KPCI_HUMAN
Evidence for PS localization
Functions
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001635 | DOC_AGCK_PIF_2 | DOC | 579 | 584 | - |
| ELMI001635 | DOC_AGCK_PIF_2 | DOC | 579 | 584 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KPCI_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 42.8571 | 4 | yes |
| GO:0000166 | nucleotide binding | 42.0635 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 42.0635 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 40.4762 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 38.0952 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 30.1587 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 28.5714 | 5 | yes |
| GO:0005524 | ATP binding | 26.1905 | 5 | yes |
| GO:0003723 | RNA binding | 23.0159 | 4 | no |
| GO:0019900 | kinase binding | 21.4286 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 20.6349 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 20.6349 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.6349 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.6349 | 6 | no |
| GO:0043169 | cation binding | 18.2540 | 4 | yes |
| GO:0046872 | metal ion binding | 18.2540 | 5 | yes |
| GO:0016301 | kinase activity | 14.2857 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 14.2857 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 10.3175 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 9.5238 | 4 | yes |
| GO:0004697 | diacylglycerol-dependent serine/threonine kinase activity | 4.7619 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KPCI_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.0794 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 61.9048 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 59.5238 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 58.7302 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 58.7302 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.3810 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.0317 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 44.4444 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 44.4444 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.6508 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 43.6508 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 42.0635 | 5 | no |
| GO:0010468 | regulation of gene expression | 42.0635 | 6 | yes |
| GO:0051128 | regulation of cellular component organization | 41.2698 | 4 | yes |
| GO:0006996 | organelle organization | 41.2698 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.4762 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 38.8889 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.0952 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 37.3016 | 5 | no |
| GO:0008104 | protein localization | 35.7143 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 35.7143 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 35.7143 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 34.9206 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 34.1270 | 4 | yes |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0031399 | regulation of protein modification process | 31.7460 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 31.7460 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 31.7460 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 30.9524 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.9524 | 5 | yes |
| GO:0051049 | regulation of transport | 28.5714 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 28.5714 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 28.5714 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 27.7778 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.7778 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.7778 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.9841 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.1905 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 26.1905 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 26.1905 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.1905 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.1905 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.1905 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.1905 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.1905 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 25.3968 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.3968 | 6 | no |
| GO:0009894 | regulation of catabolic process | 25.3968 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.3968 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 25.3968 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 24.6032 | 7 | no |
| GO:0032880 | regulation of protein localization | 24.6032 | 5 | yes |
| GO:0036211 | protein modification process | 24.6032 | 4 | yes |
| GO:0043412 | macromolecule modification | 24.6032 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 23.8095 | 6 | no |
| GO:0071702 | organic substance transport | 23.8095 | 4 | no |
| GO:0080134 | regulation of response to stress | 23.8095 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.0159 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 23.0159 | 6 | yes |
| GO:0071705 | nitrogen compound transport | 23.0159 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.0159 | 7 | yes |
| GO:0007010 | cytoskeleton organization | 23.0159 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 22.2222 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 22.2222 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.4286 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.4286 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.6349 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.6349 | 6 | no |
| GO:0033043 | regulation of organelle organization | 20.6349 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 19.8413 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 19.8413 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 19.8413 | 4 | yes |
| GO:1903829 | positive regulation of protein localization | 19.0476 | 5 | yes |
| GO:0016310 | phosphorylation | 18.2540 | 5 | yes |
| GO:0061024 | membrane organization | 17.4603 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 16.6667 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 16.6667 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 16.6667 | 5 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 15.8730 | 4 | yes |
| GO:0051050 | positive regulation of transport | 15.0794 | 4 | yes |
| GO:0006468 | protein phosphorylation | 15.0794 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 13.4921 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 13.4921 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 13.4921 | 5 | yes |
| GO:0060284 | regulation of cell development | 12.6984 | 5 | yes |
| GO:0032870 | cellular response to hormone stimulus | 11.9048 | 4 | yes |
| GO:0031346 | positive regulation of cell projection organization | 11.1111 | 6 | yes |
| GO:0043065 | positive regulation of apoptotic process | 11.1111 | 6 | yes |
| GO:0043068 | positive regulation of programmed cell death | 11.1111 | 5 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 10.3175 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 10.3175 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 10.3175 | 7 | yes |
| GO:0018193 | peptidyl-amino acid modification | 10.3175 | 5 | yes |
| GO:0007015 | actin filament organization | 9.5238 | 5 | yes |
| GO:0034097 | response to cytokine | 9.5238 | 4 | yes |
| GO:1905475 | regulation of protein localization to membrane | 8.7302 | 6 | yes |
| GO:0006605 | protein targeting | 8.7302 | 4 | yes |
| GO:0034330 | cell junction organization | 8.7302 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 8.7302 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 7.1429 | 5 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 7.1429 | 6 | yes |
| GO:1905477 | positive regulation of protein localization to membrane | 7.1429 | 6 | yes |
| GO:0010720 | positive regulation of cell development | 7.1429 | 6 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 7.1429 | 6 | yes |
| GO:0050767 | regulation of neurogenesis | 6.3492 | 6 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 6.3492 | 4 | yes |
| GO:0071375 | cellular response to peptide hormone stimulus | 6.3492 | 5 | yes |
| GO:0010976 | positive regulation of neuron projection development | 6.3492 | 7 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 6.3492 | 6 | yes |
| GO:0018209 | peptidyl-serine modification | 6.3492 | 6 | yes |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 6.3492 | 4 | yes |
| GO:0043434 | response to peptide hormone | 6.3492 | 4 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 6.3492 | 5 | yes |
| GO:0046903 | secretion | 6.3492 | 4 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 5.5556 | 5 | yes |
| GO:1904377 | positive regulation of protein localization to cell periphery | 5.5556 | 6 | yes |
| GO:0043524 | negative regulation of neuron apoptotic process | 5.5556 | 7 | yes |
| GO:0045216 | cell-cell junction organization | 5.5556 | 5 | yes |
| GO:0048666 | neuron development | 4.7619 | 4 | yes |
| GO:0051962 | positive regulation of nervous system development | 4.7619 | 5 | yes |
| GO:0072657 | protein localization to membrane | 4.7619 | 4 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 4.7619 | 7 | yes |
| GO:1903078 | positive regulation of protein localization to plasma membrane | 4.7619 | 7 | yes |
| GO:0050769 | positive regulation of neurogenesis | 3.9683 | 6 | yes |
| GO:0070555 | response to interleukin-1 | 3.9683 | 5 | yes |
| GO:0032868 | response to insulin | 3.9683 | 5 | yes |
| GO:0032869 | cellular response to insulin stimulus | 3.9683 | 6 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 3.9683 | 5 | yes |
| GO:0061162 | establishment of monopolar cell polarity | 3.1746 | 4 | yes |
| GO:0090150 | establishment of protein localization to membrane | 3.1746 | 4 | yes |
| GO:1904035 | regulation of epithelial cell apoptotic process | 3.1746 | 6 | yes |
| GO:2000351 | regulation of endothelial cell apoptotic process | 3.1746 | 7 | yes |
| GO:0034350 | regulation of glial cell apoptotic process | 3.1746 | 6 | yes |
| GO:0034351 | negative regulation of glial cell apoptotic process | 3.1746 | 7 | yes |
| GO:0035089 | establishment of apical/basal cell polarity | 3.1746 | 5 | yes |
| GO:0060251 | regulation of glial cell proliferation | 2.3810 | 5 | yes |
| GO:0060252 | positive regulation of glial cell proliferation | 2.3810 | 6 | yes |
| GO:0006612 | protein targeting to membrane | 2.3810 | 5 | yes |
| GO:0008593 | regulation of Notch signaling pathway | 2.3810 | 5 | yes |
| GO:0014013 | regulation of gliogenesis | 2.3810 | 7 | yes |
| GO:0014015 | positive regulation of gliogenesis | 2.3810 | 7 | yes |
| GO:0016050 | vesicle organization | 2.3810 | 5 | yes |
| GO:0042461 | photoreceptor cell development | 2.3810 | 5 | yes |
| GO:0042462 | eye photoreceptor cell development | 2.3810 | 6 | yes |
| GO:0048194 | Golgi vesicle budding | 1.5873 | 6 | yes |
| GO:1904037 | positive regulation of epithelial cell apoptotic process | 1.5873 | 7 | yes |
| GO:2000353 | positive regulation of endothelial cell apoptotic process | 1.5873 | 8 | yes |
| GO:0006900 | vesicle budding from membrane | 1.5873 | 5 | yes |
| GO:0010827 | regulation of glucose transmembrane transport | 1.5873 | 5 | yes |
| GO:0010828 | positive regulation of glucose transmembrane transport | 1.5873 | 6 | yes |
| GO:0045747 | positive regulation of Notch signaling pathway | 1.5873 | 6 | yes |
| GO:0046324 | regulation of glucose import | 1.5873 | 6 | yes |
| GO:0046326 | positive regulation of glucose import | 1.5873 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PDPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ELF3_HUMAN | [view interactions] | Low throughput | no | no |
| EXOC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTSS1_HUMAN | [view interactions] | Low throughput | no | no |
| SOX2_HUMAN | [view interactions] | Low throughput | no | yes |
| SMG1_HUMAN | [view interactions] | Low throughput | no | yes |
| FRS2_HUMAN | [view interactions] | Low throughput | no | no |
| ADAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| G3P_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
| IKKA_HUMAN | [view interactions] | Low throughput | no | yes |
| GAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| CCNT1_HUMAN | [view interactions] | Low throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ASPP2_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAR6A_HUMAN | [view interactions] | Low throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDK7_HUMAN | [view interactions] | Low throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DIDO1_HUMAN | [view interactions] | Low throughput | no | yes |
| FCG3A_HUMAN | [view interactions] | Low throughput | no | no |
| ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PARD3_HUMAN | [view interactions] | Low throughput | no | yes |
| MARK4_HUMAN | [view interactions] | Low throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLI1_HUMAN | [view interactions] | Low throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| BIG1_HUMAN | [view interactions] | High throughput | no | yes |
| STK24_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C5_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NOC2L_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RT18C_HUMAN | [view interactions] | High throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| MFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| MBB1A_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| TCF25_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM53_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| BRX1_HUMAN | [view interactions] | High throughput | no | no |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| RM10_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| S35G1_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MOGS_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAT1_HUMAN | [view interactions] | High throughput | no | yes |
| S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RT09_HUMAN | [view interactions] | High throughput | no | yes |
| RT34_HUMAN | [view interactions] | High throughput | no | yes |
| RT35_HUMAN | [view interactions] | High throughput | no | yes |
| RT10_HUMAN | [view interactions] | High throughput | no | yes |
| RT25_HUMAN | [view interactions] | High throughput | no | yes |
| RT22_HUMAN | [view interactions] | High throughput | no | yes |
| CSK23_HUMAN | [view interactions] | High throughput | no | no |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| RT29_HUMAN | [view interactions] | High throughput | no | yes |
| CPT1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S1A7A_HUMAN | [view interactions] | High throughput | no | no |
| S10A7_HUMAN | [view interactions] | High throughput | no | no |
| KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| HSP77_HUMAN | [view interactions] | High throughput | no | no |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL1D1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPOM_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| RM15_HUMAN | [view interactions] | High throughput | no | yes |
| RM39_HUMAN | [view interactions] | High throughput | no | yes |
| RT18A_HUMAN | [view interactions] | High throughput | no | yes |
| RM47_HUMAN | [view interactions] | High throughput | no | yes |
| RM45_HUMAN | [view interactions] | High throughput | no | no |
| RM38_HUMAN | [view interactions] | High throughput | no | yes |
| PRP16_HUMAN | [view interactions] | High throughput | no | yes |
| RM43_HUMAN | [view interactions] | High throughput | no | no |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| RM02_HUMAN | [view interactions] | High throughput | no | yes |
| RM23_HUMAN | [view interactions] | High throughput | no | yes |
| DDX10_HUMAN | [view interactions] | High throughput | no | yes |
| RM28_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| CASP8_HUMAN | [view interactions] | High throughput | no | yes |
| IL1AP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| NACC1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| DUS1_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| MP2K5_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRX_HUMAN | [view interactions] | High throughput | no | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RASF8_HUMAN | [view interactions] | High throughput | no | yes |
| TM208_HUMAN | [view interactions] | High throughput | no | yes |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| GWL_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5E_HUMAN | [view interactions] | High throughput | no | no |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOL8_HUMAN | [view interactions] | High throughput | no | yes |
| PRR3_HUMAN | [view interactions] | High throughput | no | no |
| INT14_HUMAN | [view interactions] | High throughput | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FARP2_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGG_HUMAN | [view interactions] | High throughput | no | yes |
| PDGFD_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| KIBRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| C2C4A_HUMAN | [view interactions] | High throughput | no | no |
| ST14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPXN4_HUMAN | [view interactions] | High throughput | no | no |
| IL17F_HUMAN | [view interactions] | High throughput | no | no |
| S66AL_HUMAN | [view interactions] | High throughput | no | no |
| GNLY_HUMAN | [view interactions] | High throughput | no | no |
| EP3B_HUMAN | [view interactions] | High throughput | no | no |
| LRC17_HUMAN | [view interactions] | High throughput | no | no |
| IL7RA_HUMAN | [view interactions] | High throughput | no | no |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| GREM2_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAR6B_HUMAN | [view interactions] | High throughput | no | no |
| PAR6G_HUMAN | [view interactions] | High throughput | no | no |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| FABP4_HUMAN | [view interactions] | High throughput | no | no |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| TTHY_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1A_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1B_HUMAN | [view interactions] | High throughput | no | yes |
| L2GL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP20_HUMAN | [view interactions] | High throughput | no | yes |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF3B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| L2GL2_HUMAN | [view interactions] | High throughput | no | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| RPGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| RINI_HUMAN | [view interactions] | High throughput | no | yes |
| MYO10_HUMAN | [view interactions] | High throughput | no | no |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| GNS_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAKAI_HUMAN | [view interactions] | High throughput | no | yes |
| TAF6_HUMAN | [view interactions] | High throughput | no | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| TIM23_HUMAN | [view interactions] | High throughput | no | yes |
| SMD3_HUMAN | [view interactions] | High throughput | no | yes |
| TM165_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF3_HUMAN | [view interactions] | High throughput | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM160_HUMAN | [view interactions] | High throughput | no | no |
| IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT5EL_HUMAN | [view interactions] | High throughput | no | no |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MBD4_HUMAN | [view interactions] | High throughput | no | yes |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT18B_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| LSG1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPV_HUMAN | [view interactions] | High throughput | no | yes |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADRM1_HUMAN | [view interactions] | High throughput | no | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| LAMA1_HUMAN | [view interactions] | High throughput | no | no |
| 5MP2_HUMAN | [view interactions] | High throughput | no | yes |
| LA_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN609_HUMAN | [view interactions] | High throughput | no | yes |
| TOPK_HUMAN | [view interactions] | High throughput | no | no |
| MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| DDX23_HUMAN | [view interactions] | High throughput | no | yes |
| KERA_HUMAN | [view interactions] | High throughput | no | no |
| NADAP_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| GP156_HUMAN | [view interactions] | High throughput | no | no |
| BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| NGEF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |