Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

COF1_HUMAN

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed). Required for the centralization of the mitotic spindle and symmetric division of zygotes . Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed). Required for neural tube morphogenesis and neural crest cell migration . [View more on UniProt]

020406080100120140160
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
LOADING 91%

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

050100150200250300350400450500550600
COF1_HUMAN
LOADING 67%
020406080100120140160
COF1_HUMAN
LOADING 67%

COF1_HUMAN has binary interactions with 50 proteins

COF1_HUMAN1433G_HUMANPP1B_HUMANPTEN_HUMANMYCB2_HUMANARP2_HUMANARRB1_HUMANCAP1_HUMANUBC12_HUMANDREB_HUMANCOF2_HUMANKCMA1_HUMANSRC8_HUMANERBB2_HUMANSYNPO_HUMANHS105_HUMANCAZA2_HUMANLIMK1_HUMANDEST_HUMANIQGA1_HUMANCOF1_HUMANPSN1_HUMANACTG_HUMANERBB4_HUMANDLG4_HUMANFGFR1_HUMANMY18A_HUMANLIMA1_HUMANRASK_HUMANMDHM_HUMANMYH9_HUMANTAU_HUMANFBX31_HUMANJIP2_HUMAN1433Z_HUMANKPCZ_HUMANNDKB_HUMANPRDX1_HUMANMYO1C_HUMANRAB7A_HUMANPCBP1_HUMANAT1A1_HUMANARRB2_HUMANKAP0_HUMANPRKN_HUMANCAP2_HUMANACTB_HUMANPPIA_HUMANFLNA_HUMANKS6A1_HUMANPRDX5_HUMANCOF1_HUMAN1433G_HUMANPP1B_HUMANPTEN_HUMANMYCB2_HUMANARP2_HUMANARRB1_HUMANCAP1_HUMANUBC12_HUMANDREB_HUMANCOF2_HUMANKCMA1_HUMANSRC8_HUMANERBB2_HUMANSYNPO_HUMANHS105_HUMANCAZA2_HUMANLIMK1_HUMANDEST_HUMANIQGA1_HUMANCOF1_HUMANPSN1_HUMANACTG_HUMANERBB4_HUMANDLG4_HUMANFGFR1_HUMANMY18A_HUMANLIMA1_HUMANRASK_HUMANMDHM_HUMANMYH9_HUMANTAU_HUMANFBX31_HUMANJIP2_HUMAN1433Z_HUMANKPCZ_HUMANNDKB_HUMANPRDX1_HUMANMYO1C_HUMANRAB7A_HUMANPCBP1_HUMANAT1A1_HUMANARRB2_HUMANKAP0_HUMANPRKN_HUMANCAP2_HUMANACTB_HUMANPPIA_HUMANFLNA_HUMANKS6A1_HUMANPRDX5_HUMAN
Download full PS network for entry.
020406080100120140160180200
Interacting regions
Canonical [COF1_HUMAN]
Isoform [G3V1A4] alignment
Isoform [E9PS23] alignment
Isoform [E9PQB7] alignment
Isoform [E9PP50] alignment
Isoform [E9PLJ3] alignment
Isoform [E9PK25] alignment
LOADING 94%

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Biological process

Disease

No data found.

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