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SYGP1_HUMAN

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SYGP1_HUMAN
GO:0017076 purine nucleotide binding 27.0833 4 no
GO:0032555 purine ribonucleotide binding 27.0833 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.3889 4 no
GO:0046872 metal ion binding 20.1389 4 no
GO:0030695 GTPase regulator activity 18.0556 4 yes
GO:0005096 GTPase activator activity 13.8889 4 yes
GO:0017124 SH3 domain binding 6.9444 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SYGP1_HUMAN
GO:0010646 regulation of cell communication 58.3333 4 yes
GO:0048522 positive regulation of cellular process 50.6944 4 no
GO:0009966 regulation of signal transduction 47.9167 4 yes
GO:0051128 regulation of cellular component organization 43.0556 4 yes
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0080090 regulation of primary metabolic process 36.8056 4 no
GO:0048523 negative regulation of cellular process 36.1111 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 35.4167 4 no
GO:0050804 modulation of chemical synaptic transmission 34.0278 5 yes
GO:0099177 regulation of trans-synaptic signaling 34.0278 4 yes
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0006996 organelle organization 30.5556 4 yes
GO:0008104 protein localization 29.1667 4 yes
GO:0009893 positive regulation of metabolic process 29.1667 4 no
GO:0051049 regulation of transport 29.1667 4 no
GO:0051246 regulation of protein metabolic process 27.7778 5 no
GO:1902531 regulation of intracellular signal transduction 27.0833 5 yes
GO:0022607 cellular component assembly 27.0833 4 no
GO:0010604 positive regulation of macromolecule metabolic process 26.3889 5 no
GO:0010647 positive regulation of cell communication 26.3889 5 no
GO:0023056 positive regulation of signaling 26.3889 4 no
GO:0010468 regulation of gene expression 25.6944 5 no
GO:0051130 positive regulation of cellular component organization 24.3056 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 24.3056 5 no
GO:0033043 regulation of organelle organization 24.3056 5 no
GO:0030030 cell projection organization 23.6111 4 yes
GO:0031325 positive regulation of cellular metabolic process 23.6111 5 no
GO:0031344 regulation of cell projection organization 22.2222 5 yes
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.5278 6 yes
GO:0051247 positive regulation of protein metabolic process 21.5278 6 no
GO:0048584 positive regulation of response to stimulus 21.5278 4 no
GO:0019220 regulation of phosphate metabolic process 20.8333 6 no
GO:0051174 regulation of phosphorus metabolic process 20.8333 5 no
GO:0009889 regulation of biosynthetic process 20.8333 4 no
GO:0031326 regulation of cellular biosynthetic process 20.8333 5 no
GO:0022603 regulation of anatomical structure morphogenesis 20.1389 4 yes
GO:0016192 vesicle-mediated transport 20.1389 4 no
GO:0010556 regulation of macromolecule biosynthetic process 20.1389 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.1389 5 no
GO:0045595 regulation of cell differentiation 18.7500 4 yes
GO:0120036 plasma membrane bounded cell projection organization 18.7500 5 yes
GO:0051336 regulation of hydrolase activity 17.3611 4 yes
GO:0010975 regulation of neuron projection development 16.6667 7 yes
GO:0034330 cell junction organization 16.6667 4 yes
GO:2000026 regulation of multicellular organismal development 16.6667 4 yes
GO:0010648 negative regulation of cell communication 15.2778 5 yes
GO:0023057 negative regulation of signaling 15.2778 4 yes
GO:0048585 negative regulation of response to stimulus 14.5833 4 yes
GO:0060284 regulation of cell development 14.5833 5 yes
GO:0010941 regulation of cell death 13.8889 4 yes
GO:0050890 cognition 13.8889 4 yes
GO:0051960 regulation of nervous system development 13.8889 5 yes
GO:0072657 protein localization to membrane 13.8889 4 yes
GO:0009968 negative regulation of signal transduction 13.1944 5 yes
GO:0031175 neuron projection development 13.1944 6 yes
GO:0043087 regulation of GTPase activity 13.1944 5 yes
GO:0043408 regulation of MAPK cascade 12.5000 6 yes
GO:0050767 regulation of neurogenesis 12.5000 6 yes
GO:0050808 synapse organization 12.5000 5 yes
GO:0042981 regulation of apoptotic process 11.8056 6 yes
GO:0043067 regulation of programmed cell death 11.8056 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 11.8056 6 yes
GO:0051129 negative regulation of cellular component organization 11.1111 5 yes
GO:0007612 learning 10.4167 4 yes
GO:0060548 negative regulation of cell death 9.0278 5 yes
GO:1902532 negative regulation of intracellular signal transduction 9.0278 6 yes
GO:0048168 regulation of neuronal synaptic plasticity 8.3333 4 yes
GO:0043066 negative regulation of apoptotic process 7.6389 7 yes
GO:0043069 negative regulation of programmed cell death 7.6389 6 yes
GO:0007264 small GTPase mediated signal transduction 6.9444 4 yes
GO:0045596 negative regulation of cell differentiation 6.9444 5 yes
GO:0046578 regulation of Ras protein signal transduction 6.9444 7 yes
GO:0051093 negative regulation of developmental process 6.9444 4 yes
GO:0051241 negative regulation of multicellular organismal process 6.9444 4 yes
GO:1901214 regulation of neuron death 6.9444 5 yes
GO:0043113 receptor clustering 6.2500 5 yes
GO:1901215 negative regulation of neuron death 6.2500 6 yes
GO:0008306 associative learning 5.5556 5 yes
GO:0031345 negative regulation of cell projection organization 5.5556 6 yes
GO:0009416 response to light stimulus 4.8611 4 yes
GO:0010721 negative regulation of cell development 4.8611 6 yes
GO:0043523 regulation of neuron apoptotic process 4.8611 6 yes
GO:0048169 regulation of long-term neuronal synaptic plasticity 4.8611 5 yes
GO:0050770 regulation of axonogenesis 4.8611 5 yes
GO:0007265 Ras protein signal transduction 4.1667 5 yes
GO:0043524 negative regulation of neuron apoptotic process 4.1667 7 yes
GO:0043954 cellular component maintenance 4.1667 4 yes
GO:0050768 negative regulation of neurogenesis 4.1667 6 yes
GO:0051961 negative regulation of nervous system development 4.1667 5 yes
GO:0008542 visual learning 3.4722 4 yes
GO:0034331 cell junction maintenance 3.4722 5 yes
GO:0046580 negative regulation of Ras protein signal transduction 3.4722 8 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 3.4722 7 yes
GO:0010977 negative regulation of neuron projection development 2.7778 7 yes
GO:0097106 postsynaptic density organization 2.7778 6 yes
GO:0099084 postsynaptic specialization organization 2.7778 5 yes
GO:0099558 maintenance of synapse structure 2.0833 6 yes
GO:0050771 negative regulation of axonogenesis 1.3889 6 yes
GO:0098880 maintenance of postsynaptic specialization structure 1.3889 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in SYGP1_HUMAN
DOID:331 central nervous system disease 2.7778 3 no
DOID:936 brain disease 2.0833 4 no
DOID:574 peripheral nervous system disease 2.0833 3 no
DOID:870 neuropathy 2.0833 4 no
DOID:0060038 specific developmental disorder 1.3889 3 no
DOID:1059 intellectual disability 1.3889 4 no
DOID:0050701 electroclinical syndrome 1.3889 6 no
DOID:0112202 developmental and epileptic encephalopathy 1.3889 7 no
DOID:1826 epilepsy 1.3889 5 no
DOID:1891 optic nerve disease 1.3889 6 no
DOID:5656 cranial nerve disease 1.3889 5 no
DOID:5723 optic atrophy 1.3889 7 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MET_HUMAN [view interactions] Low throughput no yes
ULK1_HUMAN [view interactions] Low throughput no no
EGFR_HUMAN [view interactions] Low throughput no no
PGFRB_HUMAN [view interactions] Low throughput no yes
ULK2_HUMAN [view interactions] Low throughput no yes
MPDZ_HUMAN [view entry] [view interactions] Low throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NHRF3_HUMAN [view interactions] Low throughput no no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2B_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNA4_HUMAN [view entry] [view interactions] High throughput yes yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
IQEC2_HUMAN [view entry] [view interactions] High throughput yes no
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE4_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
NMDE1_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA3_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] High throughput yes yes
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
GLNA_HUMAN [view entry] [view interactions] High throughput yes yes
GUAD_HUMAN [view interactions] High throughput no yes
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
FA81A_HUMAN [view entry] [view interactions] High throughput yes yes
E41L2_HUMAN [view entry] [view interactions] High throughput yes yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
DMXL2_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP3_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP2_HUMAN [view entry] [view interactions] High throughput yes no
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
DLG2_HUMAN [view entry] [view interactions] High throughput yes yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG32_HUMAN [view entry] [view interactions] High throughput yes yes
WDR7_HUMAN [view entry] [view interactions] High throughput yes no
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
RASL1_HUMAN [view entry] [view interactions] High throughput yes yes
PI4KA_HUMAN [view entry] [view interactions] High throughput yes yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
NCAN_HUMAN [view entry] [view interactions] High throughput yes no
NCAM1_HUMAN [view entry] [view interactions] High throughput yes no
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
KCNB2_HUMAN [view interactions] High throughput no no
KBTBB_HUMAN [view entry] [view interactions] High throughput yes no
IP3KA_HUMAN [view entry] [view interactions] High throughput yes no
IQGA2_HUMAN [view interactions] High throughput no yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
GNAZ_HUMAN [view entry] [view interactions] High throughput yes yes
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
ARC_HUMAN [view entry] [view interactions] High throughput yes no
AMPH_HUMAN [view entry] [view interactions] High throughput yes yes
ARBK2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
HSF2B_HUMAN [view interactions] High throughput no yes
TRI27_HUMAN [view interactions] High throughput no yes
SUOX_HUMAN [view interactions] High throughput no no
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
NTAQ1_HUMAN [view interactions] High throughput no yes
VENTX_HUMAN [view interactions] High throughput no no
TLX3_HUMAN [view interactions] High throughput no no
EFHC1_HUMAN [view interactions] High throughput no yes
MKRN3_HUMAN [view interactions] High throughput no yes
