Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

VIGLN_HUMAN

Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in VIGLN_HUMAN
GO:0003723 RNA binding 37.0968 4 yes
GO:0017076 purine nucleotide binding 30.6452 4 no
GO:0032555 purine ribonucleotide binding 27.4194 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.4194 4 no
GO:0030554 adenyl nucleotide binding 25.8065 5 no
GO:0005524 ATP binding 22.5806 5 no
GO:0032559 adenyl ribonucleotide binding 22.5806 5 no
GO:0045296 cadherin binding 17.7419 4 yes
GO:0003729 mRNA binding 8.0645 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in VIGLN_HUMAN
GO:0031323 regulation of cellular metabolic process 56.4516 4 no
GO:0048523 negative regulation of cellular process 56.4516 4 no
GO:0048522 positive regulation of cellular process 53.2258 4 no
GO:0051171 regulation of nitrogen compound metabolic process 51.6129 4 no
GO:0060255 regulation of macromolecule metabolic process 51.6129 4 no
GO:0080090 regulation of primary metabolic process 51.6129 4 no
GO:0010646 regulation of cell communication 48.3871 4 no
GO:0009966 regulation of signal transduction 45.1613 4 no
GO:0051128 regulation of cellular component organization 43.5484 4 no
GO:0051246 regulation of protein metabolic process 41.9355 5 no
GO:0009893 positive regulation of metabolic process 41.9355 4 no
GO:0010468 regulation of gene expression 41.9355 5 no
GO:0009889 regulation of biosynthetic process 40.3226 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.3226 5 no
GO:0031326 regulation of cellular biosynthetic process 40.3226 5 no
GO:0009892 negative regulation of metabolic process 38.7097 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.7097 5 no
GO:0010605 negative regulation of macromolecule metabolic process 37.0968 5 no
GO:1902531 regulation of intracellular signal transduction 37.0968 5 no
GO:0010556 regulation of macromolecule biosynthetic process 37.0968 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.0968 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 35.4839 5 no
GO:0031325 positive regulation of cellular metabolic process 35.4839 5 no
GO:0051252 regulation of RNA metabolic process 35.4839 5 no
GO:0006996 organelle organization 33.8710 4 no
GO:0048584 positive regulation of response to stimulus 33.8710 4 no
GO:0071310 cellular response to organic substance 33.8710 4 no
GO:0008104 protein localization 32.2581 4 no
GO:0010941 regulation of cell death 30.6452 4 no
GO:0031324 negative regulation of cellular metabolic process 30.6452 5 no
GO:0048585 negative regulation of response to stimulus 30.6452 4 no
GO:0051248 negative regulation of protein metabolic process 30.6452 6 no
GO:0006355 regulation of DNA-templated transcription 30.6452 6 no
GO:0010647 positive regulation of cell communication 30.6452 5 no
GO:0023056 positive regulation of signaling 30.6452 4 no
GO:1903506 regulation of nucleic acid-templated transcription 30.6452 7 no
GO:2001141 regulation of RNA biosynthetic process 30.6452 6 no
GO:0071702 organic substance transport 29.0323 4 yes
GO:0031399 regulation of protein modification process 29.0323 6 no
GO:0042981 regulation of apoptotic process 29.0323 6 no
GO:0043067 regulation of programmed cell death 29.0323 5 no
GO:0044087 regulation of cellular component biogenesis 29.0323 4 no
GO:0080134 regulation of response to stress 29.0323 4 no
GO:0009967 positive regulation of signal transduction 29.0323 5 no
GO:0022607 cellular component assembly 29.0323 4 no
GO:0051247 positive regulation of protein metabolic process 29.0323 6 no
GO:0009894 regulation of catabolic process 27.4194 4 no
GO:0043412 macromolecule modification 27.4194 4 no
GO:0010628 positive regulation of gene expression 27.4194 6 no
GO:0071705 nitrogen compound transport 27.4194 4 no
GO:0016192 vesicle-mediated transport 27.4194 4 no
GO:0051049 regulation of transport 27.4194 4 no
GO:0010648 negative regulation of cell communication 25.8065 5 no
GO:0023057 negative regulation of signaling 25.8065 4 no
GO:0060548 negative regulation of cell death 25.8065 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.8065 6 no
GO:0051130 positive regulation of cellular component organization 25.8065 5 no
GO:0006796 phosphate-containing compound metabolic process 25.8065 4 no
GO:0009968 negative regulation of signal transduction 24.1935 5 no
GO:0031329 regulation of cellular catabolic process 24.1935 5 no
GO:0043066 negative regulation of apoptotic process 24.1935 7 no
GO:0043069 negative regulation of programmed cell death 24.1935 6 no
GO:0036211 protein modification process 24.1935 4 no
GO:0019220 regulation of phosphate metabolic process 24.1935 6 no
GO:0033043 regulation of organelle organization 24.1935 5 no
GO:0051174 regulation of phosphorus metabolic process 24.1935 5 no
