Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FLRT3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina . Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members . Promotes neurite outgrowth (in vitro) (PubMed). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
69 Gln Lys Hypogonadotropichypogonadism21withorwithoutanosmia(HH21) -
97 Glu Gly Hypogonadotropichypogonadism21withorwithoutanosmia(HH21) -
144 Ser Ile Hypogonadotropichypogonadism21withorwithoutanosmia(HH21) -
339 Lys Arg Hypogonadotropichypogonadism21withorwithoutanosmia(HH21) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FLRT3_HUMAN
GO:0042803 protein homodimerization activity 33.3333 4 yes
GO:0048018 receptor ligand activity 25.0000 4 yes
GO:0070851 growth factor receptor binding 25.0000 4 yes
GO:0003924 GTPase activity 25.0000 7 no
GO:0005525 GTP binding 25.0000 5 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0019001 guanyl nucleotide binding 25.0000 5 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032561 guanyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0004930 G protein-coupled receptor activity 25.0000 4 no
GO:0005104 fibroblast growth factor receptor binding 16.6667 5 yes
GO:0045499 chemorepellent activity 16.6667 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FLRT3_HUMAN
GO:0048522 positive regulation of cellular process 83.3333 4 yes
GO:0022607 cellular component assembly 66.6667 4 yes
GO:0051128 regulation of cellular component organization 58.3333 4 yes
GO:0034330 cell junction organization 50.0000 4 yes
GO:0030030 cell projection organization 41.6667 4 yes
GO:0034329 cell junction assembly 41.6667 5 yes
GO:0044087 regulation of cellular component biogenesis 41.6667 4 yes
GO:0050807 regulation of synapse organization 41.6667 5 yes
GO:0050808 synapse organization 41.6667 5 yes
GO:0051094 positive regulation of developmental process 41.6667 4 yes
GO:0051130 positive regulation of cellular component organization 41.6667 5 yes
GO:0120036 plasma membrane bounded cell projection organization 41.6667 5 yes
GO:0006996 organelle organization 41.6667 4 no
GO:0009893 positive regulation of metabolic process 41.6667 4 no
GO:0009966 regulation of signal transduction 41.6667 4 no
GO:0010468 regulation of gene expression 41.6667 5 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0010646 regulation of cell communication 41.6667 4 no
GO:0042127 regulation of cell population proliferation 41.6667 4 no
GO:0048523 negative regulation of cellular process 41.6667 4 no
GO:0051049 regulation of transport 41.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:1902531 regulation of intracellular signal transduction 41.6667 5 no
GO:0031175 neuron projection development 33.3333 6 yes
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 yes
GO:0051963 regulation of synapse assembly 33.3333 6 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 33.3333 4 yes
GO:1901888 regulation of cell junction assembly 33.3333 5 yes
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010628 positive regulation of gene expression 33.3333 6 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 33.3333 4 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 33.3333 5 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0007416 synapse assembly 33.3333 6 yes
GO:0007507 heart development 25.0000 4 yes
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 yes
GO:0097485 neuron projection guidance 25.0000 7 yes
GO:2000026 regulation of multicellular organismal development 25.0000 4 yes
GO:0002009 morphogenesis of an epithelium 25.0000 4 no
GO:0008104 protein localization 25.0000 4 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of ion transmembrane transport 25.0000 5 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043269 regulation of ion transport 25.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:1904062 regulation of cation transmembrane transport 25.0000 6 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0007411 axon guidance 25.0000 8 yes
GO:0008543 fibroblast growth factor receptor signaling pathway 16.6667 6 yes
GO:0048678 response to axon injury 16.6667 4 yes
GO:0051960 regulation of nervous system development 16.6667 5 yes
GO:0051962 positive regulation of nervous system development 16.6667 5 yes
GO:0051965 positive regulation of synapse assembly 16.6667 6 yes
GO:0060973 cell migration involved in heart development 16.6667 4 yes
GO:0099560 synaptic membrane adhesion 16.6667 5 yes
GO:1901890 positive regulation of cell junction assembly 16.6667 6 yes
GO:1990138 neuron projection extension 16.6667 4 yes
GO:0003345 proepicardium cell migration involved in pericardium morphogenesis 16.6667 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 16.6667 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 16.6667 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in FLRT3_HUMAN
DOID:0090070 hypogonadotropic hypogonadism 16.6667 5 yes
DOID:0090093 hypogonadotropic hypogonadism 21 with or without anosmia 16.6667 6 yes
DOID:1924 hypogonadism 16.6667 4 yes
DOID:2277 gonadal disease 16.6667 3 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
FLRT3_HUMAN [view entry] [view interactions] Low throughput yes yes
AGRL3_HUMAN [view entry] [view interactions] Low throughput yes yes
UNC5B_HUMAN [view interactions] Low throughput no yes
AGRL1_HUMAN [view entry] [view interactions] Low throughput yes no
AGRL2_HUMAN [view entry] [view interactions] Low throughput yes no
FLRT1_HUMAN [view interactions] High throughput no no
MBLC2_HUMAN [view interactions] High throughput no yes
CALR_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
ROBO1_HUMAN [view interactions] Computational no yes
RND1_HUMAN [view interactions] Computational no no
MACD2_HUMAN [view interactions] Computational no yes