Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KKCC2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals . Seems to be involved in hippocampal activation of CREB1 . May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KKCC2_HUMAN
GO:0000166 nucleotide binding 38.2353 4 yes
GO:0005524 ATP binding 38.2353 5 yes
GO:0017076 purine nucleotide binding 38.2353 5 yes
GO:0030554 adenyl nucleotide binding 38.2353 6 yes
GO:0032555 purine ribonucleotide binding 38.2353 4 yes
GO:0032559 adenyl ribonucleotide binding 38.2353 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 38.2353 4 yes
GO:0043168 anion binding 38.2353 4 yes
GO:0019900 kinase binding 38.2353 4 no
GO:0043169 cation binding 35.2941 4 yes
GO:0046872 metal ion binding 35.2941 5 yes
GO:0019901 protein kinase binding 35.2941 5 no
GO:0003723 RNA binding 26.4706 4 no
GO:0005509 calcium ion binding 20.5882 6 yes
GO:0019887 protein kinase regulator activity 20.5882 4 no
GO:0004674 protein serine/threonine kinase activity 17.6471 4 yes
GO:0016301 kinase activity 17.6471 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 17.6471 4 yes
GO:0106310 protein serine kinase activity 17.6471 4 yes
GO:0004683 calmodulin-dependent protein kinase activity 11.7647 5 yes
GO:0004713 protein tyrosine kinase activity 5.8824 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KKCC2_HUMAN
GO:0060255 regulation of macromolecule metabolic process 67.6471 4 yes
GO:0080090 regulation of primary metabolic process 67.6471 4 yes
GO:0031323 regulation of cellular metabolic process 64.7059 4 yes
GO:0051246 regulation of protein metabolic process 58.8235 5 yes
GO:0048522 positive regulation of cellular process 55.8824 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 yes
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0010468 regulation of gene expression 47.0588 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 47.0588 5 yes
GO:0019220 regulation of phosphate metabolic process 47.0588 6 yes
GO:0031325 positive regulation of cellular metabolic process 47.0588 5 yes
GO:0031399 regulation of protein modification process 47.0588 6 yes
GO:0051174 regulation of phosphorus metabolic process 47.0588 5 yes
GO:0009892 negative regulation of metabolic process 47.0588 4 no
GO:0001932 regulation of protein phosphorylation 44.1176 7 yes
GO:0042325 regulation of phosphorylation 44.1176 7 yes
GO:0051247 positive regulation of protein metabolic process 44.1176 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 44.1176 5 no
GO:0043549 regulation of kinase activity 41.1765 5 yes
GO:0045859 regulation of protein kinase activity 41.1765 6 yes
GO:0051128 regulation of cellular component organization 41.1765 4 yes
GO:0051338 regulation of transferase activity 41.1765 4 yes
GO:0031324 negative regulation of cellular metabolic process 41.1765 5 no
GO:0009894 regulation of catabolic process 38.2353 4 yes
GO:0051252 regulation of RNA metabolic process 38.2353 5 yes
GO:0009966 regulation of signal transduction 38.2353 4 no
GO:0010646 regulation of cell communication 38.2353 4 no
GO:0051049 regulation of transport 38.2353 4 no
GO:0001934 positive regulation of protein phosphorylation 35.2941 8 yes
GO:0006355 regulation of DNA-templated transcription 35.2941 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 35.2941 6 yes
GO:0031401 positive regulation of protein modification process 35.2941 7 yes
GO:0036211 protein modification process 35.2941 4 yes
GO:0042327 positive regulation of phosphorylation 35.2941 8 yes
GO:0043412 macromolecule modification 35.2941 4 yes
GO:0045937 positive regulation of phosphate metabolic process 35.2941 7 yes
GO:2001141 regulation of RNA biosynthetic process 35.2941 6 yes
GO:0051248 negative regulation of protein metabolic process 35.2941 6 no
GO:0006996 organelle organization 35.2941 4 no
GO:0009891 positive regulation of biosynthetic process 32.3529 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 32.3529 6 yes
GO:1902531 regulation of intracellular signal transduction 32.3529 5 no
GO:0006796 phosphate-containing compound metabolic process 29.4118 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 29.4118 6 yes
GO:0051050 positive regulation of transport 29.4118 4 no
GO:0060341 regulation of cellular localization 29.4118 4 no
GO:0022607 cellular component assembly 29.4118 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.4706 5 yes
GO:1901701 cellular response to oxygen-containing compound 26.4706 4 yes
GO:0031400 negative regulation of protein modification process 26.4706 7 no
GO:0033674 positive regulation of kinase activity 26.4706 6 no
GO:0034762 regulation of transmembrane transport 26.4706 4 no
GO:0043085 positive regulation of catalytic activity 26.4706 4 no
GO:0045860 positive regulation of protein kinase activity 26.4706 7 no
GO:0051347 positive regulation of transferase activity 26.4706 5 no
GO:0051726 regulation of cell cycle 26.4706 4 no
GO:0032880 regulation of protein localization 26.4706 5 no
GO:0042981 regulation of apoptotic process 26.4706 5 no
GO:0043067 regulation of programmed cell death 26.4706 4 no
GO:0071702 organic substance transport 26.4706 4 no
GO:0090304 nucleic acid metabolic process 26.4706 4 no
GO:0006468 protein phosphorylation 23.5294 5 yes
GO:0016310 phosphorylation 23.5294 5 yes
GO:0031329 regulation of cellular catabolic process 23.5294 5 yes
GO:0141124 intracellular signaling cassette 23.5294 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 23.5294 6 no
GO:0010959 regulation of metal ion transport 23.5294 6 no
GO:0034765 regulation of monoatomic ion transmembrane transport 23.5294 5 no
GO:0043269 regulation of monoatomic ion transport 23.5294 5 no
GO:0044057 regulation of system process 23.5294 4 no
GO:0045936 negative regulation of phosphate metabolic process 23.5294 7 no
GO:1904062 regulation of monoatomic cation transmembrane transport 23.5294 6 no
GO:0006357 regulation of transcription by RNA polymerase II 23.5294 8 no
GO:0008104 protein localization 23.5294 4 no
GO:0009890 negative regulation of biosynthetic process 23.5294 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0031327 negative regulation of cellular biosynthetic process 23.5294 6 no
GO:0043066 negative regulation of apoptotic process 23.5294 6 no
GO:0043069 negative regulation of programmed cell death 23.5294 5 no
GO:0048584 positive regulation of response to stimulus 23.5294 4 no
GO:0048585 negative regulation of response to stimulus 23.5294 4 no
GO:0071310 cellular response to organic substance 23.5294 4 no
GO:0080134 regulation of response to stress 23.5294 4 no
GO:1903829 positive regulation of protein localization 23.5294 5 no
GO:0045595 regulation of cell differentiation 23.5294 4 no
GO:0045893 positive regulation of DNA-templated transcription 20.5882 8 yes
GO:0051130 positive regulation of cellular component organization 20.5882 5 yes
GO:0051254 positive regulation of RNA metabolic process 20.5882 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 20.5882 7 yes
GO:0001933 negative regulation of protein phosphorylation 20.5882 8 no
GO:0008016 regulation of heart contraction 20.5882 6 no
GO:0042326 negative regulation of phosphorylation 20.5882 8 no
GO:1903522 regulation of blood circulation 20.5882 5 no
GO:0009968 negative regulation of signal transduction 20.5882 5 no
GO:0010647 positive regulation of cell communication 20.5882 5 no
GO:0010648 negative regulation of cell communication 20.5882 5 no
GO:0023056 positive regulation of signaling 20.5882 4 no
GO:0023057 negative regulation of signaling 20.5882 4 no
GO:0032101 regulation of response to external stimulus 20.5882 4 no
GO:0032386 regulation of intracellular transport 20.5882 5 no
GO:0042176 regulation of protein catabolic process 20.5882 5 no
GO:0046822 regulation of nucleocytoplasmic transport 20.5882 6 no
GO:0010243 response to organonitrogen compound 20.5882 4 no
GO:0009896 positive regulation of catabolic process 17.6471 5 yes
GO:0010506 regulation of autophagy 17.6471 6 yes
GO:0019722 calcium-mediated signaling 17.6471 5 yes
GO:0033043 regulation of organelle organization 17.6471 5 yes
GO:0010638 positive regulation of organelle organization 11.7647 6 yes
GO:0010821 regulation of mitochondrion organization 11.7647 6 yes
GO:0031331 positive regulation of cellular catabolic process 11.7647 6 yes
GO:0062197 cellular response to chemical stress 11.7647 4 yes
GO:0000302 response to reactive oxygen species 8.8235 4 yes
GO:0010508 positive regulation of autophagy 8.8235 7 yes
GO:0034599 cellular response to oxidative stress 8.8235 4 yes
GO:0034614 cellular response to reactive oxygen species 8.8235 5 yes
GO:1903146 regulation of autophagy of mitochondrion 8.8235 7 yes
GO:1903599 positive regulation of autophagy of mitochondrion 8.8235 7 yes
GO:0000165 MAPK cascade 5.8824 5 yes
GO:0046777 protein autophosphorylation 5.8824 6 yes
GO:0061762 CAMKK-AMPK signaling cascade 5.8824 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KKCC2_HUMAN [view entry] [view interactions] Low throughput yes yes
AAPK2_HUMAN [view interactions] Low throughput no yes
PPM1F_HUMAN [view interactions] Low throughput no yes
SGK1_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC1A_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
SMC1A_HUMAN [view interactions] High throughput no yes
FLNC_HUMAN [view entry] [view interactions] High throughput yes no
IQGA2_HUMAN [view interactions] High throughput no yes
GCN1_HUMAN [view interactions] High throughput no yes
ATG4B_HUMAN [view interactions] High throughput no yes
FANCI_HUMAN [view interactions] High throughput no yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
ESYT2_HUMAN [view entry] [view interactions] High throughput yes yes
XPOT_HUMAN [view interactions] High throughput no no
SMC3_HUMAN [view entry] [view interactions] High throughput yes yes
OBSL1_HUMAN [view interactions] High throughput no yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
AAKG1_HUMAN [view interactions] High throughput no no
MK14_HUMAN [view interactions] High throughput no yes
WRP73_HUMAN [view interactions] High throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
CSF1_HUMAN [view interactions] High throughput no no
KCC4_HUMAN [view entry] [view interactions] High throughput yes yes
FEZF1_HUMAN [view interactions] High throughput no yes
DCMC_HUMAN [view interactions] High throughput no no
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
HINT1_HUMAN [view interactions] High throughput no yes
TXTP_HUMAN [view entry] [view interactions] High throughput yes no
YTHD3_HUMAN [view interactions] High throughput no no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
IRAK1_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
GFRP_HUMAN [view interactions] High throughput no no
LOX5_HUMAN [view interactions] High throughput no no
CF141_HUMAN [view interactions] High throughput no no
INSY2_HUMAN [view entry] [view interactions] High throughput yes no
TRI25_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
KAISO_HUMAN [view interactions] High throughput no yes
IREB2_HUMAN [view interactions] High throughput no no
THA11_HUMAN [view interactions] High throughput no yes
MYL4_HUMAN [view entry] [view interactions] High throughput yes no
FLIP1_HUMAN [view entry] [view interactions] High throughput yes no
AAKB1_HUMAN [view interactions] High throughput no yes
DUS16_HUMAN [view interactions] High throughput no yes
FKBP5_HUMAN [view interactions] High throughput no yes
DNAI2_HUMAN [view interactions] High throughput no no
EFMT3_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
NPAS1_HUMAN [view interactions] High throughput no no
ATG7_HUMAN [view interactions] High throughput no yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
BOREA_HUMAN [view interactions] High throughput no yes
HS74L_HUMAN [view entry] [view interactions] High throughput yes no
GEMI_HUMAN [view interactions] High throughput no no
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CRYAA_HUMAN [view interactions] High throughput no no
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes