AL7A1_HUMAN
Evidence for PS localization
Functions
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AL7A1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 5 | no |
| GO:0003723 | RNA binding | 21.1538 | 4 | no |
| GO:0000166 | nucleotide binding | 21.1538 | 4 | no |
| GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | 9.6154 | 4 | yes |
| GO:0004029 | aldehyde dehydrogenase (NAD+) activity | 5.7692 | 6 | yes |
| GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity | 5.7692 | 5 | yes |
| GO:0004043 | L-aminoadipate-semialdehyde dehydrogenase activity | 3.8462 | 5 | yes |
| GO:0008802 | betaine-aldehyde dehydrogenase activity | 3.8462 | 7 | yes |
| GO:0043878 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity | 3.8462 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AL7A1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 46.1538 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.1538 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 44.2308 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.2308 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 40.3846 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.3846 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 40.3846 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.4615 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.4615 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 32.6923 | 4 | no |
| GO:0010646 | regulation of cell communication | 28.8462 | 4 | no |
| GO:0051049 | regulation of transport | 28.8462 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 28.8462 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 26.9231 | 4 | no |
| GO:0071310 | cellular response to organic substance | 26.9231 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 26.9231 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 26.9231 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.9231 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.9231 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.9231 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.9231 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.9231 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 26.9231 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.9231 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.9231 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:1901565 | organonitrogen compound catabolic process | 23.0769 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 23.0769 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.0769 | 7 | no |
| GO:0008104 | protein localization | 23.0769 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.0769 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.0769 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 23.0769 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 23.0769 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.0769 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.1538 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.1538 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.1538 | 4 | no |
| GO:0006996 | organelle organization | 21.1538 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 7.6923 | 4 | yes |
| GO:0006577 | amino-acid betaine metabolic process | 5.7692 | 4 | yes |
| GO:0009308 | amine metabolic process | 5.7692 | 4 | yes |
| GO:0006578 | amino-acid betaine biosynthetic process | 3.8462 | 5 | yes |
| GO:0007600 | sensory perception | 3.8462 | 4 | yes |
| GO:0007605 | sensory perception of sound | 3.8462 | 6 | yes |
| GO:0009310 | amine catabolic process | 3.8462 | 5 | yes |
| GO:0019285 | glycine betaine biosynthetic process from choline | 3.8462 | 4 | yes |
| GO:0031455 | glycine betaine metabolic process | 3.8462 | 5 | yes |
| GO:0031456 | glycine betaine biosynthetic process | 3.8462 | 6 | yes |
| GO:0042398 | cellular modified amino acid biosynthetic process | 3.8462 | 4 | yes |
| GO:0042402 | cellular biogenic amine catabolic process | 3.8462 | 6 | yes |
| GO:0042426 | choline catabolic process | 3.8462 | 4 | yes |
| GO:0050954 | sensory perception of mechanical stimulus | 3.8462 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BMI1_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| CAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF5_HUMAN | [view interactions] | High throughput | no | yes |
| AGAL_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RISC_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GABT_HUMAN | [view interactions] | High throughput | no | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIBCH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHSO_HUMAN | [view interactions] | High throughput | no | no |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| GSTO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CATD_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| THEM4_HUMAN | [view interactions] | High throughput | no | no |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLGT3_HUMAN | [view interactions] | High throughput | no | no |
| NPS3B_HUMAN | [view interactions] | High throughput | no | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| NAMPT_HUMAN | [view interactions] | High throughput | no | no |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFC1_HUMAN | [view interactions] | High throughput | no | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S14L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BLVRB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10AB_HUMAN | [view interactions] | High throughput | no | no |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AK1C2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| MMSA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TKFC_HUMAN | [view interactions] | High throughput | no | no |
| RIFK_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| DDA1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| MK15_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ5_HUMAN | [view interactions] | High throughput | no | no |
| NBEL2_HUMAN | [view interactions] | High throughput | no | no |
| SWAP1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NGAL_HUMAN | [view interactions] | High throughput | no | no |
| XRCC4_HUMAN | [view interactions] | High throughput | no | yes |
| T3HPD_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| PKNX2_HUMAN | [view interactions] | High throughput | no | yes |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| SIKE1_HUMAN | [view interactions] | High throughput | no | yes |
| ZFYV1_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTN_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMGB3_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STK24_HUMAN | [view interactions] | High throughput | no | yes |
| TBCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |