AGRL2_HUMAN
Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in AGRL2_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 45.7143 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 45.7143 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 45.7143 | 4 | no |
GO:0003924 | GTPase activity | 34.2857 | 7 | no |
GO:0005525 | GTP binding | 34.2857 | 5 | no |
GO:0016462 | pyrophosphatase activity | 34.2857 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 34.2857 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 34.2857 | 6 | no |
GO:0019001 | guanyl nucleotide binding | 34.2857 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 34.2857 | 5 | no |
GO:0019900 | kinase binding | 31.4286 | 4 | no |
GO:0019901 | protein kinase binding | 31.4286 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in AGRL2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 71.4286 | 4 | no |
GO:0048523 | negative regulation of cellular process | 62.8571 | 4 | no |
GO:0010646 | regulation of cell communication | 57.1429 | 4 | no |
GO:0022607 | cellular component assembly | 57.1429 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 54.2857 | 4 | no |
GO:0009966 | regulation of signal transduction | 51.4286 | 4 | no |
GO:0030030 | cell projection organization | 48.5714 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 48.5714 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 48.5714 | 4 | no |
GO:0051049 | regulation of transport | 48.5714 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 45.7143 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 45.7143 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 45.7143 | 4 | no |
GO:0006996 | organelle organization | 45.7143 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 42.8571 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 42.8571 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 42.8571 | 4 | no |
GO:0008104 | protein localization | 42.8571 | 4 | no |
GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
GO:0031175 | neuron projection development | 40.0000 | 6 | no |
GO:0031344 | regulation of cell projection organization | 40.0000 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 40.0000 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 40.0000 | 6 | no |
GO:0016192 | vesicle-mediated transport | 40.0000 | 4 | no |
GO:0071702 | organic substance transport | 40.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 40.0000 | 4 | no |
GO:0030155 | regulation of cell adhesion | 37.1429 | 4 | no |
GO:0030334 | regulation of cell migration | 37.1429 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 37.1429 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 37.1429 | 4 | no |
GO:0051094 | positive regulation of developmental process | 37.1429 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 37.1429 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 37.1429 | 5 | no |
GO:2000145 | regulation of cell motility | 37.1429 | 4 | no |
GO:0010468 | regulation of gene expression | 37.1429 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 34.2857 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 34.2857 | 4 | no |
GO:0042325 | regulation of phosphorylation | 34.2857 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 34.2857 | 5 | no |
GO:0071310 | cellular response to organic substance | 34.2857 | 4 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 34.2857 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 31.4286 | 7 | no |
GO:0009967 | positive regulation of signal transduction | 31.4286 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 31.4286 | 6 | no |
GO:0031399 | regulation of protein modification process | 31.4286 | 6 | no |
GO:0034330 | cell junction organization | 31.4286 | 4 | no |
GO:0042327 | positive regulation of phosphorylation | 31.4286 | 8 | no |
GO:0045595 | regulation of cell differentiation | 31.4286 | 4 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 31.4286 | 7 | no |
GO:0051247 | positive regulation of protein metabolic process | 31.4286 | 6 | no |
GO:0033043 | regulation of organelle organization | 31.4286 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 31.4286 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 28.5714 | 8 | no |
GO:0008284 | positive regulation of cell population proliferation | 28.5714 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 28.5714 | 7 | no |
GO:0050807 | regulation of synapse organization | 28.5714 | 5 | no |
GO:0007010 | cytoskeleton organization | 28.5714 | 5 | no |
GO:0061024 | membrane organization | 28.5714 | 4 | no |
GO:0051050 | positive regulation of transport | 28.5714 | 4 | no |
GO:0010243 | response to organonitrogen compound | 25.7143 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 25.7143 | 5 | no |
GO:0010648 | negative regulation of cell communication | 25.7143 | 5 | no |
GO:0023057 | negative regulation of signaling | 25.7143 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 25.7143 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 25.7143 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 25.7143 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 25.7143 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 25.7143 | 6 | no |
GO:0007264 | small GTPase mediated signal transduction | 25.7143 | 4 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 25.7143 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 25.7143 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 25.7143 | 6 | no |
GO:0015031 | protein transport | 25.7143 | 4 | no |
GO:0032880 | regulation of protein localization | 25.7143 | 5 | no |
GO:0051046 | regulation of secretion | 25.7143 | 5 | no |
GO:0060341 | regulation of cellular localization | 25.7143 | 4 | no |
GO:1903530 | regulation of secretion by cell | 25.7143 | 4 | no |
GO:0007411 | axon guidance | 22.8571 | 8 | no |
GO:0010975 | regulation of neuron projection development | 22.8571 | 7 | no |
GO:0022604 | regulation of cell morphogenesis | 22.8571 | 5 | no |
GO:0030335 | positive regulation of cell migration | 22.8571 | 6 | no |
GO:0031346 | positive regulation of cell projection organization | 22.8571 | 6 | no |
GO:0040017 | positive regulation of locomotion | 22.8571 | 4 | no |
GO:0043549 | regulation of kinase activity | 22.8571 | 5 | no |
GO:0045597 | positive regulation of cell differentiation | 22.8571 | 5 | no |
GO:0045785 | positive regulation of cell adhesion | 22.8571 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 22.8571 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 22.8571 | 4 | no |
GO:0051241 | negative regulation of multicellular organismal process | 22.8571 | 4 | no |
GO:0051338 | regulation of transferase activity | 22.8571 | 4 | no |
GO:0097485 | neuron projection guidance | 22.8571 | 7 | no |
GO:1901701 | cellular response to oxygen-containing compound | 22.8571 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 22.8571 | 4 | no |
GO:2000147 | positive regulation of cell motility | 22.8571 | 5 | no |
GO:0007015 | actin filament organization | 22.8571 | 5 | no |
GO:0097435 | supramolecular fiber organization | 22.8571 | 4 | no |
GO:0007265 | Ras protein signal transduction | 22.8571 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 22.8571 | 4 | no |
GO:0010941 | regulation of cell death | 22.8571 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.8571 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 22.8571 | 5 | no |
GO:0034329 | cell junction assembly | 22.8571 | 5 | no |
GO:0042981 | regulation of apoptotic process | 22.8571 | 6 | no |
GO:0043067 | regulation of programmed cell death | 22.8571 | 5 | no |
GO:0007420 | brain development | 8.5714 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SHAN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FLRT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCK1_HUMAN | [view interactions] | High throughput | no | yes |
S38A1_HUMAN | [view interactions] | High throughput | no | yes |
CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TSN5_HUMAN | [view interactions] | High throughput | no | no |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UN93B_HUMAN | [view interactions] | High throughput | no | yes |
MET_HUMAN | [view interactions] | High throughput | no | yes |
IRF3_HUMAN | [view interactions] | High throughput | no | yes |
S15A4_HUMAN | [view interactions] | High throughput | no | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
TM216_HUMAN | [view interactions] | High throughput | no | no |
CTDSL_HUMAN | [view interactions] | High throughput | no | no |
EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STYK1_HUMAN | [view interactions] | High throughput | no | yes |
FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
CLN3_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
FLRT1_HUMAN | [view interactions] | High throughput | no | no |
TM11B_HUMAN | [view interactions] | High throughput | no | no |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
PTPRO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
BRD8_HUMAN | [view interactions] | High throughput | no | yes |
TRI66_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND1_HUMAN | [view interactions] | High throughput | no | no |
RND2_HUMAN | [view interactions] | High throughput | no | no |
RND3_HUMAN | [view interactions] | High throughput | no | no |
CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
OTULL_HUMAN | [view interactions] | High throughput | no | no |
MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DJC16_HUMAN | [view interactions] | High throughput | no | no |
DJC25_HUMAN | [view interactions] | High throughput | no | yes |
DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
HS12B_HUMAN | [view interactions] | High throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AFAD_HUMAN | [view interactions] | High throughput | no | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PARD3_HUMAN | [view interactions] | High throughput | no | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MGAT1_HUMAN | [view interactions] | Computational | no | yes |
TEN2_HUMAN | [view entry] [view interactions] | Computational | yes | no |