GO:1902533 positive regulation of intracellular signal transduction 24.1935 6 no
GO:0051094 positive regulation of developmental process 24.1935 4 no
GO:0042325 regulation of phosphorylation 22.5806 7 no
GO:0009891 positive regulation of biosynthetic process 22.5806 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.5806 6 no
GO:0060341 regulation of cellular localization 22.5806 4 no
GO:0080135 regulation of cellular response to stress 20.9677 4 no
GO:0015031 protein transport 20.9677 4 no
GO:0051254 positive regulation of RNA metabolic process 20.9677 6 no
GO:0032880 regulation of protein localization 20.9677 5 no

Disease

Term Name % Distance from top the of the tree Annotated in VIGLN_HUMAN
DOID:1289 neurodegenerative disease 4.8387 4 no
DOID:331 central nervous system disease 4.8387 3 no
DOID:0050890 synucleinopathy 3.2258 5 no
DOID:0060892 late onset Parkinsons disease 3.2258 7 no
DOID:14330 Parkinsons disease 3.2258 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
XPOT_HUMAN [view interactions] Low throughput no no
CTCF_HUMAN [view interactions] Low throughput no yes
BRCA1_HUMAN [view interactions] Low throughput no yes
RAD51_HUMAN [view interactions] Low throughput no yes
XRCC5_HUMAN [view interactions] Low throughput no yes
PRKDC_HUMAN [view entry] [view interactions] Low throughput yes yes
DSRAD_HUMAN [view entry] [view interactions] Low throughput yes yes
DHX9_HUMAN [view interactions] Low throughput no yes
SUV91_HUMAN [view interactions] Low throughput no no
CBX5_HUMAN [view interactions] Low throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
NFIX_HUMAN [view interactions] High throughput no yes
NFX1_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DNJC8_HUMAN [view interactions] High throughput no yes
EIF3H_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
P53_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
HXC5_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
CHKB_HUMAN [view interactions] High throughput no yes
PABP5_HUMAN [view interactions] High throughput no yes
MMTA2_HUMAN [view interactions] High throughput no yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
HNRC2_HUMAN [view interactions] High throughput no no
TCPQM_HUMAN [view interactions] High throughput no no
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
RL26L_HUMAN [view interactions] High throughput no yes
GRK7_HUMAN [view interactions] High throughput no no
SIR5_HUMAN [view interactions] High throughput no yes
TNS2_HUMAN [view interactions] High throughput no no
TNR1B_HUMAN [view interactions] High throughput no no
OSGEP_HUMAN [view interactions] High throughput no yes
NTNG1_HUMAN [view interactions] High throughput no no
PSG11_HUMAN [view interactions] High throughput no no
PAIRB_HUMAN [view interactions] High throughput no yes
CDKAL_HUMAN [view interactions] High throughput no no
SYT6_HUMAN [view entry] [view interactions] High throughput yes no
RFXK_HUMAN [view interactions] High throughput no yes
NPAS1_HUMAN [view interactions] High throughput no no
GGH_HUMAN [view interactions] High throughput no yes
UBP32_HUMAN [view interactions] High throughput no yes
CIA2A_HUMAN [view interactions] High throughput no yes
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
WASC3_HUMAN [view interactions] High throughput no yes
EFMT3_HUMAN [view interactions] High throughput no no
GSTM3_HUMAN [view entry] [view interactions] High throughput yes yes
RM42_HUMAN [view interactions] High throughput no yes
WIF1_HUMAN [view entry] [view interactions] High throughput yes no
FBXW7_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
CLU_HUMAN [view interactions] High throughput no yes
ATG13_HUMAN [view interactions] High throughput no no
EMC9_HUMAN [view interactions] High throughput no no
G3BP2_HUMAN [view entry] [view interactions] High throughput yes yes
PDZD8_HUMAN [view interactions] High throughput no yes
PSPC1_HUMAN [view interactions] High throughput no yes
RACK1_HUMAN [view interactions] High throughput no yes
RL19_HUMAN [view entry] [view interactions] High throughput yes yes
RS11_HUMAN [view entry] [view interactions] High throughput yes yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view interactions] High throughput no yes
PSD12_HUMAN [view interactions] High throughput no yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
S10AB_HUMAN [view interactions] High throughput no no
VPS29_HUMAN [view entry] [view interactions] High throughput yes yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
VPS36_HUMAN [view interactions] High throughput no yes
UBA6_HUMAN [view interactions] High throughput no no
VPS25_HUMAN [view interactions] High throughput no yes
TTC4_HUMAN [view interactions] High throughput no yes
TYRO3_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
UPAR_HUMAN [view interactions] High throughput no yes
TOPB1_HUMAN [view interactions] High throughput no yes
TTK_HUMAN [view interactions] High throughput no yes
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
S10AA_HUMAN [view interactions] High throughput no no
ZW10_HUMAN [view interactions] High throughput no yes
UBE4B_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
EIF2A_HUMAN [view interactions] High throughput no yes
RS30_HUMAN [view interactions] High throughput no yes
KCMF1_HUMAN [view interactions] High throughput no yes
NEMO_HUMAN [view interactions] High throughput no yes
DDX43_HUMAN [view interactions] High throughput no no
GLMN_HUMAN [view interactions] High throughput no no
SPSY_HUMAN [view interactions] High throughput no no
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
DRG1_HUMAN [view interactions] High throughput no yes
F120A_HUMAN [view interactions] High throughput no yes
MP2K4_HUMAN [view interactions] High throughput no yes
C1TC_HUMAN [view entry] [view interactions] High throughput yes no
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG18_HUMAN [view interactions] High throughput no yes
RHG01_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
Z3H7A_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
RO60_HUMAN [view interactions] High throughput no yes
ANR28_HUMAN [view interactions] High throughput no no
SIR1_HUMAN [view interactions] High throughput no yes
TDRD3_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
ZCCHV_HUMAN [view interactions] High throughput no yes
MEX3B_HUMAN [view interactions] High throughput no no
ANR52_HUMAN [view interactions] High throughput no yes
ABCF3_HUMAN [view entry] [view interactions] High throughput yes yes
FBX42_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
NECD_HUMAN [view interactions] High throughput no no
RN183_HUMAN [view interactions] High throughput no no
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
ZYX_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
SLN11_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
SMAD4_HUMAN [view interactions] High throughput no yes
HMGB2_HUMAN [view interactions] High throughput no yes
HMGB1_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX1_HUMAN [view interactions] High throughput no yes
HIF1N_HUMAN [view interactions] High throughput no yes
KIF11_HUMAN [view interactions] High throughput no yes
BOREA_HUMAN [view interactions] High throughput no yes
B4GT1_HUMAN [view interactions] High throughput no yes
RFIP1_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view interactions] High throughput no yes
MLH1_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
T2EB_HUMAN [view interactions] High throughput no yes
SNR27_HUMAN [view interactions] High throughput no yes
C102B_HUMAN [view interactions] High throughput no yes
I20RA_HUMAN [view interactions] High throughput no no
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
PAI2_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TM171_HUMAN [view interactions] High throughput no yes
WDR59_HUMAN [view interactions] High throughput no yes
UBP47_HUMAN [view interactions] High throughput no yes
CP1A1_HUMAN [view interactions] High throughput no yes
PAK4_HUMAN [view interactions] High throughput no yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
STYX_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
MYH16_HUMAN [view interactions] High throughput no no
GLRB_HUMAN [view entry] [view interactions] High throughput yes no
IGSF3_HUMAN [view interactions] High throughput no yes
O51M1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
MGT4D_HUMAN [view interactions] High throughput no no
MEX3C_HUMAN [view interactions] High throughput no yes
CBL_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
AKTIP_HUMAN [view interactions] High throughput no yes
MAGA6_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
HDAC4_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
CSN5_HUMAN [view interactions] High throughput no yes
STK4_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
TET5A_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
PLCB1_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
LGR4_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
SPB5_HUMAN [view interactions] High throughput no no
PMGE_HUMAN [view interactions] High throughput no no
PTCRA_HUMAN [view interactions] High throughput no no
ZCHC7_HUMAN [view interactions] High throughput no yes
SPB3_HUMAN [view interactions] High throughput no no
ACL6A_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
HDHD2_HUMAN [view interactions] High throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
PRP8_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes