MRP_HUMAN
Evidence for PS localization
Functions
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed). When unphosphorylated, induces cell migration . When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration . May be involved in coupling the protein kinase C and calmodulin signal transduction systems . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MRP_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 57.1429 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 57.1429 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 57.1429 | 4 | no |
| GO:0019900 | kinase binding | 45.7143 | 4 | no |
| GO:0019901 | protein kinase binding | 45.7143 | 5 | no |
| GO:0003924 | GTPase activity | 37.1429 | 7 | no |
| GO:0005525 | GTP binding | 37.1429 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 37.1429 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 37.1429 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 37.1429 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 37.1429 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 37.1429 | 5 | no |
| GO:0019003 | GDP binding | 25.7143 | 4 | no |
| GO:0003779 | actin binding | 14.2857 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MRP_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 62.8571 | 4 | no |
| GO:0006996 | organelle organization | 57.1429 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 57.1429 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 54.2857 | 4 | no |
| GO:0051049 | regulation of transport | 54.2857 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.2857 | 4 | no |
| GO:0008104 | protein localization | 54.2857 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.4286 | 4 | no |
| GO:0022607 | cellular component assembly | 48.5714 | 4 | no |
| GO:0009966 | regulation of signal transduction | 48.5714 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 48.5714 | 5 | no |
| GO:0010646 | regulation of cell communication | 48.5714 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 48.5714 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 48.5714 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 48.5714 | 4 | no |
| GO:0033043 | regulation of organelle organization | 45.7143 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 45.7143 | 4 | no |
| GO:0032880 | regulation of protein localization | 45.7143 | 5 | no |
| GO:0060341 | regulation of cellular localization | 45.7143 | 4 | no |
| GO:0007010 | cytoskeleton organization | 42.8571 | 5 | no |
| GO:0010468 | regulation of gene expression | 42.8571 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 42.8571 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 42.8571 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 42.8571 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 40.0000 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 40.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 37.1429 | 5 | no |
| GO:0010941 | regulation of cell death | 37.1429 | 4 | no |
| GO:0023056 | positive regulation of signaling | 37.1429 | 4 | no |
| GO:0030334 | regulation of cell migration | 37.1429 | 5 | no |
| GO:0031399 | regulation of protein modification process | 37.1429 | 6 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 37.1429 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 37.1429 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 37.1429 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 37.1429 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 37.1429 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 37.1429 | 6 | no |
| GO:2000145 | regulation of cell motility | 37.1429 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 34.2857 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 34.2857 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 34.2857 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 34.2857 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 34.2857 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 34.2857 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 34.2857 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 34.2857 | 6 | no |
| GO:0051050 | positive regulation of transport | 34.2857 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 34.2857 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 31.4286 | 7 | no |
| GO:0007264 | small GTPase mediated signal transduction | 31.4286 | 4 | no |
| GO:0007265 | Ras protein signal transduction | 31.4286 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.4286 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 31.4286 | 4 | no |
| GO:0030030 | cell projection organization | 31.4286 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 31.4286 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 31.4286 | 7 | no |
| GO:0040017 | positive regulation of locomotion | 31.4286 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 31.4286 | 6 | no |
| GO:2000147 | positive regulation of cell motility | 31.4286 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 31.4286 | 4 | no |
| GO:0051223 | regulation of protein transport | 31.4286 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 31.4286 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 28.5714 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 28.5714 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 28.5714 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 28.5714 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 28.5714 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 28.5714 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 28.5714 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 28.5714 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 28.5714 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 28.5714 | 4 | no |
| GO:0071702 | organic substance transport | 28.5714 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.5714 | 4 | no |
| GO:0051222 | positive regulation of protein transport | 28.5714 | 5 | no |
| GO:1904951 | positive regulation of establishment of protein localization | 28.5714 | 6 | no |
| GO:0060491 | regulation of cell projection assembly | 28.5714 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 28.5714 | 4 | no |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 28.5714 | 6 | no |
| GO:0007015 | actin filament organization | 25.7143 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.7143 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 25.7143 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.7143 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 25.7143 | 5 | no |
| GO:0022604 | regulation of cell morphogenesis | 25.7143 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.7143 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.7143 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.7143 | 8 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.7143 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.7143 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.7143 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 25.7143 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.7143 | 7 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.7143 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.7143 | 4 | no |
| GO:0051338 | regulation of transferase activity | 25.7143 | 4 | no |
| GO:0060548 | negative regulation of cell death | 25.7143 | 5 | no |
| GO:0061024 | membrane organization | 25.7143 | 4 | no |
| GO:0110053 | regulation of actin filament organization | 25.7143 | 6 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 25.7143 | 5 | no |
| GO:0033365 | protein localization to organelle | 25.7143 | 5 | no |
| GO:0080134 | regulation of response to stress | 25.7143 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.7143 | 4 | no |
| GO:0036211 | protein modification process | 25.7143 | 4 | no |
| GO:0043412 | macromolecule modification | 25.7143 | 4 | no |
| GO:1905475 | regulation of protein localization to membrane | 25.7143 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.7143 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.7143 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 25.7143 | 6 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 22.8571 | 8 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.8571 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 22.8571 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 22.8571 | 5 | no |
| GO:0043549 | regulation of kinase activity | 22.8571 | 5 | no |
| GO:0045785 | positive regulation of cell adhesion | 22.8571 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.8571 | 5 | no |
| GO:0051726 | regulation of cell cycle | 22.8571 | 4 | no |
| GO:0015031 | protein transport | 22.8571 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 22.8571 | 5 | no |
| GO:0031346 | positive regulation of cell projection organization | 22.8571 | 6 | no |
| GO:0051046 | regulation of secretion | 22.8571 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 22.8571 | 4 | no |
| GO:1904375 | regulation of protein localization to cell periphery | 22.8571 | 6 | no |
| GO:0050776 | regulation of immune response | 22.8571 | 4 | no |
| GO:0007417 | central nervous system development | 8.5714 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DCTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GPSM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LOXL2_HUMAN | [view interactions] | Low throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STB5L_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| BCCIP_HUMAN | [view interactions] | High throughput | no | no |
| NMT1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3A_HUMAN | [view interactions] | High throughput | no | yes |
| AT11C_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM16_HUMAN | [view interactions] | High throughput | no | yes |
| RALB_HUMAN | [view interactions] | High throughput | no | no |
| ZBT43_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB5_HUMAN | [view interactions] | High throughput | no | yes |
| RM46_HUMAN | [view interactions] | High throughput | no | yes |
| RALA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRM3_HUMAN | [view interactions] | High throughput | no | yes |
| RM30_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDH7_HUMAN | [view interactions] | High throughput | no | no |
| RM22_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CNBP_HUMAN | [view interactions] | High throughput | no | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| DJB14_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| SPHK1_HUMAN | [view interactions] | High throughput | no | yes |
| RMI1_HUMAN | [view interactions] | High throughput | no | no |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| PP4R2_HUMAN | [view interactions] | High throughput | no | yes |
| SCRN2_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| SNX21_HUMAN | [view interactions] | High throughput | no | yes |
| RET4_HUMAN | [view interactions] | High throughput | no | no |
| NMT2_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| KPCD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |