RALA_HUMAN
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
25 | Val | Leu | Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) | - |
25 | Val | Met | Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) | - |
128 | Lys | Arg | Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) | - |
130 | Asp | Gly | Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) | - |
157 | Ser | Ala | Hiatt-Neu-Cooperneurodevelopmentalsyndrome(HINCONS) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RALA_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 42.8571 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 42.8571 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 42.8571 | 4 | yes |
GO:0016462 | pyrophosphatase activity | 30.1587 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 30.1587 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 30.1587 | 6 | yes |
GO:0003924 | GTPase activity | 26.9841 | 7 | yes |
GO:0005525 | GTP binding | 26.9841 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 26.9841 | 5 | yes |
GO:0032561 | guanyl ribonucleotide binding | 26.9841 | 5 | yes |
GO:0019900 | kinase binding | 26.9841 | 4 | no |
GO:0019901 | protein kinase binding | 26.9841 | 5 | no |
GO:0019003 | GDP binding | 15.8730 | 4 | yes |
GO:0017022 | myosin binding | 9.5238 | 4 | yes |
GO:0001664 | G protein-coupled receptor binding | 6.3492 | 4 | yes |
GO:0031625 | ubiquitin protein ligase binding | 3.1746 | 5 | yes |
GO:0044389 | ubiquitin-like protein ligase binding | 3.1746 | 4 | yes |
GO:0051117 | ATPase binding | 3.1746 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RALA_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 58.7302 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 47.6190 | 4 | no |
GO:0008104 | protein localization | 46.0317 | 4 | yes |
GO:0016192 | vesicle-mediated transport | 46.0317 | 4 | yes |
GO:0006996 | organelle organization | 44.4444 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 42.8571 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 41.2698 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 41.2698 | 4 | no |
GO:0071702 | organic substance transport | 41.2698 | 4 | no |
GO:0051049 | regulation of transport | 39.6825 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 39.6825 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 39.6825 | 4 | no |
GO:0071705 | nitrogen compound transport | 39.6825 | 4 | no |
GO:0010646 | regulation of cell communication | 38.0952 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 36.5079 | 4 | no |
GO:0015031 | protein transport | 36.5079 | 4 | no |
GO:0022607 | cellular component assembly | 34.9206 | 4 | no |
GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.7460 | 5 | no |
GO:0007010 | cytoskeleton organization | 30.1587 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 30.1587 | 5 | no |
GO:0030030 | cell projection organization | 30.1587 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | no |
GO:0033043 | regulation of organelle organization | 26.9841 | 5 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 25.3968 | 4 | yes |
GO:0046903 | secretion | 25.3968 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 25.3968 | 4 | no |
GO:0010468 | regulation of gene expression | 25.3968 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 25.3968 | 6 | no |
GO:0031399 | regulation of protein modification process | 25.3968 | 6 | no |
GO:0042325 | regulation of phosphorylation | 25.3968 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 25.3968 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 25.3968 | 5 | no |
GO:0097435 | supramolecular fiber organization | 25.3968 | 4 | no |
GO:0051050 | positive regulation of transport | 25.3968 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 23.8095 | 7 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 23.8095 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.8095 | 6 | no |
GO:0007015 | actin filament organization | 23.8095 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 22.2222 | 4 | no |
GO:0032880 | regulation of protein localization | 22.2222 | 5 | no |
GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
GO:0032970 | regulation of actin filament-based process | 22.2222 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | no |
GO:0006887 | exocytosis | 20.6349 | 4 | yes |
GO:0031344 | regulation of cell projection organization | 20.6349 | 5 | yes |
GO:0044087 | regulation of cellular component biogenesis | 20.6349 | 4 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 20.6349 | 4 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.6349 | 6 | yes |
GO:0009889 | regulation of biosynthetic process | 20.6349 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.6349 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 20.6349 | 5 | no |
GO:0043549 | regulation of kinase activity | 20.6349 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.6349 | 5 | no |
GO:0051338 | regulation of transferase activity | 20.6349 | 4 | no |
GO:0098876 | vesicle-mediated transport to the plasma membrane | 20.6349 | 4 | no |
GO:0030334 | regulation of cell migration | 20.6349 | 5 | no |
GO:2000145 | regulation of cell motility | 20.6349 | 4 | no |
GO:0010941 | regulation of cell death | 20.6349 | 4 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 20.6349 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 20.6349 | 6 | no |
GO:0071310 | cellular response to organic substance | 20.6349 | 4 | no |
GO:0051094 | positive regulation of developmental process | 19.0476 | 4 | yes |
GO:0007264 | small GTPase mediated signal transduction | 17.4603 | 4 | yes |
GO:0010638 | positive regulation of organelle organization | 15.8730 | 6 | yes |
GO:0033365 | protein localization to organelle | 15.8730 | 5 | yes |
GO:0044089 | positive regulation of cellular component biogenesis | 15.8730 | 5 | yes |
GO:0051046 | regulation of secretion | 15.8730 | 5 | yes |
GO:0007265 | Ras protein signal transduction | 14.2857 | 5 | yes |
GO:0031346 | positive regulation of cell projection organization | 14.2857 | 6 | yes |
GO:1903530 | regulation of secretion by cell | 14.2857 | 4 | yes |
GO:0060491 | regulation of cell projection assembly | 12.6984 | 5 | yes |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 11.1111 | 6 | yes |
GO:0017157 | regulation of exocytosis | 9.5238 | 5 | yes |
GO:0072594 | establishment of protein localization to organelle | 9.5238 | 4 | yes |
GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 7.9365 | 6 | yes |
GO:0031532 | actin cytoskeleton reorganization | 6.3492 | 4 | yes |
GO:0010821 | regulation of mitochondrion organization | 4.7619 | 6 | yes |
GO:0051489 | regulation of filopodium assembly | 4.7619 | 7 | yes |
GO:0001843 | neural tube closure | 3.1746 | 5 | yes |
GO:0010822 | positive regulation of mitochondrion organization | 3.1746 | 7 | yes |
GO:0051491 | positive regulation of filopodium assembly | 3.1746 | 7 | yes |
GO:0060606 | tube closure | 3.1746 | 4 | yes |
GO:0070585 | protein localization to mitochondrion | 3.1746 | 6 | yes |
GO:0072655 | establishment of protein localization to mitochondrion | 3.1746 | 5 | yes |
GO:0090140 | regulation of mitochondrial fission | 3.1746 | 5 | yes |
GO:0090141 | positive regulation of mitochondrial fission | 3.1746 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in RALA_HUMAN |
---|---|---|---|---|
DOID:114 | heart disease | 6.3492 | 3 | no |
DOID:0050700 | cardiomyopathy | 4.7619 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 4.7619 | 5 | no |
DOID:2843 | long QT syndrome | 3.1746 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RGDSR_HUMAN | [view interactions] | Low throughput | no | no |
PLD1_HUMAN | [view interactions] | Low throughput | no | no |
ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GLSL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RGPS2_HUMAN | [view interactions] | Low throughput | no | yes |
RGPS1_HUMAN | [view interactions] | Low throughput | no | no |
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CTCF_HUMAN | [view interactions] | Low throughput | no | yes |
RBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EXOC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CCND1_HUMAN | [view interactions] | Low throughput | no | yes |
RGL2_HUMAN | [view interactions] | Low throughput | no | yes |
EXOC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PLCD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
YBOX3_HUMAN | [view interactions] | Low throughput | no | yes |
RAB34_HUMAN | [view interactions] | Low throughput | no | yes |
LSM2_HUMAN | [view interactions] | Low throughput | no | yes |
PIHD2_HUMAN | [view interactions] | Low throughput | no | no |
UBP33_HUMAN | [view interactions] | Low throughput | no | yes |
CNKR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
TSC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EXOC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EXOC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EMC1_HUMAN | [view interactions] | High throughput | no | yes |
EMC5_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
APR_HUMAN | [view interactions] | High throughput | no | yes |
UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
AN13D_HUMAN | [view interactions] | High throughput | no | yes |
AN13A_HUMAN | [view interactions] | High throughput | no | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
MOT1_HUMAN | [view interactions] | High throughput | no | no |
MYO1G_HUMAN | [view interactions] | High throughput | no | no |
MPV17_HUMAN | [view interactions] | High throughput | no | no |
MRP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
NONO_HUMAN | [view interactions] | High throughput | no | yes |
MSLN_HUMAN | [view interactions] | High throughput | no | no |
NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FAM3C_HUMAN | [view interactions] | High throughput | no | yes |
ILF3_HUMAN | [view interactions] | High throughput | no | yes |
NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
RAP2B_HUMAN | [view interactions] | High throughput | no | no |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
2AAB_HUMAN | [view interactions] | High throughput | no | yes |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP4M1_HUMAN | [view interactions] | High throughput | no | yes |
MCM5_HUMAN | [view interactions] | High throughput | no | no |
K2013_HUMAN | [view interactions] | High throughput | no | yes |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
ARK72_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALAT1_HUMAN | [view interactions] | High throughput | no | no |
ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
ZNHI3_HUMAN | [view interactions] | High throughput | no | yes |
CEP55_HUMAN | [view interactions] | High throughput | no | yes |
VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
FBH1_HUMAN | [view interactions] | High throughput | no | no |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
RMXL2_HUMAN | [view interactions] | High throughput | no | no |
DEND_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DJB11_HUMAN | [view interactions] | High throughput | no | yes |
ZBT10_HUMAN | [view interactions] | High throughput | no | yes |
SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
HASP_HUMAN | [view interactions] | High throughput | no | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
CNDD3_HUMAN | [view interactions] | High throughput | no | no |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL7_HUMAN | [view interactions] | High throughput | no | yes |
CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
S2541_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INT7_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
PKHA2_HUMAN | [view interactions] | High throughput | no | no |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
CXCR4_HUMAN | [view interactions] | High throughput | no | no |
MYO5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RGL1_HUMAN | [view interactions] | Computational | no | yes |
EXOC6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MK09_HUMAN | [view interactions] | Computational | no | yes |
RHOQ_HUMAN | [view interactions] | Computational | no | no |
EXC6B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EXOC7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
C2CD5_HUMAN | [view interactions] | Computational | no | yes |
SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RAB14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EXOC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RLGPB_HUMAN | [view interactions] | Computational | no | yes |
PLD2_HUMAN | [view interactions] | Computational | no | yes |
MK11_HUMAN | [view interactions] | Computational | no | yes |
STAT4_HUMAN | [view interactions] | Computational | no | yes |
RGPA2_HUMAN | [view interactions] | Computational | no | yes |
RAB10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAB8A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GNDS_HUMAN | [view interactions] | Computational | no | yes |
MK08_HUMAN | [view interactions] | Computational | no | yes |
RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RALB_HUMAN | [view interactions] | Computational | no | no |
EXOC5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RB11A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MYO1E_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GLUT4_HUMAN | [view interactions] | Computational | no | no |
RAB13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MK14_HUMAN | [view interactions] | Computational | no | yes |