UCHL1_HUMAN
Evidence for PS localization
Functions
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (PubMed, PubMed, PubMed, PubMed). Also binds to free monoubiquitin and may prevent its degradation in lysosomes . The homodimer may have ATP-independent ubiquitin ligase activity (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 93 | Ile | Met | Parkinsondisease5(PARK5) | - |
| 7 | Glu | Ala | Spasticparaplegia79,autosomalrecessive(SPG79) | - |
| 178 | Arg | Gln | Spasticparaplegia79,autosomalrecessive(SPG79) | - |
| 216 | Ala | Asp | Spasticparaplegia79,autosomalrecessive(SPG79) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UCHL1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.4348 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 29.3478 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.3478 | 4 | no |
| GO:0046872 | metal ion binding | 28.2609 | 4 | no |
| GO:0003723 | RNA binding | 27.1739 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.8261 | 5 | no |
| GO:0005524 | ATP binding | 21.7391 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.7391 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 18.4783 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 17.3913 | 5 | yes |
| GO:0001664 | G protein-coupled receptor binding | 9.7826 | 4 | yes |
| GO:0008234 | cysteine-type peptidase activity | 5.4348 | 4 | yes |
| GO:0004175 | endopeptidase activity | 4.3478 | 4 | yes |
| GO:0004197 | cysteine-type endopeptidase activity | 4.3478 | 5 | yes |
| GO:0004843 | cysteine-type deubiquitinase activity | 4.3478 | 5 | yes |
| GO:0019783 | ubiquitin-like protein peptidase activity | 4.3478 | 4 | yes |
| GO:0031690 | adrenergic receptor binding | 4.3478 | 5 | yes |
| GO:0043130 | ubiquitin binding | 4.3478 | 4 | yes |
| GO:0101005 | deubiquitinase activity | 4.3478 | 5 | yes |
| GO:0031694 | alpha-2A adrenergic receptor binding | 3.2609 | 6 | yes |
| GO:0008242 | omega peptidase activity | 2.1739 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UCHL1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.5217 | 4 | no |
| GO:0010646 | regulation of cell communication | 51.0870 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.8261 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 46.7391 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 46.7391 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 43.4783 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 43.4783 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.4783 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 39.1304 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 38.0435 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.0435 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.9565 | 5 | no |
| GO:0006996 | organelle organization | 36.9565 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.7826 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 34.7826 | 4 | no |
| GO:0036211 | protein modification process | 33.6957 | 4 | yes |
| GO:0043412 | macromolecule modification | 33.6957 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 33.6957 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 33.6957 | 5 | no |
| GO:0010941 | regulation of cell death | 32.6087 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 31.5217 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 31.5217 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.4348 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 29.3478 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.3478 | 6 | no |
| GO:0080134 | regulation of response to stress | 29.3478 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 28.2609 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.2609 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.2609 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.2609 | 5 | no |
| GO:0071310 | cellular response to organic substance | 28.2609 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.1739 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.1739 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 27.1739 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 26.0870 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 26.0870 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0870 | 5 | yes |
| GO:0008104 | protein localization | 26.0870 | 4 | no |
| GO:0022607 | cellular component assembly | 26.0870 | 4 | no |
| GO:0051049 | regulation of transport | 26.0870 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 23.9130 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 23.9130 | 7 | yes |
| GO:0051252 | regulation of RNA metabolic process | 23.9130 | 5 | no |
| GO:0060548 | negative regulation of cell death | 23.9130 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.9130 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.8261 | 7 | yes |
| GO:0032880 | regulation of protein localization | 22.8261 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 22.8261 | 7 | no |
| GO:0051338 | regulation of transferase activity | 21.7391 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 21.7391 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.7391 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.7391 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.7391 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.7391 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 21.7391 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.7391 | 4 | no |
| GO:0071702 | organic substance transport | 21.7391 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.7391 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.7391 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 20.6522 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 20.6522 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 20.6522 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.6522 | 6 | no |
| GO:0051050 | positive regulation of transport | 20.6522 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.6522 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 20.6522 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 19.5652 | 5 | yes |
| GO:0043408 | regulation of MAPK cascade | 19.5652 | 6 | yes |
| GO:0043549 | regulation of kinase activity | 19.5652 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 19.5652 | 6 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 19.5652 | 5 | yes |
| GO:0006508 | proteolysis | 17.3913 | 4 | yes |
| GO:0045859 | regulation of protein kinase activity | 16.3043 | 6 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 15.2174 | 6 | yes |
| GO:0031400 | negative regulation of protein modification process | 15.2174 | 7 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 15.2174 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 15.2174 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 15.2174 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 14.1304 | 4 | yes |
| GO:0043086 | negative regulation of catalytic activity | 13.0435 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 11.9565 | 4 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 10.8696 | 7 | yes |
| GO:0010506 | regulation of autophagy | 10.8696 | 6 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 10.8696 | 6 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 10.8696 | 7 | yes |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 10.8696 | 7 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 10.8696 | 6 | yes |
| GO:0010970 | transport along microtubule | 9.7826 | 4 | yes |
| GO:0030163 | protein catabolic process | 9.7826 | 4 | yes |
| GO:0042326 | negative regulation of phosphorylation | 9.7826 | 8 | yes |
| GO:0051348 | negative regulation of transferase activity | 9.7826 | 5 | yes |
| GO:0099111 | microtubule-based transport | 9.7826 | 4 | yes |
| GO:0001933 | negative regulation of protein phosphorylation | 8.6957 | 8 | yes |
| GO:0033673 | negative regulation of kinase activity | 8.6957 | 6 | yes |
| GO:0008088 | axo-dendritic transport | 7.6087 | 5 | yes |
| GO:0006469 | negative regulation of protein kinase activity | 6.5217 | 7 | yes |
| GO:0008344 | adult locomotory behavior | 6.5217 | 4 | yes |
| GO:0010498 | proteasomal protein catabolic process | 6.5217 | 5 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 6.5217 | 6 | yes |
| GO:0050905 | neuromuscular process | 6.5217 | 4 | yes |
| GO:0070646 | protein modification by small protein removal | 6.5217 | 5 | yes |
| GO:0072384 | organelle transport along microtubule | 6.5217 | 4 | yes |
| GO:0016241 | regulation of macroautophagy | 5.4348 | 7 | yes |
| GO:0016579 | protein deubiquitination | 5.4348 | 6 | yes |
| GO:0034643 | establishment of mitochondrion localization, microtubule-mediated | 5.4348 | 4 | yes |
| GO:0043405 | regulation of MAP kinase activity | 5.4348 | 8 | yes |
| GO:0043409 | negative regulation of MAPK cascade | 5.4348 | 7 | yes |
| GO:0047497 | mitochondrion transport along microtubule | 5.4348 | 5 | yes |
| GO:0051654 | establishment of mitochondrion localization | 5.4348 | 4 | yes |
| GO:0098930 | axonal transport | 5.4348 | 6 | yes |
| GO:0007600 | sensory perception | 4.3478 | 4 | yes |
| GO:0019896 | axonal transport of mitochondrion | 4.3478 | 6 | yes |
| GO:0071466 | cellular response to xenobiotic stimulus | 4.3478 | 4 | yes |
| GO:0071901 | negative regulation of protein serine/threonine kinase activity | 4.3478 | 8 | yes |
| GO:0019233 | sensory perception of pain | 3.2609 | 5 | yes |
| GO:0043407 | negative regulation of MAP kinase activity | 3.2609 | 8 | yes |
| GO:0055001 | muscle cell development | 3.2609 | 4 | yes |
| GO:0007628 | adult walking behavior | 2.1739 | 5 | yes |
| GO:0042755 | eating behavior | 2.1739 | 4 | yes |
| GO:0090659 | walking behavior | 2.1739 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in UCHL1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 9.7826 | 3 | yes |
| DOID:936 | brain disease | 4.3478 | 4 | no |
| DOID:1289 | neurodegenerative disease | 4.3478 | 4 | no |
| DOID:0050890 | synucleinopathy | 2.1739 | 5 | no |
| DOID:0060894 | early-onset Parkinsons disease | 2.1739 | 7 | no |
| DOID:14330 | Parkinsons disease | 2.1739 | 6 | no |
| DOID:0112344 | hereditary spastic paraplegia 79 | 2.1739 | 6 | yes |
| DOID:2476 | hereditary spastic paraplegia | 2.1739 | 5 | yes |
| DOID:607 | paraplegia | 2.1739 | 4 | yes |
| DOID:0050686 | organ system cancer | 2.1739 | 3 | no |
| DOID:0050701 | electroclinical syndrome | 2.1739 | 6 | no |
| DOID:0112202 | developmental and epileptic encephalopathy | 2.1739 | 7 | no |
| DOID:1826 | epilepsy | 2.1739 | 5 | no |
| DOID:231 | motor neuron disease | 2.1739 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| CDK4_HUMAN | [view interactions] | Low throughput | no | no |
| CDK2_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TE2IP_HUMAN | [view interactions] | Low throughput | no | yes |
| AKT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
| CDN1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK1_HUMAN | [view interactions] | Low throughput | no | no |
| NCAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| CDK6_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADA2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMN_HUMAN | [view interactions] | Low throughput | no | yes |
| MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
| PTOV1_HUMAN | [view interactions] | Low throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | Low throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APR_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERN1_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TERF2_HUMAN | [view interactions] | Low throughput | no | yes |
| MITF_HUMAN | [view interactions] | Low throughput | no | no |
| PRDX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BCL6_HUMAN | [view interactions] | Low throughput | no | no |
| ILF3_HUMAN | [view interactions] | Low throughput | no | yes |
| CCNB1_HUMAN | [view interactions] | Low throughput | no | no |
| ANXA6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CPT1B_HUMAN | [view interactions] | Low throughput | no | no |
