Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RALA_HUMAN

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1. [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
25 Val Leu Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) -
25 Val Met Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) -
128 Lys Arg Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) -
130 Asp Gly Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) -
157 Ser Ala Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RALA_HUMAN
GO:0017076 purine nucleotide binding 42.8571 4 yes
GO:0032555 purine ribonucleotide binding 42.8571 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 42.8571 4 yes
GO:0016462 pyrophosphatase activity 30.1587 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 30.1587 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 30.1587 6 yes
GO:0003924 GTPase activity 26.9841 7 yes
GO:0005525 GTP binding 26.9841 5 yes
GO:0019001 guanyl nucleotide binding 26.9841 5 yes
GO:0032561 guanyl ribonucleotide binding 26.9841 5 yes
GO:0019900 kinase binding 26.9841 4 no
GO:0019901 protein kinase binding 26.9841 5 no
GO:0019003 GDP binding 15.8730 4 yes
GO:0017022 myosin binding 9.5238 4 yes
GO:0001664 G protein-coupled receptor binding 6.3492 4 yes
GO:0031625 ubiquitin protein ligase binding 3.1746 5 yes
GO:0044389 ubiquitin-like protein ligase binding 3.1746 4 yes
GO:0051117 ATPase binding 3.1746 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RALA_HUMAN
GO:0048522 positive regulation of cellular process 58.7302 4 yes
GO:0031323 regulation of cellular metabolic process 47.6190 4 no
GO:0008104 protein localization 46.0317 4 yes
GO:0016192 vesicle-mediated transport 46.0317 4 yes
GO:0006996 organelle organization 44.4444 4 yes
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:0051171 regulation of nitrogen compound metabolic process 41.2698 4 no
GO:0080090 regulation of primary metabolic process 41.2698 4 no
GO:0071702 organic substance transport 41.2698 4 no
GO:0051049 regulation of transport 39.6825 4 yes
GO:0051128 regulation of cellular component organization 39.6825 4 yes
GO:0048523 negative regulation of cellular process 39.6825 4 no
GO:0071705 nitrogen compound transport 39.6825 4 no
GO:0010646 regulation of cell communication 38.0952 4 no
GO:0009893 positive regulation of metabolic process 36.5079 4 no
GO:0015031 protein transport 36.5079 4 no
GO:0022607 cellular component assembly 34.9206 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.7460 5 no
GO:0007010 cytoskeleton organization 30.1587 5 yes
GO:0031325 positive regulation of cellular metabolic process 30.1587 5 no
GO:0030030 cell projection organization 30.1587 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0033043 regulation of organelle organization 26.9841 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 25.3968 4 yes
GO:0046903 secretion 25.3968 4 yes
GO:0009892 negative regulation of metabolic process 25.3968 4 no
GO:0010468 regulation of gene expression 25.3968 5 no
GO:0019220 regulation of phosphate metabolic process 25.3968 6 no
GO:0031399 regulation of protein modification process 25.3968 6 no
GO:0042325 regulation of phosphorylation 25.3968 7 no
GO:0051174 regulation of phosphorus metabolic process 25.3968 5 no
GO:0120036 plasma membrane bounded cell projection organization 25.3968 5 no
GO:0097435 supramolecular fiber organization 25.3968 4 no
GO:0051050 positive regulation of transport 25.3968 4 no
GO:0001932 regulation of protein phosphorylation 23.8095 7 no
GO:0010605 negative regulation of macromolecule metabolic process 23.8095 5 no
GO:0051247 positive regulation of protein metabolic process 23.8095 6 no
GO:0007015 actin filament organization 23.8095 5 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 yes
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0032970 regulation of actin filament-based process 22.2222 4 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0006887 exocytosis 20.6349 4 yes
GO:0031344 regulation of cell projection organization 20.6349 5 yes
GO:0044087 regulation of cellular component biogenesis 20.6349 4 yes
GO:0060627 regulation of vesicle-mediated transport 20.6349 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.6349 6 yes
GO:0009889 regulation of biosynthetic process 20.6349 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.6349 5 no
GO:0031326 regulation of cellular biosynthetic process 20.6349 5 no
GO:0043549 regulation of kinase activity 20.6349 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 20.6349 5 no
GO:0051338 regulation of transferase activity 20.6349 4 no
GO:0098876 vesicle-mediated transport to the plasma membrane 20.6349 4 no
GO:0030334 regulation of cell migration 20.6349 5 no
GO:2000145 regulation of cell motility 20.6349 4 no
GO:0010941 regulation of cell death 20.6349 4 no
GO:0032956 regulation of actin cytoskeleton organization 20.6349 5 no
GO:0051493 regulation of cytoskeleton organization 20.6349 6 no
GO:0071310 cellular response to organic substance 20.6349 4 no
GO:0051094 positive regulation of developmental process 19.0476 4 yes
GO:0007264 small GTPase mediated signal transduction 17.4603 4 yes
GO:0010638 positive regulation of organelle organization 15.8730 6 yes
GO:0033365 protein localization to organelle 15.8730 5 yes
GO:0044089 positive regulation of cellular component biogenesis 15.8730 5 yes
GO:0051046 regulation of secretion 15.8730 5 yes
GO:0007265 Ras protein signal transduction 14.2857 5 yes
GO:0031346 positive regulation of cell projection organization 14.2857 6 yes
GO:1903530 regulation of secretion by cell 14.2857 4 yes
GO:0060491 regulation of cell projection assembly 12.6984 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 11.1111 6 yes
GO:0017157 regulation of exocytosis 9.5238 5 yes
GO:0072594 establishment of protein localization to organelle 9.5238 4 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 7.9365 6 yes
GO:0031532 actin cytoskeleton reorganization 6.3492 4 yes
GO:0010821 regulation of mitochondrion organization 4.7619 6 yes
GO:0051489 regulation of filopodium assembly 4.7619 7 yes
GO:0001843 neural tube closure 3.1746 5 yes
GO:0010822 positive regulation of mitochondrion organization 3.1746 7 yes
GO:0051491 positive regulation of filopodium assembly 3.1746 7 yes
GO:0060606 tube closure 3.1746 4 yes
GO:0070585 protein localization to mitochondrion 3.1746 6 yes
GO:0072655 establishment of protein localization to mitochondrion 3.1746 5 yes
GO:0090140 regulation of mitochondrial fission 3.1746 5 yes
GO:0090141 positive regulation of mitochondrial fission 3.1746 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in RALA_HUMAN
DOID:114 heart disease 6.3492 3 no
DOID:0050700 cardiomyopathy 4.7619 4 no
DOID:0060036 intrinsic cardiomyopathy 4.7619 5 no
DOID:2843 long QT syndrome 3.1746 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RGDSR_HUMAN [view interactions] Low throughput no no
PLD1_HUMAN [view interactions] Low throughput no no
ARF1_HUMAN [view entry] [view interactions] Low throughput yes yes
GLSL_HUMAN [view entry] [view interactions] Low throughput yes yes
RGPS2_HUMAN [view interactions] Low throughput no yes
RGPS1_HUMAN [view interactions] Low throughput no no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
CTCF_HUMAN [view interactions] Low throughput no yes
RBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
EXOC2_HUMAN [view entry] [view interactions] Low throughput yes no
CCND1_HUMAN [view interactions] Low throughput no yes
RGL2_HUMAN [view interactions] Low throughput no yes
EXOC8_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCD1_HUMAN [view entry] [view interactions] Low throughput yes yes
YBOX3_HUMAN [view interactions] Low throughput no yes
RAB34_HUMAN [view interactions] Low throughput no yes
LSM2_HUMAN [view interactions] Low throughput no yes
PIHD2_HUMAN [view interactions] Low throughput no no
UBP33_HUMAN [view interactions] Low throughput no yes
CNKR2_HUMAN [view entry] [view interactions] Low throughput yes no
TSC2_HUMAN [view entry] [view interactions] Low throughput yes yes
FLNA_HUMAN [view entry] [view interactions] Low throughput yes no
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
EXOC4_HUMAN [view entry] [view interactions] Low throughput yes yes
EXOC3_HUMAN [view entry] [view interactions] Low throughput yes no
EMC1_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
NPC1_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
UBQL1_HUMAN [view interactions] High throughput no yes
AN13D_HUMAN [view interactions] High throughput no yes
AN13A_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
MOT1_HUMAN [view interactions] High throughput no no
MYO1G_HUMAN [view interactions] High throughput no no
MPV17_HUMAN [view interactions] High throughput no no
MRP_HUMAN [view entry] [view interactions] High throughput yes no
LTOR3_HUMAN [view interactions] High throughput no yes
NONO_HUMAN [view interactions] High throughput no yes
MSLN_HUMAN [view interactions] High throughput no no
NDUS6_HUMAN [view entry] [view interactions] High throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
FAM3C_HUMAN [view interactions] High throughput no yes
ILF3_HUMAN [view interactions] High throughput no yes
NB5R3_HUMAN [view interactions] High throughput no yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
NIPS2_HUMAN [view interactions] High throughput no yes
RAP2B_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
LAMP2_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
SMAD4_HUMAN [view interactions] High throughput no yes
2AAB_HUMAN [view interactions] High throughput no yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
TMOD3_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
AP4M1_HUMAN [view interactions] High throughput no yes
MCM5_HUMAN [view interactions] High throughput no no
K2013_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
ARK72_HUMAN [view entry] [view interactions] High throughput yes yes
ALAT1_HUMAN [view interactions] High throughput no no
ATP5J_HUMAN [view interactions] High throughput no yes
ZNHI3_HUMAN [view interactions] High throughput no yes
CEP55_HUMAN [view interactions] High throughput no yes
VPS4B_HUMAN [view interactions] High throughput no yes
FBH1_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
RMXL2_HUMAN [view interactions] High throughput no no
DEND_HUMAN [view entry] [view interactions] High throughput yes no
DJB11_HUMAN [view interactions] High throughput no yes
ZBT10_HUMAN [view interactions] High throughput no yes
SMC3_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
HASP_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
HSC20_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
CNDD3_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
S2541_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
CAPON_HUMAN [view entry] [view interactions] High throughput yes yes
INT7_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
PKHA2_HUMAN [view interactions] High throughput no no
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
BIRC3_HUMAN [view interactions] High throughput no no
CXCR4_HUMAN [view interactions] High throughput no no
MYO5A_HUMAN [view entry] [view interactions] Computational yes yes
RGL1_HUMAN [view interactions] Computational no yes
EXOC6_HUMAN [view entry] [view interactions] Computational yes yes
MK09_HUMAN [view interactions] Computational no yes
RHOQ_HUMAN [view interactions] Computational no no
EXC6B_HUMAN [view entry] [view interactions] Computational yes yes
EXOC7_HUMAN [view entry] [view interactions] Computational yes yes
C2CD5_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
RAB14_HUMAN [view entry] [view interactions] Computational yes yes
EXOC1_HUMAN [view entry] [view interactions] Computational yes yes
RLGPB_HUMAN [view interactions] Computational no yes
PLD2_HUMAN [view interactions] Computational no yes
MK11_HUMAN [view interactions] Computational no yes
STAT4_HUMAN [view interactions] Computational no yes
RGPA2_HUMAN [view interactions] Computational no yes
RAB10_HUMAN [view entry] [view interactions] Computational yes yes
RAB8A_HUMAN [view entry] [view interactions] Computational yes no
GNDS_HUMAN [view interactions] Computational no yes
MK08_HUMAN [view interactions] Computational no yes
RAC3_HUMAN [view entry] [view interactions] Computational yes no
RALB_HUMAN [view interactions] Computational no no
EXOC5_HUMAN [view entry] [view interactions] Computational yes yes
RB11A_HUMAN [view entry] [view interactions] Computational yes yes
RAC2_HUMAN [view entry] [view interactions] Computational yes yes
MYO1E_HUMAN [view entry] [view interactions] Computational yes yes
GLUT4_HUMAN [view interactions] Computational no no
RAB13_HUMAN [view entry] [view interactions] Computational yes yes
RAC1_HUMAN [view entry] [view interactions] Computational yes no
MK14_HUMAN [view interactions] Computational no yes