SMC3_HUMAN
Evidence for PS localization
Functions
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SMC3_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 35.5263 | 4 | yes |
| GO:0003723 | RNA binding | 34.2105 | 4 | no |
| GO:0000166 | nucleotide binding | 32.8947 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.5789 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 30.2632 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.9474 | 4 | yes |
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.3684 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 21.0526 | 5 | yes |
| GO:0005524 | ATP binding | 19.7368 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 15.7895 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 15.7895 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 15.7895 | 6 | yes |
| GO:0003677 | DNA binding | 14.4737 | 4 | yes |
| GO:0015631 | tubulin binding | 11.8421 | 4 | yes |
| GO:0003690 | double-stranded DNA binding | 9.2105 | 5 | yes |
| GO:0016887 | ATP hydrolysis activity | 7.8947 | 7 | yes |
| GO:0046982 | protein heterodimerization activity | 6.5789 | 4 | yes |
| GO:0048487 | beta-tubulin binding | 2.6316 | 5 | yes |
| GO:0061775 | cohesin loader activity | 2.6316 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SMC3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.9474 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.3684 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 46.0526 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 42.1053 | 4 | no |
| GO:0006996 | organelle organization | 39.4737 | 4 | yes |
| GO:0022607 | cellular component assembly | 39.4737 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.1579 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.8421 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.5263 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 35.5263 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.5263 | 5 | no |
| GO:0008104 | protein localization | 35.5263 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.2105 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.2105 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.2105 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.2105 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 34.2105 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.8947 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.2632 | 5 | no |
| GO:0043933 | protein-containing complex organization | 28.9474 | 4 | no |
| GO:0007010 | cytoskeleton organization | 27.6316 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.3158 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 26.3158 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.6842 | 5 | no |
| GO:0043412 | macromolecule modification | 23.6842 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.6842 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.6842 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 22.3684 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 22.3684 | 4 | no |
| GO:0036211 | protein modification process | 22.3684 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.3684 | 4 | no |
| GO:0031399 | regulation of protein modification process | 22.3684 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 22.3684 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.3684 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.3684 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.3684 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 21.0526 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 21.0526 | 5 | no |
| GO:0071702 | organic substance transport | 21.0526 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.0526 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.0526 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.0526 | 5 | no |
| GO:0070925 | organelle assembly | 18.4211 | 5 | yes |
| GO:0140694 | non-membrane-bounded organelle assembly | 13.1579 | 6 | yes |
| GO:0006974 | DNA damage response | 10.5263 | 4 | yes |
| GO:0007052 | mitotic spindle organization | 9.2105 | 4 | yes |
| GO:0051225 | spindle assembly | 9.2105 | 4 | yes |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 9.2105 | 4 | yes |
| GO:0006259 | DNA metabolic process | 7.8947 | 5 | yes |
| GO:0006281 | DNA repair | 6.5789 | 5 | yes |
| GO:0051052 | regulation of DNA metabolic process | 6.5789 | 5 | yes |
| GO:0090307 | mitotic spindle assembly | 6.5789 | 5 | yes |
| GO:0051276 | chromosome organization | 5.2632 | 5 | yes |
| GO:0006275 | regulation of DNA replication | 3.9474 | 6 | yes |
| GO:0007064 | mitotic sister chromatid cohesion | 2.6316 | 4 | yes |
| GO:0034087 | establishment of mitotic sister chromatid cohesion | 2.6316 | 4 | yes |
| GO:0034089 | establishment of meiotic sister chromatid cohesion | 2.6316 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SRBP1_HUMAN | [view interactions] | Low throughput | no | yes |
| SSU72_HUMAN | [view interactions] | Low throughput | no | yes |
| REC8_HUMAN | [view interactions] | Low throughput | no | yes |
| ATRX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MECP2_HUMAN | [view interactions] | Low throughput | no | yes |
| SMC1B_HUMAN | [view interactions] | Low throughput | no | no |
| RAE1L_HUMAN | [view interactions] | Low throughput | no | no |
| NIPBL_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK8_HUMAN | [view interactions] | Low throughput | no | no |
| TERB1_HUMAN | [view interactions] | Low throughput | no | no |
| NDC80_HUMAN | [view interactions] | Low throughput | no | no |
| ESCO2_HUMAN | [view interactions] | Low throughput | no | no |
| NSE2_HUMAN | [view interactions] | Low throughput | no | yes |
| MXI1_HUMAN | [view interactions] | Low throughput | no | yes |
| MAD3_HUMAN | [view interactions] | Low throughput | no | no |
| MAD4_HUMAN | [view interactions] | Low throughput | no | no |
| MAD1_HUMAN | [view interactions] | Low throughput | no | yes |
| KIFA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FEZ1_HUMAN | [view interactions] | Low throughput | no | no |
| SYCP3_HUMAN | [view interactions] | Low throughput | no | no |
| NUMA1_HUMAN | [view interactions] | Low throughput | no | yes |
| TBB5_HUMAN | [view interactions] | Low throughput | no | yes |
| STAG3_HUMAN | [view interactions] | Low throughput | no | no |
| ATM_HUMAN | [view interactions] | Low throughput | no | yes |
| WFDC5_HUMAN | [view interactions] | Low throughput | no | no |
| SRRM1_HUMAN | [view interactions] | Low throughput | no | yes |
| RPGR_HUMAN | [view interactions] | Low throughput | no | yes |
| CTCF_HUMAN | [view interactions] | Low throughput | no | yes |
| SYCP2_HUMAN | [view interactions] | Low throughput | no | no |
| HORM1_HUMAN | [view interactions] | Low throughput | no | no |
| UBP37_HUMAN | [view interactions] | Low throughput | no | no |
| NDE1_HUMAN | [view interactions] | Low throughput | no | yes |
| DCA15_HUMAN | [view interactions] | Low throughput | no | no |
| TRI43_HUMAN | [view interactions] | Low throughput | no | no |
| STAG1_HUMAN | [view interactions] | Low throughput | no | yes |
| STAG2_HUMAN | [view interactions] | Low throughput | no | yes |
| RAD21_HUMAN | [view interactions] | Low throughput | no | yes |
| WAPL_HUMAN | [view interactions] | Low throughput | no | yes |
| PDS5A_HUMAN | [view interactions] | Low throughput | no | yes |
| SMC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDCA5_HUMAN | [view interactions] | Low throughput | no | yes |
| SMC1A_HUMAN | [view interactions] | Low throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| NAT10_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM165_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNL3L_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| RBM15_HUMAN | [view interactions] | High throughput | no | yes |
| CAB45_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| SPB12_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| RORA_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRRAP_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIM26_HUMAN | [view interactions] | High throughput | no | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC4G_HUMAN | [view interactions] | High throughput | no | no |
| ANKK1_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MSD3_HUMAN | [view interactions] | High throughput | no | no |
| DMBT1_HUMAN | [view interactions] | High throughput | no | no |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFRP3_HUMAN | [view interactions] | High throughput | no | no |
| LEG7_HUMAN | [view interactions] | High throughput | no | no |
| TYY1_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM232_HUMAN | [view interactions] | High throughput | no | no |
| HAND2_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HELLS_HUMAN | [view interactions] | High throughput | no | yes |
| GPTC2_HUMAN | [view interactions] | High throughput | no | yes |
| INT1_HUMAN | [view interactions] | High throughput | no | yes |
| RALA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPRP_HUMAN | [view interactions] | High throughput | no | no |
| EVI2B_HUMAN | [view interactions] | High throughput | no | no |
| LYSC_HUMAN | [view interactions] | High throughput | no | no |
| PRAX_HUMAN | [view interactions] | High throughput | no | no |
| PWP2_HUMAN | [view interactions] | High throughput | no | no |
| FA76A_HUMAN | [view interactions] | High throughput | no | yes |
| PSD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
| PB1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOP2_HUMAN | [view interactions] | High throughput | no | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| RL14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDSN_HUMAN | [view interactions] | High throughput | no | no |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| GP142_HUMAN | [view interactions] | High throughput | no | no |
| KLF8_HUMAN | [view interactions] | High throughput | no | no |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP4_HUMAN | [view interactions] | High throughput | no | yes |
| ZA2G_HUMAN | [view interactions] | High throughput | no | no |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK6_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DDX47_HUMAN | [view interactions] | High throughput | no | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| PDS5B_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| MCMBP_HUMAN | [view interactions] | High throughput | no | yes |
| PPIE_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| MKRN1_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| RD21L_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| CE290_HUMAN | [view interactions] | High throughput | no | no |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CST9L_HUMAN | [view interactions] | High throughput | no | no |
| CITE1_HUMAN | [view interactions] | High throughput | no | no |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXC1_HUMAN | [view interactions] | High throughput | no | no |
| HDGF_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| FOXB1_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| FOXG1_HUMAN | [view interactions] | High throughput | no | no |
| CAVN3_HUMAN | [view interactions] | High throughput | no | no |
| FOXJ2_HUMAN | [view interactions] | High throughput | no | yes |
| AATF_HUMAN | [view interactions] | High throughput | no | yes |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| NFAC1_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TEAD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFDP1_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| MDM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFAH_HUMAN | [view interactions] | High throughput | no | no |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| TET5C_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOB3C_HUMAN | [view interactions] | High throughput | no | no |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| RING1_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MESP1_HUMAN | [view interactions] | High throughput | no | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| ETV3_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| FEV_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HME1_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNF4A_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| KLF12_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| LHX1_HUMAN | [view interactions] | High throughput | no | no |
| SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
| LHX2_HUMAN | [view interactions] | High throughput | no | no |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| LHX3_HUMAN | [view interactions] | High throughput | no | no |
| MYB_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFIX_HUMAN | [view interactions] | High throughput | no | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| COPG1_HUMAN | [view interactions] | High throughput | no | yes |
| TEAD1_HUMAN | [view interactions] | High throughput | no | no |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLX1_HUMAN | [view interactions] | High throughput | no | no |
| MARE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| PLIN4_HUMAN | [view interactions] | High throughput | no | no |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| LA_HUMAN | [view interactions] | High throughput | no | yes |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| NSE1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SRPRA_HUMAN | [view interactions] | High throughput | no | no |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| MTA2_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| RPA1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| MBD3_HUMAN | [view interactions] | High throughput | no | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF3C4_HUMAN | [view interactions] | High throughput | no | no |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| XPC_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| MTA1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| RBBP7_HUMAN | [view interactions] | High throughput | no | yes |
| PLCH1_HUMAN | [view interactions] | High throughput | no | no |
| PHF5A_HUMAN | [view interactions] | High throughput | no | yes |
| FEZ2_HUMAN | [view interactions] | High throughput | no | yes |
| BAZ1A_HUMAN | [view interactions] | High throughput | no | no |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| MBD2_HUMAN | [view interactions] | High throughput | no | yes |
| PI4KB_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| PMS1_HUMAN | [view interactions] | High throughput | no | no |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| SMRCD_HUMAN | [view interactions] | High throughput | no | yes |
| RPB1_HUMAN | [view interactions] | High throughput | no | no |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| LMBL2_HUMAN | [view interactions] | High throughput | no | no |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FND3A_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGC_HUMAN | [view interactions] | High throughput | no | yes |
| NEUL4_HUMAN | [view interactions] | High throughput | no | yes |
| TAF1_HUMAN | [view interactions] | High throughput | no | yes |
| OBSCN_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC1_HUMAN | [view interactions] | High throughput | no | no |
| ELF5_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| RN126_HUMAN | [view interactions] | High throughput | no | yes |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2L6_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7A_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI29_HUMAN | [view interactions] | High throughput | no | no |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| SET1A_HUMAN | [view interactions] | High throughput | no | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| UBP13_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| AIRE_HUMAN | [view interactions] | High throughput | no | no |
| NGB_HUMAN | [view interactions] | High throughput | no | yes |
| KKCC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| BECN1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG4_HUMAN | [view interactions] | High throughput | no | yes |
| FGD1_HUMAN | [view interactions] | High throughput | no | no |
| HDAC8_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC9_HUMAN | [view interactions] | High throughput | no | yes |
| DSRAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDA11_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NANP8_HUMAN | [view interactions] | High throughput | no | no |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| MDN1_HUMAN | [view interactions] | High throughput | no | no |
| T11L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C6C_HUMAN | [view interactions] | High throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| PRR12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COA3_HUMAN | [view interactions] | High throughput | no | yes |
| ANR11_HUMAN | [view interactions] | High throughput | no | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM10_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY26_HUMAN | [view interactions] | High throughput | no | yes |
| U520_HUMAN | [view interactions] | High throughput | no | yes |
| TR150_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| MGAP_HUMAN | [view interactions] | High throughput | no | yes |
| KIF22_HUMAN | [view interactions] | High throughput | no | no |
| MYOF_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TF3C1_HUMAN | [view interactions] | High throughput | no | yes |
| DEFM_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| TRI38_HUMAN | [view interactions] | High throughput | no | yes |
| DDX60_HUMAN | [view interactions] | High throughput | no | no |
| MTREX_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
| GPKOW_HUMAN | [view interactions] | High throughput | no | yes |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUSC2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAF12_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| ARI5B_HUMAN | [view interactions] | High throughput | no | yes |
| RRP5_HUMAN | [view interactions] | High throughput | no | yes |
| TAF5_HUMAN | [view interactions] | High throughput | no | yes |
| MSH2_HUMAN | [view interactions] | High throughput | no | yes |
| MVD1_HUMAN | [view interactions] | High throughput | no | yes |
| PRP31_HUMAN | [view interactions] | High throughput | no | yes |
| RL37A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |