Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CTNA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system . Required for proper regulation of cortical neuronal migration and neurite growth (PubMed). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CTNA2_HUMAN
GO:0045296 cadherin binding 42.8571 4 yes
GO:0019900 kinase binding 32.1429 4 no
GO:0003779 actin binding 28.5714 4 yes
GO:0019901 protein kinase binding 28.5714 5 no
GO:0017076 purine nucleotide binding 21.4286 4 no
GO:0032555 purine ribonucleotide binding 21.4286 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.4286 4 no
GO:0046872 metal ion binding 21.4286 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CTNA2_HUMAN
GO:0048523 negative regulation of cellular process 67.8571 4 yes
GO:0010646 regulation of cell communication 67.8571 4 no
GO:0009966 regulation of signal transduction 64.2857 4 no
GO:0022607 cellular component assembly 64.2857 4 no
GO:0048522 positive regulation of cellular process 60.7143 4 no
GO:0034330 cell junction organization 57.1429 4 no
GO:0051128 regulation of cellular component organization 53.5714 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0030030 cell projection organization 46.4286 4 yes
GO:2000145 regulation of cell motility 46.4286 4 yes
GO:0048584 positive regulation of response to stimulus 46.4286 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.4286 4 no
GO:0080090 regulation of primary metabolic process 46.4286 4 no
GO:0008104 protein localization 46.4286 4 no
GO:0034329 cell junction assembly 46.4286 5 no
GO:0030334 regulation of cell migration 42.8571 5 yes
GO:0048585 negative regulation of response to stimulus 42.8571 4 yes
GO:0010647 positive regulation of cell communication 42.8571 5 no
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0045216 cell-cell junction organization 42.8571 5 no
GO:0009893 positive regulation of metabolic process 39.2857 4 no
GO:0009967 positive regulation of signal transduction 39.2857 5 no
GO:0010604 positive regulation of macromolecule metabolic process 39.2857 5 no
GO:0051246 regulation of protein metabolic process 39.2857 5 no
GO:0071310 cellular response to organic substance 39.2857 4 no
GO:1902531 regulation of intracellular signal transduction 39.2857 5 no
GO:0009968 negative regulation of signal transduction 35.7143 5 no
GO:0010648 negative regulation of cell communication 35.7143 5 no
GO:0022603 regulation of anatomical structure morphogenesis 35.7143 4 no
GO:0023057 negative regulation of signaling 35.7143 4 no
GO:0031325 positive regulation of cellular metabolic process 35.7143 5 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 35.7143 5 no
GO:1901701 cellular response to oxygen-containing compound 35.7143 4 no
GO:0007043 cell-cell junction assembly 35.7143 6 no
GO:0051049 regulation of transport 35.7143 4 no
GO:0001932 regulation of protein phosphorylation 32.1429 7 no
GO:0010243 response to organonitrogen compound 32.1429 4 no
GO:0019220 regulation of phosphate metabolic process 32.1429 6 no
GO:0030155 regulation of cell adhesion 32.1429 4 no
GO:0042325 regulation of phosphorylation 32.1429 7 no
GO:0051174 regulation of phosphorus metabolic process 32.1429 5 no
GO:0120036 plasma membrane bounded cell projection organization 32.1429 5 no
GO:0009889 regulation of biosynthetic process 32.1429 4 no
GO:0010468 regulation of gene expression 32.1429 5 no
GO:0010556 regulation of macromolecule biosynthetic process 32.1429 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.1429 5 no
GO:0031326 regulation of cellular biosynthetic process 32.1429 5 no
GO:0032880 regulation of protein localization 32.1429 5 no
GO:0051252 regulation of RNA metabolic process 32.1429 5 no
GO:0060341 regulation of cellular localization 32.1429 4 no
GO:1903506 regulation of nucleic acid-templated transcription 32.1429 7 no
GO:2001141 regulation of RNA biosynthetic process 32.1429 6 no
GO:0006996 organelle organization 32.1429 4 no
GO:0010941 regulation of cell death 32.1429 4 no
GO:0042981 regulation of apoptotic process 32.1429 6 no
GO:0043067 regulation of programmed cell death 32.1429 5 no
GO:0010975 regulation of neuron projection development 28.5714 7 yes
GO:0031344 regulation of cell projection organization 28.5714 5 yes
GO:0033043 regulation of organelle organization 28.5714 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 yes
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0050808 synapse organization 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0071417 cellular response to organonitrogen compound 28.5714 4 no
GO:1901699 cellular response to nitrogen compound 28.5714 4 no
GO:1902533 positive regulation of intracellular signal transduction 28.5714 6 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no
GO:0006355 regulation of DNA-templated transcription 28.5714 6 no
GO:0032990 cell part morphogenesis 25.0000 4 yes
GO:0048812 neuron projection morphogenesis 25.0000 7 yes
GO:0048858 cell projection morphogenesis 25.0000 5 yes
GO:0050807 regulation of synapse organization 25.0000 5 yes
GO:0051129 negative regulation of cellular component organization 25.0000 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.0000 6 yes
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 yes
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0030111 regulation of Wnt signaling pathway 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0032970 regulation of actin filament-based process 21.4286 4 yes
GO:0051493 regulation of cytoskeleton organization 21.4286 6 yes
GO:0002009 morphogenesis of an epithelium 21.4286 4 no
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 no
GO:0030335 positive regulation of cell migration 21.4286 6 no
GO:0031175 neuron projection development 21.4286 6 no
GO:0033674 positive regulation of kinase activity 21.4286 6 no
GO:0040013 negative regulation of locomotion 21.4286 4 no
GO:0040017 positive regulation of locomotion 21.4286 4 no
GO:0043410 positive regulation of MAPK cascade 21.4286 7 no
GO:0043549 regulation of kinase activity 21.4286 5 no
GO:0045596 negative regulation of cell differentiation 21.4286 5 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0045860 positive regulation of protein kinase activity 21.4286 7 no
GO:0051093 negative regulation of developmental process 21.4286 4 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 no
GO:0051241 negative regulation of multicellular organismal process 21.4286 4 no
GO:0060284 regulation of cell development 21.4286 5 no
GO:2000146 negative regulation of cell motility 21.4286 5 no
GO:2000147 positive regulation of cell motility 21.4286 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0060828 regulation of canonical Wnt signaling pathway 21.4286 6 no
GO:0071407 cellular response to organic cyclic compound 21.4286 5 no
GO:0097305 response to alcohol 21.4286 4 no
GO:0007010 cytoskeleton organization 21.4286 5 no
GO:0010942 positive regulation of cell death 21.4286 5 no
GO:0043065 positive regulation of apoptotic process 21.4286 7 no
GO:0043066 negative regulation of apoptotic process 21.4286 7 no
GO:0043068 positive regulation of programmed cell death 21.4286 6 no
GO:0043069 negative regulation of programmed cell death 21.4286 6 no
GO:0060548 negative regulation of cell death 21.4286 5 no
GO:0031400 negative regulation of protein modification process 21.4286 7 no
GO:0032956 regulation of actin cytoskeleton organization 17.8571 5 yes
GO:0110053 regulation of actin filament organization 17.8571 6 yes
GO:0007409 axonogenesis 14.2857 8 yes
GO:0010639 negative regulation of organelle organization 14.2857 6 yes
GO:0032101 regulation of response to external stimulus 14.2857 4 yes
GO:0048854 brain morphogenesis 14.2857 4 yes
GO:0051494 negative regulation of cytoskeleton organization 14.2857 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 14.2857 6 yes
GO:0032102 negative regulation of response to external stimulus 10.7143 5 yes
GO:0021535 cell migration in hindbrain 7.1429 4 yes
GO:0021932 hindbrain radial glia guided cell migration 7.1429 5 yes
GO:0021942 radial glia guided migration of Purkinje cell 7.1429 6 yes
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 7.1429 8 yes
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation 7.1429 8 yes
GO:0048813 dendrite morphogenesis 7.1429 8 yes
GO:0051125 regulation of actin nucleation 7.1429 7 yes
GO:0051126 negative regulation of actin nucleation 7.1429 7 yes
GO:0051823 regulation of synapse structural plasticity 7.1429 6 yes
GO:0060134 prepulse inhibition 7.1429 6 yes
GO:2001222 regulation of neuron migration 7.1429 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ZN639_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
YAP1_HUMAN [view interactions] Low throughput no yes
PLAK_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNA2_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
PAN2_HUMAN [view interactions] High throughput no no
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
FBW1B_HUMAN [view interactions] High throughput no yes
CD27_HUMAN [view interactions] High throughput no no
SAS10_HUMAN [view interactions] High throughput no yes
SAPC1_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
SDHF2_HUMAN [view interactions] High throughput no yes
TYW3_HUMAN [view interactions] High throughput no yes
GAN_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
LNX1_HUMAN [view interactions] High throughput no yes
CADH8_HUMAN [view interactions] High throughput no no
CADH5_HUMAN [view interactions] High throughput no yes
CNBP1_HUMAN [view interactions] High throughput no no
DUS22_HUMAN [view interactions] High throughput no yes
FBXL5_HUMAN [view interactions] High throughput no yes
CIR1_HUMAN [view interactions] High throughput no yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP1_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
TES_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
CTIP_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
FBSP1_HUMAN [view entry] [view interactions] High throughput yes no
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAD12_HUMAN [view interactions] High throughput no no
TX1B3_HUMAN [view interactions] High throughput no no
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
PCDA8_HUMAN [view interactions] High throughput no no
NAAA_HUMAN [view interactions] High throughput no yes
LRN4L_HUMAN [view interactions] High throughput no yes
UPK2_HUMAN [view interactions] High throughput no no
NXPH3_HUMAN [view interactions] High throughput no no
CLC4A_HUMAN [view interactions] High throughput no no
CLC2B_HUMAN [view interactions] High throughput no yes
SLIRP_HUMAN [view interactions] High throughput no yes
PVR_HUMAN [view interactions] High throughput no yes
PCD20_HUMAN [view interactions] High throughput no no
RYK_HUMAN [view interactions] High throughput no no
GSTT1_HUMAN [view interactions] High throughput no no
NBR1_HUMAN [view interactions] High throughput no yes
MP2K3_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
MB212_HUMAN [view interactions] High throughput no no
TF7L2_HUMAN [view interactions] High throughput no yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] Computational yes yes
VINC_HUMAN [view entry] [view interactions] Computational yes no
MP2K6_HUMAN [view interactions] Computational no yes
ZO1_HUMAN [view entry] [view interactions] Computational yes no
ACTG_HUMAN [view entry] [view interactions] Computational yes yes
CTND1_HUMAN [view entry] [view interactions] Computational yes no
CADH2_HUMAN [view entry] [view interactions] Computational yes no
CAD17_HUMAN [view interactions] Computational no no
ACTN4_HUMAN [view entry] [view interactions] Computational yes yes
CTND2_HUMAN [view entry] [view interactions] Computational yes no
CTNA3_HUMAN [view interactions] Computational no no