ANX11_HUMAN
Evidence for PS localization
Functions
Binds specifically to calcyclin in a calcium-dependent manner . Required for midbody formation and completion of the terminal phase of cytokinesis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002656 | LIG_EF_ALG2_ABM_1 | LIG | 4 | 14 | - |
| ELMI002656 | LIG_EF_ALG2_ABM_1 | LIG | 4 | 14 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANX11_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 30.5556 | 4 | no |
| GO:0043169 | cation binding | 27.7778 | 4 | yes |
| GO:0046872 | metal ion binding | 27.7778 | 5 | yes |
| GO:0003723 | RNA binding | 22.2222 | 4 | yes |
| GO:0000166 | nucleotide binding | 22.2222 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.2222 | 5 | no |
| GO:0005509 | calcium ion binding | 11.1111 | 6 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 8.3333 | 4 | yes |
| GO:0023026 | MHC class II protein complex binding | 5.5556 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANX11_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.4444 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.4444 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.8889 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 38.8889 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.1111 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.1111 | 4 | no |
| GO:0023056 | positive regulation of signaling | 36.1111 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.1111 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:1901565 | organonitrogen compound catabolic process | 30.5556 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 30.5556 | 5 | no |
| GO:0022607 | cellular component assembly | 30.5556 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 30.5556 | 4 | no |
| GO:0051049 | regulation of transport | 30.5556 | 4 | no |
| GO:0006996 | organelle organization | 30.5556 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.7778 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 27.7778 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 27.7778 | 5 | no |
| GO:0060341 | regulation of cellular localization | 27.7778 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 5 | no |
| GO:0080134 | regulation of response to stress | 25.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 7 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0036211 | protein modification process | 22.2222 | 4 | no |
| GO:0043412 | macromolecule modification | 22.2222 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 22.2222 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 22.2222 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 22.2222 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 22.2222 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.2222 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.2222 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.2222 | 6 | no |
| GO:0006163 | purine nucleotide metabolic process | 22.2222 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 22.2222 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 22.2222 | 5 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 22.2222 | 6 | no |
| GO:0009259 | ribonucleotide metabolic process | 22.2222 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 22.2222 | 4 | no |
| GO:0072521 | purine-containing compound metabolic process | 22.2222 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0071702 | organic substance transport | 22.2222 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 22.2222 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
| GO:0071310 | cellular response to organic substance | 22.2222 | 4 | no |
| GO:0098657 | import into cell | 13.8889 | 4 | yes |
| GO:0010038 | response to metal ion | 11.1111 | 4 | yes |
| GO:0006909 | phagocytosis | 5.5556 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PDCD6_HUMAN | [view interactions] | Low throughput | no | no |
| ALG2_HUMAN | [view interactions] | Low throughput | no | yes |
| S10A6_HUMAN | [view interactions] | Low throughput | no | yes |
| RGAP1_HUMAN | [view interactions] | High throughput | no | no |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| MUS81_HUMAN | [view interactions] | High throughput | no | no |
| CYTM_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| ZDH17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| KRA62_HUMAN | [view interactions] | High throughput | no | no |
| KR132_HUMAN | [view interactions] | High throughput | no | no |
| ARSA_HUMAN | [view interactions] | High throughput | no | yes |
| IKBD_HUMAN | [view interactions] | High throughput | no | no |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH3_HUMAN | [view interactions] | High throughput | no | no |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| DRA_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| DRB3_HUMAN | [view interactions] | High throughput | no | no |
| DRB4_HUMAN | [view interactions] | High throughput | no | no |
| DRB5_HUMAN | [view interactions] | High throughput | no | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RN208_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| OAT_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB2_HUMAN | [view interactions] | High throughput | no | no |
| ANXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF2_HUMAN | [view interactions] | High throughput | no | no |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| CK054_HUMAN | [view interactions] | High throughput | no | no |
| CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEF1_HUMAN | [view interactions] | High throughput | no | no |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SORCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| PMM2_HUMAN | [view interactions] | High throughput | no | no |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NQO1_HUMAN | [view interactions] | High throughput | no | no |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THTR_HUMAN | [view interactions] | High throughput | no | yes |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| NIT2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |