RALA_HUMAN
Evidence for PS localization
Functions
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 25 | Val | Leu | Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) | - |
| 25 | Val | Met | Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) | - |
| 128 | Lys | Arg | Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) | - |
| 130 | Asp | Gly | Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) | - |
| 157 | Ser | Ala | Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RALA_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 37.7358 | 4 | yes |
| GO:0000166 | nucleotide binding | 33.9623 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 33.9623 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 33.9623 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.0755 | 4 | yes |
| GO:0043169 | cation binding | 26.4151 | 4 | no |
| GO:0046872 | metal ion binding | 26.4151 | 5 | no |
| GO:0019900 | kinase binding | 22.6415 | 4 | no |
| GO:0019901 | protein kinase binding | 22.6415 | 5 | no |
| GO:0003779 | actin binding | 20.7547 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 18.8679 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 18.8679 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 18.8679 | 6 | yes |
| GO:0003924 | GTPase activity | 16.9811 | 7 | yes |
| GO:0005525 | GTP binding | 16.9811 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 16.9811 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 16.9811 | 5 | yes |
| GO:0019003 | GDP binding | 11.3208 | 5 | yes |
| GO:0001664 | G protein-coupled receptor binding | 7.5472 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 7.5472 | 5 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 7.5472 | 4 | yes |
| GO:0017022 | myosin binding | 3.7736 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RALA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 67.9245 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.8302 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.8302 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.9434 | 4 | no |
| GO:0010646 | regulation of cell communication | 49.0566 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 49.0566 | 4 | no |
| GO:0009966 | regulation of signal transduction | 47.1698 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.2830 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 45.2830 | 4 | no |
| GO:0008104 | protein localization | 41.5094 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.5094 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 41.5094 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.7358 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 35.8491 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.9623 | 4 | yes |
| GO:0006996 | organelle organization | 33.9623 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.9623 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.9623 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.9623 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.9623 | 5 | no |
| GO:0051049 | regulation of transport | 32.0755 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 32.0755 | 6 | no |
| GO:0022607 | cellular component assembly | 32.0755 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 30.1887 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 30.1887 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 30.1887 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 30.1887 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.1887 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.1887 | 6 | no |
| GO:0071702 | organic substance transport | 30.1887 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 28.3019 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 28.3019 | 7 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.3019 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.3019 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.3019 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 28.3019 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.3019 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.3019 | 5 | no |
| GO:0071705 | nitrogen compound transport | 28.3019 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 26.4151 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 26.4151 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 26.4151 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 24.5283 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 24.5283 | 4 | no |
| GO:0007010 | cytoskeleton organization | 24.5283 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.5283 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 24.5283 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 24.5283 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 24.5283 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.5283 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 22.6415 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 22.6415 | 6 | yes |
| GO:0043549 | regulation of kinase activity | 22.6415 | 5 | no |
| GO:0051338 | regulation of transferase activity | 22.6415 | 4 | no |
| GO:0051726 | regulation of cell cycle | 22.6415 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.6415 | 7 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.6415 | 6 | no |
| GO:0015031 | protein transport | 22.6415 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.6415 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.6415 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 20.7547 | 4 | yes |
| GO:0045859 | regulation of protein kinase activity | 20.7547 | 6 | no |
| GO:0051050 | positive regulation of transport | 20.7547 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.7547 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.7547 | 5 | no |
| GO:2000145 | regulation of cell motility | 20.7547 | 4 | no |
| GO:0030030 | cell projection organization | 20.7547 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 20.7547 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 18.8679 | 6 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 18.8679 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 18.8679 | 5 | yes |
| GO:0098657 | import into cell | 18.8679 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 18.8679 | 6 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 16.9811 | 5 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 15.0943 | 5 | yes |
| GO:0046903 | secretion | 15.0943 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 13.2075 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 13.2075 | 4 | yes |
| GO:0031346 | positive regulation of cell projection organization | 11.3208 | 6 | yes |
| GO:0033365 | protein localization to organelle | 9.4340 | 5 | yes |
| GO:0060491 | regulation of cell projection assembly | 9.4340 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 9.4340 | 6 | yes |
| GO:0007265 | Ras protein signal transduction | 7.5472 | 6 | yes |
| GO:0010821 | regulation of mitochondrion organization | 7.5472 | 6 | yes |
| GO:0051046 | regulation of secretion | 7.5472 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 7.5472 | 4 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 5.6604 | 6 | yes |
| GO:0051489 | regulation of filopodium assembly | 5.6604 | 7 | yes |
| GO:0072594 | establishment of protein localization to organelle | 5.6604 | 4 | yes |
| GO:0090140 | regulation of mitochondrial fission | 5.6604 | 5 | yes |
| GO:0090141 | positive regulation of mitochondrial fission | 5.6604 | 5 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 5.6604 | 6 | yes |
| GO:0001843 | neural tube closure | 3.7736 | 5 | yes |
| GO:0002090 | regulation of receptor internalization | 3.7736 | 7 | yes |
| GO:0017157 | regulation of exocytosis | 3.7736 | 5 | yes |
| GO:0051491 | positive regulation of filopodium assembly | 3.7736 | 7 | yes |
| GO:0060606 | tube closure | 3.7736 | 4 | yes |
| GO:0070585 | protein localization to mitochondrion | 3.7736 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EXOC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCND1_HUMAN | [view interactions] | Low throughput | no | yes |
| RGL2_HUMAN | [view interactions] | Low throughput | no | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLCD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| YBOX3_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB34_HUMAN | [view interactions] | Low throughput | no | yes |
| LSM2_HUMAN | [view interactions] | Low throughput | no | yes |
| PIHD2_HUMAN | [view interactions] | Low throughput | no | no |
| UBP33_HUMAN | [view interactions] | Low throughput | no | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TSC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EXOC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RGDSR_HUMAN | [view interactions] | Low throughput | no | no |
| PLD1_HUMAN | [view interactions] | Low throughput | no | no |
| ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLSL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGPS2_HUMAN | [view interactions] | Low throughput | no | yes |
| RGPS1_HUMAN | [view interactions] | Low throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTCF_HUMAN | [view interactions] | Low throughput | no | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| ALAT1_HUMAN | [view interactions] | High throughput | no | no |
| ARK72_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| K2013_HUMAN | [view interactions] | High throughput | no | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| RMXL2_HUMAN | [view interactions] | High throughput | no | no |
| DEND_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT10_HUMAN | [view interactions] | High throughput | no | yes |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT7_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| AN13D_HUMAN | [view interactions] | High throughput | no | yes |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| MOT1_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1G_HUMAN | [view interactions] | High throughput | no | no |
| MPV17_HUMAN | [view interactions] | High throughput | no | no |
| MRP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| MSLN_HUMAN | [view interactions] | High throughput | no | no |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAM3C_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| RAP2B_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAB_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP4M1_HUMAN | [view interactions] | High throughput | no | yes |
| FBH1_HUMAN | [view interactions] | High throughput | no | no |
| VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| ZNHI3_HUMAN | [view interactions] | High throughput | no | yes |