Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KKCC2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals . Seems to be involved in hippocampal activation of CREB1 . May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KKCC2_HUMAN
GO:0005524 ATP binding 40.0000 5 yes
GO:0017076 purine nucleotide binding 40.0000 4 yes
GO:0030554 adenyl nucleotide binding 40.0000 5 yes
GO:0032555 purine ribonucleotide binding 40.0000 4 yes
GO:0032559 adenyl ribonucleotide binding 40.0000 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 40.0000 4 yes
GO:0046872 metal ion binding 37.1429 4 yes
GO:0019900 kinase binding 37.1429 4 no
GO:0019901 protein kinase binding 34.2857 5 no
GO:0003723 RNA binding 25.7143 4 no
GO:0004674 protein serine/threonine kinase activity 22.8571 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 22.8571 4 yes
GO:0005509 calcium ion binding 22.8571 5 yes
GO:0016301 kinase activity 22.8571 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 22.8571 4 yes
GO:0106310 protein serine kinase activity 22.8571 4 yes
GO:0004683 calmodulin-dependent protein kinase activity 17.1429 5 yes
GO:0004713 protein tyrosine kinase activity 5.7143 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KKCC2_HUMAN
GO:0031323 regulation of cellular metabolic process 65.7143 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 65.7143 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.7143 4 yes
GO:0080090 regulation of primary metabolic process 65.7143 4 yes
GO:0048522 positive regulation of cellular process 60.0000 4 yes
GO:0051246 regulation of protein metabolic process 57.1429 5 yes
GO:0009893 positive regulation of metabolic process 48.5714 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 48.5714 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 48.5714 5 yes
GO:0001932 regulation of protein phosphorylation 45.7143 7 yes
GO:0019220 regulation of phosphate metabolic process 45.7143 6 yes
GO:0031325 positive regulation of cellular metabolic process 45.7143 5 yes
GO:0031399 regulation of protein modification process 45.7143 6 yes
GO:0042325 regulation of phosphorylation 45.7143 7 yes
GO:0051174 regulation of phosphorus metabolic process 45.7143 5 yes
GO:0051247 positive regulation of protein metabolic process 45.7143 6 yes
GO:0048523 negative regulation of cellular process 45.7143 4 no
GO:0010468 regulation of gene expression 42.8571 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.8571 5 yes
GO:0043549 regulation of kinase activity 42.8571 5 yes
GO:0045859 regulation of protein kinase activity 42.8571 6 yes
GO:0051128 regulation of cellular component organization 42.8571 4 yes
GO:0051338 regulation of transferase activity 42.8571 4 yes
GO:0009889 regulation of biosynthetic process 40.0000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 40.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 yes
GO:0009892 negative regulation of metabolic process 40.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 40.0000 5 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 40.0000 5 no
GO:0001934 positive regulation of protein phosphorylation 37.1429 8 yes
GO:0010562 positive regulation of phosphorus metabolic process 37.1429 6 yes
GO:0031401 positive regulation of protein modification process 37.1429 7 yes
GO:0036211 protein modification process 37.1429 4 yes
GO:0042327 positive regulation of phosphorylation 37.1429 8 yes
GO:0043412 macromolecule modification 37.1429 4 yes
GO:0045937 positive regulation of phosphate metabolic process 37.1429 7 yes
GO:0006996 organelle organization 37.1429 4 no
GO:0009966 regulation of signal transduction 37.1429 4 no
GO:0031324 negative regulation of cellular metabolic process 37.1429 5 no
GO:0051049 regulation of transport 37.1429 4 no
GO:0006796 phosphate-containing compound metabolic process 34.2857 4 yes
GO:0009894 regulation of catabolic process 34.2857 4 yes
GO:0051252 regulation of RNA metabolic process 34.2857 5 yes
GO:0006355 regulation of DNA-templated transcription 31.4286 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 31.4286 7 yes
GO:2001141 regulation of RNA biosynthetic process 31.4286 6 yes
GO:0033674 positive regulation of kinase activity 31.4286 6 no
GO:0043085 positive regulation of catalytic activity 31.4286 4 no
GO:0045860 positive regulation of protein kinase activity 31.4286 7 no
GO:0051248 negative regulation of protein metabolic process 31.4286 6 no
GO:0051347 positive regulation of transferase activity 31.4286 5 no
GO:1902531 regulation of intracellular signal transduction 31.4286 5 no
GO:0051050 positive regulation of transport 31.4286 4 no
GO:0006468 protein phosphorylation 28.5714 5 yes
GO:0009891 positive regulation of biosynthetic process 28.5714 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 yes
GO:0016310 phosphorylation 28.5714 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 yes
GO:0043269 regulation of ion transport 28.5714 5 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0008104 protein localization 28.5714 4 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0010941 regulation of cell death 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 5 no
GO:0031329 regulation of cellular catabolic process 25.7143 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.7143 6 yes
GO:1901701 cellular response to oxygen-containing compound 25.7143 4 yes
GO:0071702 organic substance transport 25.7143 4 no
GO:0010243 response to organonitrogen compound 25.7143 4 no
GO:0032880 regulation of protein localization 25.7143 5 no
GO:0034762 regulation of transmembrane transport 25.7143 4 no
GO:0034765 regulation of ion transmembrane transport 25.7143 5 no
GO:0051726 regulation of cell cycle 25.7143 4 no
GO:1904062 regulation of cation transmembrane transport 25.7143 6 no
GO:0051130 positive regulation of cellular component organization 22.8571 5 yes
GO:0010959 regulation of metal ion transport 22.8571 6 no
GO:0031400 negative regulation of protein modification process 22.8571 7 no
GO:0044057 regulation of system process 22.8571 4 no
GO:0071310 cellular response to organic substance 22.8571 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 22.8571 7 no
GO:1903829 positive regulation of protein localization 22.8571 5 no
GO:0022607 cellular component assembly 22.8571 4 no
GO:0042176 regulation of protein catabolic process 22.8571 5 no
GO:0060548 negative regulation of cell death 22.8571 5 no
GO:0019722 calcium-mediated signaling 20.0000 5 yes
GO:0019932 second-messenger-mediated signaling 20.0000 4 yes
GO:0045893 positive regulation of DNA-templated transcription 20.0000 7 yes
GO:0051254 positive regulation of RNA metabolic process 20.0000 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 20.0000 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 20.0000 8 yes
GO:0009896 positive regulation of catabolic process 17.1429 5 yes
GO:0033043 regulation of organelle organization 17.1429 5 yes
GO:0046777 protein autophosphorylation 17.1429 6 yes
GO:0010506 regulation of autophagy 14.2857 6 yes
GO:0010821 regulation of mitochondrion organization 14.2857 6 yes
GO:0031331 positive regulation of cellular catabolic process 11.4286 6 yes
GO:0000165 MAPK cascade 8.5714 4 yes
GO:0000302 response to reactive oxygen species 8.5714 4 yes
GO:0010508 positive regulation of autophagy 8.5714 7 yes
GO:0010638 positive regulation of organelle organization 8.5714 6 yes
GO:0010822 positive regulation of mitochondrion organization 8.5714 7 yes
GO:0034599 cellular response to oxidative stress 8.5714 4 yes
GO:0034614 cellular response to reactive oxygen species 8.5714 5 yes
GO:0062197 cellular response to chemical stress 8.5714 4 yes
GO:1903146 regulation of autophagy of mitochondrion 8.5714 7 yes
GO:1903599 positive regulation of autophagy of mitochondrion 8.5714 8 yes
GO:0061762 CAMKK-AMPK signaling cascade 5.7143 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in KKCC2_HUMAN
DOID:114 heart disease 11.4286 3 no
DOID:0050700 cardiomyopathy 8.5714 4 no
DOID:0060036 intrinsic cardiomyopathy 8.5714 5 no
DOID:2843 long QT syndrome 5.7143 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC1A_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
AAPK2_HUMAN [view interactions] Low throughput no yes
KKCC2_HUMAN [view entry] [view interactions] Low throughput yes yes
PPM1F_HUMAN [view interactions] Low throughput no yes
SGK1_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
THA11_HUMAN [view interactions] High throughput no yes
MYL4_HUMAN [view entry] [view interactions] High throughput yes no
FLIP1_HUMAN [view entry] [view interactions] High throughput yes no
AAKB1_HUMAN [view interactions] High throughput no yes
DUS16_HUMAN [view interactions] High throughput no yes
FKBP5_HUMAN [view interactions] High throughput no yes
DNAI2_HUMAN [view interactions] High throughput no no
EFMT3_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
NPAS1_HUMAN [view interactions] High throughput no no
ATG7_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
MK14_HUMAN [view interactions] High throughput no yes
AAKG1_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
OBSL1_HUMAN [view interactions] High throughput no yes
SMC3_HUMAN [view entry] [view interactions] High throughput yes yes
XPOT_HUMAN [view interactions] High throughput no no
ESYT2_HUMAN [view entry] [view interactions] High throughput yes yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
FANCI_HUMAN [view interactions] High throughput no yes
ATG4B_HUMAN [view interactions] High throughput no yes
GCN1_HUMAN [view interactions] High throughput no yes
IQGA2_HUMAN [view interactions] High throughput no yes
FLNC_HUMAN [view entry] [view interactions] High throughput yes no
SMC1A_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
WRP73_HUMAN [view interactions] High throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
CSF1_HUMAN [view interactions] High throughput no no
KCC4_HUMAN [view entry] [view interactions] High throughput yes yes
YTHD3_HUMAN [view interactions] High throughput no no
TXTP_HUMAN [view entry] [view interactions] High throughput yes no
HINT1_HUMAN [view interactions] High throughput no yes
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
DCMC_HUMAN [view interactions] High throughput no no
FEZF1_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
IRAK1_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
GFRP_HUMAN [view interactions] High throughput no no
LOX5_HUMAN [view interactions] High throughput no no
CF141_HUMAN [view interactions] High throughput no no
INSY2_HUMAN [view entry] [view interactions] High throughput yes no
TRI25_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
KAISO_HUMAN [view interactions] High throughput no yes
IREB2_HUMAN [view interactions] High throughput no no
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
AAKG2_HUMAN [view interactions] Computational no yes
AAKG3_HUMAN [view interactions] Computational no no
STK11_HUMAN [view interactions] Computational no yes
AAKB2_HUMAN [view interactions] Computational no yes
KKCC1_HUMAN [view entry] [view interactions] Computational yes yes
CALL6_HUMAN [view interactions] Computational no no
CALL3_HUMAN [view interactions] Computational no yes
CALL5_HUMAN [view entry] [view interactions] Computational yes no