 positive regulation of signal transduction 50.0000 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 yes
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0010700 negative regulation of norepinephrine secretion 50.0000 7 yes
GO:0014060 regulation of epinephrine secretion 50.0000 6 yes
GO:0014061 regulation of norepinephrine secretion 50.0000 6 yes
GO:0019229 regulation of vasoconstriction 50.0000 6 yes
GO:0023056 positive regulation of signaling 50.0000 4 yes
GO:0031401 positive regulation of protein modification process 50.0000 7 yes
GO:0032147 activation of protein kinase activity 50.0000 8 yes
GO:0032148 activation of protein kinase B activity 50.0000 9 yes
GO:0032811 negative regulation of epinephrine secretion 50.0000 7 yes
GO:0033604 negative regulation of catecholamine secretion 50.0000 6 yes
GO:0033674 positive regulation of kinase activity 50.0000 6 yes
GO:0035150 regulation of tube size 50.0000 4 yes
GO:0035296 regulation of tube diameter 50.0000 5 yes
GO:0035624 receptor transactivation 50.0000 5 yes
GO:0042327 positive regulation of phosphorylation 50.0000 8 yes
GO:0043085 positive regulation of catalytic activity 50.0000 4 yes
GO:0043410 positive regulation of MAPK cascade 50.0000 7 yes
GO:0044057 regulation of system process 50.0000 4 yes
GO:0045860 positive regulation of protein kinase activity 50.0000 7 yes
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 yes
GO:0050433 regulation of catecholamine secretion 50.0000 5 yes
GO:0051048 negative regulation of secretion 50.0000 5 yes
GO:0051051 negative regulation of transport 50.0000 4 yes
GO:0051247 positive regulation of protein metabolic process 50.0000 6 yes
GO:0051347 positive regulation of transferase activity 50.0000 5 yes
GO:0051952 regulation of amine transport 50.0000 5 yes
GO:0051953 negative regulation of amine transport 50.0000 5 yes
GO:0071875 adrenergic receptor signaling pathway 50.0000 4 yes
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 50.0000 5 yes
GO:0090257 regulation of muscle system process 50.0000 5 yes
GO:0097746 blood vessel diameter maintenance 50.0000 5 yes
GO:1902533 positive regulation of intracellular signal transduction 50.0000 6 yes
GO:1903522 regulation of blood circulation 50.0000 5 yes
GO:1903531 negative regulation of secretion by cell 50.0000 5 yes
GO:2000273 positive regulation of signaling receptor activity 50.0000 4 yes
GO:0009894 regulation of catabolic process 50.0000 4 no
GO:0010648 negative regulation of cell communication 50.0000 5 no
GO:0023057 negative regulation of signaling 50.0000 4 no
GO:0043405 regulation of MAP kinase activity 50.0000 8 no
GO:0048585 negative regulation of response to stimulus 50.0000 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 50.0000 7 no
GO:0042127 regulation of cell population proliferation 50.0000 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 yes
GO:0045597 positive regulation of cell differentiation 33.3333 5 yes
GO:0045664 regulation of neuron differentiation 33.3333 5 yes
GO:0045666 positive regulation of neuron differentiation 33.3333 6 yes
GO:0051094 positive regulation of developmental process 33.3333 4 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0031329 regulation of cellular catabolic process 33.3333 5 no
GO:0071466 cellular response to xenobiotic stimulus 33.3333 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0033365 protein localization to organelle 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0090304 nucleic acid metabolic process 33.3333 4 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0010628 positive regulation of gene expression 33.3333 7 no
GO:0017157 regulation of exocytosis 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0042176 regulation of protein catabolic process 33.3333 5 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051241 negative regulation of multicellular organismal process 33.3333 4 no
GO:0060627 regulation of vesicle-mediated transport 33.3333 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ADA2A_HUMAN [view entry] [view interactions] Low throughput yes no
ADA2C_HUMAN [view entry] [view interactions] Low throughput yes no
EI2BA_HUMAN [view interactions] Low throughput no yes
NEB2_HUMAN [view entry] [view interactions] Low throughput yes yes
UCHL1_HUMAN [view entry] [view interactions] Low throughput yes yes
MDFI_HUMAN [view interactions] High throughput no no
CNPY2_HUMAN [view interactions] High throughput no yes
CHCH2_HUMAN [view interactions] High throughput no yes
KLH38_HUMAN [view interactions] High throughput no no
MKRN3_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
KRT34_HUMAN [view interactions] High throughput no no
P4HA3_HUMAN [view interactions] High throughput no no
CCD24_HUMAN [view interactions] High throughput no no
MEIS2_HUMAN [view interactions] High throughput no yes
MGT5B_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no