IQEC1_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed, PubMed). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin (PubMed). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in IQEC1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 30.7692 | 4 | no |
| GO:0019900 | kinase binding | 25.6410 | 4 | no |
| GO:0019901 | protein kinase binding | 23.0769 | 5 | no |
| GO:0030695 | GTPase regulator activity | 20.5128 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 20.5128 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 20.5128 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.5128 | 4 | no |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 10.2564 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in IQEC1_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 66.6667 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 61.5385 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 53.8462 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 53.8462 | 4 | no |
| GO:0009966 | regulation of signal transduction | 51.2821 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.2821 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 51.2821 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 51.2821 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.7179 | 4 | no |
| GO:0008104 | protein localization | 46.1538 | 4 | no |
| GO:0006996 | organelle organization | 43.5897 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 43.5897 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 43.5897 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 43.5897 | 4 | no |
| GO:0022607 | cellular component assembly | 35.8974 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.8974 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 35.8974 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.8974 | 4 | no |
| GO:0030030 | cell projection organization | 35.8974 | 4 | no |
| GO:0051049 | regulation of transport | 35.8974 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 33.3333 | 5 | no |
| GO:0050890 | cognition | 30.7692 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.7692 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 30.7692 | 4 | no |
| GO:0032880 | regulation of protein localization | 30.7692 | 5 | no |
| GO:0060341 | regulation of cellular localization | 30.7692 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 30.7692 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.7692 | 6 | no |
| GO:0031399 | regulation of protein modification process | 30.7692 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 30.7692 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.7692 | 5 | no |
| GO:0007010 | cytoskeleton organization | 28.2051 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 28.2051 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 28.2051 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 28.2051 | 6 | no |
| GO:0010468 | regulation of gene expression | 28.2051 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.2051 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 28.2051 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.2051 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.2051 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.6410 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 25.6410 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.6410 | 6 | no |
| GO:0071702 | organic substance transport | 25.6410 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.6410 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.6410 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 23.0769 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 23.0769 | 6 | no |
| GO:0010941 | regulation of cell death | 23.0769 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 23.0769 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 23.0769 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.0769 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 23.0769 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.0769 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.0769 | 5 | no |
| GO:0031175 | neuron projection development | 23.0769 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.0769 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.0769 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.0769 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0043549 | regulation of kinase activity | 23.0769 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.0769 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.0769 | 4 | no |
| GO:0051338 | regulation of transferase activity | 23.0769 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.5128 | 5 | no |
| GO:0007612 | learning | 20.5128 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.5128 | 4 | no |
| GO:0009894 | regulation of catabolic process | 20.5128 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 20.5128 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 20.5128 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.5128 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 20.5128 | 6 | no |
| GO:0072657 | protein localization to membrane | 20.5128 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.5128 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.5128 | 5 | no |
| GO:0034330 | cell junction organization | 20.5128 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.5128 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 20.5128 | 7 | no |
| GO:0033365 | protein localization to organelle | 20.5128 | 5 | no |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 17.9487 | 6 | yes |
| GO:0046578 | regulation of Ras protein signal transduction | 15.3846 | 7 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 15.3846 | 5 | yes |
| GO:2000145 | regulation of cell motility | 15.3846 | 4 | yes |
| GO:0030334 | regulation of cell migration | 12.8205 | 5 | yes |
| GO:0010632 | regulation of epithelial cell migration | 10.2564 | 4 | yes |
| GO:0043087 | regulation of GTPase activity | 10.2564 | 5 | yes |
| GO:0010634 | positive regulation of epithelial cell migration | 7.6923 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 7.6923 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 7.6923 | 4 | yes |
| GO:0043547 | positive regulation of GTPase activity | 7.6923 | 6 | yes |
| GO:2000147 | positive regulation of cell motility | 7.6923 | 5 | yes |
| GO:0032012 | regulation of ARF protein signal transduction | 5.1282 | 8 | yes |
| GO:0051547 | regulation of keratinocyte migration | 5.1282 | 5 | yes |
| GO:0051549 | positive regulation of keratinocyte migration | 5.1282 | 6 | yes |
| GO:0120182 | regulation of focal adhesion disassembly | 5.1282 | 6 | yes |
| GO:0120183 | positive regulation of focal adhesion disassembly | 5.1282 | 7 | yes |
| GO:0150116 | regulation of cell-substrate junction organization | 5.1282 | 5 | yes |
| GO:0150117 | positive regulation of cell-substrate junction organization | 5.1282 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in IQEC1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 12.8205 | 3 | no |
| DOID:1289 | neurodegenerative disease | 10.2564 | 4 | no |
| DOID:0111198 | autosomal dominant distal hereditary motor neuronopathy | 5.1282 | 7 | no |
| DOID:12377 | spinal muscular atrophy | 5.1282 | 6 | no |
| DOID:231 | motor neuron disease | 5.1282 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ALS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SODC_HUMAN | [view interactions] | Low throughput | no | yes |
| TADBP_HUMAN | [view interactions] | Low throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GNAQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| TOR1A_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRC5_HUMAN | [view interactions] | High throughput | no | no |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| TFDP3_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HEY1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| PROZ_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| HAVR2_HUMAN | [view interactions] | High throughput | no | no |
| FBLN5_HUMAN | [view interactions] | High throughput | no | no |
| IQEC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CF141_HUMAN | [view interactions] | High throughput | no | no |
| ST1C4_HUMAN | [view interactions] | High throughput | no | no |
| ACL6B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| BRNP1_HUMAN | [view interactions] | High throughput | no | yes |
| ASB4_HUMAN | [view interactions] | High throughput | no | no |
| TRFM_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| CCG7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANM6_HUMAN | [view interactions] | High throughput | no | yes |
| BSND_HUMAN | [view interactions] | High throughput | no | no |
| FA83A_HUMAN | [view interactions] | High throughput | no | no |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| FYCO1_HUMAN | [view interactions] | High throughput | no | no |
| B4GT2_HUMAN | [view interactions] | High throughput | no | no |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| CRBB3_HUMAN | [view interactions] | High throughput | no | no |
| ST32C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| GALT9_HUMAN | [view interactions] | High throughput | no | no |
| PELI3_HUMAN | [view interactions] | High throughput | no | yes |
| B2L12_HUMAN | [view interactions] | High throughput | no | yes |
| DACT2_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| PP2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS9_HUMAN | [view interactions] | High throughput | no | yes |
| CYH4_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| HACE1_HUMAN | [view interactions] | High throughput | no | no |
| LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC7A_HUMAN | [view interactions] | High throughput | no | yes |
| ZC12C_HUMAN | [view interactions] | High throughput | no | yes |
| MIO_HUMAN | [view interactions] | High throughput | no | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| IRF7_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| SRPRA_HUMAN | [view interactions] | High throughput | no | no |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| INSY2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SKP2_HUMAN | [view interactions] | High throughput | no | yes |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| APBA2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMK2_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EGFR_HUMAN | [view interactions] | Computational | no | no |
| EGF_HUMAN | [view interactions] | Computational | no | no |