INSY2_HUMAN
Evidence for PS localization
Functions
Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in INSY2_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 71.4286 | 4 | no |
| GO:0017076 | purine nucleotide binding | 71.4286 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 71.4286 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 71.4286 | 4 | no |
| GO:0043168 | anion binding | 71.4286 | 4 | no |
| GO:0043169 | cation binding | 71.4286 | 4 | no |
| GO:0046872 | metal ion binding | 71.4286 | 5 | no |
| GO:0005525 | GTP binding | 57.1429 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 57.1429 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 57.1429 | 5 | no |
| GO:0003924 | GTPase activity | 28.5714 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 28.5714 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.5714 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.5714 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in INSY2_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 71.4286 | 4 | no |
| GO:0007010 | cytoskeleton organization | 57.1429 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 57.1429 | 4 | no |
| GO:0030030 | cell projection organization | 28.5714 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 28.5714 | 4 | no |
| GO:0010821 | regulation of mitochondrion organization | 28.5714 | 6 | no |
| GO:0033043 | regulation of organelle organization | 28.5714 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 28.5714 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | no |
| GO:0006915 | apoptotic process | 28.5714 | 4 | no |
| GO:0009966 | regulation of signal transduction | 28.5714 | 4 | no |
| GO:0010646 | regulation of cell communication | 28.5714 | 4 | no |
| GO:0010970 | transport along microtubule | 28.5714 | 4 | no |
| GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 28.5714 | 4 | no |
| GO:0043933 | protein-containing complex organization | 28.5714 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 28.5714 | 5 | no |
| GO:0072384 | organelle transport along microtubule | 28.5714 | 4 | no |
| GO:0099111 | microtubule-based transport | 28.5714 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NOP56_HUMAN | [view interactions] | High throughput | no | yes |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC3_HUMAN | [view interactions] | High throughput | no | no |
| STAT2_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FP100_HUMAN | [view interactions] | High throughput | no | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP5B1_HUMAN | [view interactions] | High throughput | no | yes |
| EMAL3_HUMAN | [view interactions] | High throughput | no | no |
| BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRUN1_HUMAN | [view interactions] | High throughput | no | no |
| SGF29_HUMAN | [view interactions] | High throughput | no | yes |
| METH_HUMAN | [view interactions] | High throughput | no | yes |
| WDCP_HUMAN | [view interactions] | High throughput | no | yes |
| BACH2_HUMAN | [view interactions] | High throughput | no | yes |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| RUND1_HUMAN | [view interactions] | High throughput | no | yes |
| EFL1_HUMAN | [view interactions] | High throughput | no | yes |
| STX5_HUMAN | [view interactions] | High throughput | no | yes |
| LRBA_HUMAN | [view interactions] | High throughput | no | yes |
| UBP4_HUMAN | [view interactions] | High throughput | no | no |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| SBP2L_HUMAN | [view interactions] | High throughput | no | yes |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KKCC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD50_HUMAN | [view interactions] | High throughput | no | yes |
| CHD1L_HUMAN | [view interactions] | High throughput | no | yes |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| ZNG1A_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| DC2L1_HUMAN | [view interactions] | High throughput | no | no |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |