Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LIMK1_HUMAN

Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in LIMK1_HUMAN
GO:0000166 nucleotide binding 60.9756 4 yes
GO:0017076 purine nucleotide binding 60.9756 5 yes
GO:0030554 adenyl nucleotide binding 60.9756 6 yes
GO:0032555 purine ribonucleotide binding 58.5366 4 yes
GO:0032559 adenyl ribonucleotide binding 58.5366 5 yes
GO:0043168 anion binding 58.5366 4 yes
GO:0005524 ATP binding 56.0976 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 56.0976 4 yes
GO:0016301 kinase activity 46.3415 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 46.3415 4 yes
GO:0043169 cation binding 41.4634 4 yes
GO:0046872 metal ion binding 41.4634 5 yes
GO:0019900 kinase binding 39.0244 4 no
GO:0019901 protein kinase binding 39.0244 5 no
GO:0004674 protein serine/threonine kinase activity 36.5854 4 yes
GO:0106310 protein serine kinase activity 34.1463 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LIMK1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 75.6098 4 yes
GO:0080090 regulation of primary metabolic process 73.1707 4 yes
GO:0048522 positive regulation of cellular process 65.8537 4 yes
GO:0031323 regulation of cellular metabolic process 65.8537 4 no
GO:0048523 negative regulation of cellular process 65.8537 4 no
GO:0010646 regulation of cell communication 63.4146 4 no
GO:0006796 phosphate-containing compound metabolic process 60.9756 4 yes
GO:0051128 regulation of cellular component organization 58.5366 4 yes
GO:0051246 regulation of protein metabolic process 58.5366 5 yes
GO:0009966 regulation of signal transduction 56.0976 4 no
GO:0009892 negative regulation of metabolic process 53.6585 4 yes
GO:0016310 phosphorylation 53.6585 5 yes
GO:0048584 positive regulation of response to stimulus 53.6585 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 51.2195 5 yes
GO:0036211 protein modification process 51.2195 4 yes
GO:0043412 macromolecule modification 51.2195 4 yes
GO:0009893 positive regulation of metabolic process 51.2195 4 no
GO:0009889 regulation of biosynthetic process 51.2195 4 no
GO:0010556 regulation of macromolecule biosynthetic process 51.2195 5 no
GO:0031326 regulation of cellular biosynthetic process 51.2195 5 no
GO:0006996 organelle organization 48.7805 4 yes
GO:0031399 regulation of protein modification process 48.7805 6 yes
GO:0031325 positive regulation of cellular metabolic process 48.7805 5 no
GO:1902531 regulation of intracellular signal transduction 48.7805 5 no
GO:0010468 regulation of gene expression 48.7805 6 no
GO:0010604 positive regulation of macromolecule metabolic process 46.3415 5 no
GO:0010647 positive regulation of cell communication 46.3415 5 no
GO:0019220 regulation of phosphate metabolic process 46.3415 6 no
GO:0023056 positive regulation of signaling 46.3415 4 no
GO:0051174 regulation of phosphorus metabolic process 46.3415 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 46.3415 5 no
GO:0051049 regulation of transport 46.3415 4 no
GO:0006468 protein phosphorylation 43.9024 5 yes
GO:0008104 protein localization 43.9024 4 no
GO:0009967 positive regulation of signal transduction 41.4634 5 no
GO:0042325 regulation of phosphorylation 41.4634 7 no
GO:0031324 negative regulation of cellular metabolic process 41.4634 5 no
GO:0022607 cellular component assembly 39.0244 4 yes
GO:0051240 positive regulation of multicellular organismal process 39.0244 4 yes
GO:0001932 regulation of protein phosphorylation 39.0244 7 no
GO:0051247 positive regulation of protein metabolic process 39.0244 6 no
GO:0042981 regulation of apoptotic process 39.0244 5 no
GO:0043067 regulation of programmed cell death 39.0244 4 no
GO:0032880 regulation of protein localization 36.5854 5 no
GO:0060341 regulation of cellular localization 36.5854 4 no
GO:0044087 regulation of cellular component biogenesis 36.5854 4 yes
GO:0051248 negative regulation of protein metabolic process 36.5854 6 yes
GO:0043408 regulation of MAPK cascade 36.5854 6 no
GO:0080134 regulation of response to stress 36.5854 4 no
GO:0051252 regulation of RNA metabolic process 36.5854 5 no
GO:0002684 positive regulation of immune system process 34.1463 4 yes
GO:0031400 negative regulation of protein modification process 34.1463 7 yes
GO:0050776 regulation of immune response 34.1463 4 yes
GO:0051130 positive regulation of cellular component organization 34.1463 5 yes
GO:0032101 regulation of response to external stimulus 34.1463 4 no
GO:1902533 positive regulation of intracellular signal transduction 34.1463 6 no
GO:0031328 positive regulation of cellular biosynthetic process 31.7073 6 no
GO:0045595 regulation of cell differentiation 31.7073 4 yes
GO:0051094 positive regulation of developmental process 31.7073 4 yes
GO:0051338 regulation of transferase activity 31.7073 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 31.7073 6 no
GO:0031401 positive regulation of protein modification process 31.7073 7 no
GO:0042327 positive regulation of phosphorylation 31.7073 8 no
GO:0045937 positive regulation of phosphate metabolic process 31.7073 7 no
GO:0009894 regulation of catabolic process 31.7073 4 no
GO:0010243 response to organonitrogen compound 31.7073 4 no
GO:0043066 negative regulation of apoptotic process 31.7073 6 no
GO:0043069 negative regulation of programmed cell death 31.7073 5 no
GO:0009891 positive regulation of biosynthetic process 31.7073 5 no
GO:0051050 positive regulation of transport 29.2683 4 no
GO:0071310 cellular response to organic substance 29.2683 4 no
GO:1903829 positive regulation of protein localization 29.2683 5 no
GO:0001934 positive regulation of protein phosphorylation 29.2683 8 no
GO:0006355 regulation of DNA-templated transcription 29.2683 7 no
GO:2001141 regulation of RNA biosynthetic process 29.2683 6 no
GO:0010648 negative regulation of cell communication 26.8293 5 no
GO:0023057 negative regulation of signaling 26.8293 4 no
GO:0048585 negative regulation of response to stimulus 26.8293 4 no
GO:0071702 organic substance transport 26.8293 4 no
GO:0071705 nitrogen compound transport 26.8293 4 no
GO:0070201 regulation of establishment of protein localization 26.8293 6 no
GO:0045597 positive regulation of cell differentiation 26.8293 5 yes
GO:0050778 positive regulation of immune response 26.8293 5 yes
GO:0031347 regulation of defense response 26.8293 5 no
GO:0043549 regulation of kinase activity 26.8293 5 no
GO:0009890 negative regulation of biosynthetic process 26.8293 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 26.8293 6 no
GO:0031327 negative regulation of cellular biosynthetic process 26.8293 6 no
GO:0009968 negative regulation of signal transduction 26.8293 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.8293 6 no
GO:0051223 regulation of protein transport 24.3902 5 no
GO:0007010 cytoskeleton organization 24.3902 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 24.3902 4 yes
GO:0031344 regulation of cell projection organization 24.3902 5 yes
GO:0031396 regulation of protein ubiquitination 24.3902 9 yes
GO:0032970 regulation of actin filament-based process 24.3902 4 yes
GO:0033043 regulation of organelle organization 24.3902 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 24.3902 6 yes
GO:0141124 intracellular signaling cassette 24.3902 4 yes
GO:1901873 regulation of post-translational protein modification 24.3902 7 yes
GO:1902903 regulation of supramolecular fiber organization 24.3902 5 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 24.3902 8 yes
GO:2000026 regulation of multicellular organismal development 24.3902 4 yes
GO:0002831 regulation of response to biotic stimulus 24.3902 4 no
GO:0006915 apoptotic process 24.3902 4 no
GO:0032103 positive regulation of response to external stimulus 24.3902 5 no
GO:0043410 positive regulation of MAPK cascade 24.3902 7 no
GO:0043933 protein-containing complex organization 24.3902 4 no
GO:0030162 regulation of proteolysis 24.3902 6 no
GO:0050804 modulation of chemical synaptic transmission 24.3902 5 no
GO:0099177 regulation of trans-synaptic signaling 24.3902 4 no
GO:0010563 negative regulation of phosphorus metabolic process 21.9512 6 no
GO:0010628 positive regulation of gene expression 21.9512 7 no
GO:0015031 protein transport 21.9512 4 no
GO:0045936 negative regulation of phosphate metabolic process 21.9512 7 no
