KALRN_HUMAN
Evidence for PS localization
Functions
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KALRN_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 28.3784 | 4 | yes |
| GO:0000166 | nucleotide binding | 25.6757 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 25.6757 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.6757 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 24.3243 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 24.3243 | 5 | yes |
| GO:0043169 | cation binding | 24.3243 | 4 | yes |
| GO:0046872 | metal ion binding | 24.3243 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.6216 | 4 | yes |
| GO:0005524 | ATP binding | 20.2703 | 5 | yes |
| GO:0016301 | kinase activity | 17.5676 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 17.5676 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 16.2162 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 12.1622 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 12.1622 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 8.1081 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KALRN_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 64.8649 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.0541 | 4 | no |
| GO:0009966 | regulation of signal transduction | 48.6486 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.2973 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 41.8919 | 4 | no |
| GO:0006996 | organelle organization | 39.1892 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 37.8378 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 37.8378 | 4 | no |
| GO:0051049 | regulation of transport | 37.8378 | 4 | no |
| GO:0022607 | cellular component assembly | 36.4865 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.1351 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 33.7838 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.7838 | 4 | no |
| GO:0008104 | protein localization | 31.0811 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 31.0811 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 29.7297 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 29.7297 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.7297 | 6 | no |
| GO:0030030 | cell projection organization | 28.3784 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 28.3784 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 28.3784 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.3784 | 5 | no |
| GO:0007010 | cytoskeleton organization | 27.0270 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.0270 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 24.3243 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.3243 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.3243 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 24.3243 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.3243 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.3243 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.3243 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 22.9730 | 7 | no |
| GO:0048812 | neuron projection morphogenesis | 21.6216 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 21.6216 | 5 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 21.6216 | 4 | no |
| GO:0010468 | regulation of gene expression | 21.6216 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.6216 | 4 | no |
| GO:0050807 | regulation of synapse organization | 20.2703 | 5 | no |
| GO:0044057 | regulation of system process | 20.2703 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 20.2703 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 18.9189 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 18.9189 | 5 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 17.5676 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 16.2162 | 5 | yes |
| GO:0016310 | phosphorylation | 16.2162 | 5 | yes |
| GO:0031175 | neuron projection development | 16.2162 | 6 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 14.8649 | 6 | yes |
| GO:0036211 | protein modification process | 13.5135 | 4 | yes |
| GO:0043412 | macromolecule modification | 13.5135 | 4 | yes |
| GO:0006468 | protein phosphorylation | 12.1622 | 5 | yes |
| GO:0007399 | nervous system development | 10.8108 | 4 | yes |
| GO:0007411 | axon guidance | 5.4054 | 8 | yes |
| GO:0048013 | ephrin receptor signaling pathway | 5.4054 | 6 | yes |
| GO:0097485 | neuron projection guidance | 5.4054 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AMD_HUMAN | [view interactions] | Low throughput | no | yes |
| SNCAP_HUMAN | [view interactions] | Low throughput | no | no |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NLGN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| GFI1B_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX7_HUMAN | [view interactions] | High throughput | no | no |
| CAC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKA11_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DZAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K9_HUMAN | [view interactions] | High throughput | no | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SESD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| GRIK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
| NRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| MORC3_HUMAN | [view interactions] | High throughput | no | yes |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| CAD10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IQEC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDE4D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPGF4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHSA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| RHG23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG6_HUMAN | [view interactions] | High throughput | no | no |
| ARHG9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIN_HUMAN | [view interactions] | High throughput | no | no |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| METK2_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| DICER_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSHR_HUMAN | [view interactions] | High throughput | no | no |
| PREX2_HUMAN | [view interactions] | High throughput | no | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |