Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLCD1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed). Essential for trophoblast and placental development . Binds phosphatidylinositol 4,5-bisphosphate (PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
209 Thr Arg Naildisorder,non-syndromiccongenital,3(NDNC3) -
574 Ile Thr Naildisorder,non-syndromiccongenital,3(NDNC3) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLCD1_HUMAN
GO:0017076 purine nucleotide binding 50.0000 4 no
GO:0032555 purine ribonucleotide binding 50.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 no
GO:0046872 metal ion binding 36.3636 4 yes
GO:0005524 ATP binding 27.2727 5 no
GO:0030554 adenyl nucleotide binding 27.2727 5 no
GO:0032559 adenyl ribonucleotide binding 27.2727 5 no
GO:0005525 GTP binding 27.2727 5 no
GO:0016462 pyrophosphatase activity 27.2727 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 27.2727 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 27.2727 6 no
GO:0019001 guanyl nucleotide binding 27.2727 5 no
GO:0032561 guanyl ribonucleotide binding 27.2727 5 no
GO:0016301 kinase activity 22.7273 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 22.7273 4 no
GO:0003924 GTPase activity 22.7273 7 no
GO:0019003 GDP binding 22.7273 4 no
GO:0035091 phosphatidylinositol binding 18.1818 4 yes
GO:1901981 phosphatidylinositol phosphate binding 13.6364 5 yes
GO:0004435 phosphatidylinositol phospholipase C activity 9.0909 7 yes
GO:0004620 phospholipase activity 9.0909 5 yes
GO:0004629 phospholipase C activity 9.0909 6 yes
GO:0005509 calcium ion binding 9.0909 5 yes
GO:0008081 phosphoric diester hydrolase activity 9.0909 5 yes
GO:0016298 lipase activity 9.0909 4 yes
GO:0042578 phosphoric ester hydrolase activity 9.0909 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLCD1_HUMAN
GO:0048522 positive regulation of cellular process 54.5455 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0010646 regulation of cell communication 45.4545 4 no
GO:0006996 organelle organization 45.4545 4 no
GO:0051128 regulation of cellular component organization 45.4545 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.9091 4 no
GO:0060255 regulation of macromolecule metabolic process 40.9091 4 no
GO:0009966 regulation of signal transduction 40.9091 4 no
GO:0022607 cellular component assembly 40.9091 4 no
GO:0044087 regulation of cellular component biogenesis 40.9091 4 no
GO:0009893 positive regulation of metabolic process 36.3636 4 no
GO:0051049 regulation of transport 36.3636 4 no
GO:0051246 regulation of protein metabolic process 36.3636 5 no
GO:0016192 vesicle-mediated transport 36.3636 4 no
GO:0033043 regulation of organelle organization 36.3636 5 no
GO:0019220 regulation of phosphate metabolic process 36.3636 6 no
GO:0042325 regulation of phosphorylation 36.3636 7 no
GO:0051174 regulation of phosphorus metabolic process 36.3636 5 no
GO:0006796 phosphate-containing compound metabolic process 31.8182 4 yes
GO:0009892 negative regulation of metabolic process 31.8182 4 no
GO:0009894 regulation of catabolic process 31.8182 4 no
GO:0031325 positive regulation of cellular metabolic process 31.8182 5 no
GO:0031399 regulation of protein modification process 31.8182 6 no
GO:0007010 cytoskeleton organization 31.8182 5 no
GO:0042127 regulation of cell population proliferation 31.8182 4 no
GO:0008104 protein localization 31.8182 4 no
GO:0043549 regulation of kinase activity 31.8182 5 no
GO:0051338 regulation of transferase activity 31.8182 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.2727 5 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0060627 regulation of vesicle-mediated transport 27.2727 4 no
GO:0061024 membrane organization 27.2727 4 no
GO:1902531 regulation of intracellular signal transduction 27.2727 5 no
GO:0051130 positive regulation of cellular component organization 27.2727 5 no
GO:0071702 organic substance transport 27.2727 4 no
GO:0044089 positive regulation of cellular component biogenesis 27.2727 5 no
GO:0001932 regulation of protein phosphorylation 27.2727 7 no
GO:0010468 regulation of gene expression 27.2727 5 no
GO:0010941 regulation of cell death 22.7273 4 no
GO:0042981 regulation of apoptotic process 22.7273 6 no
GO:0043067 regulation of programmed cell death 22.7273 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.7273 5 no
GO:0060548 negative regulation of cell death 22.7273 5 no
GO:0007264 small GTPase mediated signal transduction 22.7273 4 no
GO:0007265 Ras protein signal transduction 22.7273 5 no
GO:0015031 protein transport 22.7273 4 no
GO:0071705 nitrogen compound transport 22.7273 4 no
GO:0031329 regulation of cellular catabolic process 22.7273 5 no
GO:0051726 regulation of cell cycle 22.7273 4 no
GO:0009967 positive regulation of signal transduction 22.7273 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.7273 6 no
GO:0031324 negative regulation of cellular metabolic process 22.7273 5 no
GO:0045859 regulation of protein kinase activity 22.7273 6 no
GO:0006644 phospholipid metabolic process 18.1818 4 yes
GO:0006650 glycerophospholipid metabolic process 18.1818 5 yes
GO:0046486 glycerolipid metabolic process 18.1818 4 yes
GO:0046488 phosphatidylinositol metabolic process 18.1818 6 yes
GO:0016042 lipid catabolic process 9.0909 4 yes
GO:0048015 phosphatidylinositol-mediated signaling 9.0909 5 yes
GO:0048017 inositol lipid-mediated signaling 9.0909 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IMB1_HUMAN [view entry] [view interactions] Low throughput yes yes
TGM2_HUMAN [view interactions] Low throughput no no
IQGA1_HUMAN [view entry] [view interactions] Low throughput yes no
RALA_HUMAN [view entry] [view interactions] Low throughput yes yes
NEUM_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
RBM24_HUMAN [view interactions] High throughput no yes
GDF5_HUMAN [view interactions] High throughput no no
FBXL4_HUMAN [view interactions] High throughput no yes
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
NTAQ1_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI1_HUMAN [view interactions] High throughput no no
TEX35_HUMAN [view interactions] High throughput no no
IFIX_HUMAN [view interactions] High throughput no no
SMRD1_HUMAN [view interactions] High throughput no yes
IL31R_HUMAN [view interactions] High throughput no no
GPBP1_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
FBX3_HUMAN [view interactions] High throughput no no
PNMA2_HUMAN [view interactions] High throughput no yes
PTSS1_HUMAN [view interactions] High throughput no no
DYM_HUMAN [view interactions] High throughput no yes
US6NL_HUMAN [view interactions] High throughput no yes
SRMS_HUMAN [view interactions] High throughput no no
CGAT1_HUMAN [view interactions] High throughput no no
RB39B_HUMAN [view interactions] High throughput no no
SGIP1_HUMAN [view entry] [view interactions] High throughput yes yes
ERD22_HUMAN [view interactions] High throughput no yes
ANXA9_HUMAN [view interactions] High throughput no yes
ITAD_HUMAN [view interactions] High throughput no no
DHR12_HUMAN [view interactions] High throughput no yes
PEMT_HUMAN [view interactions] High throughput no yes
KCNE3_HUMAN [view interactions] High throughput no yes
JAM1_HUMAN [view interactions] High throughput no yes
DUS14_HUMAN [view interactions] High throughput no yes
PLD5_HUMAN [view interactions] High throughput no no
7B2_HUMAN [view interactions] High throughput no yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
TMTC4_HUMAN [view interactions] High throughput no yes
IQUB_HUMAN [view interactions] High throughput no no
SRFB1_HUMAN [view interactions] High throughput no no
FOS_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
PI42B_HUMAN [view entry] [view interactions] Computational yes no
PI5L1_HUMAN [view interactions] Computational no no
IMPA2_HUMAN [view interactions] Computational no no
PI51B_HUMAN [view interactions] Computational no yes
KPCG_HUMAN [view entry] [view interactions] Computational yes yes
RHG07_HUMAN [view interactions] Computational no no
PLCD3_HUMAN [view entry] [view interactions] Computational yes yes
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
PI42C_HUMAN [view interactions] Computational no yes
ITPR2_HUMAN [view interactions] Computational no yes
INP5E_HUMAN [view interactions] Computational no yes
PI42A_HUMAN [view entry] [view interactions] Computational yes yes
PLCD4_HUMAN [view interactions] Computational no no
PI51C_HUMAN [view entry] [view interactions] Computational yes yes
PI51A_HUMAN [view interactions] Computational no yes
ITPR3_HUMAN [view interactions] Computational no yes