TSSK3_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
OPTN_HUMAN [view interactions] High throughput no yes
TRIM1_HUMAN [view interactions] High throughput no no
OSTF1_HUMAN [view interactions] High throughput no yes
SPAG8_HUMAN [view interactions] High throughput no no
GUCD1_HUMAN [view interactions] High throughput no no
MGT5B_HUMAN [view interactions] High throughput no no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP1_HUMAN [view entry] [view interactions] High throughput yes no
RHG39_HUMAN [view entry] [view interactions] High throughput yes no
ASAP2_HUMAN [view interactions] High throughput no yes
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
GRM5_HUMAN [view entry] [view interactions] High throughput yes no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
PITM2_HUMAN [view interactions] High throughput no yes
FAK2_HUMAN [view entry] [view interactions] High throughput yes yes
SHSA6_HUMAN [view entry] [view interactions] High throughput yes no
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
LNX1_HUMAN [view interactions] High throughput no yes
LNX2_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
CP250_HUMAN [view interactions] High throughput no no
ANS1A_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
FP100_HUMAN [view interactions] High throughput no yes
FBX28_HUMAN [view interactions] High throughput no yes
NGAP_HUMAN [view entry] [view interactions] High throughput yes yes
CEP44_HUMAN [view interactions] High throughput no yes
GULP1_HUMAN [view interactions] High throughput no no
CCAR1_HUMAN [view interactions] High throughput no yes
NEMO_HUMAN [view interactions] High throughput no yes
SAAL1_HUMAN [view interactions] High throughput no yes
RHG15_HUMAN [view interactions] High throughput no no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
CHIO_HUMAN [view interactions] High throughput no yes
DAB2P_HUMAN [view entry] [view interactions] High throughput yes no
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
FCHO2_HUMAN [view interactions] High throughput no yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
LPXN_HUMAN [view interactions] High throughput no yes
PDE6B_HUMAN [view interactions] High throughput no no
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PIAS3_HUMAN [view interactions] High throughput no yes
PRIC1_HUMAN [view interactions] High throughput no yes
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RPGF2_HUMAN [view entry] [view interactions] High throughput yes no
RGF1B_HUMAN [view interactions] High throughput no no
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP1_HUMAN [view interactions] High throughput no no
STA13_HUMAN [view interactions] High throughput no yes
STRP2_HUMAN [view interactions] High throughput no yes
SYNE2_HUMAN [view interactions] High throughput no no
RHG40_HUMAN [view interactions] High throughput no no
RHG42_HUMAN [view interactions] High throughput no yes
PCNT_HUMAN [view interactions] High throughput no yes
NLGN2_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
TRIP6_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
H14_HUMAN [view interactions] High throughput no yes
SNUT1_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
ESR2_HUMAN [view interactions] High throughput no no
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
KLH17_HUMAN [view entry] [view interactions] High throughput yes no
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
AGRB2_HUMAN [view interactions] High throughput no no
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
DEND_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
DGKZ_HUMAN [view entry] [view interactions] High throughput yes yes
CNTP1_HUMAN [view entry] [view interactions] High throughput yes yes
CNRP1_HUMAN [view interactions] High throughput no no
CCG2_HUMAN [view entry] [view interactions] High throughput yes no
CACB2_HUMAN [view interactions] High throughput no yes
BTBD9_HUMAN [view interactions] High throughput no yes
BEGIN_HUMAN [view entry] [view interactions] High throughput yes no
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
ARF3_HUMAN [view entry] [view interactions] High throughput yes no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ADAM9_HUMAN [view interactions] High throughput no no
ADA22_HUMAN [view entry] [view interactions] High throughput yes no
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
UBR5_HUMAN [view interactions] High throughput no no
SYNJ1_HUMAN [view entry] [view interactions] High throughput yes yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
EAA1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SHAN2_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB10_HUMAN [view entry] [view interactions] High throughput yes yes
PURA_HUMAN [view entry] [view interactions] High throughput yes no
KPCG_HUMAN [view entry] [view interactions] High throughput yes yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
PRAF2_HUMAN [view entry] [view interactions] High throughput yes yes
PLCL1_HUMAN [view interactions] High throughput no yes
MYO5A_HUMAN [view entry] [view interactions] High throughput yes yes
LRRC7_HUMAN [view entry] [view interactions] High throughput yes no
KCJ10_HUMAN [view interactions] High throughput no no
KCAB2_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] Computational yes no