PLEC_HUMAN
Evidence for PS localization
Functions
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 2110 | Arg | Trp | Epidermolysisbullosasimplex5A,Ognatype(EBS5A) | - |
| 3945 | Gly | Ser | Musculardystrophy,limb-girdle,autosomalrecessive17(LGMDR17) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PLEC_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 30.8271 | 4 | no |
| GO:0046872 | metal ion binding | 30.8271 | 5 | no |
| GO:0043168 | anion binding | 29.3233 | 4 | no |
| GO:0000166 | nucleotide binding | 24.8120 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.3083 | 5 | no |
| GO:0003723 | RNA binding | 22.5564 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 22.5564 | 4 | no |
| GO:0019900 | kinase binding | 22.5564 | 4 | no |
| GO:0019901 | protein kinase binding | 21.0526 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.3008 | 4 | no |
| GO:0045296 | cadherin binding | 19.5489 | 4 | yes |
| GO:0003779 | actin binding | 18.7970 | 4 | yes |
| GO:0030506 | ankyrin binding | 2.2556 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PLEC_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.3835 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.3759 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.3684 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.3684 | 4 | no |
| GO:0006996 | organelle organization | 44.3609 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.3609 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | no |
| GO:0010646 | regulation of cell communication | 41.3534 | 4 | no |
| GO:0022607 | cellular component assembly | 37.5940 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 36.0902 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.0902 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.5865 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.5865 | 5 | no |
| GO:0010468 | regulation of gene expression | 33.8346 | 6 | no |
| GO:0008104 | protein localization | 33.0827 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 32.3308 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0007010 | cytoskeleton organization | 28.5714 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.8195 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.8195 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.8195 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.0677 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.8120 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.8120 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.0602 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.0602 | 4 | no |
| GO:0051049 | regulation of transport | 24.0602 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.3083 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.3083 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.3083 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.5564 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 22.5564 | 5 | no |
| GO:0036211 | protein modification process | 22.5564 | 4 | no |
| GO:0043412 | macromolecule modification | 22.5564 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.5564 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.5564 | 6 | no |
| GO:0009894 | regulation of catabolic process | 21.8045 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.8045 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.8045 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.0526 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.0526 | 4 | no |
| GO:0030030 | cell projection organization | 20.3008 | 4 | no |
| GO:0043933 | protein-containing complex organization | 18.0451 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 15.0376 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 14.2857 | 4 | yes |
| GO:0034330 | cell junction organization | 12.7820 | 4 | yes |
| GO:0070925 | organelle assembly | 12.0301 | 5 | yes |
| GO:0009059 | macromolecule biosynthetic process | 11.2782 | 4 | yes |
| GO:0061024 | membrane organization | 9.0226 | 4 | yes |
| GO:0034329 | cell junction assembly | 7.5188 | 5 | yes |
| GO:0001667 | ameboidal-type cell migration | 6.7669 | 4 | yes |
| GO:0002064 | epithelial cell development | 6.7669 | 4 | yes |
| GO:0007015 | actin filament organization | 6.7669 | 5 | yes |
| GO:0140694 | non-membrane-bounded organelle assembly | 6.0150 | 6 | yes |
| GO:0031032 | actomyosin structure organization | 5.2632 | 4 | yes |
| GO:0045109 | intermediate filament organization | 5.2632 | 4 | yes |
| GO:0045216 | cell-cell junction organization | 5.2632 | 5 | yes |
| GO:0062197 | cellular response to chemical stress | 5.2632 | 4 | yes |
| GO:0007009 | plasma membrane organization | 4.5113 | 5 | yes |
| GO:0072676 | lymphocyte migration | 4.5113 | 4 | yes |
| GO:0007044 | cell-substrate junction assembly | 3.7594 | 6 | yes |
| GO:0010467 | gene expression | 3.7594 | 5 | yes |
| GO:0034332 | adherens junction organization | 3.7594 | 6 | yes |
| GO:0042060 | wound healing | 3.7594 | 4 | yes |
| GO:0060429 | epithelium development | 3.7594 | 4 | yes |
| GO:0072678 | T cell migration | 3.7594 | 5 | yes |
| GO:0150115 | cell-substrate junction organization | 3.7594 | 5 | yes |
| GO:0003018 | vascular process in circulatory system | 3.0075 | 4 | yes |
| GO:0008544 | epidermis development | 3.0075 | 4 | yes |
| GO:0045445 | myoblast differentiation | 3.0075 | 4 | yes |
| GO:0060326 | cell chemotaxis | 3.0075 | 4 | yes |
| GO:0071229 | cellular response to acid chemical | 3.0075 | 4 | yes |
| GO:0071260 | cellular response to mechanical stimulus | 3.0075 | 4 | yes |
| GO:0003334 | keratinocyte development | 2.2556 | 5 | yes |
| GO:0006997 | nucleus organization | 2.2556 | 5 | yes |
| GO:0010761 | fibroblast migration | 2.2556 | 5 | yes |
| GO:0022900 | electron transport chain | 2.2556 | 4 | yes |
| GO:0022904 | respiratory electron transport chain | 2.2556 | 5 | yes |
| GO:0031581 | hemidesmosome assembly | 2.2556 | 7 | yes |
| GO:0043217 | myelin maintenance | 2.2556 | 6 | yes |
| GO:0045214 | sarcomere organization | 2.2556 | 5 | yes |
| GO:0055001 | muscle cell development | 2.2556 | 4 | yes |
| GO:0061436 | establishment of skin barrier | 2.2556 | 6 | yes |
| GO:0071462 | cellular response to water stimulus | 2.2556 | 4 | yes |
| GO:0071464 | cellular response to hydrostatic pressure | 2.2556 | 4 | yes |
| GO:0098773 | skin epidermis development | 2.2556 | 5 | yes |
| GO:0010818 | T cell chemotaxis | 1.5038 | 5 | yes |
| GO:0014866 | skeletal myofibril assembly | 1.5038 | 5 | yes |
| GO:0014904 | myotube cell development | 1.5038 | 5 | yes |
| GO:0019226 | transmission of nerve impulse | 1.5038 | 4 | yes |
| GO:0030239 | myofibril assembly | 1.5038 | 4 | yes |
| GO:0032287 | peripheral nervous system myelin maintenance | 1.5038 | 7 | yes |
| GO:0048247 | lymphocyte chemotaxis | 1.5038 | 4 | yes |
| GO:0048741 | skeletal muscle fiber development | 1.5038 | 6 | yes |
| GO:0055006 | cardiac cell development | 1.5038 | 4 | yes |
| GO:0055013 | cardiac muscle cell development | 1.5038 | 5 | yes |
| GO:0071498 | cellular response to fluid shear stress | 1.5038 | 4 | yes |
| GO:0120193 | tight junction organization | 1.5038 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PLEC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ETS1_HUMAN | [view interactions] | Low throughput | no | no |
| BRCA2_HUMAN | [view interactions] | Low throughput | no | no |
| MTAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPTA1_HUMAN | [view interactions] | Low throughput | no | no |
| ACTH_HUMAN | [view interactions] | Low throughput | no | no |
| FUS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBP56_HUMAN | [view interactions] | Low throughput | no | yes |
| EWS_HUMAN | [view interactions] | Low throughput | no | yes |
| DESM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RED1_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| VIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QSER1_HUMAN | [view interactions] | High throughput | no | no |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| NUP88_HUMAN | [view interactions] | High throughput | no | yes |
| ARFG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| URGCP_HUMAN | [view interactions] | High throughput | no | yes |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| RSPH1_HUMAN | [view interactions] | High throughput | no | no |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| TSG10_HUMAN | [view interactions] | High throughput | no | no |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| NOS2_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HACE1_HUMAN | [view interactions] | High throughput | no | no |
| RPGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS6_HUMAN | [view interactions] | High throughput | no | yes |
| CCD68_HUMAN | [view interactions] | High throughput | no | yes |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| TFDP3_HUMAN | [view interactions] | High throughput | no | no |
| GFOD1_HUMAN | [view interactions] | High throughput | no | yes |
| NSD2_HUMAN | [view interactions] | High throughput | no | yes |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHF8_HUMAN | [view interactions] | High throughput | no | yes |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| ATOH1_HUMAN | [view interactions] | High throughput | no | no |
| CF141_HUMAN | [view interactions] | High throughput | no | no |
| GSDME_HUMAN | [view interactions] | High throughput | no | yes |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPGF5_HUMAN | [view interactions] | High throughput | no | yes |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCND2_HUMAN | [view interactions] | High throughput | no | yes |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HEY1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD9_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| BECN1_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| CF418_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| UBP20_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| BACD1_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP78_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSME3_HUMAN | [view interactions] | High throughput | no | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| ARM12_HUMAN | [view interactions] | High throughput | no | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| TET2_HUMAN | [view interactions] | High throughput | no | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| BCL9_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| SDCG8_HUMAN | [view interactions] | High throughput | no | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRR_HUMAN | [view interactions] | High throughput | no | yes |
| RHG42_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG4_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE2_HUMAN | [view interactions] | High throughput | no | no |
| ECT2L_HUMAN | [view interactions] | High throughput | no | no |
| ARHGP_HUMAN | [view interactions] | High throughput | no | yes |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO9A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| 3BP1_HUMAN | [view interactions] | High throughput | no | no |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| NF2L2_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| GRHL1_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RO52_HUMAN | [view interactions] | High throughput | no | yes |
| MBTD1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| C2CD3_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| KANL3_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| CNPY3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| YC018_HUMAN | [view interactions] | High throughput | no | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAT6_HUMAN | [view interactions] | High throughput | no | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| SCG2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| CDK12_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSX6_HUMAN | [view interactions] | High throughput | no | no |
| SOSD1_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM6_HUMAN | [view interactions] | High throughput | no | yes |
| PTSS1_HUMAN | [view interactions] | High throughput | no | no |
| CATZ_HUMAN | [view interactions] | High throughput | no | yes |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| PGBD4_HUMAN | [view interactions] | High throughput | no | no |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| MAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KT222_HUMAN | [view interactions] | High throughput | no | no |
| KAZRN_HUMAN | [view interactions] | High throughput | no | yes |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| AXDN1_HUMAN | [view interactions] | High throughput | no | no |
| K1C39_HUMAN | [view interactions] | High throughput | no | no |
| TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| SCMC2_HUMAN | [view interactions] | High throughput | no | yes |
| K2C78_HUMAN | [view interactions] | High throughput | no | no |
| OR4KH_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| GLT14_HUMAN | [view interactions] | High throughput | no | no |
| K1C23_HUMAN | [view interactions] | High throughput | no | no |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| EXO1_HUMAN | [view interactions] | High throughput | no | no |
| THB_HUMAN | [view interactions] | High throughput | no | no |
| PLCD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| CRSPL_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| G37L1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| ADH6_HUMAN | [view interactions] | High throughput | no | no |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| MY18B_HUMAN | [view interactions] | High throughput | no | no |
| FBX43_HUMAN | [view interactions] | High throughput | no | no |
| GBP6_HUMAN | [view interactions] | High throughput | no | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UTP11_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOLR1_HUMAN | [view interactions] | High throughput | no | no |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF38_HUMAN | [view interactions] | High throughput | no | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| K2C6C_HUMAN | [view interactions] | High throughput | no | no |
| UBP53_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MALT1_HUMAN | [view interactions] | High throughput | no | no |
| MBB1A_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| IFNA2_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| URB2_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KIF3C_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ASH1L_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIFC1_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| ATR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| TMIG1_HUMAN | [view interactions] | High throughput | no | no |
| PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELYS_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| SPN1_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| MXRA5_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| DNA2_HUMAN | [view interactions] | High throughput | no | yes |
| RN138_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANS4B_HUMAN | [view interactions] | High throughput | no | no |
| TR150_HUMAN | [view interactions] | High throughput | no | yes |
| KPCL_HUMAN | [view interactions] | High throughput | no | yes |
| MAGB4_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPAL_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPS1_HUMAN | [view interactions] | High throughput | no | no |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GANP_HUMAN | [view interactions] | High throughput | no | yes |
| ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN451_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITB2_HUMAN | [view interactions] | High throughput | no | no |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYH5_HUMAN | [view interactions] | High throughput | no | no |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| ZN721_HUMAN | [view interactions] | High throughput | no | no |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| METH_HUMAN | [view interactions] | High throughput | no | yes |
| NEIL3_HUMAN | [view interactions] | High throughput | no | no |
| DYH3_HUMAN | [view interactions] | High throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKN1_HUMAN | [view interactions] | High throughput | no | yes |
| NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSRC2_HUMAN | [view interactions] | High throughput | no | yes |
| TRA2A_HUMAN | [view interactions] | High throughput | no | yes |
| MOAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASQ2_HUMAN | [view interactions] | High throughput | no | no |
| SLTM_HUMAN | [view interactions] | High throughput | no | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD62_HUMAN | [view interactions] | High throughput | no | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD27_HUMAN | [view interactions] | High throughput | no | no |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| FANCM_HUMAN | [view interactions] | High throughput | no | no |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| RRP44_HUMAN | [view interactions] | High throughput | no | yes |
| CND3_HUMAN | [view interactions] | High throughput | no | yes |
| PR15A_HUMAN | [view interactions] | High throughput | no | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| N4BP2_HUMAN | [view interactions] | High throughput | no | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| PAPP1_HUMAN | [view interactions] | High throughput | no | no |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP50_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABLM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATD_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| FES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| ATX2L_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FIL1L_HUMAN | [view interactions] | High throughput | no | yes |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GP161_HUMAN | [view interactions] | High throughput | no | yes |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPSP_HUMAN | [view interactions] | High throughput | no | no |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| PER2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| TDRKH_HUMAN | [view interactions] | High throughput | no | no |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPR3B_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| SPC1L_HUMAN | [view interactions] | High throughput | no | no |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDH7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |