Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FLRT3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina . Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members . Promotes neurite outgrowth (in vitro) (PubMed). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
69 Gln Lys Hypogonadotropichypogonadism21withorwithoutanosmia(HH21) -
97 Glu Gly Hypogonadotropichypogonadism21withorwithoutanosmia(HH21) -
144 Ser Ile Hypogonadotropichypogonadism21withorwithoutanosmia(HH21) -
339 Lys Arg Hypogonadotropichypogonadism21withorwithoutanosmia(HH21) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FLRT3_HUMAN
GO:0043168 anion binding 35.7143 4 no
GO:0043169 cation binding 28.5714 4 no
GO:0046872 metal ion binding 28.5714 5 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0042803 protein homodimerization activity 21.4286 4 yes
GO:0048018 receptor ligand activity 21.4286 4 yes
GO:0003924 GTPase activity 21.4286 7 no
GO:0005525 GTP binding 21.4286 5 no
GO:0016462 pyrophosphatase activity 21.4286 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.4286 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.4286 6 no
GO:0019001 guanyl nucleotide binding 21.4286 6 no
GO:0032561 guanyl ribonucleotide binding 21.4286 5 no
GO:0005104 fibroblast growth factor receptor binding 14.2857 5 yes
GO:0045499 chemorepellent activity 14.2857 5 yes
GO:0070851 growth factor receptor binding 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FLRT3_HUMAN
GO:0048522 positive regulation of cellular process 78.5714 4 yes
GO:0022607 cellular component assembly 64.2857 4 yes
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0006996 organelle organization 50.0000 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009891 positive regulation of biosynthetic process 50.0000 5 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 50.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 50.0000 6 no
GO:0042127 regulation of cell population proliferation 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:0034330 cell junction organization 42.8571 4 yes
GO:0044087 regulation of cellular component biogenesis 42.8571 4 yes
GO:0007010 cytoskeleton organization 42.8571 5 no
GO:0009967 positive regulation of signal transduction 42.8571 5 no
GO:0010647 positive regulation of cell communication 42.8571 5 no
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0048584 positive regulation of response to stimulus 42.8571 4 no
GO:0071702 organic substance transport 42.8571 4 no
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:1902533 positive regulation of intracellular signal transduction 42.8571 6 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0034329 cell junction assembly 35.7143 5 yes
GO:0050808 synapse organization 35.7143 5 yes
GO:0051130 positive regulation of cellular component organization 35.7143 5 yes
GO:0051240 positive regulation of multicellular organismal process 35.7143 4 yes
GO:0006355 regulation of DNA-templated transcription 35.7143 7 no
GO:0008104 protein localization 35.7143 4 no
GO:0009892 negative regulation of metabolic process 35.7143 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.7143 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.7143 5 no
GO:0045595 regulation of cell differentiation 35.7143 4 no
GO:0051246 regulation of protein metabolic process 35.7143 5 no
GO:0051252 regulation of RNA metabolic process 35.7143 5 no
GO:0071705 nitrogen compound transport 35.7143 4 no
GO:2000145 regulation of cell motility 35.7143 4 no
GO:2001141 regulation of RNA biosynthetic process 35.7143 6 no
GO:0010628 positive regulation of gene expression 35.7143 7 no
GO:0007416 synapse assembly 28.5714 6 yes
GO:0030030 cell projection organization 28.5714 4 yes
GO:0050807 regulation of synapse organization 28.5714 5 yes
GO:0051094 positive regulation of developmental process 28.5714 4 yes
GO:0051963 regulation of synapse assembly 28.5714 6 yes
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 yes
GO:1901888 regulation of cell junction assembly 28.5714 5 yes
GO:2000026 regulation of multicellular organismal development 28.5714 4 yes
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0006915 apoptotic process 28.5714 4 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0015031 protein transport 28.5714 4 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0042981 regulation of apoptotic process 28.5714 5 no
GO:0043067 regulation of programmed cell death 28.5714 4 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0030334 regulation of cell migration 28.5714 5 no
GO:0051093 negative regulation of developmental process 28.5714 4 no
GO:0008284 positive regulation of cell population proliferation 28.5714 5 no
GO:0009890 negative regulation of biosynthetic process 28.5714 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.4286 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 21.4286 5 yes
GO:0007507 heart development 21.4286 4 yes
GO:0031175 neuron projection development 21.4286 6 yes
GO:0044089 positive regulation of cellular component biogenesis 21.4286 5 yes
GO:0051960 regulation of nervous system development 21.4286 5 yes
GO:0051962 positive regulation of nervous system development 21.4286 5 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 21.4286 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 21.4286 8 no
GO:0008285 negative regulation of cell population proliferation 21.4286 5 no
GO:0009968 negative regulation of signal transduction 21.4286 5 no
GO:0021782 glial cell development 21.4286 4 no
GO:0043066 negative regulation of apoptotic process 21.4286 6 no
GO:0043069 negative regulation of programmed cell death 21.4286 5 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0043410 positive regulation of MAPK cascade 21.4286 7 no
GO:0043933 protein-containing complex organization 21.4286 4 no
GO:0045893 positive regulation of DNA-templated transcription 21.4286 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 21.4286 6 no
GO:0051254 positive regulation of RNA metabolic process 21.4286 6 no
GO:0051336 regulation of hydrolase activity 21.4286 4 no
GO:0065003 protein-containing complex assembly 21.4286 5 no
GO:0141124 intracellular signaling cassette 21.4286 4 no
GO:1902680 positive regulation of RNA biosynthetic process 21.4286 7 no
GO:0006886 intracellular protein transport 21.4286 4 no
GO:0030335 positive regulation of cell migration 21.4286 6 no
GO:0030865 cortical cytoskeleton organization 21.4286 6 no
GO:0032970 regulation of actin filament-based process 21.4286 4 no
GO:0033043 regulation of organelle organization 21.4286 5 no
GO:0033365 protein localization to organelle 21.4286 5 no
GO:0040017 positive regulation of locomotion 21.4286 4 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0098657 import into cell 21.4286 4 no
GO:2000147 positive regulation of cell motility 21.4286 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0006873 intracellular monoatomic ion homeostasis 21.4286 4 no
GO:0030003 intracellular monoatomic cation homeostasis 21.4286 5 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0044057 regulation of system process 21.4286 4 no
GO:0055080 monoatomic cation homeostasis 21.4286 4 no
GO:0002009 morphogenesis of an epithelium 21.4286 4 no
GO:0002684 positive regulation of immune system process 21.4286 4 no
GO:0010564 regulation of cell cycle process 21.4286 5 no
GO:0032101 regulation of response to external stimulus 21.4286 4 no
GO:0032103 positive regulation of response to external stimulus 21.4286 5 no
GO:0045787 positive regulation of cell cycle 21.4286 5 no
GO:0051241 negative regulation of multicellular organismal process 21.4286 4 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:1901222 regulation of non-canonical NF-kappaB signal transduction 21.4286 6 no
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction 21.4286 7 no
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 no
GO:0045596 negative regulation of cell differentiation 21.4286 5 no
GO:0010629 negative regulation of gene expression 21.4286 7 no
GO:0003345 proepicardium cell migration involved in pericardium morphogenesis 14.2857 5 yes
GO:0007411 axon guidance 14.2857 8 yes
GO:0008543 fibroblast growth factor receptor signaling pathway 14.2857 6 yes
GO:0048678 response to axon injury 14.2857 4 yes
GO:0051965 positive regulation of synapse assembly 14.2857 6 yes
GO:0060973 cell migration involved in heart development 14.2857 4 yes
GO:0097485 neuron projection guidance 14.2857 7 yes
GO:0099560 synaptic membrane adhesion 14.2857 5 yes
GO:1901890 positive regulation of cell junction assembly 14.2857 6 yes
GO:1990138 neuron projection extension 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
AGRL3_HUMAN [view entry] [view interactions] Low throughput yes yes
FLRT3_HUMAN [view entry] [view interactions] Low throughput yes yes
UNC5B_HUMAN [view interactions] Low throughput no yes
AGRL1_HUMAN [view interactions] Low throughput no no
AGRL2_HUMAN [view entry] [view interactions] Low throughput yes no
FLRT1_HUMAN [view interactions] High throughput no no
MBLC2_HUMAN [view interactions] High throughput no yes
CALR_HUMAN [view entry] [view interactions] High throughput yes yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
EFNA1_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes