AL7A1_HUMAN
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in AL7A1_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 20.4082 | 4 | no |
GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | 10.2041 | 4 | yes |
GO:0004029 | aldehyde dehydrogenase (NAD+) activity | 6.1224 | 6 | yes |
GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity | 6.1224 | 5 | yes |
GO:0004043 | L-aminoadipate-semialdehyde dehydrogenase activity | 4.0816 | 5 | yes |
GO:0008802 | betaine-aldehyde dehydrogenase activity | 4.0816 | 7 | yes |
GO:0043878 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity | 4.0816 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in AL7A1_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 38.7755 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 34.6939 | 4 | no |
GO:0019752 | carboxylic acid metabolic process | 34.6939 | 5 | no |
GO:0043436 | oxoacid metabolic process | 34.6939 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 32.6531 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 32.6531 | 4 | no |
GO:0048522 | positive regulation of cellular process | 30.6122 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 30.6122 | 4 | no |
GO:0051049 | regulation of transport | 28.5714 | 4 | no |
GO:0010646 | regulation of cell communication | 24.4898 | 4 | no |
GO:0010468 | regulation of gene expression | 24.4898 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 24.4898 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 22.4490 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 22.4490 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 22.4490 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 22.4490 | 4 | no |
GO:1901565 | organonitrogen compound catabolic process | 20.4082 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 20.4082 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.4082 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 20.4082 | 5 | no |
GO:0016054 | organic acid catabolic process | 20.4082 | 4 | no |
GO:0046395 | carboxylic acid catabolic process | 20.4082 | 5 | no |
GO:0010243 | response to organonitrogen compound | 20.4082 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.4082 | 5 | no |
GO:1901566 | organonitrogen compound biosynthetic process | 14.2857 | 4 | yes |
GO:0044271 | cellular nitrogen compound biosynthetic process | 8.1633 | 4 | yes |
GO:0006577 | amino-acid betaine metabolic process | 6.1224 | 4 | yes |
GO:0006578 | amino-acid betaine biosynthetic process | 4.0816 | 5 | yes |
GO:0007600 | sensory perception | 4.0816 | 4 | yes |
GO:0007605 | sensory perception of sound | 4.0816 | 6 | yes |
GO:0009308 | amine metabolic process | 4.0816 | 4 | yes |
GO:0009310 | amine catabolic process | 4.0816 | 5 | yes |
GO:0019285 | glycine betaine biosynthetic process from choline | 4.0816 | 4 | yes |
GO:0031455 | glycine betaine metabolic process | 4.0816 | 5 | yes |
GO:0031456 | glycine betaine biosynthetic process | 4.0816 | 6 | yes |
GO:0042398 | cellular modified amino acid biosynthetic process | 4.0816 | 4 | yes |
GO:0042402 | cellular biogenic amine catabolic process | 4.0816 | 6 | yes |
GO:0042426 | choline catabolic process | 4.0816 | 4 | yes |
GO:0050954 | sensory perception of mechanical stimulus | 4.0816 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
EPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AL7A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
BMI1_HUMAN | [view interactions] | Low throughput | no | yes |
CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CPT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HIBCH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHSO_HUMAN | [view interactions] | High throughput | no | no |
SUCB2_HUMAN | [view interactions] | High throughput | no | no |
GSTO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CATD_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBCA_HUMAN | [view interactions] | High throughput | no | yes |
THEM4_HUMAN | [view interactions] | High throughput | no | no |
SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLGT3_HUMAN | [view interactions] | High throughput | no | no |
NPS3B_HUMAN | [view interactions] | High throughput | no | yes |
COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHM_HUMAN | [view interactions] | High throughput | no | yes |
NAMPT_HUMAN | [view interactions] | High throughput | no | no |
AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UFC1_HUMAN | [view interactions] | High throughput | no | yes |
ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK11_HUMAN | [view interactions] | High throughput | no | yes |
CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
UBA5_HUMAN | [view interactions] | High throughput | no | yes |
DDA1_HUMAN | [view interactions] | High throughput | no | yes |
RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIPK4_HUMAN | [view interactions] | High throughput | no | no |
MK15_HUMAN | [view interactions] | High throughput | no | no |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
RECQ5_HUMAN | [view interactions] | High throughput | no | no |
NBEL2_HUMAN | [view interactions] | High throughput | no | no |
NGAL_HUMAN | [view interactions] | High throughput | no | no |
XRCC4_HUMAN | [view interactions] | High throughput | no | yes |
T3HPD_HUMAN | [view interactions] | High throughput | no | yes |
KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERP44_HUMAN | [view interactions] | High throughput | no | yes |
KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
WWOX_HUMAN | [view interactions] | High throughput | no | yes |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
EMC1_HUMAN | [view interactions] | High throughput | no | yes |
EMC2_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
WDR5_HUMAN | [view interactions] | High throughput | no | no |
PKNX2_HUMAN | [view interactions] | High throughput | no | yes |
LDH6A_HUMAN | [view interactions] | High throughput | no | no |
TFPT_HUMAN | [view interactions] | High throughput | no | yes |
SIKE1_HUMAN | [view interactions] | High throughput | no | yes |
ZFYV1_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BAG1_HUMAN | [view interactions] | High throughput | no | yes |
CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COPE_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
FERM2_HUMAN | [view interactions] | High throughput | no | yes |
G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HMGB3_HUMAN | [view interactions] | High throughput | no | no |
LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STK24_HUMAN | [view interactions] | High throughput | no | yes |
TBCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASNS_HUMAN | [view interactions] | High throughput | no | yes |
CAN2_HUMAN | [view interactions] | High throughput | no | no |
IF5_HUMAN | [view interactions] | High throughput | no | yes |
AGAL_HUMAN | [view interactions] | High throughput | no | yes |
PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RISC_HUMAN | [view interactions] | High throughput | no | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GABT_HUMAN | [view interactions] | High throughput | no | yes |
GATM_HUMAN | [view interactions] | Computational | no | no |
PDE5A_HUMAN | [view interactions] | Computational | no | yes |
AT2L2_HUMAN | [view interactions] | Computational | no | yes |
PDE4B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GLNA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BODG_HUMAN | [view interactions] | Computational | no | no |
MMSA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GADL1_HUMAN | [view interactions] | Computational | no | no |
SPYA_HUMAN | [view interactions] | Computational | no | no |
FUMH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AKAP6_HUMAN | [view interactions] | Computational | no | no |
ASMT_HUMAN | [view interactions] | Computational | no | no |
GLCTK_HUMAN | [view interactions] | Computational | no | yes |
CNDP1_HUMAN | [view interactions] | Computational | no | yes |
AKAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AK1A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CNDP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AASS_HUMAN | [view interactions] | Computational | no | yes |
AADAT_HUMAN | [view interactions] | Computational | no | no |
3HIDH_HUMAN | [view interactions] | Computational | no | yes |
ACSF3_HUMAN | [view interactions] | Computational | no | no |
ODB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PDE4D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PDE4A_HUMAN | [view interactions] | Computational | no | no |
ECHP_HUMAN | [view interactions] | Computational | no | no |
ACSS3_HUMAN | [view interactions] | Computational | no | no |
BHMT1_HUMAN | [view interactions] | Computational | no | no |
CHDH_HUMAN | [view interactions] | Computational | no | yes |
ECHD1_HUMAN | [view interactions] | Computational | no | no |
ACO12_HUMAN | [view interactions] | Computational | no | no |
AL4A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACADS_HUMAN | [view interactions] | Computational | no | yes |
DCE2_HUMAN | [view interactions] | Computational | no | yes |
PEPD_HUMAN | [view interactions] | Computational | no | yes |
PDE7A_HUMAN | [view interactions] | Computational | no | yes |
BUP1_HUMAN | [view interactions] | Computational | no | no |
TALDO_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TPIS_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AOC1_HUMAN | [view interactions] | Computational | no | no |
CRNS1_HUMAN | [view interactions] | Computational | no | no |
AGT2_HUMAN | [view interactions] | Computational | no | no |
PLPHP_HUMAN | [view interactions] | Computational | no | yes |