ESYT2_HUMAN
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ESYT2_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 44.2623 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 42.6230 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 42.6230 | 4 | no |
GO:0003924 | GTPase activity | 32.7869 | 7 | no |
GO:0005525 | GTP binding | 32.7869 | 5 | no |
GO:0016462 | pyrophosphatase activity | 32.7869 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 32.7869 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 32.7869 | 6 | no |
GO:0019001 | guanyl nucleotide binding | 32.7869 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 32.7869 | 5 | no |
GO:0046872 | metal ion binding | 19.6721 | 4 | yes |
GO:0005509 | calcium ion binding | 16.3934 | 5 | yes |
GO:0045296 | cadherin binding | 16.3934 | 4 | yes |
GO:0035091 | phosphatidylinositol binding | 8.1967 | 4 | yes |
GO:0005544 | calcium-dependent phospholipid binding | 4.9180 | 4 | yes |
GO:0008429 | phosphatidylethanolamine binding | 4.9180 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ESYT2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 54.0984 | 4 | no |
GO:0006996 | organelle organization | 49.1803 | 4 | no |
GO:0008104 | protein localization | 44.2623 | 4 | no |
GO:0071702 | organic substance transport | 42.6230 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 42.6230 | 4 | no |
GO:0010646 | regulation of cell communication | 39.3443 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 39.3443 | 4 | no |
GO:0071705 | nitrogen compound transport | 37.7049 | 4 | no |
GO:0016192 | vesicle-mediated transport | 34.4262 | 4 | yes |
GO:0022607 | cellular component assembly | 34.4262 | 4 | no |
GO:0051049 | regulation of transport | 34.4262 | 4 | no |
GO:0009966 | regulation of signal transduction | 34.4262 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 34.4262 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 32.7869 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 32.7869 | 4 | no |
GO:0015031 | protein transport | 31.1475 | 4 | no |
GO:0048523 | negative regulation of cellular process | 31.1475 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 31.1475 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 29.5082 | 4 | no |
GO:0010468 | regulation of gene expression | 27.8689 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 27.8689 | 5 | no |
GO:0010647 | positive regulation of cell communication | 27.8689 | 5 | no |
GO:0023056 | positive regulation of signaling | 27.8689 | 4 | no |
GO:0030030 | cell projection organization | 27.8689 | 4 | no |
GO:0061024 | membrane organization | 26.2295 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 26.2295 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 26.2295 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 24.5902 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 24.5902 | 5 | no |
GO:0030334 | regulation of cell migration | 24.5902 | 5 | no |
GO:2000145 | regulation of cell motility | 24.5902 | 4 | no |
GO:0006886 | intracellular protein transport | 22.9508 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 22.9508 | 5 | no |
GO:0007010 | cytoskeleton organization | 22.9508 | 5 | no |
GO:0031344 | regulation of cell projection organization | 22.9508 | 5 | no |
GO:0033043 | regulation of organelle organization | 22.9508 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.9508 | 6 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 22.9508 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 21.3115 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 21.3115 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 21.3115 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.3115 | 5 | no |
GO:0071310 | cellular response to organic substance | 21.3115 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 21.3115 | 5 | no |
GO:0007264 | small GTPase mediated signal transduction | 21.3115 | 4 | no |
GO:0006897 | endocytosis | 14.7541 | 5 | yes |
GO:0006869 | lipid transport | 6.5574 | 5 | yes |
GO:0061817 | endoplasmic reticulum-plasma membrane tethering | 6.5574 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in ESYT2_HUMAN |
---|---|---|---|---|
DOID:12377 | spinal muscular atrophy | 3.2787 | 6 | no |
DOID:1289 | neurodegenerative disease | 3.2787 | 4 | no |
DOID:231 | motor neuron disease | 3.2787 | 5 | no |
DOID:331 | central nervous system disease | 3.2787 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ESYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ESYT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ESYT3_HUMAN | [view interactions] | Low throughput | no | no |
DERL1_HUMAN | [view interactions] | High throughput | no | yes |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COQ8A_HUMAN | [view interactions] | High throughput | no | no |
SG196_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
MK15_HUMAN | [view interactions] | High throughput | no | no |
IRF3_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
S15A4_HUMAN | [view interactions] | High throughput | no | yes |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
BET1_HUMAN | [view interactions] | High throughput | no | no |
CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CTDSL_HUMAN | [view interactions] | High throughput | no | no |
VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
FGD1_HUMAN | [view interactions] | High throughput | no | no |
PAEP_HUMAN | [view interactions] | High throughput | no | no |
RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NOP56_HUMAN | [view interactions] | High throughput | no | yes |
ELL2_HUMAN | [view interactions] | High throughput | no | no |
NICA_HUMAN | [view interactions] | High throughput | no | yes |
MPP8_HUMAN | [view interactions] | High throughput | no | yes |
TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATP7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCNK1_HUMAN | [view interactions] | High throughput | no | yes |
KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMN_HUMAN | [view interactions] | High throughput | no | yes |
FBX21_HUMAN | [view interactions] | High throughput | no | yes |
TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAF2_HUMAN | [view interactions] | High throughput | no | yes |
NKX21_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
RNF31_HUMAN | [view interactions] | High throughput | no | yes |
WWOX_HUMAN | [view interactions] | High throughput | no | yes |
GRWD1_HUMAN | [view interactions] | High throughput | no | no |
CTDP1_HUMAN | [view interactions] | High throughput | no | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
H4_HUMAN | [view interactions] | High throughput | no | yes |
S15A3_HUMAN | [view interactions] | High throughput | no | yes |
DUS7_HUMAN | [view interactions] | High throughput | no | yes |
CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
DJC25_HUMAN | [view interactions] | High throughput | no | yes |
SEC63_HUMAN | [view interactions] | High throughput | no | yes |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
AGO2_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
SACA1_HUMAN | [view interactions] | High throughput | no | no |
FURIN_HUMAN | [view interactions] | High throughput | no | yes |
AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMEM9_HUMAN | [view interactions] | High throughput | no | no |
ANR22_HUMAN | [view interactions] | High throughput | no | no |
NIPA3_HUMAN | [view interactions] | High throughput | no | no |
RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GP182_HUMAN | [view interactions] | High throughput | no | no |
APOM_HUMAN | [view interactions] | High throughput | no | no |
KLRB1_HUMAN | [view interactions] | High throughput | no | yes |
CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
GPIX_HUMAN | [view interactions] | High throughput | no | no |
AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
PCDB3_HUMAN | [view interactions] | High throughput | no | no |
CLC4E_HUMAN | [view interactions] | High throughput | no | no |
REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACHA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND2_HUMAN | [view interactions] | High throughput | no | no |
AR6P1_HUMAN | [view interactions] | High throughput | no | yes |
ATLA3_HUMAN | [view interactions] | High throughput | no | no |
COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COPE_HUMAN | [view interactions] | High throughput | no | yes |
OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
RRAS2_HUMAN | [view interactions] | High throughput | no | yes |
RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCD47_HUMAN | [view interactions] | High throughput | no | yes |
PM34_HUMAN | [view interactions] | High throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NIN_HUMAN | [view interactions] | High throughput | no | no |
RHBL4_HUMAN | [view interactions] | High throughput | no | no |
OTULL_HUMAN | [view interactions] | High throughput | no | no |
SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
ST7_HUMAN | [view interactions] | High throughput | no | yes |
FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN1_HUMAN | [view interactions] | High throughput | no | yes |
MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RMD3_HUMAN | [view interactions] | High throughput | no | yes |
S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SEC62_HUMAN | [view interactions] | High throughput | no | yes |
DJC14_HUMAN | [view interactions] | High throughput | no | yes |
DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
BAP31_HUMAN | [view interactions] | High throughput | no | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX8A_HUMAN | [view interactions] | High throughput | no | yes |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
EMD_HUMAN | [view interactions] | High throughput | no | yes |
ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
DHB11_HUMAN | [view interactions] | High throughput | no | yes |
3BHS7_HUMAN | [view interactions] | High throughput | no | no |
K2C8_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
LNP_HUMAN | [view interactions] | High throughput | no | yes |
LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MET7A_HUMAN | [view interactions] | High throughput | no | no |
NU155_HUMAN | [view interactions] | High throughput | no | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PANX1_HUMAN | [view interactions] | High throughput | no | no |
PEX3_HUMAN | [view interactions] | High throughput | no | yes |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB3B_HUMAN | [view interactions] | High throughput | no | no |
RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC61B_HUMAN | [view interactions] | High throughput | no | yes |
SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STIM1_HUMAN | [view interactions] | High throughput | no | yes |
STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNE3_HUMAN | [view interactions] | High throughput | no | no |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
BROMI_HUMAN | [view interactions] | High throughput | no | no |
DPP4_HUMAN | [view interactions] | High throughput | no | no |
TM11B_HUMAN | [view interactions] | High throughput | no | no |
UFO_HUMAN | [view interactions] | High throughput | no | no |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLN3_HUMAN | [view interactions] | High throughput | no | no |
KKCC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PR15A_HUMAN | [view interactions] | High throughput | no | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
MOT11_HUMAN | [view interactions] | High throughput | no | no |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
P2RY6_HUMAN | [view interactions] | High throughput | no | no |
UN93B_HUMAN | [view interactions] | High throughput | no | yes |
VAMP5_HUMAN | [view interactions] | High throughput | no | no |