ACSL3_HUMAN
Evidence for PS localization
Functions
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACSL3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 51.5625 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 51.5625 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 51.5625 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 31.2500 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 31.2500 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 31.2500 | 6 | no |
| GO:0003924 | GTPase activity | 28.1250 | 7 | no |
| GO:0005525 | GTP binding | 28.1250 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 28.1250 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 28.1250 | 5 | no |
| GO:0005524 | ATP binding | 23.4375 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.4375 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.4375 | 5 | yes |
| GO:0019900 | kinase binding | 21.8750 | 4 | yes |
| GO:0019901 | protein kinase binding | 21.8750 | 5 | yes |
| GO:0046872 | metal ion binding | 20.3125 | 4 | no |
| GO:0016405 | CoA-ligase activity | 3.1250 | 4 | yes |
| GO:0016878 | acid-thiol ligase activity | 3.1250 | 4 | yes |
| GO:0047676 | arachidonate-CoA ligase activity | 3.1250 | 4 | yes |
| GO:0090433 | palmitoyl-CoA ligase activity | 3.1250 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACSL3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 67.1875 | 4 | yes |
| GO:0010646 | regulation of cell communication | 46.8750 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.7500 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.7500 | 4 | no |
| GO:0051049 | regulation of transport | 43.7500 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 42.1875 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 39.0625 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 39.0625 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.0625 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.5000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 37.5000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 35.9375 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.9375 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.9375 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 34.3750 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.8125 | 5 | no |
| GO:0006996 | organelle organization | 32.8125 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.8125 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 31.2500 | 4 | no |
| GO:0060341 | regulation of cellular localization | 31.2500 | 4 | yes |
| GO:0071702 | organic substance transport | 31.2500 | 4 | yes |
| GO:0008104 | protein localization | 29.6875 | 4 | no |
| GO:0033043 | regulation of organelle organization | 29.6875 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 29.6875 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.6875 | 5 | no |
| GO:0071705 | nitrogen compound transport | 28.1250 | 4 | no |
| GO:0010941 | regulation of cell death | 28.1250 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.1250 | 6 | yes |
| GO:0032880 | regulation of protein localization | 28.1250 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.1250 | 5 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 28.1250 | 5 | yes |
| GO:0030030 | cell projection organization | 26.5625 | 4 | no |
| GO:0030334 | regulation of cell migration | 26.5625 | 5 | no |
| GO:2000145 | regulation of cell motility | 26.5625 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.5625 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 25.0000 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | yes |
| GO:0015031 | protein transport | 23.4375 | 4 | no |
| GO:0036211 | protein modification process | 23.4375 | 4 | no |
| GO:0043412 | macromolecule modification | 23.4375 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.4375 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.4375 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.4375 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.4375 | 5 | no |
| GO:0061024 | membrane organization | 23.4375 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.4375 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.4375 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.4375 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 23.4375 | 4 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.4375 | 6 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 23.4375 | 5 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.4375 | 7 | yes |
| GO:1903829 | positive regulation of protein localization | 21.8750 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 21.8750 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 21.8750 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 21.8750 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.8750 | 8 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.8750 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 21.8750 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.8750 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.8750 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.8750 | 4 | yes |
| GO:0051223 | regulation of protein transport | 21.8750 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 21.8750 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 21.8750 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 20.3125 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.3125 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.3125 | 6 | no |
| GO:0031175 | neuron projection development | 20.3125 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.3125 | 5 | no |
| GO:0051046 | regulation of secretion | 20.3125 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 18.7500 | 6 | yes |
| GO:0051222 | positive regulation of protein transport | 18.7500 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 15.6250 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 15.6250 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 14.0625 | 6 | yes |
| GO:0051047 | positive regulation of secretion | 12.5000 | 5 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 10.9375 | 6 | yes |
| GO:1905477 | positive regulation of protein localization to membrane | 10.9375 | 6 | yes |
| GO:0019216 | regulation of lipid metabolic process | 10.9375 | 5 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 9.3750 | 7 | yes |
| GO:0043933 | protein-containing complex organization | 9.3750 | 4 | yes |
| GO:0045834 | positive regulation of lipid metabolic process | 9.3750 | 5 | yes |
| GO:1903078 | positive regulation of protein localization to plasma membrane | 7.8125 | 7 | yes |
| GO:1904377 | positive regulation of protein localization to cell periphery | 7.8125 | 6 | yes |
