CD44_HUMAN
Evidence for PS localization
Functions
Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed, PubMed, PubMed). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed, PubMed). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004255 | TRG_DiLeu_BaEn_1 | TRG | 708 | 713 | - |
| ELMI004255 | TRG_DiLeu_BaEn_1 | TRG | 708 | 713 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CD44_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 46.6667 | 4 | no |
| GO:0043168 | anion binding | 46.6667 | 4 | no |
| GO:0017076 | purine nucleotide binding | 45.5556 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 43.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 42.2222 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.7778 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.5556 | 5 | no |
| GO:0019900 | kinase binding | 25.5556 | 4 | no |
| GO:0019901 | protein kinase binding | 25.5556 | 5 | no |
| GO:0005524 | ATP binding | 24.4444 | 5 | no |
| GO:0005540 | hyaluronic acid binding | 3.3333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CD44_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 75.5556 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 55.5556 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 53.3333 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.2222 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.2222 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 51.1111 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 47.7778 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 43.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 42.2222 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 42.2222 | 5 | yes |
| GO:0010468 | regulation of gene expression | 42.2222 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.2222 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 42.2222 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 41.1111 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 41.1111 | 5 | yes |
| GO:0006996 | organelle organization | 41.1111 | 4 | no |
| GO:0008104 | protein localization | 40.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 38.8889 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 38.8889 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 38.8889 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 38.8889 | 5 | yes |
| GO:0022607 | cellular component assembly | 37.7778 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 36.6667 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 35.5556 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | yes |
| GO:0032880 | regulation of protein localization | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 32.2222 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 32.2222 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 32.2222 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 32.2222 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 32.2222 | 4 | no |
| GO:2000145 | regulation of cell motility | 32.2222 | 4 | no |
| GO:0051049 | regulation of transport | 32.2222 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 31.1111 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.1111 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 31.1111 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 31.1111 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 30.0000 | 6 | yes |
| GO:0030334 | regulation of cell migration | 30.0000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 30.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.8889 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 28.8889 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 28.8889 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 28.8889 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.8889 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 28.8889 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.8889 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.7778 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 27.7778 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 27.7778 | 7 | no |
| GO:0141124 | intracellular signaling cassette | 27.7778 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.7778 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.6667 | 4 | yes |
| GO:1903829 | positive regulation of protein localization | 26.6667 | 5 | no |
| GO:0030030 | cell projection organization | 26.6667 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 25.5556 | 7 | yes |
| GO:0045595 | regulation of cell differentiation | 25.5556 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.5556 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.4444 | 7 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 24.4444 | 6 | yes |
| GO:0030155 | regulation of cell adhesion | 24.4444 | 4 | yes |
| GO:0031401 | positive regulation of protein modification process | 24.4444 | 7 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 24.4444 | 7 | yes |
| GO:0080134 | regulation of response to stress | 24.4444 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 24.4444 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 24.4444 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.4444 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 23.3333 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 23.3333 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 23.3333 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 23.3333 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 23.3333 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 23.3333 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.3333 | 4 | no |
| GO:0071702 | organic substance transport | 23.3333 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 23.3333 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 23.3333 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.3333 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 23.3333 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.3333 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 22.2222 | 8 | yes |
| GO:0042327 | positive regulation of phosphorylation | 22.2222 | 8 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 22.2222 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.2222 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.2222 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 22.2222 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 21.1111 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.1111 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.1111 | 6 | no |
| GO:0043408 | regulation of MAPK cascade | 20.0000 | 6 | yes |
| GO:0045785 | positive regulation of cell adhesion | 20.0000 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 20.0000 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 18.8889 | 5 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 17.7778 | 5 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 16.6667 | 7 | yes |
| GO:0022409 | positive regulation of cell-cell adhesion | 14.4444 | 6 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 14.4444 | 4 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 14.4444 | 6 | yes |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | 14.4444 | 6 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 13.3333 | 6 | yes |
| GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 13.3333 | 7 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 13.3333 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 12.2222 | 6 | yes |
| GO:0043086 | negative regulation of catalytic activity | 11.1111 | 4 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 11.1111 | 7 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 11.1111 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 10.0000 | 4 | yes |
| GO:1902743 | regulation of lamellipodium organization | 10.0000 | 7 | yes |
| GO:2001234 | negative regulation of apoptotic signaling pathway | 10.0000 | 6 | yes |
| GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 10.0000 | 6 | yes |
| GO:0006954 | inflammatory response | 8.8889 | 4 | yes |
| GO:0052547 | regulation of peptidase activity | 8.8889 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 8.8889 | 6 | yes |
| GO:0019221 | cytokine-mediated signaling pathway | 7.7778 | 4 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 7.7778 | 5 | yes |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 7.7778 | 8 | yes |
| GO:0080135 | regulation of cellular response to stress | 7.7778 | 4 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 7.7778 | 7 | yes |
| GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | 7.7778 | 7 | yes |
| GO:0007159 | leukocyte cell-cell adhesion | 6.6667 | 4 | yes |
| GO:0007160 | cell-matrix adhesion | 6.6667 | 4 | yes |
| GO:0042110 | T cell activation | 6.6667 | 4 | yes |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 6.6667 | 8 | yes |
| GO:0045861 | negative regulation of proteolysis | 6.6667 | 7 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 6.6667 | 8 | yes |
| GO:0010466 | negative regulation of peptidase activity | 5.5556 | 6 | yes |
| GO:0010951 | negative regulation of endopeptidase activity | 5.5556 | 7 | yes |
| GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 5.5556 | 7 | yes |
| GO:0044319 | wound healing, spreading of cells | 5.5556 | 4 | yes |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 5.5556 | 9 | yes |
| GO:1901136 | carbohydrate derivative catabolic process | 5.5556 | 4 | yes |
| GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 5.5556 | 8 | yes |
| GO:0033135 | regulation of peptidyl-serine phosphorylation | 4.4444 | 8 | yes |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 4.4444 | 9 | yes |
| GO:0034114 | regulation of heterotypic cell-cell adhesion | 4.4444 | 6 | yes |
| GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 4.4444 | 7 | yes |
| GO:0070486 | leukocyte aggregation | 4.4444 | 5 | yes |
| GO:2000392 | regulation of lamellipodium morphogenesis | 4.4444 | 6 | yes |
| GO:0006022 | aminoglycan metabolic process | 3.3333 | 4 | yes |
| GO:0006026 | aminoglycan catabolic process | 3.3333 | 5 | yes |
| GO:0006027 | glycosaminoglycan catabolic process | 3.3333 | 6 | yes |
| GO:0030203 | glycosaminoglycan metabolic process | 3.3333 | 5 | yes |
| GO:0030212 | hyaluronan metabolic process | 3.3333 | 7 | yes |
| GO:0030214 | hyaluronan catabolic process | 3.3333 | 7 | yes |
| GO:1901796 | regulation of signal transduction by p53 class mediator | 3.3333 | 6 | yes |
| GO:1903510 | mucopolysaccharide metabolic process | 3.3333 | 6 | yes |
| GO:0043516 | regulation of DNA damage response, signal transduction by p53 class mediator | 2.2222 | 5 | yes |
| GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 2.2222 | 6 | yes |
| GO:0044344 | cellular response to fibroblast growth factor stimulus | 2.2222 | 5 | yes |
| GO:0051216 | cartilage development | 2.2222 | 4 | yes |
| GO:0070487 | monocyte aggregation | 2.2222 | 6 | yes |
| GO:0071774 | response to fibroblast growth factor | 2.2222 | 4 | yes |
| GO:1900623 | regulation of monocyte aggregation | 2.2222 | 7 | yes |
| GO:1900625 | positive regulation of monocyte aggregation | 2.2222 | 8 | yes |
| GO:1901797 | negative regulation of signal transduction by p53 class mediator | 2.2222 | 7 | yes |
| GO:1902165 | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 2.2222 | 6 | yes |
| GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 2.2222 | 7 | yes |
| GO:1902229 | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 2.2222 | 5 | yes |
| GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 2.2222 | 6 | yes |
| GO:1902253 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 2.2222 | 7 | yes |
| GO:1902254 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 2.2222 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IBP3_HUMAN | [view interactions] | Low throughput | no | no |
| TIAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RADI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| XCT_HUMAN | [view interactions] | Low throughput | no | no |
| 4F2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EZRI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MOES_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TGFR1_HUMAN | [view interactions] | Low throughput | no | no |
| LEG9_HUMAN | [view interactions] | Low throughput | no | yes |
| HYAL2_HUMAN | [view interactions] | Low throughput | no | no |
| ITA4_HUMAN | [view interactions] | Low throughput | no | no |
