MARK2_HUMAN
Evidence for PS localization
Functions
Serine/threonine-protein kinase (PubMed). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MARK2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 39.7727 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 39.7727 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 39.7727 | 4 | yes |
| GO:0019900 | kinase binding | 29.5455 | 4 | no |
| GO:0019901 | protein kinase binding | 29.5455 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 22.7273 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.7273 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.7273 | 6 | no |
| GO:0005524 | ATP binding | 21.5909 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 21.5909 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 21.5909 | 5 | yes |
| GO:0046872 | metal ion binding | 19.3182 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 15.9091 | 4 | yes |
| GO:0016301 | kinase activity | 15.9091 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 15.9091 | 4 | yes |
| GO:0003723 | RNA binding | 13.6364 | 4 | yes |
| GO:0045296 | cadherin binding | 13.6364 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 12.5000 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 12.5000 | 4 | yes |
| GO:0019887 | protein kinase regulator activity | 10.2273 | 4 | yes |
| GO:0048156 | tau protein binding | 9.0909 | 4 | yes |
| GO:0000287 | magnesium ion binding | 5.6818 | 5 | yes |
| GO:0050321 | tau-protein kinase activity | 4.5455 | 4 | yes |
| GO:0019209 | kinase activator activity | 3.4091 | 4 | yes |
| GO:0030295 | protein kinase activator activity | 3.4091 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MARK2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 76.1364 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 62.5000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 61.3636 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 57.9545 | 4 | yes |
| GO:0006996 | organelle organization | 56.8182 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 53.4091 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 53.4091 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.2727 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 46.5909 | 4 | no |
| GO:0008104 | protein localization | 46.5909 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.4545 | 4 | yes |
| GO:0051049 | regulation of transport | 45.4545 | 4 | no |
| GO:0009966 | regulation of signal transduction | 43.1818 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 42.0455 | 5 | yes |
| GO:0010468 | regulation of gene expression | 40.9091 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 40.9091 | 5 | yes |
| GO:0071702 | organic substance transport | 39.7727 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.6364 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 37.5000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 36.3636 | 4 | no |
| GO:0007010 | cytoskeleton organization | 35.2273 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 35.2273 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 35.2273 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 34.0909 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 32.9545 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.9545 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 32.9545 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 32.9545 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 32.9545 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 32.9545 | 5 | yes |
| GO:0051050 | positive regulation of transport | 32.9545 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 31.8182 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.8182 | 5 | no |
| GO:0030030 | cell projection organization | 31.8182 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 31.8182 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 31.8182 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.6818 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.5455 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.5455 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.5455 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 29.5455 | 7 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 29.5455 | 6 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 29.5455 | 6 | yes |
| GO:0015031 | protein transport | 29.5455 | 4 | no |
| GO:0071310 | cellular response to organic substance | 29.5455 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.4091 | 5 | no |
| GO:0010941 | regulation of cell death | 28.4091 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 28.4091 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 28.4091 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.4091 | 4 | no |
| GO:0060341 | regulation of cellular localization | 28.4091 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.2727 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 27.2727 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.2727 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 27.2727 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 27.2727 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 27.2727 | 7 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.2727 | 5 | yes |
| GO:0032880 | regulation of protein localization | 27.2727 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.1364 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 26.1364 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.1364 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 26.1364 | 4 | yes |
| GO:0043412 | macromolecule modification | 26.1364 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 25.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | yes |
| GO:0006886 | intracellular protein transport | 25.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.8636 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.8636 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.8636 | 4 | no |
| GO:0030334 | regulation of cell migration | 23.8636 | 5 | no |
| GO:2000145 | regulation of cell motility | 23.8636 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 22.7273 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.7273 | 6 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.7273 | 7 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 21.5909 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 21.5909 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 21.5909 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 21.5909 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 21.5909 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.5909 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 21.5909 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 21.5909 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.5909 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 21.5909 | 7 | yes |
| GO:0031401 | positive regulation of protein modification process | 21.5909 | 7 | yes |
| GO:0042327 | positive regulation of phosphorylation | 21.5909 | 8 | yes |
| GO:0043933 | protein-containing complex organization | 21.5909 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.5909 | 5 | no |
| GO:0061024 | membrane organization | 20.4545 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.4545 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.4545 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 20.4545 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 20.4545 | 4 | no |
| GO:0051726 | regulation of cell cycle | 20.4545 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 20.4545 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.4545 | 5 | no |
| GO:0043549 | regulation of kinase activity | 20.4545 | 5 | yes |
| GO:0051338 | regulation of transferase activity | 20.4545 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 19.3182 | 8 | yes |
| GO:0031175 | neuron projection development | 19.3182 | 6 | yes |
| GO:0031346 | positive regulation of cell projection organization | 19.3182 | 6 | yes |
| GO:0045859 | regulation of protein kinase activity | 18.1818 | 6 | yes |
| GO:0006468 | protein phosphorylation | 15.9091 | 5 | yes |
| GO:0016310 | phosphorylation | 15.9091 | 5 | yes |
| GO:0022604 | regulation of cell morphogenesis | 15.9091 | 5 | yes |
| GO:0032886 | regulation of microtubule-based process | 15.9091 | 4 | yes |
| GO:0033674 | positive regulation of kinase activity | 15.9091 | 6 | yes |
| GO:0051347 | positive regulation of transferase activity | 15.9091 | 5 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 15.9091 | 5 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 12.5000 | 7 | yes |
| GO:0008360 | regulation of cell shape | 11.3636 | 6 | yes |
| GO:0018193 | peptidyl-amino acid modification | 11.3636 | 5 | yes |
| GO:0007005 | mitochondrion organization | 10.2273 | 5 | yes |
| GO:0010976 | positive regulation of neuron projection development | 10.2273 | 7 | yes |
| GO:0016055 | Wnt signaling pathway | 10.2273 | 5 | yes |
| GO:0043393 | regulation of protein binding | 10.2273 | 4 | yes |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 10.2273 | 4 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 9.0909 | 6 | yes |
| GO:0018209 | peptidyl-serine modification | 9.0909 | 6 | yes |
| GO:0022411 | cellular component disassembly | 9.0909 | 4 | yes |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 7.9545 | 4 | yes |
| GO:0046777 | protein autophosphorylation | 7.9545 | 6 | yes |
| GO:0001764 | neuron migration | 6.8182 | 4 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 6.8182 | 5 | yes |
| GO:1903008 | organelle disassembly | 6.8182 | 5 | yes |
| GO:0050770 | regulation of axonogenesis | 5.6818 | 5 | yes |
| GO:0018107 | peptidyl-threonine phosphorylation | 4.5455 | 6 | yes |
| GO:0018210 | peptidyl-threonine modification | 4.5455 | 6 | yes |
| GO:1904526 | regulation of microtubule binding | 4.5455 | 5 | yes |
| GO:0000422 | autophagy of mitochondrion | 3.4091 | 4 | yes |
| GO:0032147 | activation of protein kinase activity | 3.4091 | 8 | yes |
| GO:0061564 | axon development | 3.4091 | 7 | yes |
| GO:0061726 | mitochondrion disassembly | 3.4091 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MARK2_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 3.4091 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.4091 | 5 | no |
| DOID:114 | heart disease | 3.4091 | 3 | no |
| DOID:0111962 | combined immunodeficiency | 2.2727 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 2.2727 | 3 | no |
| DOID:0050686 | organ system cancer | 2.2727 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARHG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KI13B_HUMAN | [view interactions] | Low throughput | no | yes |
| MTCL1_HUMAN | [view interactions] | Low throughput | no | yes |
| UTRN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRTC2_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCD1_HUMAN | [view interactions] | Low throughput | no | yes |
| TAOK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | Low throughput | no | yes |
| KCC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC7_HUMAN | [view interactions] | Low throughput | no | no |
| PTPA_HUMAN | [view interactions] | Low throughput | no | yes |
| DMD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| GAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| PARD3_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF41_HUMAN | [view interactions] | Low throughput | no | yes |
| CD44_HUMAN | [view interactions] | Low throughput | no | yes |
| STK4_HUMAN | [view interactions] | Low throughput | no | yes |
| STK3_HUMAN | [view interactions] | Low throughput | no | yes |
| STK11_HUMAN | [view interactions] | Low throughput | no | yes |
| RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKD1_HUMAN | [view interactions] | Low throughput | no | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EIF2A_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP21_HUMAN | [view interactions] | Low throughput | no | no |
| KPCI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| UTP18_HUMAN | [view interactions] | High throughput | no | yes |
| CERT_HUMAN | [view interactions] | High throughput | no | yes |
| MARK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP_HUMAN | [view interactions] | High throughput | no | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TRPM7_HUMAN | [view interactions] | High throughput | no | no |
| FXL16_HUMAN | [view interactions] | High throughput | no | yes |
| WDR46_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD7_HUMAN | [view interactions] | High throughput | no | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD82_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| NUP42_HUMAN | [view interactions] | High throughput | no | no |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RSF1_HUMAN | [view interactions] | High throughput | no | yes |
| FRYL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPHLN_HUMAN | [view interactions] | High throughput | no | yes |
| EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARK72_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERI3_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CSF1_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM22_HUMAN | [view interactions] | High throughput | no | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PTPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP89_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAR3L_HUMAN | [view interactions] | High throughput | no | yes |
| MARK4_HUMAN | [view interactions] | High throughput | no | yes |
| TAD2A_HUMAN | [view interactions] | High throughput | no | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| PAR6A_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| CEP57_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NP1L5_HUMAN | [view interactions] | High throughput | no | yes |
| CDK15_HUMAN | [view interactions] | High throughput | no | no |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LDHD_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| CYH1_HUMAN | [view interactions] | High throughput | no | no |
| SRSF8_HUMAN | [view interactions] | High throughput | no | yes |
| TMCC2_HUMAN | [view interactions] | High throughput | no | yes |
| LRC33_HUMAN | [view interactions] | High throughput | no | yes |
| NUAK2_HUMAN | [view interactions] | High throughput | no | yes |
| SIX2_HUMAN | [view interactions] | High throughput | no | no |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| CAD19_HUMAN | [view interactions] | High throughput | no | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| CC14A_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLI1_HUMAN | [view interactions] | High throughput | no | no |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| FGF13_HUMAN | [view interactions] | High throughput | no | no |
| GPSM3_HUMAN | [view interactions] | High throughput | no | no |
| TMM74_HUMAN | [view interactions] | High throughput | no | no |
| MACC1_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC9_HUMAN | [view interactions] | High throughput | no | yes |
| JKIP1_HUMAN | [view interactions] | High throughput | no | no |
| RBM25_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| TPC11_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NED4L_HUMAN | [view interactions] | High throughput | no | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| PAR6G_HUMAN | [view interactions] | High throughput | no | no |
| GASP1_HUMAN | [view interactions] | High throughput | no | yes |
| FUCO_HUMAN | [view interactions] | High throughput | no | yes |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE85L_HUMAN | [view interactions] | High throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S10A8_HUMAN | [view interactions] | Computational | no | no |
| STRAA_HUMAN | [view interactions] | Computational | no | yes |
| STRAB_HUMAN | [view interactions] | Computational | no | no |
| MIB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAB39_HUMAN | [view interactions] | Computational | no | yes |