COF1_HUMAN
Evidence for PS localization
Functions
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed). Required for the centralization of the mitotic spindle and symmetric division of zygotes . Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed). Required for neural tube morphogenesis and neural crest cell migration . [View more on UniProt]
Protein features
![](/static/images/legend1.gif)
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
![](/static/images/legend2.gif)
Network
COF1_HUMAN has binary interactions with 50 proteins
Isoforms
![](/static/images/legend3.gif)
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in COF1_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 34.2857 | 4 | no |
GO:0000166 | nucleotide binding | 30.7143 | 4 | no |
GO:0017076 | purine nucleotide binding | 30.7143 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 27.1429 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 26.4286 | 6 | no |
GO:0043169 | cation binding | 25.7143 | 4 | no |
GO:0046872 | metal ion binding | 25.7143 | 5 | no |
GO:0003723 | RNA binding | 25.7143 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 24.2857 | 5 | no |
GO:0019900 | kinase binding | 23.5714 | 4 | no |
GO:0003779 | actin binding | 22.8571 | 4 | yes |
GO:0005524 | ATP binding | 22.8571 | 5 | no |
GO:0019901 | protein kinase binding | 21.4286 | 5 | no |
GO:0045296 | cadherin binding | 20.7143 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in COF1_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 60.7143 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 59.2857 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 56.4286 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 55.7143 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 52.8571 | 4 | no |
GO:0051128 | regulation of cellular component organization | 52.1429 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 47.8571 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 46.4286 | 5 | no |
GO:0006996 | organelle organization | 45.7143 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 45.7143 | 5 | no |
GO:0010646 | regulation of cell communication | 45.7143 | 4 | no |
GO:0010468 | regulation of gene expression | 45.0000 | 6 | no |
GO:0009893 | positive regulation of metabolic process | 42.1429 | 4 | no |
GO:0009966 | regulation of signal transduction | 42.1429 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 38.5714 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 37.8571 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 37.1429 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 37.1429 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 35.0000 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 34.2857 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 34.2857 | 5 | no |
GO:0042981 | regulation of apoptotic process | 33.5714 | 5 | yes |
GO:0043067 | regulation of programmed cell death | 33.5714 | 4 | yes |
GO:0022607 | cellular component assembly | 33.5714 | 4 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AAPK1_HUMAN | [view interactions] | High throughput | no | no |
AAR2_HUMAN | [view interactions] | High throughput | no | no |
AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACOT1_HUMAN | [view interactions] | High throughput | no | yes |
ACTA_HUMAN | [view interactions] | High throughput | no | no |
ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ACTBL_HUMAN | [view interactions] | High throughput | no | no |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTS_HUMAN | [view interactions] | Low throughput | no | no |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
AK1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ALAT1_HUMAN | [view interactions] | High throughput | no | no |
ALAT2_HUMAN | [view interactions] | High throughput | no | yes |
ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |