CXA1_HUMAN
Evidence for PS localization
Functions
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract . May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles . [View more on UniProt]
Protein features
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 82%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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CXA1_HUMAN has binary interactions with 50 proteins
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CXA1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 29.7500 | 4 | no |
| GO:0000166 | nucleotide binding | 29.2500 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.5000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.5000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.2500 | 4 | no |
| GO:0043169 | cation binding | 23.7500 | 4 | no |
| GO:0046872 | metal ion binding | 22.7500 | 5 | no |
| GO:0003723 | RNA binding | 22.5000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 20.7500 | 6 | no |
| GO:0019900 | kinase binding | 16.0000 | 4 | yes |
| GO:0019901 | protein kinase binding | 15.0000 | 5 | yes |
| GO:0015631 | tubulin binding | 5.5000 | 4 | yes |
| GO:0015267 | channel activity | 3.2500 | 4 | yes |
| GO:1990782 | protein tyrosine kinase binding | 3.0000 | 6 | yes |
| GO:0022829 | wide pore channel activity | 1.2500 | 5 | yes |
| GO:0048487 | beta-tubulin binding | 1.2500 | 5 | yes |
| GO:0005243 | gap junction channel activity | 0.5000 | 6 | yes |
| GO:0034634 | glutathione transmembrane transporter activity | 0.5000 | 4 | yes |
| GO:0035673 | oligopeptide transmembrane transporter activity | 0.5000 | 4 | yes |
| GO:0042937 | tripeptide transmembrane transporter activity | 0.5000 | 5 | yes |
| GO:0043014 | alpha-tubulin binding | 0.5000 | 5 | yes |
| GO:0055077 | gap junction hemi-channel activity | 0.5000 | 6 | yes |
| GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling | 0.5000 | 8 | yes |
| GO:1903763 | gap junction channel activity involved in cell communication by electrical coupling | 0.5000 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CXA1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 47.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 41.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 38.2500 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 38.2500 | 4 | yes |
| GO:0010646 | regulation of cell communication | 36.5000 | 4 | yes |
| GO:0006996 | organelle organization | 35.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 34.7500 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 31.7500 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 31.0000 | 4 | yes |
| GO:0008104 | protein localization | 30.5000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 30.5000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.5000 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | yes |
| GO:0022607 | cellular component assembly | 29.2500 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.0000 | 5 | yes |
| GO:0010468 | regulation of gene expression | 27.5000 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.2500 | 5 | yes |
| GO:0051049 | regulation of transport | 25.5000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 24.7500 | 5 | yes |
| GO:0071702 | organic substance transport | 24.5000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 23.7500 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.7500 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 22.2500 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 22.2500 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 21.7500 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5HT2C_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5HT3C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5NTD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCB7_HUMAN | [view interactions] | High throughput | no | yes |
| ACADL_HUMAN | [view interactions] | High throughput | no | no |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| ACADS_HUMAN | [view interactions] | High throughput | no | yes |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSF2_HUMAN | [view interactions] | High throughput | no | no |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| ACSL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |