COF1_HUMAN
Evidence for PS localization
Functions
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed). Required for the centralization of the mitotic spindle and symmetric division of zygotes . Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed). Required for neural tube morphogenesis and neural crest cell migration . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in COF1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.1905 | 4 | no |
| GO:0003779 | actin binding | 25.3968 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.3968 | 4 | no |
| GO:0019900 | kinase binding | 24.6032 | 4 | no |
| GO:0046872 | metal ion binding | 23.8095 | 4 | no |
| GO:0003723 | RNA binding | 23.8095 | 4 | no |
| GO:0019901 | protein kinase binding | 23.8095 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.8095 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 21.4286 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.6349 | 5 | no |
| GO:0045296 | cadherin binding | 20.6349 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in COF1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 61.9048 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 57.9365 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 55.5556 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 53.1746 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.1746 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 51.5873 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.7937 | 4 | yes |
| GO:0006996 | organelle organization | 50.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 44.4444 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 42.8571 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.4762 | 5 | no |
| GO:0010646 | regulation of cell communication | 40.4762 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.6825 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 37.3016 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 37.3016 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.3016 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 37.3016 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.5079 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 36.5079 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.5079 | 5 | no |
| GO:0033043 | regulation of organelle organization | 34.9206 | 5 | no |
| GO:0010941 | regulation of cell death | 34.1270 | 4 | yes |
| GO:0022607 | cellular component assembly | 34.1270 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 34.1270 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.1270 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.1270 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 32.5397 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 32.5397 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.7460 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.9524 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 30.1587 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 30.1587 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 30.1587 | 6 | no |
| GO:0036211 | protein modification process | 29.3651 | 4 | no |
| GO:0043412 | macromolecule modification | 29.3651 | 4 | no |
| GO:0007010 | cytoskeleton organization | 28.5714 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 28.5714 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.5714 | 5 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0031399 | regulation of protein modification process | 27.7778 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.7778 | 6 | no |
| GO:0008104 | protein localization | 27.7778 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 26.9841 | 7 | no |
| GO:0060548 | negative regulation of cell death | 26.1905 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 26.1905 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.1905 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 25.3968 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 25.3968 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.3968 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.3968 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 24.6032 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 24.6032 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 24.6032 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.8095 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 23.8095 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.8095 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.0159 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.0159 | 6 | no |
| GO:0071310 | cellular response to organic substance | 23.0159 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 23.0159 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.2222 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0030030 | cell projection organization | 22.2222 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.2222 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.2222 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 21.4286 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.4286 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 21.4286 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 21.4286 | 4 | no |
| GO:0051338 | regulation of transferase activity | 21.4286 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.4286 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 21.4286 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.4286 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.6349 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 20.6349 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 20.6349 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.6349 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.6349 | 7 | no |
| GO:0032880 | regulation of protein localization | 20.6349 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.6349 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 20.6349 | 5 | no |
| GO:0043933 | protein-containing complex organization | 19.8413 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 19.0476 | 5 | yes |
| GO:0007015 | actin filament organization | 18.2540 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 18.2540 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 15.8730 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 15.0794 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 11.1111 | 7 | yes |
| GO:0007264 | small GTPase mediated signal transduction | 8.7302 | 4 | yes |
| GO:0022411 | cellular component disassembly | 8.7302 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 8.7302 | 5 | yes |
| GO:0007265 | Ras protein signal transduction | 7.9365 | 5 | yes |
| GO:0008154 | actin polymerization or depolymerization | 7.9365 | 6 | yes |
| GO:0032984 | protein-containing complex disassembly | 6.3492 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 6.3492 | 6 | yes |
| GO:0007266 | Rho protein signal transduction | 4.7619 | 6 | yes |
| GO:0030042 | actin filament depolymerization | 4.7619 | 7 | yes |
| GO:0051261 | protein depolymerization | 4.7619 | 6 | yes |
| GO:0061001 | regulation of dendritic spine morphogenesis | 4.7619 | 5 | yes |
| GO:0030043 | actin filament fragmentation | 3.9683 | 8 | yes |
| GO:0044788 | modulation by host of viral process | 3.1746 | 5 | yes |
| GO:0045995 | regulation of embryonic development | 3.1746 | 5 | yes |
| GO:0051293 | establishment of spindle localization | 3.1746 | 4 | yes |
| GO:0051851 | modulation by host of symbiont process | 3.1746 | 4 | yes |
| GO:0040019 | positive regulation of embryonic development | 2.3810 | 5 | yes |
| GO:0044794 | positive regulation by host of viral process | 1.5873 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in COF1_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 3.9683 | 3 | no |
| DOID:0050700 | cardiomyopathy | 3.1746 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.1746 | 5 | no |
| DOID:1289 | neurodegenerative disease | 3.1746 | 4 | no |
| DOID:331 | central nervous system disease | 3.1746 | 3 | no |
| DOID:2843 | long QT syndrome | 1.5873 | 6 | no |
| DOID:0050686 | organ system cancer | 1.5873 | 3 | no |
| DOID:120 | female reproductive organ cancer | 1.5873 | 5 | no |
| DOID:193 | reproductive organ cancer | 1.5873 | 4 | no |
| DOID:12930 | dilated cardiomyopathy | 1.5873 | 6 | no |
| DOID:231 | motor neuron disease | 1.5873 | 5 | no |
| DOID:332 | amyotrophic lateral sclerosis | 1.5873 | 6 | no |
| DOID:0050890 | synucleinopathy | 1.5873 | 5 | no |
| DOID:0060894 | early-onset Parkinsons disease | 1.5873 | 7 | no |
| DOID:14330 | Parkinsons disease | 1.5873 | 6 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 1.5873 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 1.5873 | 6 | no |
| DOID:440 | neuromuscular disease | 1.5873 | 5 | no |
| DOID:574 | peripheral nervous system disease | 1.5873 | 3 | no |
| DOID:870 | neuropathy | 1.5873 | 4 | no |
| DOID:65 | connective tissue disease | 1.5873 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLD1_HUMAN | [view interactions] | Low throughput | no | no |
| PLD2_HUMAN | [view interactions] | Low throughput | no | yes |
| SSH1_HUMAN | [view interactions] | Low throughput | no | yes |
| LIMK1_HUMAN | [view interactions] | Low throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HS105_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TXD17_HUMAN | [view interactions] | Low throughput | no | yes |
| CAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| ROCK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIMK2_HUMAN | [view interactions] | Low throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IF2B1_HUMAN | [view interactions] | Low throughput | no | no |
| SSH2_HUMAN | [view interactions] | Low throughput | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HUNK_HUMAN | [view interactions] | Low throughput | no | yes |
| IPO9_HUMAN | [view interactions] | Low throughput | no | no |
| PTPRR_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| THIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG35_HUMAN | [view interactions] | High throughput | no | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYCM_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DXO_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAIN_HUMAN | [view interactions] | High throughput | no | no |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSX1_HUMAN | [view interactions] | High throughput | no | no |
| UBP45_HUMAN | [view interactions] | High throughput | no | yes |
| T10IP_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| EIF3D_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| IRGM_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TPH1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SATB2_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| MYCBP_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| STYX_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| DC4L2_HUMAN | [view interactions] | High throughput | no | no |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2L6_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| TISD_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCD15_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| VRK3_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NGB_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| RHG31_HUMAN | [view interactions] | High throughput | no | yes |
| ARGAL_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGI_HUMAN | [view interactions] | High throughput | no | no |
| SYDE2_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAISO_HUMAN | [view interactions] | High throughput | no | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| EMAL4_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI15_HUMAN | [view interactions] | High throughput | no | no |
| RPAC1_HUMAN | [view interactions] | High throughput | no | no |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| MTAP_HUMAN | [view interactions] | High throughput | no | no |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| GABT_HUMAN | [view interactions] | High throughput | no | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| AK1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CKS2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| COTL1_HUMAN | [view interactions] | High throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALAT1_HUMAN | [view interactions] | High throughput | no | no |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| ALAT2_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KYNU_HUMAN | [view interactions] | High throughput | no | no |
| NU214_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTGR1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRXN1_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX17_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUT_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| HDHD1_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JUPI1_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| SESD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYPA2_HUMAN | [view interactions] | High throughput | no | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| TNG2_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| CASP9_HUMAN | [view interactions] | High throughput | no | yes |
| KAD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTA2_HUMAN | [view interactions] | High throughput | no | yes |
| ISOC2_HUMAN | [view interactions] | High throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STAT4_HUMAN | [view interactions] | Computational | no | yes |
| CI072_HUMAN | [view interactions] | Computational | no | no |
| CLCN5_HUMAN | [view interactions] | Computational | no | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TXND9_HUMAN | [view interactions] | Computational | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WASP_HUMAN | [view interactions] | Computational | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SSH3_HUMAN | [view interactions] | Computational | no | yes |
| COR1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |