Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLCD1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed). Essential for trophoblast and placental development . Binds phosphatidylinositol 4,5-bisphosphate (PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
209 Thr Arg Naildisorder,non-syndromiccongenital,3(NDNC3) -
574 Ile Thr Naildisorder,non-syndromiccongenital,3(NDNC3) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLCD1_HUMAN
GO:0043168 anion binding 56.2500 4 yes
GO:0000166 nucleotide binding 37.5000 4 no
GO:0016462 pyrophosphatase activity 37.5000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 37.5000 4 no
GO:0017076 purine nucleotide binding 37.5000 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 37.5000 6 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0043169 cation binding 31.2500 4 yes
GO:0046872 metal ion binding 31.2500 5 yes
GO:0003924 GTPase activity 31.2500 7 no
GO:0005525 GTP binding 31.2500 5 no
GO:0019001 guanyl nucleotide binding 31.2500 6 no
GO:0019003 GDP binding 31.2500 5 no
GO:0032561 guanyl ribonucleotide binding 31.2500 5 no
GO:0035091 phosphatidylinositol binding 25.0000 4 yes
GO:0031267 small GTPase binding 25.0000 5 no
GO:0051020 GTPase binding 25.0000 4 no
GO:1901981 phosphatidylinositol phosphate binding 18.7500 5 yes
GO:0005509 calcium ion binding 12.5000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLCD1_HUMAN
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 43.7500 4 yes
GO:0008104 protein localization 43.7500 4 no
GO:0051128 regulation of cellular component organization 43.7500 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0080090 regulation of primary metabolic process 37.5000 4 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0006996 organelle organization 37.5000 4 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0044087 regulation of cellular component biogenesis 37.5000 4 no
GO:0001932 regulation of protein phosphorylation 31.2500 7 no
GO:0009889 regulation of biosynthetic process 31.2500 4 no
GO:0009893 positive regulation of metabolic process 31.2500 4 no
GO:0009967 positive regulation of signal transduction 31.2500 5 no
GO:0010468 regulation of gene expression 31.2500 6 no
GO:0010556 regulation of macromolecule biosynthetic process 31.2500 5 no
GO:0010604 positive regulation of macromolecule metabolic process 31.2500 5 no
GO:0010647 positive regulation of cell communication 31.2500 5 no
GO:0019220 regulation of phosphate metabolic process 31.2500 6 no
GO:0023056 positive regulation of signaling 31.2500 4 no
GO:0031323 regulation of cellular metabolic process 31.2500 4 no
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 no
GO:0031326 regulation of cellular biosynthetic process 31.2500 5 no
GO:0031399 regulation of protein modification process 31.2500 6 no
GO:0042325 regulation of phosphorylation 31.2500 7 no
GO:0048584 positive regulation of response to stimulus 31.2500 4 no
GO:0051174 regulation of phosphorus metabolic process 31.2500 5 no
GO:0015031 protein transport 31.2500 4 no
GO:0071702 organic substance transport 31.2500 4 no
GO:0071705 nitrogen compound transport 31.2500 4 no
GO:0007010 cytoskeleton organization 31.2500 5 no
GO:0007264 small GTPase-mediated signal transduction 31.2500 5 no
GO:0098657 import into cell 31.2500 4 no
GO:0141124 intracellular signaling cassette 31.2500 4 no
GO:0042127 regulation of cell population proliferation 31.2500 4 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0070925 organelle assembly 25.0000 5 no
GO:0007265 Ras protein signal transduction 25.0000 6 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 12.5000 4 yes
GO:0006811 monoatomic ion transport 12.5000 4 yes
GO:0006812 monoatomic cation transport 12.5000 5 yes
GO:0030001 metal ion transport 12.5000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IMB1_HUMAN [view entry] [view interactions] Low throughput yes yes
TGM2_HUMAN [view interactions] Low throughput no no
IQGA1_HUMAN [view entry] [view interactions] Low throughput yes no
RALA_HUMAN [view entry] [view interactions] Low throughput yes yes
NEUM_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
RBM24_HUMAN [view interactions] High throughput no yes
GDF5_HUMAN [view interactions] High throughput no no
FBXL4_HUMAN [view interactions] High throughput no yes
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
NTAQ1_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI1_HUMAN [view interactions] High throughput no no
TEX35_HUMAN [view interactions] High throughput no no
IFIX_HUMAN [view interactions] High throughput no no
SMRD1_HUMAN [view interactions] High throughput no yes
IL31R_HUMAN [view interactions] High throughput no no
GPBP1_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
FBX3_HUMAN [view interactions] High throughput no no
PNMA2_HUMAN [view interactions] High throughput no yes
PTSS1_HUMAN [view interactions] High throughput no no
DYM_HUMAN [view interactions] High throughput no yes
US6NL_HUMAN [view interactions] High throughput no yes
SRMS_HUMAN [view interactions] High throughput no no
CGAT1_HUMAN [view interactions] High throughput no no
RB39B_HUMAN [view interactions] High throughput no no
SGIP1_HUMAN [view entry] [view interactions] High throughput yes yes
ERD22_HUMAN [view interactions] High throughput no yes
ANXA9_HUMAN [view interactions] High throughput no yes
ITAD_HUMAN [view interactions] High throughput no no
DHR12_HUMAN [view interactions] High throughput no yes
PEMT_HUMAN [view interactions] High throughput no yes
KCNE3_HUMAN [view interactions] High throughput no yes
JAM1_HUMAN [view interactions] High throughput no yes
DUS14_HUMAN [view interactions] High throughput no yes
PLD5_HUMAN [view interactions] High throughput no no
7B2_HUMAN [view interactions] High throughput no yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
TMTC4_HUMAN [view interactions] High throughput no yes
IQUB_HUMAN [view interactions] High throughput no no
SRFB1_HUMAN [view interactions] High throughput no no
FOS_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no