VPS45_HUMAN
Evidence for PS localization
Functions
May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 224 | Thr | Asn | Neutropenia,severecongenital5,autosomalrecessive(SCN5) | - |
| 238 | Glu | Lys | Neutropenia,severecongenital5,autosomalrecessive(SCN5) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS45_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 44.4444 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 44.4444 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 44.4444 | 4 | no |
| GO:0005525 | GTP binding | 40.7407 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 40.7407 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 40.7407 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 38.8889 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 38.8889 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 38.8889 | 6 | no |
| GO:0003924 | GTPase activity | 37.0370 | 7 | no |
| GO:0019900 | kinase binding | 22.2222 | 4 | no |
| GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
| GO:0019003 | GDP binding | 22.2222 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS45_HUMAN |
|---|---|---|---|---|
| GO:0016192 | vesicle-mediated transport | 62.9630 | 4 | yes |
| GO:0008104 | protein localization | 61.1111 | 4 | yes |
| GO:0006996 | organelle organization | 61.1111 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 61.1111 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 57.4074 | 4 | no |
| GO:0071702 | organic substance transport | 55.5556 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 55.5556 | 4 | yes |
| GO:0015031 | protein transport | 53.7037 | 4 | yes |
| GO:0051049 | regulation of transport | 46.2963 | 4 | no |
| GO:0022607 | cellular component assembly | 42.5926 | 4 | no |
| GO:0006886 | intracellular protein transport | 40.7407 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 38.8889 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.8889 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.0370 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.0370 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.1852 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0061024 | membrane organization | 33.3333 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.4815 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 31.4815 | 4 | no |
| GO:0010646 | regulation of cell communication | 31.4815 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.4815 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.4815 | 5 | no |
| GO:0033043 | regulation of organelle organization | 29.6296 | 5 | no |
| GO:0009966 | regulation of signal transduction | 29.6296 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.6296 | 5 | no |
| GO:0032880 | regulation of protein localization | 27.7778 | 5 | no |
| GO:0060341 | regulation of cellular localization | 27.7778 | 4 | no |
| GO:0030030 | cell projection organization | 27.7778 | 4 | no |
| GO:0016050 | vesicle organization | 27.7778 | 5 | no |
| GO:0007010 | cytoskeleton organization | 25.9259 | 5 | no |
| GO:0030334 | regulation of cell migration | 25.9259 | 5 | no |
| GO:2000145 | regulation of cell motility | 25.9259 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.0741 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 24.0741 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.0741 | 6 | no |
| GO:0071310 | cellular response to organic substance | 24.0741 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.0741 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.0741 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.2222 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.2222 | 5 | no |
| GO:0007264 | small GTPase mediated signal transduction | 22.2222 | 4 | no |
| GO:0023056 | positive regulation of signaling | 22.2222 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 22.2222 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.2222 | 6 | no |
| GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
| GO:0048193 | Golgi vesicle transport | 20.3704 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 20.3704 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.3704 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 20.3704 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.3704 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.3704 | 5 | no |
| GO:0010468 | regulation of gene expression | 20.3704 | 5 | no |
| GO:0007265 | Ras protein signal transduction | 20.3704 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.3704 | 5 | no |
| GO:0010941 | regulation of cell death | 20.3704 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.3704 | 4 | no |
| GO:0061025 | membrane fusion | 20.3704 | 5 | no |
| GO:0006897 | endocytosis | 20.3704 | 5 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in VPS45_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.7037 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RBNS5_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNTG1_HUMAN | [view interactions] | Low throughput | no | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| VPS18_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| CASP8_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAX2_HUMAN | [view interactions] | High throughput | no | no |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| RFX3_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| STX16_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM171_HUMAN | [view interactions] | High throughput | no | yes |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| GPC5D_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP4_HUMAN | [view interactions] | High throughput | no | yes |
| NPAL3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| HVCN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| TYB10_HUMAN | [view interactions] | High throughput | no | no |
| VTI1A_HUMAN | [view interactions] | High throughput | no | yes |
| SNAG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| TMM9B_HUMAN | [view interactions] | High throughput | no | yes |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| STX10_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAZ1A_HUMAN | [view interactions] | High throughput | no | no |
| HDAC8_HUMAN | [view interactions] | High throughput | no | yes |
| MA2A1_HUMAN | [view interactions] | High throughput | no | no |
| ARI2_HUMAN | [view interactions] | High throughput | no | no |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| TPC11_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBL1R_HUMAN | [view interactions] | High throughput | no | yes |
| TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
| VPS51_HUMAN | [view interactions] | High throughput | no | yes |
| ARL5B_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| ZN827_HUMAN | [view interactions] | High throughput | no | yes |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |