IQEC1_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed, PubMed). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin (PubMed). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in IQEC1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 33.3333 | 4 | no |
| GO:0046872 | metal ion binding | 33.3333 | 5 | no |
| GO:0043168 | anion binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 22.9167 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.9167 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 22.9167 | 4 | no |
| GO:0030695 | GTPase regulator activity | 20.8333 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.8333 | 4 | no |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 10.4167 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in IQEC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 68.7500 | 4 | yes |
| GO:0010646 | regulation of cell communication | 66.6667 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 58.3333 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 58.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 54.1667 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 54.1667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 54.1667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.0833 | 4 | no |
| GO:0008104 | protein localization | 47.9167 | 4 | no |
| GO:0006996 | organelle organization | 45.8333 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 43.7500 | 5 | no |
| GO:0022607 | cellular component assembly | 41.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.5833 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 39.5833 | 5 | no |
| GO:0023056 | positive regulation of signaling | 39.5833 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 37.5000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 37.5000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 35.4167 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 31.2500 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 31.2500 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 31.2500 | 6 | no |
| GO:0031399 | regulation of protein modification process | 31.2500 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 31.2500 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 31.2500 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 31.2500 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.2500 | 5 | no |
| GO:0007010 | cytoskeleton organization | 29.1667 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 29.1667 | 4 | no |
| GO:0030030 | cell projection organization | 29.1667 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.1667 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 29.1667 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.1667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.1667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.1667 | 5 | no |
| GO:0043933 | protein-containing complex organization | 29.1667 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.0833 | 5 | yes |
| GO:0141124 | intracellular signaling cassette | 27.0833 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 27.0833 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 27.0833 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0050890 | cognition | 25.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 22.9167 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.9167 | 4 | no |
| GO:0071702 | organic substance transport | 22.9167 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.9167 | 4 | no |
| GO:0043549 | regulation of kinase activity | 22.9167 | 5 | no |
| GO:0051338 | regulation of transferase activity | 22.9167 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 20.8333 | 7 | no |
| GO:0072657 | protein localization to membrane | 20.8333 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.8333 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.8333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.8333 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 20.8333 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.8333 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 20.8333 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 20.8333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 20.8333 | 5 | no |
| GO:0032880 | regulation of protein localization | 20.8333 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.8333 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 20.8333 | 6 | no |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 18.7500 | 6 | yes |
| GO:2000145 | regulation of cell motility | 18.7500 | 4 | yes |
| GO:0030334 | regulation of cell migration | 14.5833 | 5 | yes |
| GO:0010632 | regulation of epithelial cell migration | 10.4167 | 4 | yes |
| GO:0030335 | positive regulation of cell migration | 10.4167 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 10.4167 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 10.4167 | 5 | yes |
| GO:0010634 | positive regulation of epithelial cell migration | 8.3333 | 5 | yes |
| GO:0032012 | regulation of ARF protein signal transduction | 6.2500 | 7 | yes |
| GO:0051547 | regulation of keratinocyte migration | 6.2500 | 5 | yes |
| GO:0051549 | positive regulation of keratinocyte migration | 6.2500 | 6 | yes |
| GO:0120182 | regulation of focal adhesion disassembly | 6.2500 | 6 | yes |
| GO:0120183 | positive regulation of focal adhesion disassembly | 6.2500 | 7 | yes |
| GO:0150116 | regulation of cell-substrate junction organization | 6.2500 | 5 | yes |
| GO:0150117 | positive regulation of cell-substrate junction organization | 6.2500 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ALS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SODC_HUMAN | [view interactions] | Low throughput | no | yes |
| TADBP_HUMAN | [view interactions] | Low throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| TOR1A_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRC5_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| TFDP3_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4HA2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HEY1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| PROZ_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| HAVR2_HUMAN | [view interactions] | High throughput | no | no |
| FBLN5_HUMAN | [view interactions] | High throughput | no | no |
| IQEC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CF141_HUMAN | [view interactions] | High throughput | no | no |
| ST1C4_HUMAN | [view interactions] | High throughput | no | no |
| ACL6B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| BRNP1_HUMAN | [view interactions] | High throughput | no | yes |
| ASB4_HUMAN | [view interactions] | High throughput | no | no |
| TRFM_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| CCG7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANM6_HUMAN | [view interactions] | High throughput | no | yes |
| BSND_HUMAN | [view interactions] | High throughput | no | no |
| FA83A_HUMAN | [view interactions] | High throughput | no | no |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| FYCO1_HUMAN | [view interactions] | High throughput | no | no |
| B4GT2_HUMAN | [view interactions] | High throughput | no | no |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| CRBB3_HUMAN | [view interactions] | High throughput | no | no |
| ST32C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| GALT9_HUMAN | [view interactions] | High throughput | no | no |
| PELI3_HUMAN | [view interactions] | High throughput | no | yes |
| B2L12_HUMAN | [view interactions] | High throughput | no | yes |
| DACT2_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| PP2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS9_HUMAN | [view interactions] | High throughput | no | yes |
| CYH4_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| HACE1_HUMAN | [view interactions] | High throughput | no | no |
| LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC7A_HUMAN | [view interactions] | High throughput | no | yes |
| ZC12C_HUMAN | [view interactions] | High throughput | no | yes |
| MIOS_HUMAN | [view interactions] | High throughput | no | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| IRF7_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| SRPRA_HUMAN | [view interactions] | High throughput | no | no |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| INSY2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SKP2_HUMAN | [view interactions] | High throughput | no | yes |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| APBA2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMK2_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |