KALRN_HUMAN
Evidence for PS localization
Functions
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KALRN_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 33.3333 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.6667 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 25.3333 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 25.3333 | 5 | yes |
| GO:0005524 | ATP binding | 22.6667 | 5 | yes |
| GO:0016301 | kinase activity | 21.3333 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 20.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 20.0000 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 18.6667 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 17.3333 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 13.3333 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 13.3333 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 8.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KALRN_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 56.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 54.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 52.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 49.3333 | 4 | no |
| GO:0006996 | organelle organization | 44.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0051049 | regulation of transport | 40.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 37.3333 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.3333 | 4 | no |
| GO:0030030 | cell projection organization | 36.0000 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 36.0000 | 6 | no |
| GO:0007010 | cytoskeleton organization | 33.3333 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 32.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 32.0000 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 32.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.6667 | 5 | yes |
| GO:0008104 | protein localization | 30.6667 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.6667 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 29.3333 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 29.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.3333 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.3333 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.6667 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 26.6667 | 7 | no |
| GO:0051246 | regulation of protein metabolic process | 26.6667 | 5 | no |
| GO:0043269 | regulation of ion transport | 25.3333 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 24.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 24.0000 | 4 | no |
| GO:0034330 | cell junction organization | 24.0000 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.6667 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 22.6667 | 4 | yes |
| GO:0031175 | neuron projection development | 22.6667 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 22.6667 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 22.6667 | 5 | no |
| GO:0050807 | regulation of synapse organization | 22.6667 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.6667 | 6 | no |
| GO:0032990 | cell part morphogenesis | 22.6667 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.6667 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.6667 | 4 | no |
| GO:0048812 | neuron projection morphogenesis | 22.6667 | 7 | no |
| GO:0048858 | cell projection morphogenesis | 22.6667 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.6667 | 5 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 22.6667 | 6 | no |
| GO:0060341 | regulation of cellular localization | 22.6667 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 21.3333 | 4 | yes |
| GO:0016310 | phosphorylation | 21.3333 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 21.3333 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 21.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.3333 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.3333 | 5 | no |
| GO:0006468 | protein phosphorylation | 20.0000 | 5 | yes |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 20.0000 | 5 | yes |
| GO:0036211 | protein modification process | 20.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 20.0000 | 4 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 16.0000 | 6 | yes |
| GO:0007399 | nervous system development | 12.0000 | 4 | yes |
| GO:0007411 | axon guidance | 9.3333 | 8 | yes |
| GO:0048013 | ephrin receptor signaling pathway | 9.3333 | 6 | yes |
| GO:0097485 | neuron projection guidance | 9.3333 | 7 | yes |
| GO:0007417 | central nervous system development | 4.0000 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KALRN_HUMAN |
|---|---|---|---|---|
| DOID:0060038 | specific developmental disorder | 5.3333 | 3 | no |
| DOID:1059 | intellectual disability | 5.3333 | 4 | no |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | 4.0000 | 5 | no |
| DOID:0111962 | combined immunodeficiency | 2.6667 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 2.6667 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AMD_HUMAN | [view interactions] | Low throughput | no | yes |
| SNCAP_HUMAN | [view interactions] | Low throughput | no | no |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NLGN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| GFI1B_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX7_HUMAN | [view interactions] | High throughput | no | no |
| CAC1A_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DZAN1_HUMAN | [view interactions] | High throughput | no | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| SESD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K9_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKA11_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| ADA22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| CAD10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IQEC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDE4D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPGF4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHSA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| RHG23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG6_HUMAN | [view interactions] | High throughput | no | no |
| ARHG9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIN_HUMAN | [view interactions] | High throughput | no | no |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| METK2_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DICER_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSHR_HUMAN | [view interactions] | High throughput | no | no |
| PREX2_HUMAN | [view interactions] | High throughput | no | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EFNB1_HUMAN | [view interactions] | Computational | no | yes |
| MAPK5_HUMAN | [view interactions] | Computational | no | yes |
| EPHB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK06_HUMAN | [view interactions] | Computational | no | yes |
| APBA1_HUMAN | [view interactions] | Computational | no | no |
| RHG31_HUMAN | [view interactions] | Computational | no | yes |
| EFNB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |