Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AGRL2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AGRL2_HUMAN
GO:0000166 nucleotide binding 45.9459 4 no
GO:0017076 purine nucleotide binding 45.9459 5 no
GO:0032555 purine ribonucleotide binding 45.9459 4 no
GO:0043168 anion binding 45.9459 4 no
GO:0035639 purine ribonucleoside triphosphate binding 43.2432 4 no
GO:0003924 GTPase activity 32.4324 7 no
GO:0005525 GTP binding 32.4324 5 no
GO:0016462 pyrophosphatase activity 32.4324 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 32.4324 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 32.4324 6 no
GO:0019001 guanyl nucleotide binding 32.4324 6 no
GO:0032561 guanyl ribonucleotide binding 32.4324 5 no
GO:0019900 kinase binding 27.0270 4 no
GO:0019901 protein kinase binding 27.0270 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in AGRL2_HUMAN
GO:0048522 positive regulation of cellular process 75.6757 4 no
GO:0051128 regulation of cellular component organization 64.8649 4 no
GO:0022607 cellular component assembly 56.7568 4 no
GO:0048523 negative regulation of cellular process 56.7568 4 no
GO:0010646 regulation of cell communication 51.3514 4 no
GO:0060255 regulation of macromolecule metabolic process 48.6486 4 no
GO:0009893 positive regulation of metabolic process 45.9459 4 no
GO:0009966 regulation of signal transduction 45.9459 4 no
GO:0010604 positive regulation of macromolecule metabolic process 45.9459 5 no
GO:0008104 protein localization 45.9459 4 no
GO:0006996 organelle organization 43.2432 4 no
GO:0031323 regulation of cellular metabolic process 43.2432 4 no
GO:0051049 regulation of transport 43.2432 4 no
GO:0030334 regulation of cell migration 40.5405 5 no
GO:0031325 positive regulation of cellular metabolic process 40.5405 5 no
GO:2000145 regulation of cell motility 40.5405 4 no
GO:0030030 cell projection organization 37.8378 4 no
GO:0030155 regulation of cell adhesion 37.8378 4 no
GO:0031344 regulation of cell projection organization 37.8378 5 no
GO:0048584 positive regulation of response to stimulus 37.8378 4 no
GO:0080090 regulation of primary metabolic process 37.8378 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.8378 6 no
GO:0009889 regulation of biosynthetic process 35.1351 4 no
GO:0010468 regulation of gene expression 35.1351 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.1351 5 no
GO:0010647 positive regulation of cell communication 35.1351 5 no
GO:0023056 positive regulation of signaling 35.1351 4 no
GO:0031326 regulation of cellular biosynthetic process 35.1351 5 no
GO:0071702 organic substance transport 35.1351 4 no
GO:0071705 nitrogen compound transport 35.1351 4 no
GO:1902531 regulation of intracellular signal transduction 35.1351 5 no
GO:0044087 regulation of cellular component biogenesis 35.1351 4 no
GO:0042127 regulation of cell population proliferation 32.4324 4 no
GO:0051130 positive regulation of cellular component organization 32.4324 5 no
GO:0051246 regulation of protein metabolic process 32.4324 5 no
GO:0120036 plasma membrane bounded cell projection organization 32.4324 5 no
GO:0034330 cell junction organization 32.4324 4 no
GO:0031175 neuron projection development 29.7297 6 no
GO:0051094 positive regulation of developmental process 29.7297 4 no
GO:0051247 positive regulation of protein metabolic process 29.7297 6 no
GO:0060627 regulation of vesicle-mediated transport 29.7297 4 no
GO:0050807 regulation of synapse organization 29.7297 5 no
GO:0001932 regulation of protein phosphorylation 27.0270 7 no
GO:0001934 positive regulation of protein phosphorylation 27.0270 8 no
GO:0008284 positive regulation of cell population proliferation 27.0270 5 no
GO:0009967 positive regulation of signal transduction 27.0270 5 no
GO:0010562 positive regulation of phosphorus metabolic process 27.0270 6 no
GO:0019220 regulation of phosphate metabolic process 27.0270 6 no
GO:0031399 regulation of protein modification process 27.0270 6 no
GO:0031401 positive regulation of protein modification process 27.0270 7 no
GO:0042325 regulation of phosphorylation 27.0270 7 no
GO:0042327 positive regulation of phosphorylation 27.0270 8 no
GO:0045595 regulation of cell differentiation 27.0270 4 no
GO:0045937 positive regulation of phosphate metabolic process 27.0270 7 no
GO:0051174 regulation of phosphorus metabolic process 27.0270 5 no
GO:2000026 regulation of multicellular organismal development 27.0270 4 no
GO:0050804 modulation of chemical synaptic transmission 27.0270 5 no
GO:0099177 regulation of trans-synaptic signaling 27.0270 4 no
GO:0022603 regulation of anatomical structure morphogenesis 27.0270 4 no
GO:0044089 positive regulation of cellular component biogenesis 27.0270 5 no
GO:0141124 intracellular signaling cassette 27.0270 4 no
GO:0060341 regulation of cellular localization 27.0270 4 no
GO:0010975 regulation of neuron projection development 24.3243 7 no
GO:0030335 positive regulation of cell migration 24.3243 6 no
GO:0032101 regulation of response to external stimulus 24.3243 4 no
GO:0040017 positive regulation of locomotion 24.3243 4 no
GO:0045785 positive regulation of cell adhesion 24.3243 5 no
GO:0051240 positive regulation of multicellular organismal process 24.3243 4 no
GO:0051241 negative regulation of multicellular organismal process 24.3243 4 no
GO:0071310 cellular response to organic substance 24.3243 4 no
GO:1902533 positive regulation of intracellular signal transduction 24.3243 6 no
GO:2000147 positive regulation of cell motility 24.3243 5 no
GO:0051129 negative regulation of cellular component organization 24.3243 5 no
GO:0034329 cell junction assembly 24.3243 5 no
GO:0007010 cytoskeleton organization 24.3243 5 no
GO:0007264 small GTPase-mediated signal transduction 24.3243 5 no
GO:0061024 membrane organization 24.3243 4 no
GO:0032880 regulation of protein localization 24.3243 5 no
GO:0009891 positive regulation of biosynthetic process 24.3243 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.3243 6 no
GO:0031328 positive regulation of cellular biosynthetic process 24.3243 6 no
GO:0051050 positive regulation of transport 24.3243 4 no
GO:0007015 actin filament organization 21.6216 5 no
GO:0097435 supramolecular fiber organization 21.6216 4 no
GO:0002684 positive regulation of immune system process 21.6216 4 no
GO:0009892 negative regulation of metabolic process 21.6216 4 no
GO:0031346 positive regulation of cell projection organization 21.6216 6 no
GO:0042981 regulation of apoptotic process 21.6216 5 no
GO:0043067 regulation of programmed cell death 21.6216 4 no
GO:0051046 regulation of secretion 21.6216 5 no
GO:0060284 regulation of cell development 21.6216 5 no
GO:1903530 regulation of secretion by cell 21.6216 4 no
GO:0032970 regulation of actin filament-based process 21.6216 4 no
GO:0033043 regulation of organelle organization 21.6216 5 no
GO:0040013 negative regulation of locomotion 21.6216 4 no
GO:0045216 cell-cell junction organization 21.6216 5 no
GO:0015031 protein transport 21.6216 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FLRT3_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
KS6A2_HUMAN [view interactions] High throughput no yes
OTULL_HUMAN [view interactions] High throughput no no
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
DJC16_HUMAN [view interactions] High throughput no no
DJC25_HUMAN [view interactions] High throughput no yes
DNJ5B_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
HS12B_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ARL4C_HUMAN [view interactions] High throughput no yes
AR13B_HUMAN [view interactions] High throughput no yes
ARL15_HUMAN [view interactions] High throughput no yes
NCK1_HUMAN [view interactions] High throughput no yes
S38A1_HUMAN [view interactions] High throughput no yes
CD9_HUMAN [view entry] [view interactions] High throughput yes no
TSN5_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
UN93B_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
IRF3_HUMAN [view interactions] High throughput no yes
S15A4_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
TMM17_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
CTDSL_HUMAN [view interactions] High throughput no no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
STYK1_HUMAN [view interactions] High throughput no yes
FHI1A_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
CLN3_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
FLRT1_HUMAN [view interactions] High throughput no no
TM11B_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
PTPRO_HUMAN [view entry] [view interactions] High throughput yes no
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
BRD8_HUMAN [view interactions] High throughput no yes
TRI66_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no