Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

STX12_HUMAN

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) . Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in STX12_HUMAN
GO:0000166 nucleotide binding 36.5591 4 no
GO:0043168 anion binding 35.4839 4 no
GO:0017076 purine nucleotide binding 34.4086 5 no
GO:0032555 purine ribonucleotide binding 34.4086 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0016462 pyrophosphatase activity 26.8817 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 26.8817 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 26.8817 6 no
GO:0005525 GTP binding 25.8065 5 no
GO:0019001 guanyl nucleotide binding 25.8065 6 no
GO:0032561 guanyl ribonucleotide binding 25.8065 5 no
GO:0003924 GTPase activity 22.5806 7 no

Biological process

Term Name % Distance from top the of the tree Annotated in STX12_HUMAN
GO:0008104 protein localization 56.9892 4 yes
GO:0071702 organic substance transport 51.6129 4 yes
GO:0071705 nitrogen compound transport 51.6129 4 yes
GO:0015031 protein transport 49.4624 4 yes
GO:0048522 positive regulation of cellular process 49.4624 4 no
GO:0051128 regulation of cellular component organization 48.3871 4 no
GO:0006996 organelle organization 47.3118 4 yes
GO:0022607 cellular component assembly 47.3118 4 yes
GO:0051049 regulation of transport 39.7849 4 no
GO:0010646 regulation of cell communication 35.4839 4 no
GO:0048523 negative regulation of cellular process 34.4086 4 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0031323 regulation of cellular metabolic process 32.2581 4 no
GO:0061024 membrane organization 31.1828 4 yes
GO:0009893 positive regulation of metabolic process 31.1828 4 no
GO:0006886 intracellular protein transport 30.1075 4 yes
GO:0044087 regulation of cellular component biogenesis 30.1075 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.9570 5 no
GO:0043933 protein-containing complex organization 26.8817 4 no
GO:0016050 vesicle organization 25.8065 5 yes
GO:0060341 regulation of cellular localization 25.8065 4 no
GO:0060627 regulation of vesicle-mediated transport 25.8065 4 no
GO:0080090 regulation of primary metabolic process 25.8065 4 no
GO:0023056 positive regulation of signaling 24.7312 4 no
GO:0009966 regulation of signal transduction 24.7312 4 no
GO:0009889 regulation of biosynthetic process 23.6559 4 no
GO:0010556 regulation of macromolecule biosynthetic process 23.6559 5 no
GO:0031326 regulation of cellular biosynthetic process 23.6559 5 no
GO:0048584 positive regulation of response to stimulus 23.6559 4 no
GO:0032880 regulation of protein localization 22.5806 5 no
GO:0098657 import into cell 22.5806 4 no
GO:0051246 regulation of protein metabolic process 22.5806 5 no
GO:0010468 regulation of gene expression 22.5806 6 no
GO:0061025 membrane fusion 21.5054 5 yes
GO:0010647 positive regulation of cell communication 21.5054 5 no
GO:0065003 protein-containing complex assembly 21.5054 5 no
GO:0031325 positive regulation of cellular metabolic process 21.5054 5 no
GO:0051046 regulation of secretion 20.4301 5 no
GO:0033043 regulation of organelle organization 20.4301 5 no
GO:0048284 organelle fusion 19.3548 5 yes
GO:0006906 vesicle fusion 18.2796 6 yes
GO:0090174 organelle membrane fusion 18.2796 6 yes
GO:0070925 organelle assembly 16.1290 5 yes
GO:0032456 endocytic recycling 12.9032 4 yes
GO:0007033 vacuole organization 9.6774 5 yes
GO:0048278 vesicle docking 8.6022 4 yes
GO:0000045 autophagosome assembly 6.4516 6 yes
GO:1905037 autophagosome organization 6.4516 6 yes
GO:0050821 protein stabilization 3.2258 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EEA1_HUMAN [view entry] [view interactions] Low throughput yes yes
MARH2_HUMAN [view interactions] Low throughput no yes
STX6_HUMAN [view interactions] Low throughput no yes
NSG1_HUMAN [view entry] [view interactions] Low throughput yes no
SNAA_HUMAN [view entry] [view interactions] Low throughput yes yes
VAMP8_HUMAN [view interactions] Low throughput no no
VAMP1_HUMAN [view interactions] Low throughput no no
VPS50_HUMAN [view interactions] Low throughput no yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
CSTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABCA1_HUMAN [view interactions] Low throughput no yes
VAMP4_HUMAN [view entry] [view interactions] Low throughput yes yes
VTI1A_HUMAN [view interactions] Low throughput no yes
BL1S6_HUMAN [view interactions] Low throughput no yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
SNP23_HUMAN [view entry] [view interactions] Low throughput yes no
LMBD1_HUMAN [view interactions] High throughput no yes
TEBP_HUMAN [view interactions] High throughput no yes
AT11C_HUMAN [view interactions] High throughput no no
KBP_HUMAN [view interactions] High throughput no yes
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
RPAP3_HUMAN [view interactions] High throughput no yes
ENPP4_HUMAN [view interactions] High throughput no yes
VPP2_HUMAN [view interactions] High throughput no yes
FKBP5_HUMAN [view interactions] High throughput no yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
T106B_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
TNIP1_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
MLP3B_HUMAN [view interactions] High throughput no yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
EHD1_HUMAN [view entry] [view interactions] High throughput yes no
ANX11_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5L_HUMAN [view interactions] High throughput no yes
CISD1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RAP1B_HUMAN [view entry] [view interactions] High throughput yes no
RER1_HUMAN [view interactions] High throughput no yes
TM9S4_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC3_HUMAN [view entry] [view interactions] High throughput yes yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX4_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
MK14_HUMAN [view interactions] High throughput no yes
MK11_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
IFM1_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
SNP29_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
ATG9A_HUMAN [view interactions] High throughput no yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
SNP47_HUMAN [view entry] [view interactions] High throughput yes yes
RAB25_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
TP4A2_HUMAN [view interactions] High throughput no yes
TRDN_HUMAN [view interactions] High throughput no no
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
RFA2_HUMAN [view interactions] High throughput no yes
F234B_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
YKT6_HUMAN [view interactions] High throughput no yes
RNF13_HUMAN [view interactions] High throughput no yes
PPAL_HUMAN [view interactions] High throughput no no
ZKSC1_HUMAN [view interactions] High throughput no yes
CTR1_HUMAN [view interactions] High throughput no no
TXLNA_HUMAN [view interactions] High throughput no yes
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
NOP14_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
SEC20_HUMAN [view interactions] High throughput no yes
EI2BE_HUMAN [view interactions] High throughput no yes
EI2BA_HUMAN [view interactions] High throughput no yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
MSPD2_HUMAN [view interactions] High throughput no yes
SCFD2_HUMAN [view interactions] High throughput no yes
SNAG_HUMAN [view entry] [view interactions] High throughput yes yes
NOC4L_HUMAN [view interactions] High throughput no no
F234A_HUMAN [view interactions] High throughput no yes
SNAB_HUMAN [view entry] [view interactions] High throughput yes yes
TBC17_HUMAN [view entry] [view interactions] High throughput yes yes
EI2BG_HUMAN [view interactions] High throughput no yes
USE1_HUMAN [view interactions] High throughput no yes
STX18_HUMAN [view interactions] High throughput no yes
ZN219_HUMAN [view interactions] High throughput no yes
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
STX8_HUMAN [view interactions] High throughput no yes
COG6_HUMAN [view interactions] High throughput no yes
5MP1_HUMAN [view interactions] High throughput no no
VTI1B_HUMAN [view entry] [view interactions] High throughput yes yes
GATA3_HUMAN [view interactions] High throughput no no
NPC1_HUMAN [view interactions] High throughput no yes
MYEF2_HUMAN [view interactions] High throughput no no
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
APBA2_HUMAN [view interactions] High throughput no yes
L1CAM_HUMAN [view entry] [view interactions] High throughput yes yes
VPS18_HUMAN [view entry] [view interactions] High throughput yes no
HSC20_HUMAN [view interactions] High throughput no yes
CNDD3_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DTX2_HUMAN [view interactions] High throughput no yes
B2L13_HUMAN [view interactions] High throughput no no
STX1A_HUMAN [view entry] [view interactions] High throughput yes yes
KASH5_HUMAN [view interactions] High throughput no yes
STB5L_HUMAN [view interactions] High throughput no no
TMX2_HUMAN [view interactions] High throughput no yes
CISD2_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
S66A2_HUMAN [view interactions] High throughput no yes
LERL1_HUMAN [view interactions] High throughput no no
TM86B_HUMAN [view interactions] High throughput no no
MFSD6_HUMAN [view interactions] High throughput no yes
EBP_HUMAN [view interactions] High throughput no no
SOAT_HUMAN [view interactions] High throughput no no
GORAB_HUMAN [view interactions] High throughput no yes
SC11C_HUMAN [view interactions] High throughput no no
TIDC1_HUMAN [view interactions] High throughput no yes
TLCD4_HUMAN [view interactions] High throughput no no
AQP6_HUMAN [view interactions] High throughput no no
KISHB_HUMAN [view interactions] High throughput no no
ERGI3_HUMAN [view interactions] High throughput no yes
CD79A_HUMAN [view interactions] High throughput no no
TM14B_HUMAN [view interactions] High throughput no no
PLPR2_HUMAN [view interactions] High throughput no yes
PDZ1I_HUMAN [view interactions] High throughput no no
AQP8_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
TAF9_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
BET1_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
DDR2_HUMAN [view interactions] High throughput no no
FHI1B_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
STX2_HUMAN [view interactions] High throughput no no
FCERG_HUMAN [view interactions] High throughput no no
RIC3_HUMAN [view interactions] High throughput no yes
NEMP1_HUMAN [view interactions] High throughput no no
TMM31_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
VATB1_HUMAN [view interactions] High throughput no no
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
MOV10_HUMAN [view interactions] High throughput no no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
EI2BD_HUMAN [view interactions] High throughput no yes
VPS45_HUMAN [view entry] [view interactions] High throughput yes yes
GORS1_HUMAN [view interactions] High throughput no yes
STX5_HUMAN [view interactions] High throughput no yes
STXB5_HUMAN [view entry] [view interactions] High throughput yes yes
NBAS_HUMAN [view interactions] High throughput no yes
STX10_HUMAN [view interactions] High throughput no yes
TBC15_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
ADPGK_HUMAN [view interactions] High throughput no no
GOSR2_HUMAN [view interactions] High throughput no yes
GOSR1_HUMAN [view entry] [view interactions] High throughput yes yes
ANM9_HUMAN [view interactions] High throughput no no
FRMD5_HUMAN [view interactions] High throughput no no
VAMP7_HUMAN [view interactions] High throughput no yes
CC138_HUMAN [view interactions] High throughput no yes
TF_HUMAN [view interactions] High throughput no no
TR10B_HUMAN [view interactions] High throughput no no
OPN4_HUMAN [view interactions] High throughput no no
TM258_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
STXB6_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
IFM3_HUMAN [view interactions] High throughput no yes
VAMP5_HUMAN [view interactions] High throughput no no
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
NMRL1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
CXA8_HUMAN [view interactions] High throughput no no
ZDH12_HUMAN [view interactions] High throughput no yes
NRSN1_HUMAN [view interactions] High throughput no yes
IL32_HUMAN [view interactions] High throughput no no
KCNE3_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
LRRC4_HUMAN [view entry] [view interactions] High throughput yes no
TR10C_HUMAN [view interactions] High throughput no no
KDSR_HUMAN [view interactions] High throughput no yes
ASPH_HUMAN [view interactions] High throughput no yes
SEGN_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
VA0D1_HUMAN [view entry] [view interactions] High throughput yes yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
LTOR2_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
SCAM1_HUMAN [view interactions] High throughput no no
SCAM2_HUMAN [view interactions] High throughput no no
S6A15_HUMAN [view interactions] High throughput no yes
ATP9A_HUMAN [view interactions] High throughput no yes
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR5_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
VATL_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
MPRI_HUMAN [view interactions] High throughput no yes
PTTG_HUMAN [view interactions] High throughput no yes