| PYGB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EFTU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSRP3_HUMAN | [view interactions] | Low throughput | no | no |
| SMAD2_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | Low throughput | no | yes |
| CD36_HUMAN | [view interactions] | Low throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ADA2B_HUMAN | [view interactions] | Low throughput | no | no |
| ADA2C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ADRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TNR1A_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF4_HUMAN | [view interactions] | Low throughput | no | yes |
| CSN5_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC9_HUMAN | [view interactions] | Low throughput | no | yes |
| RANB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| K2C4_HUMAN | [view interactions] | High throughput | no | no |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| AIM2_HUMAN | [view interactions] | High throughput | no | no |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| PPTC7_HUMAN | [view interactions] | High throughput | no | yes |
| PHOP1_HUMAN | [view interactions] | High throughput | no | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| ATG5_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZ1I_HUMAN | [view interactions] | High throughput | no | no |
| CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN112_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| RO52_HUMAN | [view interactions] | High throughput | no | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2K_HUMAN | [view interactions] | High throughput | no | yes |
| ATF3_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC5_HUMAN | [view interactions] | High throughput | no | no |
| UBAC1_HUMAN | [view interactions] | High throughput | no | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| LSM8_HUMAN | [view interactions] | High throughput | no | yes |
| ENKUR_HUMAN | [view interactions] | High throughput | no | no |
| REBL1_HUMAN | [view interactions] | High throughput | no | yes |
| LDH6B_HUMAN | [view interactions] | High throughput | no | no |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| EPHA6_HUMAN | [view interactions] | High throughput | no | no |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NGB_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FILA2_HUMAN | [view interactions] | High throughput | no | no |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCD_HUMAN | [view interactions] | High throughput | no | no |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA24B_HUMAN | [view interactions] | High throughput | no | no |
| RL17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIP2A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
| CCD66_HUMAN | [view interactions] | High throughput | no | yes |
| XP32_HUMAN | [view interactions] | High throughput | no | no |
| HORN_HUMAN | [view interactions] | High throughput | no | no |
| U17LO_HUMAN | [view interactions] | High throughput | no | no |
| RL18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR82_HUMAN | [view interactions] | High throughput | no | no |
| BAZ1A_HUMAN | [view interactions] | High throughput | no | no |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| PDE8B_HUMAN | [view interactions] | High throughput | no | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGM4_HUMAN | [view interactions] | High throughput | no | no |
| LAMA3_HUMAN | [view interactions] | High throughput | no | no |
| C163A_HUMAN | [view interactions] | High throughput | no | no |
| RXLT1_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| SYTL4_HUMAN | [view interactions] | High throughput | no | yes |
| SPAT7_HUMAN | [view interactions] | High throughput | no | no |
| IL16_HUMAN | [view interactions] | High throughput | no | no |
| KCNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYH12_HUMAN | [view interactions] | High throughput | no | no |
| FKB10_HUMAN | [view interactions] | High throughput | no | yes |
| SYT15_HUMAN | [view interactions] | High throughput | no | yes |
| SCN3A_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF44_HUMAN | [view interactions] | High throughput | no | yes |
| ZN792_HUMAN | [view interactions] | High throughput | no | yes |
| CI131_HUMAN | [view interactions] | High throughput | no | no |
| ANKR6_HUMAN | [view interactions] | High throughput | no | yes |
| SYNEM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB_HUMAN | [view interactions] | High throughput | no | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANR31_HUMAN | [view interactions] | High throughput | no | no |
| CYS1_HUMAN | [view interactions] | High throughput | no | no |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATX2L_HUMAN | [view interactions] | High throughput | no | no |
| STAT4_HUMAN | [view interactions] | High throughput | no | yes |
| DNMT1_HUMAN | [view interactions] | High throughput | no | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| AICDA_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP28_HUMAN | [view interactions] | High throughput | no | yes |
| PA2GA_HUMAN | [view interactions] | High throughput | no | no |
| ADRO_HUMAN | [view interactions] | High throughput | no | no |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| HDHD3_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIP2_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THEM4_HUMAN | [view interactions] | High throughput | no | no |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| DDAH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| GCSH_HUMAN | [view interactions] | High throughput | no | yes |
| GLOD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN3_HUMAN | [view interactions] | High throughput | no | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| CCD14_HUMAN | [view interactions] | High throughput | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UCHL3_HUMAN | [view interactions] | Computational | no | yes |