GO:0030155 regulation of cell adhesion 21.9512 4 no
GO:1904951 positive regulation of establishment of protein localization 21.9512 6 no
GO:0032956 regulation of actin cytoskeleton organization 21.9512 5 yes
GO:0051493 regulation of cytoskeleton organization 21.9512 6 yes
GO:0110053 regulation of actin filament organization 21.9512 6 yes
GO:0033365 protein localization to organelle 21.9512 5 no
GO:0042127 regulation of cell population proliferation 21.9512 4 no
GO:0045088 regulation of innate immune response 21.9512 5 no
GO:0045859 regulation of protein kinase activity 21.9512 6 no
GO:0051726 regulation of cell cycle 21.9512 4 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 19.5122 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 19.5122 4 yes
GO:0010975 regulation of neuron projection development 19.5122 7 yes
GO:0044089 positive regulation of cellular component biogenesis 19.5122 5 yes
GO:0097435 supramolecular fiber organization 19.5122 4 yes
GO:0001558 regulation of cell growth 17.0732 4 yes
GO:0010638 positive regulation of organelle organization 17.0732 6 yes
GO:0010720 positive regulation of cell development 17.0732 6 yes
GO:0031397 negative regulation of protein ubiquitination 17.0732 10 yes
GO:0043086 negative regulation of catalytic activity 17.0732 4 yes
GO:0048638 regulation of developmental growth 17.0732 4 yes
GO:0051348 negative regulation of transferase activity 17.0732 5 yes
GO:0060284 regulation of cell development 17.0732 5 yes
GO:1901874 negative regulation of post-translational protein modification 17.0732 8 yes
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 17.0732 9 yes
GO:0002431 Fc receptor mediated stimulatory signaling pathway 14.6341 5 yes
GO:0030307 positive regulation of cell growth 14.6341 5 yes
GO:0031346 positive regulation of cell projection organization 14.6341 6 yes
GO:0032231 regulation of actin filament bundle assembly 14.6341 5 yes
GO:0038093 Fc receptor signaling pathway 14.6341 5 yes
GO:0038094 Fc-gamma receptor signaling pathway 14.6341 6 yes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 14.6341 4 yes
GO:0045927 positive regulation of growth 14.6341 4 yes
GO:0050770 regulation of axonogenesis 14.6341 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 14.6341 6 yes
GO:0007015 actin filament organization 12.1951 5 yes
GO:0031032 actomyosin structure organization 12.1951 4 yes
GO:0048639 positive regulation of developmental growth 12.1951 5 yes
GO:0051492 regulation of stress fiber assembly 12.1951 6 yes
GO:0051495 positive regulation of cytoskeleton organization 12.1951 7 yes
GO:0110020 regulation of actomyosin structure organization 12.1951 6 yes
GO:0030038 contractile actin filament bundle assembly 9.7561 6 yes
GO:0032233 positive regulation of actin filament bundle assembly 9.7561 6 yes
GO:0043149 stress fiber assembly 9.7561 5 yes
GO:0050767 regulation of neurogenesis 9.7561 6 yes
GO:0050769 positive regulation of neurogenesis 9.7561 6 yes
GO:0050772 positive regulation of axonogenesis 9.7561 6 yes
GO:0051017 actin filament bundle assembly 9.7561 5 yes
GO:0051496 positive regulation of stress fiber assembly 9.7561 7 yes
GO:0051960 regulation of nervous system development 9.7561 5 yes
GO:0051962 positive regulation of nervous system development 9.7561 5 yes
GO:0061572 actin filament bundle organization 9.7561 6 yes
GO:1990138 neuron projection extension 9.7561 4 yes
GO:0007264 small GTPase-mediated signal transduction 7.3171 5 yes
GO:0007266 Rho protein signal transduction 7.3171 6 yes
GO:0007399 nervous system development 7.3171 4 yes
GO:0030516 regulation of axon extension 7.3171 5 yes
GO:0045773 positive regulation of axon extension 7.3171 6 yes
GO:0061387 regulation of extent of cell growth 7.3171 5 yes
GO:0048675 axon extension 4.8780 5 yes
GO:0051438 regulation of ubiquitin-protein transferase activity 4.8780 5 yes
GO:0051444 negative regulation of ubiquitin-protein transferase activity 4.8780 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KIF23_HUMAN [view interactions] Low throughput no yes
PAK4_HUMAN [view interactions] Low throughput no yes
H11_HUMAN [view interactions] Low throughput no no
MBP_HUMAN [view entry] [view interactions] Low throughput yes no
PAK6_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SSH1_HUMAN [view interactions] Low throughput no yes
KPCG_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
LATS1_HUMAN [view entry] [view interactions] Low throughput yes yes
PAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
MMP14_HUMAN [view interactions] Low throughput no yes
COF1_HUMAN [view entry] [view interactions] Low throughput yes no
HUNK_HUMAN [view interactions] Low throughput no yes
MK14_HUMAN [view interactions] Low throughput no yes
MAPK2_HUMAN [view interactions] Low throughput no yes
PAK2_HUMAN [view entry] [view interactions] Low throughput yes no
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
MRCKA_HUMAN [view entry] [view interactions] Low throughput yes yes
NRG1_HUMAN [view entry] [view interactions] Low throughput yes no
BMPR2_HUMAN [view entry] [view interactions] Low throughput yes yes
CDN1C_HUMAN [view interactions] Low throughput no yes
LIMK1_HUMAN [view entry] [view interactions] Low throughput yes yes
LIMK2_HUMAN [view interactions] Low throughput no yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF6_HUMAN [view interactions] Low throughput no no
PAXI_HUMAN [view interactions] Low throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
SEP14_HUMAN [view interactions] High throughput no no
LONP2_HUMAN [view interactions] High throughput no yes
RXFP2_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
AT1A2_HUMAN [view entry] [view interactions] High throughput yes yes
RFOX3_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF6_HUMAN [view interactions] High throughput no no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
UXT_HUMAN [view interactions] High throughput no yes
OSBL5_HUMAN [view interactions] High throughput no yes
RTEL1_HUMAN [view interactions] High throughput no no
TADA3_HUMAN [view interactions] High throughput no yes
BLMH_HUMAN [view interactions] High throughput no yes
RRAS_HUMAN [view interactions] High throughput no yes
RPB4_HUMAN [view interactions] High throughput no yes
SPD2B_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
RAD54_HUMAN [view interactions] High throughput no yes
SARNP_HUMAN [view interactions] High throughput no yes
BAD_HUMAN [view entry] [view interactions] High throughput yes yes
ITA1_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
HACL2_HUMAN [view interactions] High throughput no yes
IMDH2_HUMAN [view interactions] High throughput no yes
IMDH1_HUMAN [view interactions] High throughput no yes
PUR2_HUMAN [view interactions] High throughput no yes
PYR1_HUMAN [view entry] [view interactions] High throughput yes yes
RPB2_HUMAN [view interactions] High throughput no yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
PI4KA_HUMAN [view entry] [view interactions] High throughput yes yes
KI67_HUMAN [view interactions] High throughput no no
NUP98_HUMAN [view interactions] High throughput no no
BORG5_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
AGK_HUMAN [view entry] [view interactions] High throughput yes yes
HEAT6_HUMAN [view interactions] High throughput no no
HDAC2_HUMAN [view interactions] High throughput no yes
ATPMK_HUMAN [view interactions] High throughput no no
S35E1_HUMAN [view interactions] High throughput no yes
RBM14_HUMAN [view interactions] High throughput no yes
MMS19_HUMAN [view interactions] High throughput no yes
YMEL1_HUMAN [view interactions] High throughput no yes
LGMN_HUMAN [view interactions] High throughput no yes
METH_HUMAN [view interactions] High throughput no yes
RPAP1_HUMAN [view interactions] High throughput no yes
GHC1_HUMAN [view entry] [view interactions] High throughput yes yes
LAS1L_HUMAN [view interactions] High throughput no yes
SRPK1_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view entry] [view interactions] High throughput yes yes
MFHA1_HUMAN [view interactions] High throughput no yes
DSCAM_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
CV015_HUMAN [view interactions] High throughput no no
WASH1_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
MIIP_HUMAN [view interactions] High throughput no yes