Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

STX12_HUMAN

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) . Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting . [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in STX12_HUMAN
GO:0017076 purine nucleotide binding 35.3659 4 no
GO:0032555 purine ribonucleotide binding 35.3659 4 no
GO:0035639 purine ribonucleoside triphosphate binding 35.3659 4 no
GO:0005525 GTP binding 29.2683 5 no
GO:0019001 guanyl nucleotide binding 29.2683 5 no
GO:0032561 guanyl ribonucleotide binding 29.2683 5 no
GO:0016462 pyrophosphatase activity 26.8293 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 26.8293 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 26.8293 6 no
GO:0003924 GTPase activity 25.6098 7 no

Biological process

Term Name % Distance from top the of the tree Annotated in STX12_HUMAN
GO:0008104 protein localization 60.9756 4 yes
GO:0016192 vesicle-mediated transport 58.5366 4 no
GO:0071702 organic substance transport 57.3171 4 yes
GO:0071705 nitrogen compound transport 57.3171 4 yes
GO:0015031 protein transport 54.8780 4 yes
GO:0048522 positive regulation of cellular process 53.6585 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0051128 regulation of cellular component organization 47.5610 4 no
GO:0022607 cellular component assembly 46.3415 4 yes
GO:0051049 regulation of transport 39.0244 4 no
GO:0006886 intracellular protein transport 36.5854 4 yes
GO:0010646 regulation of cell communication 35.3659 4 no
GO:0061024 membrane organization 30.4878 4 yes
GO:0009893 positive regulation of metabolic process 30.4878 4 no
GO:0031323 regulation of cellular metabolic process 30.4878 4 no
GO:0060255 regulation of macromolecule metabolic process 30.4878 4 no
GO:0048523 negative regulation of cellular process 29.2683 4 no
GO:0043933 protein-containing complex organization 28.0488 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.0488 5 no
GO:0044087 regulation of cellular component biogenesis 26.8293 4 no
GO:0060627 regulation of vesicle-mediated transport 26.8293 4 no
GO:0016050 vesicle organization 25.6098 5 yes
GO:0023056 positive regulation of signaling 24.3902 4 no
GO:0060341 regulation of cellular localization 24.3902 4 no
GO:0009966 regulation of signal transduction 24.3902 4 no
GO:0080090 regulation of primary metabolic process 24.3902 4 no
GO:0065003 protein-containing complex assembly 23.1707 5 no
GO:0051171 regulation of nitrogen compound metabolic process 23.1707 4 no
GO:0061025 membrane fusion 21.9512 5 yes
GO:0032880 regulation of protein localization 21.9512 5 no
GO:0033043 regulation of organelle organization 21.9512 5 no
GO:0016197 endosomal transport 21.9512 4 no
GO:0051246 regulation of protein metabolic process 21.9512 5 no
GO:0051050 positive regulation of transport 21.9512 4 no
GO:0048284 organelle fusion 20.7317 5 yes
GO:0010647 positive regulation of cell communication 20.7317 5 no
GO:0050804 modulation of chemical synaptic transmission 20.7317 5 no
GO:0099177 regulation of trans-synaptic signaling 20.7317 4 no
GO:0031325 positive regulation of cellular metabolic process 20.7317 5 no
GO:0048584 positive regulation of response to stimulus 20.7317 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 20.7317 5 no
GO:0006906 vesicle fusion 18.2927 6 yes
GO:0090174 organelle membrane fusion 18.2927 6 yes
GO:0070925 organelle assembly 15.8537 5 yes
GO:0048278 vesicle docking 10.9756 4 yes
GO:0007033 vacuole organization 9.7561 5 yes
GO:0000045 autophagosome assembly 4.8780 6 yes
GO:1905037 autophagosome organization 4.8780 6 yes
GO:0050821 protein stabilization 2.4390 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in STX12_HUMAN
DOID:331 central nervous system disease 2.4390 3 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 2.4390 7 no
DOID:10595 Charcot-Marie-Tooth disease 2.4390 6 no
DOID:440 neuromuscular disease 2.4390 5 no
DOID:574 peripheral nervous system disease 2.4390 3 no
DOID:870 neuropathy 2.4390 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NSG1_HUMAN [view entry] [view interactions] Low throughput yes no
STX6_HUMAN [view interactions] Low throughput no yes
VAMP8_HUMAN [view interactions] Low throughput no no
SNAA_HUMAN [view entry] [view interactions] Low throughput yes yes
VAMP1_HUMAN [view interactions] Low throughput no no
VPS50_HUMAN [view interactions] Low throughput no yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
CSTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABCA1_HUMAN [view interactions] Low throughput no yes
VAMP4_HUMAN [view interactions] Low throughput no yes
VTI1A_HUMAN [view interactions] Low throughput no yes
BL1S6_HUMAN [view interactions] Low throughput no yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
SNP23_HUMAN [view entry] [view interactions] Low throughput yes no
EEA1_HUMAN [view entry] [view interactions] Low throughput yes yes
MARH2_HUMAN [view interactions] Low throughput no yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX4_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
MK14_HUMAN [view interactions] High throughput no yes
MK11_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
IFM1_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SNP29_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
SNP47_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
TRDN_HUMAN [view interactions] High throughput no no
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
5MP1_HUMAN [view interactions] High throughput no no
COG6_HUMAN [view interactions] High throughput no yes
STX8_HUMAN [view interactions] High throughput no yes
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
ZN219_HUMAN [view interactions] High throughput no yes
STX18_HUMAN [view interactions] High throughput no yes
USE1_HUMAN [view interactions] High throughput no yes
EI2BG_HUMAN [view interactions] High throughput no yes
TBC17_HUMAN [view entry] [view interactions] High throughput yes yes
SNAB_HUMAN [view entry] [view interactions] High throughput yes yes
F234A_HUMAN [view interactions] High throughput no yes
NOC4L_HUMAN [view interactions] High throughput no no
SNAG_HUMAN [view entry] [view interactions] High throughput yes yes
SCFD2_HUMAN [view interactions] High throughput no yes
MSPD2_HUMAN [view interactions] High throughput no yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
EI2BA_HUMAN [view interactions] High throughput no yes
EI2BE_HUMAN [view interactions] High throughput no yes
SEC20_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
NOP14_HUMAN [view interactions] High throughput no yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
TXLNA_HUMAN [view interactions] High throughput no yes
SL7A1_HUMAN [view interactions] High throughput no no
ZKSC1_HUMAN [view interactions] High throughput no yes
PPAL_HUMAN [view interactions] High throughput no no
RNF13_HUMAN [view interactions] High throughput no yes
YKT6_HUMAN [view interactions] High throughput no yes
F234B_HUMAN [view interactions] High throughput no yes
VTI1B_HUMAN [view entry] [view interactions] High throughput yes yes
GATA3_HUMAN [view interactions] High throughput no no
MYEF2_HUMAN [view interactions] High throughput no no
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
L1CAM_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
APBA2_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
VPS18_HUMAN [view entry] [view interactions] High throughput yes no
HSC20_HUMAN [view interactions] High throughput no yes
CNDD3_HUMAN [view interactions] High throughput no no
DTX2_HUMAN [view interactions] High throughput no yes
B2L13_HUMAN [view interactions] High throughput no no
STX1A_HUMAN [view entry] [view interactions] High throughput yes yes
KASH5_HUMAN [view interactions] High throughput no yes
STB5L_HUMAN [view interactions] High throughput no no
TMX2_HUMAN [view interactions] High throughput no yes
CISD2_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
S66A2_HUMAN [view interactions] High throughput no yes
LERL1_HUMAN [view interactions] High throughput no no
TM86B_HUMAN [view interactions] High throughput no no
MFSD6_HUMAN [view interactions] High throughput no yes
EBP_HUMAN [view interactions] High throughput no no
SOAT_HUMAN [view interactions] High throughput no no
GORAB_HUMAN [view interactions] High throughput no yes
SC11C_HUMAN [view interactions] High throughput no no
TIDC1_HUMAN [view interactions] High throughput no yes
TLCD4_HUMAN [view interactions] High throughput no no
AQP6_HUMAN [view interactions] High throughput no no
KISHB_HUMAN [view interactions] High throughput no no
ERGI3_HUMAN [view interactions] High throughput no yes
CD79A_HUMAN [view interactions] High throughput no no
PLPR2_HUMAN [view interactions] High throughput no yes
TM14B_HUMAN [view interactions] High throughput no no
PDZ1I_HUMAN [view interactions] High throughput no no
AQP8_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
TAF9_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
BET1_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
RAB9A_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
DDR2_HUMAN [view interactions] High throughput no no
FHI1B_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
STX2_HUMAN [view interactions] High throughput no no
FCERG_HUMAN [view interactions] High throughput no no
RIC3_HUMAN [view interactions] High throughput no yes
NEMP1_HUMAN [view interactions] High throughput no no
TMM31_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
VATB1_HUMAN [view interactions] High throughput no no
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
MOV10_HUMAN [view interactions] High throughput no no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
EI2BD_HUMAN [view interactions] High throughput no yes
VPS45_HUMAN [view entry] [view interactions] High throughput yes yes
GORS1_HUMAN [view interactions] High throughput no yes
STX5_HUMAN [view interactions] High throughput no yes
STXB5_HUMAN [view entry] [view interactions] High throughput yes yes
NBAS_HUMAN [view interactions] High throughput no yes
STX10_HUMAN [view interactions] High throughput no yes
TBC15_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
ADPGK_HUMAN [view interactions] High throughput no no
GOSR2_HUMAN [view interactions] High throughput no yes
GOSR1_HUMAN [view entry] [view interactions] High throughput yes yes
ANM9_HUMAN [view interactions] High throughput no no
FRMD5_HUMAN [view interactions] High throughput no no
VAMP7_HUMAN [view interactions] High throughput no yes
CC138_HUMAN [view interactions] High throughput no yes
TF_HUMAN [view interactions] High throughput no no
TR10B_HUMAN [view interactions] High throughput no no
OPN4_HUMAN [view interactions] High throughput no no
TM258_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
STXB6_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
IFM3_HUMAN [view interactions] High throughput no yes
VAMP5_HUMAN [view interactions] High throughput no no
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
NMRL1_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
CXA8_HUMAN [view interactions] High throughput no no
ZDH12_HUMAN [view interactions] High throughput no yes
NRSN1_HUMAN [view interactions] High throughput no yes
IL32_HUMAN [view interactions] High throughput no no
KCNE3_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
LRRC4_HUMAN [view entry] [view interactions] High throughput yes no
TR10C_HUMAN [view interactions] High throughput no no
KDSR_HUMAN [view interactions] High throughput no yes
ASPH_HUMAN [view interactions] High throughput no yes
SEGN_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
VA0D1_HUMAN [view entry] [view interactions] High throughput yes yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
LTOR2_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
SCAM1_HUMAN [view interactions] High throughput no no
SCAM2_HUMAN [view interactions] High throughput no no
S6A15_HUMAN [view interactions] High throughput no yes
ATP9A_HUMAN [view interactions] High throughput no yes
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR5_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
VATL_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
MPRI_HUMAN [view interactions] High throughput no yes
PTTG_HUMAN [view interactions] High throughput no yes
LMBD1_HUMAN [view interactions] High throughput no yes
TEBP_HUMAN [view interactions] High throughput no yes
AT11C_HUMAN [view interactions] High throughput no no
KBP_HUMAN [view interactions] High throughput no yes
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
RPAP3_HUMAN [view interactions] High throughput no yes
ENPP4_HUMAN [view interactions] High throughput no yes
VPP2_HUMAN [view interactions] High throughput no yes
FKBP5_HUMAN [view interactions] High throughput no yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
T106B_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
EHD1_HUMAN [view entry] [view interactions] High throughput yes no
ANX11_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5L_HUMAN [view interactions] High throughput no yes
CISD1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RAP1B_HUMAN [view entry] [view interactions] High throughput yes no
RER1_HUMAN [view interactions] High throughput no yes
TM9S4_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC3_HUMAN [view entry] [view interactions] High throughput yes yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
VP33A_HUMAN [view entry] [view interactions] Computational yes no
VPS16_HUMAN [view entry] [view interactions] Computational yes yes
STX17_HUMAN [view interactions] Computational no yes
VP33B_HUMAN [view interactions] Computational no yes
STX11_HUMAN [view interactions] Computational no yes
STX16_HUMAN [view interactions] Computational no yes