| HG2A_HUMAN | [view interactions] | Low throughput | no | yes |
| OSTP_HUMAN | [view interactions] | Low throughput | no | yes |
| PACE1_HUMAN | [view interactions] | Low throughput | no | yes |
| CSK_HUMAN | [view interactions] | Low throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRC_HUMAN | [view interactions] | Low throughput | no | no |
| ARHG1_HUMAN | [view interactions] | Low throughput | no | no |
| MMP7_HUMAN | [view interactions] | Low throughput | no | no |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAV2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FINC_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MERL_HUMAN | [view interactions] | Low throughput | no | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD44_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSPG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARHGC_HUMAN | [view interactions] | Low throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP28_HUMAN | [view interactions] | Low throughput | no | yes |
| MARK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MOT1_HUMAN | [view interactions] | Low throughput | no | no |
| MOT5_HUMAN | [view interactions] | Low throughput | no | yes |
| MOT4_HUMAN | [view interactions] | Low throughput | no | yes |
| HBEGF_HUMAN | [view interactions] | Low throughput | no | no |
| MARH8_HUMAN | [view interactions] | Low throughput | no | no |
| ENOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FLOT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | Low throughput | no | no |
| COEA1_HUMAN | [view interactions] | Low throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LYAM2_HUMAN | [view interactions] | Low throughput | no | no |
| TIAM2_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB38_HUMAN | [view interactions] | High throughput | no | no |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB32_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| PHRF1_HUMAN | [view interactions] | High throughput | no | no |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| GMEB2_HUMAN | [view interactions] | High throughput | no | yes |
| FGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GMEB1_HUMAN | [view interactions] | High throughput | no | yes |
| DHRS2_HUMAN | [view interactions] | High throughput | no | no |
| TCAF2_HUMAN | [view interactions] | High throughput | no | no |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| AMPD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX33_HUMAN | [view interactions] | High throughput | no | yes |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| PRD10_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| SNX18_HUMAN | [view interactions] | High throughput | no | no |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| FGRL1_HUMAN | [view interactions] | High throughput | no | yes |
| VANG1_HUMAN | [view interactions] | High throughput | no | no |
| PARP2_HUMAN | [view interactions] | High throughput | no | yes |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| LAMA3_HUMAN | [view interactions] | High throughput | no | no |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCN7_HUMAN | [view interactions] | High throughput | no | yes |
| SYF1_HUMAN | [view interactions] | High throughput | no | no |
| TF3C2_HUMAN | [view interactions] | High throughput | no | no |
| PRP17_HUMAN | [view interactions] | High throughput | no | no |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| AQR_HUMAN | [view interactions] | High throughput | no | no |
| TF3C1_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C6_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM160_HUMAN | [view interactions] | High throughput | no | no |
| OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM22_HUMAN | [view interactions] | High throughput | no | yes |
| VANG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MBOA7_HUMAN | [view interactions] | High throughput | no | no |
| ISY1_HUMAN | [view interactions] | High throughput | no | yes |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IRAK3_HUMAN | [view interactions] | High throughput | no | yes |
| KI2L4_HUMAN | [view interactions] | High throughput | no | no |
| TF3C5_HUMAN | [view interactions] | High throughput | no | yes |
| NAA50_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMP3_HUMAN | [view interactions] | High throughput | no | no |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| FBX43_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CREM_HUMAN | [view interactions] | High throughput | no | no |
| MSX2_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| CDK6_HUMAN | [view interactions] | High throughput | no | yes |
| GRM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERD22_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K5_HUMAN | [view interactions] | High throughput | no | yes |
| ABCB5_HUMAN | [view interactions] | High throughput | no | no |
| ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCND2_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| CDN2B_HUMAN | [view interactions] | High throughput | no | no |
| GLIS2_HUMAN | [view interactions] | High throughput | no | no |
| MP2K3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDM4_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| DPP8_HUMAN | [view interactions] | High throughput | no | yes |
| B2L13_HUMAN | [view interactions] | High throughput | no | no |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL4C_HUMAN | [view interactions] | High throughput | no | yes |
| ARL14_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOB3C_HUMAN | [view interactions] | High throughput | no | no |
| MOB2_HUMAN | [view interactions] | High throughput | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| CHERP_HUMAN | [view interactions] | High throughput | no | no |
| CRBG1_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSN5_HUMAN | [view interactions] | High throughput | no | no |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| TSN12_HUMAN | [view interactions] | High throughput | no | yes |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| HGF_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| TR10A_HUMAN | [view interactions] | High throughput | no | no |