Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MBP_HUMAN

GO
G2C
SynGO

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MBP_HUMAN
GO:0000166 nucleotide binding 53.3333 4 no
GO:0043168 anion binding 53.3333 4 no
GO:0017076 purine nucleotide binding 51.6667 5 no
GO:0032555 purine ribonucleotide binding 51.6667 4 no
GO:0035639 purine ribonucleoside triphosphate binding 51.6667 4 no
GO:0005524 ATP binding 48.3333 5 no
GO:0030554 adenyl nucleotide binding 48.3333 6 no
GO:0032559 adenyl ribonucleotide binding 48.3333 5 no
GO:0016301 kinase activity 46.6667 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 46.6667 4 no
GO:0043169 cation binding 43.3333 4 no
GO:0046872 metal ion binding 41.6667 5 no
GO:0019900 kinase binding 35.0000 4 no
GO:0004674 protein serine/threonine kinase activity 33.3333 4 no
GO:0106310 protein serine kinase activity 33.3333 4 no
GO:0019901 protein kinase binding 31.6667 5 no
GO:0002020 protease binding 6.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MBP_HUMAN
GO:0048522 positive regulation of cellular process 81.6667 4 yes
GO:0048523 negative regulation of cellular process 76.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 yes
GO:0031323 regulation of cellular metabolic process 73.3333 4 yes
GO:0080090 regulation of primary metabolic process 73.3333 4 yes
GO:0010646 regulation of cell communication 71.6667 4 no
GO:0009966 regulation of signal transduction 66.6667 4 no
GO:0031326 regulation of cellular biosynthetic process 60.0000 5 yes
GO:0051246 regulation of protein metabolic process 60.0000 5 yes
GO:0009889 regulation of biosynthetic process 60.0000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 60.0000 5 yes
GO:0010468 regulation of gene expression 58.3333 6 yes
GO:0051128 regulation of cellular component organization 56.6667 4 no
GO:0009893 positive regulation of metabolic process 56.6667 4 yes
GO:1902531 regulation of intracellular signal transduction 55.0000 5 no
GO:0036211 protein modification process 55.0000 4 no
GO:0043412 macromolecule modification 55.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 53.3333 5 yes
GO:0031325 positive regulation of cellular metabolic process 51.6667 5 yes
GO:0006796 phosphate-containing compound metabolic process 51.6667 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0031399 regulation of protein modification process 48.3333 6 no
GO:0051049 regulation of transport 48.3333 4 no
GO:0016310 phosphorylation 48.3333 5 no
GO:0009892 negative regulation of metabolic process 46.6667 4 no
GO:0019220 regulation of phosphate metabolic process 46.6667 6 no
GO:0051174 regulation of phosphorus metabolic process 46.6667 5 no
GO:0006468 protein phosphorylation 46.6667 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 46.6667 5 no
GO:0023056 positive regulation of signaling 46.6667 4 no
GO:0051247 positive regulation of protein metabolic process 45.0000 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 45.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 43.3333 5 no
GO:0042325 regulation of phosphorylation 43.3333 7 no
GO:0010647 positive regulation of cell communication 43.3333 5 no
GO:0022607 cellular component assembly 43.3333 4 no
GO:0001932 regulation of protein phosphorylation 41.6667 7 no
GO:0051252 regulation of RNA metabolic process 41.6667 5 no
GO:0043085 positive regulation of catalytic activity 40.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 40.0000 4 yes
GO:0042981 regulation of apoptotic process 40.0000 5 no
GO:0043067 regulation of programmed cell death 40.0000 4 no
GO:0071310 cellular response to organic substance 40.0000 4 no
GO:0002684 positive regulation of immune system process 38.3333 4 no
GO:0009967 positive regulation of signal transduction 38.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 36.6667 6 yes
GO:0006355 regulation of DNA-templated transcription 36.6667 7 no
GO:1901701 cellular response to oxygen-containing compound 36.6667 4 no
GO:2001141 regulation of RNA biosynthetic process 36.6667 6 no
GO:0009891 positive regulation of biosynthetic process 36.6667 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 35.0000 6 no
GO:0042327 positive regulation of phosphorylation 35.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 35.0000 7 no
GO:0051248 negative regulation of protein metabolic process 35.0000 6 no
GO:0006996 organelle organization 35.0000 4 no
GO:0018193 peptidyl-amino acid modification 35.0000 5 no
GO:0048585 negative regulation of response to stimulus 35.0000 4 no
GO:0050776 regulation of immune response 35.0000 4 no
GO:0051130 positive regulation of cellular component organization 35.0000 5 no
GO:0141124 intracellular signaling cassette 33.3333 4 yes
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 yes
GO:0051336 regulation of hydrolase activity 31.6667 4 yes
GO:0009968 negative regulation of signal transduction 31.6667 5 no
GO:0022603 regulation of anatomical structure morphogenesis 31.6667 4 no
GO:0043066 negative regulation of apoptotic process 31.6667 6 no
GO:0043069 negative regulation of programmed cell death 31.6667 5 no
GO:0051338 regulation of transferase activity 30.0000 4 no
GO:0008104 protein localization 30.0000 4 no
GO:0009894 regulation of catabolic process 30.0000 4 no
GO:0042127 regulation of cell population proliferation 30.0000 4 no
GO:0043408 regulation of MAPK cascade 30.0000 6 no
GO:0044087 regulation of cellular component biogenesis 30.0000 4 no
GO:0050778 positive regulation of immune response 30.0000 5 no
GO:0031400 negative regulation of protein modification process 28.3333 7 no
GO:0030030 cell projection organization 28.3333 4 no
GO:0045595 regulation of cell differentiation 28.3333 4 no
GO:0050804 modulation of chemical synaptic transmission 28.3333 5 no
GO:0099177 regulation of trans-synaptic signaling 28.3333 4 no
GO:1902533 positive regulation of intracellular signal transduction 28.3333 6 no
GO:0032101 regulation of response to external stimulus 28.3333 4 no
GO:0034762 regulation of transmembrane transport 26.6667 4 no
GO:0051050 positive regulation of transport 26.6667 4 no
GO:0051726 regulation of cell cycle 26.6667 4 no
GO:0010243 response to organonitrogen compound 26.6667 4 no
GO:0031344 regulation of cell projection organization 26.6667 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.6667 5 no
GO:0051094 positive regulation of developmental process 26.6667 4 no
GO:0120036 plasma membrane bounded cell projection organization 26.6667 5 no
GO:0009890 negative regulation of biosynthetic process 26.6667 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 26.6667 6 no
GO:0031327 negative regulation of cellular biosynthetic process 26.6667 6 no
GO:0030155 regulation of cell adhesion 25.0000 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:1901699 cellular response to nitrogen compound 25.0000 4 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0030162 regulation of proteolysis 23.3333 6 yes
GO:0051345 positive regulation of hydrolase activity 23.3333 5 yes
GO:0045859 regulation of protein kinase activity 23.3333 6 no
GO:0051347 positive regulation of transferase activity 23.3333 5 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 23.3333 4 no
GO:0002768 immune response-regulating cell surface receptor signaling pathway 23.3333 4 no
GO:0006357 regulation of transcription by RNA polymerase II 23.3333 8 no
GO:0006915 apoptotic process 23.3333 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 23.3333 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 23.3333 5 no
GO:0051254 positive regulation of RNA metabolic process 23.3333 6 no
GO:0060627 regulation of vesicle-mediated transport 23.3333 4 no
GO:0071417 cellular response to organonitrogen compound 23.3333 4 no
GO:1902903 regulation of supramolecular fiber organization 23.3333 5 no
GO:0031347 regulation of defense response 23.3333 5 no
GO:0051129 negative regulation of cellular component organization 23.3333 5 no
GO:1903829 positive regulation of protein localization 23.3333 5 no
GO:0010629 negative regulation of gene expression 23.3333 7 no
GO:0010628 positive regulation of gene expression 23.3333 7 yes
GO:0042326 negative regulation of phosphorylation 21.6667 8 no
GO:0007010 cytoskeleton organization 21.6667 5 no
GO:0030334 regulation of cell migration 21.6667 5 no
GO:0031329 regulation of cellular catabolic process 21.6667 5 no
GO:0050890 cognition 21.6667 4 no
GO:0060284 regulation of cell development 21.6667 5 no
GO:0065003 protein-containing complex assembly 21.6667 5 no
GO:0018105 peptidyl-serine phosphorylation 21.6667 6 no
GO:0018209 peptidyl-serine modification 21.6667 6 no
GO:0001817 regulation of cytokine production 21.6667 4 yes
GO:0022407 regulation of cell-cell adhesion 20.0000 5 yes
GO:0061024 membrane organization 16.6667 4 yes
GO:0001819 positive regulation of cytokine production 16.6667 5 yes
GO:0042552 myelination 15.0000 4 yes
GO:0045862 positive regulation of proteolysis 15.0000 7 yes
GO:0052547 regulation of peptidase activity 15.0000 5 yes
GO:0052548 regulation of endopeptidase activity 15.0000 6 yes
GO:0000165 MAPK cascade 15.0000 5 yes
GO:0098916 anterograde trans-synaptic signaling 10.0000 6 yes
GO:0099536 synaptic signaling 10.0000 4 yes
GO:0099537 trans-synaptic signaling 10.0000 5 yes
GO:0007162 negative regulation of cell adhesion 10.0000 5 yes
GO:0007268 chemical synaptic transmission 10.0000 7 yes
GO:0010950 positive regulation of endopeptidase activity 10.0000 7 yes
GO:0010952 positive regulation of peptidase activity 10.0000 6 yes
GO:0021762 substantia nigra development 10.0000 4 yes
GO:0001894 tissue homeostasis 8.3333 4 yes
GO:0022408 negative regulation of cell-cell adhesion 8.3333 6 yes
GO:0032642 regulation of chemokine production 6.6667 5 yes
GO:0007417 central nervous system development 6.6667 4 yes
GO:0007600 sensory perception 6.6667 4 yes
GO:0032675 regulation of interleukin-6 production 5.0000 5 yes
GO:0032722 positive regulation of chemokine production 5.0000 6 yes
GO:0032755 positive regulation of interleukin-6 production 5.0000 6 yes
GO:0034114 regulation of heterotypic cell-cell adhesion 5.0000 6 yes
GO:0034115 negative regulation of heterotypic cell-cell adhesion 3.3333 7 yes
GO:0035633 maintenance of blood-brain barrier 3.3333 5 yes
GO:0050954 sensory perception of mechanical stimulus 3.3333 5 yes
GO:0070587 regulation of cell-cell adhesion involved in gastrulation 3.3333 6 yes
GO:1904683 regulation of metalloendopeptidase activity 3.3333 7 yes
GO:1904685 positive regulation of metalloendopeptidase activity 3.3333 8 yes
GO:1905048 regulation of metallopeptidase activity 3.3333 6 yes
GO:1905050 positive regulation of metallopeptidase activity 3.3333 7 yes
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 3.3333 6 yes
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 3.3333 7 yes
GO:0007605 sensory perception of sound 3.3333 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DRB1_HUMAN [view interactions] Low throughput no no
MBP_HUMAN [view entry] [view interactions] Low throughput yes no
DRB5_HUMAN [view interactions] Low throughput no no
TRAC_HUMAN [view interactions] Low throughput no no
TRBC1_HUMAN [view interactions] Low throughput no no
KCMA1_HUMAN [view entry] [view interactions] Low throughput yes no
DMA_HUMAN [view interactions] Low throughput no yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
TOPK_HUMAN [view interactions] Low throughput no no
PLK4_HUMAN [view interactions] Low throughput no yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
CCR1_HUMAN [view interactions] Low throughput no no
PTAFR_HUMAN [view interactions] Low throughput no yes
DRA_HUMAN [view interactions] Low throughput no no
RIGI_HUMAN [view interactions] Low throughput no yes
DDX54_HUMAN [view interactions] Low throughput no yes
KCNH5_HUMAN [view interactions] Low throughput no no
MYPR_HUMAN [view entry] [view interactions] Low throughput yes yes
TRPM7_HUMAN [view interactions] Low throughput no no
ANM5_HUMAN [view entry] [view interactions] Low throughput yes yes
STK39_HUMAN [view entry] [view interactions] Low throughput yes yes
TSSK6_HUMAN [view interactions] Low throughput no no
KS6A5_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCI_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
2A5G_HUMAN [view interactions] Low throughput no yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
LIMK1_HUMAN [view entry] [view interactions] Low throughput yes yes
LIMK2_HUMAN [view interactions] Low throughput no yes
PTN6_HUMAN [view interactions] Low throughput no no
TBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
IKKE_HUMAN [view interactions] Low throughput no yes
STK3_HUMAN [view interactions] Low throughput no yes
KSR1_HUMAN [view interactions] Low throughput no yes
MK14_HUMAN [view interactions] Low throughput no yes
LRRK2_HUMAN [view interactions] Low throughput no yes
PRKDC_HUMAN [view entry] [view interactions] Low throughput yes yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K5_HUMAN [view interactions] Low throughput no yes
TLK1_HUMAN [view interactions] Low throughput no yes
MELK_HUMAN [view interactions] Low throughput no yes
CDK7_HUMAN [view interactions] Low throughput no yes
CDK8_HUMAN [view interactions] Low throughput no no
CDK9_HUMAN [view interactions] Low throughput no yes
HIPK2_HUMAN [view interactions] Low throughput no yes
PKN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ULK1_HUMAN [view interactions] Low throughput no no
PAK2_HUMAN [view entry] [view interactions] Low throughput yes no
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
ILK_HUMAN [view interactions] Low throughput no no
MP2K1_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K1_HUMAN [view interactions] Low throughput no yes
MK08_HUMAN [view interactions] Low throughput no yes
PTPRA_HUMAN [view interactions] Low throughput no yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
AURKA_HUMAN [view entry] [view interactions] Low throughput yes no
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
EEA1_HUMAN [view entry] [view interactions] Low throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CATD_HUMAN [view interactions] Low throughput no yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
STING_HUMAN [view interactions] High throughput no yes
APTX_HUMAN [view interactions] High throughput no yes
ATN1_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
NCK1_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
PGFRL_HUMAN [view interactions] High throughput no no
CTDS1_HUMAN [view interactions] High throughput no no
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
RXRB_HUMAN [view interactions] High throughput no yes
CTDSL_HUMAN [view interactions] High throughput no no
PKHF2_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
RBPMS_HUMAN [view interactions] High throughput no no
EXOS8_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
SRSF9_HUMAN [view interactions] High throughput no yes
APH1A_HUMAN [view interactions] High throughput no yes
APH1B_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
MYH6_HUMAN [view entry] [view interactions] High throughput yes no
TF3C2_HUMAN [view interactions] High throughput no no
NEUL_HUMAN [view interactions] High throughput no yes
IDE_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
IFN21_HUMAN [view interactions] High throughput no no
DUS22_HUMAN [view interactions] High throughput no yes
CTDS2_HUMAN [view interactions] High throughput no yes
NMT1_HUMAN [view interactions] High throughput no yes
ZER1_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
RHG24_HUMAN [view interactions] High throughput no yes
FBX34_HUMAN [view interactions] High throughput no no
MUS81_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
IRAK4_HUMAN [view interactions] High throughput no yes
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
MK12_HUMAN [view interactions] High throughput no no
MK11_HUMAN [view interactions] High throughput no yes
MK13_HUMAN [view interactions] High throughput no yes
CDK1_HUMAN [view interactions] High throughput no no
CDK5_HUMAN [view entry] [view interactions] High throughput yes yes
M3K3_HUMAN [view interactions] High throughput no no
YES_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PHEX_HUMAN [view interactions] High throughput no no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
ITK_HUMAN [view interactions] High throughput no no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
LCK_HUMAN [view entry] [view interactions] High throughput yes no
HCK_HUMAN [view entry] [view interactions] High throughput yes no
HCLS1_HUMAN [view interactions] High throughput no no
VAV_HUMAN [view interactions] High throughput no no
NEBU_HUMAN [view interactions] High throughput no no
RASA1_HUMAN [view interactions] High throughput no yes
ABL2_HUMAN [view entry] [view interactions] High throughput yes yes
BLK_HUMAN [view interactions] High throughput no no
VAV2_HUMAN [view entry] [view interactions] High throughput yes yes
BTK_HUMAN [view interactions] High throughput no no
ARHG5_HUMAN [view interactions] High throughput no yes
ARHG7_HUMAN [view entry] [view interactions] High throughput yes yes
MPP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
STAM1_HUMAN [view interactions] High throughput no yes
PEX13_HUMAN [view interactions] High throughput no yes
P85B_HUMAN [view interactions] High throughput no yes
FYB1_HUMAN [view interactions] High throughput no no
NEIL3_HUMAN [view interactions] High throughput no no
KS6A6_HUMAN [view interactions] High throughput no yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
GSTP1_HUMAN [view entry] [view interactions] High throughput yes no
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no