| GO:0019752 | carboxylic acid metabolic process | 7.8125 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 7.8125 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 7.8125 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 6.2500 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 6.2500 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 6.2500 | 5 | yes |
| GO:0006631 | fatty acid metabolic process | 6.2500 | 4 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 6.2500 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 6.2500 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 6.2500 | 5 | yes |
| GO:0015849 | organic acid transport | 6.2500 | 5 | yes |
| GO:0030182 | neuron differentiation | 6.2500 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 6.2500 | 6 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 6.2500 | 4 | yes |
| GO:0044272 | sulfur compound biosynthetic process | 6.2500 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 6.2500 | 4 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 4.6875 | 5 | yes |
| GO:0098657 | import into cell | 4.6875 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 4.6875 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 4.6875 | 4 | yes |
| GO:0001676 | long-chain fatty acid metabolic process | 4.6875 | 5 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 4.6875 | 6 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 4.6875 | 6 | yes |
| GO:0009165 | nucleotide biosynthetic process | 4.6875 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 4.6875 | 5 | yes |
| GO:0018130 | heterocycle biosynthetic process | 4.6875 | 4 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 4.6875 | 4 | yes |
| GO:0019693 | ribose phosphate metabolic process | 4.6875 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 4.6875 | 4 | yes |
| GO:0043603 | cellular amide metabolic process | 4.6875 | 4 | yes |
| GO:0043604 | amide biosynthetic process | 4.6875 | 5 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 3.1250 | 4 | yes |
| GO:1901568 | fatty acid derivative metabolic process | 3.1250 | 4 | yes |
| GO:1901570 | fatty acid derivative biosynthetic process | 3.1250 | 5 | yes |
| GO:0006637 | acyl-CoA metabolic process | 3.1250 | 4 | yes |
| GO:0006869 | lipid transport | 3.1250 | 5 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 3.1250 | 7 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 3.1250 | 6 | yes |
| GO:0015908 | fatty acid transport | 3.1250 | 6 | yes |
| GO:0015909 | long-chain fatty acid transport | 3.1250 | 7 | yes |
| GO:0033865 | nucleoside bisphosphate metabolic process | 3.1250 | 5 | yes |
| GO:0033866 | nucleoside bisphosphate biosynthetic process | 3.1250 | 6 | yes |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 3.1250 | 6 | yes |
| GO:0034030 | ribonucleoside bisphosphate biosynthetic process | 3.1250 | 7 | yes |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 3.1250 | 5 | yes |
| GO:0034033 | purine nucleoside bisphosphate biosynthetic process | 3.1250 | 6 | yes |
| GO:0035336 | long-chain fatty-acyl-CoA metabolic process | 3.1250 | 6 | yes |
| GO:0035337 | fatty-acyl-CoA metabolic process | 3.1250 | 5 | yes |
| GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process | 3.1250 | 7 | yes |
| GO:0035384 | thioester biosynthetic process | 3.1250 | 4 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 3.1250 | 5 | yes |
| GO:0046889 | positive regulation of lipid biosynthetic process | 3.1250 | 6 | yes |
| GO:0046890 | regulation of lipid biosynthetic process | 3.1250 | 5 | yes |
| GO:0046949 | fatty-acyl-CoA biosynthetic process | 3.1250 | 6 | yes |
| GO:0071616 | acyl-CoA biosynthetic process | 3.1250 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ACSL3_HUMAN |
|---|---|---|---|---|
| DOID:0060038 | specific developmental disorder | 3.1250 | 3 | no |
| DOID:1059 | intellectual disability | 3.1250 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| STX17_HUMAN | [view interactions] | Low throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| YES_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| CP2C9_HUMAN | [view interactions] | High throughput | no | no |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| BROMI_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| SKA1_HUMAN | [view interactions] | High throughput | no | yes |
| RASF1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| ACSL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIGD6_HUMAN | [view interactions] | High throughput | no | no |
| GET4_HUMAN | [view interactions] | High throughput | no | yes |
| KI20B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAT2_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CO040_HUMAN | [view interactions] | High throughput | no | yes |
| DDX42_HUMAN | [view interactions] | High throughput | no | yes |
| DOC11_HUMAN | [view interactions] | High throughput | no | yes |
| TTBK1_HUMAN | [view interactions] | High throughput | no | yes |
| PPE1_HUMAN | [view interactions] | High throughput | no | no |
| NOD2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| SPART_HUMAN | [view interactions] | High throughput | no | yes |
| HIPK4_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| IF140_HUMAN | [view interactions] | High throughput | no | yes |
| WDR19_HUMAN | [view interactions] | High throughput | no | yes |
| T2FB_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| LBN_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLRKT_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| MK04_HUMAN | [view interactions] | High throughput | no | no |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| FGF11_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| TM41B_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| DUS7_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| SPTC1_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| PAEP_HUMAN | [view interactions] | High throughput | no | no |
| HAVR2_HUMAN | [view interactions] | High throughput | no | no |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRAD1_HUMAN | [view interactions] | High throughput | no | no |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARMC5_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
| ADIPO_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPTE_HUMAN | [view interactions] | High throughput | no | no |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC16_HUMAN | [view interactions] | High throughput | no | no |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | Computational | no | yes |
| CPT1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ELOV6_HUMAN | [view interactions] | Computational | no | yes |
| ELOV1_HUMAN | [view interactions] | Computational | no | yes |
| ACADL_HUMAN | [view interactions] | Computational | no | no |
| FADS2_HUMAN | [view interactions] | Computational | no | yes |
| ACOX2_HUMAN | [view interactions] | Computational | no | yes |