AGRL2_HUMAN
Evidence for PS localization
Functions
Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. [View more on UniProt]
Protein features
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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AGRL2_HUMAN has binary interactions with 36 proteins
Isoforms
Interacting regions
Canonical [AGRL2_HUMAN]
Isoform [O95490-2] alignment
Isoform [O95490-3] alignment
Isoform [O95490-4] alignment
Isoform [O95490-5] alignment
Isoform [O95490-6] alignment
Isoform [O95490-7] alignment
Isoform [H0Y5C0] alignment
Isoform [H0Y3V3] alignment
Isoform [A0A6I8PLG0] alignment
Isoform [A0A6I8PIV6] alignment
Isoform [A0A6I8PUE4] alignment
Isoform [A0A6I8PU30] alignment
Isoform [A0A6I8PTT2] alignment
Isoform [A0A6I8PRJ0] alignment
Isoform [A0A6I8PRM6] alignment
Isoform [A0A6I8PRQ0] alignment
Isoform [B1ALU1] alignment
Isoform [B1ALU3] alignment
Isoform [A0A8I5KUX3] alignment
LOADING 98%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in AGRL2_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 45.9459 | 4 | no |
GO:0017076 | purine nucleotide binding | 45.9459 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 45.9459 | 4 | no |
GO:0043168 | anion binding | 45.9459 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 43.2432 | 4 | no |
GO:0003924 | GTPase activity | 32.4324 | 7 | no |
GO:0005525 | GTP binding | 32.4324 | 5 | no |
GO:0016462 | pyrophosphatase activity | 32.4324 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 32.4324 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 32.4324 | 6 | no |
GO:0019001 | guanyl nucleotide binding | 32.4324 | 6 | no |
GO:0032561 | guanyl ribonucleotide binding | 32.4324 | 5 | no |
GO:0019900 | kinase binding | 27.0270 | 4 | no |
GO:0019901 | protein kinase binding | 27.0270 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in AGRL2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 75.6757 | 4 | no |
GO:0051128 | regulation of cellular component organization | 64.8649 | 4 | no |
GO:0022607 | cellular component assembly | 56.7568 | 4 | no |
GO:0048523 | negative regulation of cellular process | 56.7568 | 4 | no |
GO:0010646 | regulation of cell communication | 51.3514 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 48.6486 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 45.9459 | 4 | no |
GO:0009966 | regulation of signal transduction | 45.9459 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 45.9459 | 5 | no |
GO:0008104 | protein localization | 45.9459 | 4 | no |
GO:0006996 | organelle organization | 43.2432 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 43.2432 | 4 | no |
GO:0051049 | regulation of transport | 43.2432 | 4 | no |
GO:0030334 | regulation of cell migration | 40.5405 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 40.5405 | 5 | no |
GO:2000145 | regulation of cell motility | 40.5405 | 4 | no |
GO:0030030 | cell projection organization | 37.8378 | 4 | no |
GO:0030155 | regulation of cell adhesion | 37.8378 | 4 | no |
GO:0031344 | regulation of cell projection organization | 37.8378 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 37.8378 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 37.8378 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 37.8378 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 35.1351 | 4 | no |
GO:0010468 | regulation of gene expression | 35.1351 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 35.1351 | 5 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AR13B_HUMAN | [view interactions] | High throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARL15_HUMAN | [view interactions] | High throughput | no | yes |
ARL4C_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
BRD8_HUMAN | [view interactions] | High throughput | no | yes |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CLN3_HUMAN | [view interactions] | High throughput | no | no |
CTDSL_HUMAN | [view interactions] | High throughput | no | no |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
DJC16_HUMAN | [view interactions] | High throughput | no | no |
DJC25_HUMAN | [view interactions] | High throughput | no | yes |