Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CTNA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system . Required for proper regulation of cortical neuronal migration and neurite growth (PubMed). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CTNA2_HUMAN
GO:0043168 anion binding 31.2500 4 no
GO:0019900 kinase binding 31.2500 4 no
GO:0000166 nucleotide binding 28.1250 4 no
GO:0017076 purine nucleotide binding 28.1250 5 no
GO:0032555 purine ribonucleotide binding 28.1250 4 no
GO:0043169 cation binding 28.1250 4 no
GO:0046872 metal ion binding 28.1250 5 no
GO:0019901 protein kinase binding 28.1250 5 no
GO:0016301 kinase activity 25.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0030554 adenyl nucleotide binding 25.0000 6 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0045296 cadherin binding 21.8750 4 yes
GO:0005524 ATP binding 21.8750 5 no
GO:0003779 actin binding 18.7500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CTNA2_HUMAN
GO:0010646 regulation of cell communication 71.8750 4 no
GO:0048523 negative regulation of cellular process 65.6250 4 yes
GO:0048522 positive regulation of cellular process 65.6250 4 no
GO:0051128 regulation of cellular component organization 62.5000 4 yes
GO:0009966 regulation of signal transduction 62.5000 4 no
GO:0022607 cellular component assembly 59.3750 4 no
GO:0031323 regulation of cellular metabolic process 59.3750 4 no
GO:0060255 regulation of macromolecule metabolic process 59.3750 4 no
GO:0080090 regulation of primary metabolic process 53.1250 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0034330 cell junction organization 43.7500 4 no
GO:0030030 cell projection organization 43.7500 4 yes
GO:0048585 negative regulation of response to stimulus 43.7500 4 yes
GO:0031325 positive regulation of cellular metabolic process 43.7500 5 no
GO:0031399 regulation of protein modification process 43.7500 6 no
GO:0048584 positive regulation of response to stimulus 43.7500 4 no
GO:0009889 regulation of biosynthetic process 43.7500 4 no
GO:0010468 regulation of gene expression 43.7500 6 no
GO:0010556 regulation of macromolecule biosynthetic process 43.7500 5 no
GO:0031326 regulation of cellular biosynthetic process 43.7500 5 no
GO:0023056 positive regulation of signaling 40.6250 4 no
GO:0051247 positive regulation of protein metabolic process 40.6250 6 no
GO:1902531 regulation of intracellular signal transduction 40.6250 5 no
GO:0031344 regulation of cell projection organization 37.5000 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 yes
GO:0008104 protein localization 37.5000 4 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0036211 protein modification process 37.5000 4 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:1901701 cellular response to oxygen-containing compound 34.3750 4 no
GO:2000026 regulation of multicellular organismal development 34.3750 4 no
GO:0010975 regulation of neuron projection development 34.3750 7 yes
GO:0051129 negative regulation of cellular component organization 34.3750 5 yes
GO:2000145 regulation of cell motility 34.3750 4 yes
GO:0001932 regulation of protein phosphorylation 34.3750 7 no
GO:0009967 positive regulation of signal transduction 34.3750 5 no
GO:0009892 negative regulation of metabolic process 34.3750 4 no
GO:0009968 negative regulation of signal transduction 34.3750 5 no
GO:0010648 negative regulation of cell communication 34.3750 5 no
GO:0023057 negative regulation of signaling 34.3750 4 no
GO:0045595 regulation of cell differentiation 34.3750 4 no
GO:2001141 regulation of RNA biosynthetic process 31.2500 6 no
GO:0031324 negative regulation of cellular metabolic process 31.2500 5 no
GO:0051241 negative regulation of multicellular organismal process 31.2500 4 no
GO:0071310 cellular response to organic substance 31.2500 4 no
GO:0051049 regulation of transport 31.2500 4 no
GO:0050807 regulation of synapse organization 31.2500 5 yes
GO:0006796 phosphate-containing compound metabolic process 31.2500 4 no
GO:0006996 organelle organization 31.2500 4 no
GO:0010562 positive regulation of phosphorus metabolic process 31.2500 6 no
GO:0022603 regulation of anatomical structure morphogenesis 31.2500 4 no
GO:0031401 positive regulation of protein modification process 31.2500 7 no
GO:0042327 positive regulation of phosphorylation 31.2500 8 no
GO:0045937 positive regulation of phosphate metabolic process 31.2500 7 no
GO:0120036 plasma membrane bounded cell projection organization 31.2500 5 no
GO:0141124 intracellular signaling cassette 31.2500 4 no
GO:0006355 regulation of DNA-templated transcription 31.2500 7 no
GO:0010605 negative regulation of macromolecule metabolic process 31.2500 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.2500 5 no
GO:0042127 regulation of cell population proliferation 31.2500 4 no
GO:0043085 positive regulation of catalytic activity 31.2500 4 no
GO:0051252 regulation of RNA metabolic process 31.2500 5 no
GO:0050808 synapse organization 28.1250 5 no
GO:0060284 regulation of cell development 28.1250 5 no
GO:0032880 regulation of protein localization 28.1250 5 no
GO:0034329 cell junction assembly 28.1250 5 no
GO:0060341 regulation of cellular localization 28.1250 4 no
GO:0030334 regulation of cell migration 28.1250 5 yes
GO:0001934 positive regulation of protein phosphorylation 28.1250 8 no
GO:0010243 response to organonitrogen compound 28.1250 4 no
GO:0043933 protein-containing complex organization 28.1250 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0045216 cell-cell junction organization 25.0000 5 no
GO:0050767 regulation of neurogenesis 25.0000 6 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:0051960 regulation of nervous system development 25.0000 5 no
GO:0071417 cellular response to organonitrogen compound 25.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:1901699 cellular response to nitrogen compound 25.0000 4 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.8750 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.8750 6 no
GO:0045596 negative regulation of cell differentiation 21.8750 5 no
GO:0051130 positive regulation of cellular component organization 21.8750 5 no
GO:0033043 regulation of organelle organization 21.8750 5 yes
GO:0048812 neuron projection morphogenesis 21.8750 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 21.8750 4 yes
GO:1902533 positive regulation of intracellular signal transduction 21.8750 6 no
GO:0006357 regulation of transcription by RNA polymerase II 21.8750 8 no
GO:0006915 apoptotic process 21.8750 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.8750 6 no
GO:0043066 negative regulation of apoptotic process 21.8750 6 no
GO:0043069 negative regulation of programmed cell death 21.8750 5 no
GO:0007409 axonogenesis 18.7500 6 yes
GO:0032101 regulation of response to external stimulus 18.7500 4 yes
GO:0032970 regulation of actin filament-based process 18.7500 4 yes
GO:1902903 regulation of supramolecular fiber organization 18.7500 5 yes
GO:0051493 regulation of cytoskeleton organization 15.6250 6 yes
GO:0010639 negative regulation of organelle organization 12.5000 6 yes
GO:0032102 negative regulation of response to external stimulus 12.5000 5 yes
GO:0032956 regulation of actin cytoskeleton organization 9.3750 5 yes
GO:0048854 brain morphogenesis 9.3750 4 yes
GO:0051494 negative regulation of cytoskeleton organization 9.3750 7 yes
GO:0110053 regulation of actin filament organization 9.3750 6 yes
GO:1902904 negative regulation of supramolecular fiber organization 9.3750 6 yes
GO:0021535 cell migration in hindbrain 6.2500 4 yes
GO:0021932 hindbrain radial glia guided cell migration 6.2500 5 yes
GO:0021942 radial glia guided migration of Purkinje cell 6.2500 6 yes
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 6.2500 8 yes
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation 6.2500 8 yes
GO:0048813 dendrite morphogenesis 6.2500 6 yes
GO:0051125 regulation of actin nucleation 6.2500 7 yes
GO:0051126 negative regulation of actin nucleation 6.2500 7 yes
GO:0051823 regulation of synapse structural plasticity 6.2500 6 yes
GO:0060134 prepulse inhibition 6.2500 6 yes
GO:2001222 regulation of neuron migration 6.2500 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ZN639_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
YAP1_HUMAN [view interactions] Low throughput no yes
PLAK_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNA2_HUMAN [view entry] [view interactions] Low throughput yes yes
MP2K3_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
MB212_HUMAN [view interactions] High throughput no no
TF7L2_HUMAN [view interactions] High throughput no yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
PAN2_HUMAN [view interactions] High throughput no no
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
FBW1B_HUMAN [view interactions] High throughput no yes
CD27_HUMAN [view interactions] High throughput no no
SAS10_HUMAN [view interactions] High throughput no yes
SAPC1_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
SDHF2_HUMAN [view interactions] High throughput no yes
TYW3_HUMAN [view interactions] High throughput no yes
GAN_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
CADH8_HUMAN [view interactions] High throughput no no
CADH5_HUMAN [view interactions] High throughput no yes
CNBP1_HUMAN [view interactions] High throughput no no
DUS22_HUMAN [view interactions] High throughput no yes
FBXL5_HUMAN [view interactions] High throughput no yes
CIR1_HUMAN [view interactions] High throughput no yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP1_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
TES_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
CTIP_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
FBSP1_HUMAN [view entry] [view interactions] High throughput yes no
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAD12_HUMAN [view interactions] High throughput no no
TX1B3_HUMAN [view interactions] High throughput no no
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
PCDA8_HUMAN [view interactions] High throughput no no
NAAA_HUMAN [view interactions] High throughput no yes
LRN4L_HUMAN [view interactions] High throughput no yes
UPK2_HUMAN [view interactions] High throughput no no
NXPH3_HUMAN [view interactions] High throughput no no
CLC4A_HUMAN [view interactions] High throughput no no
CLC2B_HUMAN [view interactions] High throughput no yes
SLIRP_HUMAN [view interactions] High throughput no yes
PVR_HUMAN [view interactions] High throughput no yes
PCD20_HUMAN [view interactions] High throughput no no
RYK_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
OTU7A_HUMAN [view interactions] High throughput no no
GSTT1_HUMAN [view interactions] High throughput no no
NBR1_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes