Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MRP_HUMAN

GO
G2C
SynGO

Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed). When unphosphorylated, induces cell migration . When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration . May be involved in coupling the protein kinase C and calmodulin signal transduction systems . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MRP_HUMAN
GO:0000166 nucleotide binding 53.1915 4 no
GO:0017076 purine nucleotide binding 53.1915 5 no
GO:0032555 purine ribonucleotide binding 53.1915 4 no
GO:0043168 anion binding 53.1915 4 no
GO:0035639 purine ribonucleoside triphosphate binding 51.0638 4 no
GO:0016462 pyrophosphatase activity 38.2979 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 38.2979 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 38.2979 6 no
GO:0019900 kinase binding 31.9149 4 no
GO:0019901 protein kinase binding 31.9149 5 no
GO:0003924 GTPase activity 27.6596 7 no
GO:0005525 GTP binding 27.6596 5 no
GO:0019001 guanyl nucleotide binding 27.6596 6 no
GO:0032561 guanyl ribonucleotide binding 27.6596 5 no
GO:0030554 adenyl nucleotide binding 25.5319 6 no
GO:0032559 adenyl ribonucleotide binding 25.5319 5 no
GO:0005524 ATP binding 23.4043 5 no
GO:0003779 actin binding 10.6383 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MRP_HUMAN
GO:0048522 positive regulation of cellular process 76.5957 4 yes
GO:0031323 regulation of cellular metabolic process 61.7021 4 no
GO:0048523 negative regulation of cellular process 55.3191 4 no
GO:0051128 regulation of cellular component organization 55.3191 4 no
GO:0060255 regulation of macromolecule metabolic process 53.1915 4 no
GO:0008104 protein localization 51.0638 4 no
GO:0009893 positive regulation of metabolic process 51.0638 4 no
GO:0009966 regulation of signal transduction 51.0638 4 no
GO:0010646 regulation of cell communication 51.0638 4 no
GO:0048584 positive regulation of response to stimulus 51.0638 4 no
GO:0080090 regulation of primary metabolic process 48.9362 4 no
GO:0006996 organelle organization 48.9362 4 no
GO:0031325 positive regulation of cellular metabolic process 48.9362 5 no
GO:0010604 positive regulation of macromolecule metabolic process 46.8085 5 no
GO:0044087 regulation of cellular component biogenesis 44.6809 4 no
GO:0022607 cellular component assembly 44.6809 4 no
GO:0009889 regulation of biosynthetic process 44.6809 4 no
GO:0010647 positive regulation of cell communication 44.6809 5 no
GO:0023056 positive regulation of signaling 44.6809 4 no
GO:0010468 regulation of gene expression 42.5532 6 no
GO:0010556 regulation of macromolecule biosynthetic process 42.5532 5 no
GO:0031326 regulation of cellular biosynthetic process 42.5532 5 no
GO:0051049 regulation of transport 42.5532 4 no
GO:0009967 positive regulation of signal transduction 40.4255 5 no
GO:0051246 regulation of protein metabolic process 40.4255 5 no
GO:0060341 regulation of cellular localization 38.2979 4 no
GO:0042127 regulation of cell population proliferation 38.2979 4 yes
GO:0042981 regulation of apoptotic process 38.2979 5 no
GO:0043067 regulation of programmed cell death 38.2979 4 no
GO:1902531 regulation of intracellular signal transduction 36.1702 5 no
GO:0033043 regulation of organelle organization 36.1702 5 no
GO:0009891 positive regulation of biosynthetic process 36.1702 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.1702 5 no
GO:0032880 regulation of protein localization 36.1702 5 no
GO:0009892 negative regulation of metabolic process 36.1702 4 no
GO:0031399 regulation of protein modification process 36.1702 6 no
GO:0051130 positive regulation of cellular component organization 36.1702 5 no
GO:0071702 organic substance transport 34.0426 4 no
GO:0141124 intracellular signaling cassette 34.0426 4 no
GO:0031328 positive regulation of cellular biosynthetic process 34.0426 6 no
GO:0031324 negative regulation of cellular metabolic process 34.0426 5 no
GO:0071705 nitrogen compound transport 31.9149 4 no
GO:0007010 cytoskeleton organization 31.9149 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.9149 6 no
GO:0010605 negative regulation of macromolecule metabolic process 31.9149 5 no
GO:0019220 regulation of phosphate metabolic process 31.9149 6 no
GO:0051174 regulation of phosphorus metabolic process 31.9149 5 no
GO:0051240 positive regulation of multicellular organismal process 31.9149 4 no
GO:0051247 positive regulation of protein metabolic process 31.9149 6 no
GO:0051493 regulation of cytoskeleton organization 29.7872 6 no
GO:0009968 negative regulation of signal transduction 29.7872 5 no
GO:0010648 negative regulation of cell communication 29.7872 5 no
GO:0023057 negative regulation of signaling 29.7872 4 no
GO:0048585 negative regulation of response to stimulus 29.7872 4 no
GO:0071310 cellular response to organic substance 29.7872 4 no
GO:1902533 positive regulation of intracellular signal transduction 27.6596 6 no
GO:2000145 regulation of cell motility 27.6596 4 no
GO:0044089 positive regulation of cellular component biogenesis 27.6596 5 no
GO:0051129 negative regulation of cellular component organization 27.6596 5 no
GO:0051252 regulation of RNA metabolic process 27.6596 5 no
GO:0008284 positive regulation of cell population proliferation 27.6596 5 yes
GO:0001932 regulation of protein phosphorylation 27.6596 7 no
GO:0002684 positive regulation of immune system process 27.6596 4 no
GO:0042325 regulation of phosphorylation 27.6596 7 no
GO:0051094 positive regulation of developmental process 27.6596 4 no
GO:0060627 regulation of vesicle-mediated transport 27.6596 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.5319 6 no
GO:0043254 regulation of protein-containing complex assembly 25.5319 5 no
GO:1902903 regulation of supramolecular fiber organization 25.5319 5 no
GO:0043933 protein-containing complex organization 25.5319 4 no
GO:0006355 regulation of DNA-templated transcription 25.5319 7 no
GO:0015031 protein transport 25.5319 4 no
GO:0043066 negative regulation of apoptotic process 25.5319 6 no
GO:0043069 negative regulation of programmed cell death 25.5319 5 no
GO:2001141 regulation of RNA biosynthetic process 25.5319 6 no
GO:0010628 positive regulation of gene expression 25.5319 7 no
GO:0009894 regulation of catabolic process 25.5319 4 no
GO:0030334 regulation of cell migration 25.5319 5 no
GO:0031344 regulation of cell projection organization 25.5319 5 no
GO:0045595 regulation of cell differentiation 25.5319 4 no
GO:0080134 regulation of response to stress 23.4043 4 no
GO:2000026 regulation of multicellular organismal development 23.4043 4 no
GO:2000147 positive regulation of cell motility 23.4043 5 no
GO:0007264 small GTPase-mediated signal transduction 23.4043 5 no
GO:0032956 regulation of actin cytoskeleton organization 23.4043 5 no
GO:0032970 regulation of actin filament-based process 23.4043 4 no
GO:0010638 positive regulation of organelle organization 23.4043 6 no
GO:0009890 negative regulation of biosynthetic process 23.4043 5 no
GO:0070201 regulation of establishment of protein localization 23.4043 6 no
GO:0033365 protein localization to organelle 23.4043 5 no
GO:0097435 supramolecular fiber organization 23.4043 4 yes
GO:0006796 phosphate-containing compound metabolic process 23.4043 4 no
GO:0030335 positive regulation of cell migration 23.4043 6 no
GO:0031401 positive regulation of protein modification process 23.4043 7 no
GO:0040017 positive regulation of locomotion 23.4043 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.2766 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.2766 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.2766 6 no
GO:1903829 positive regulation of protein localization 21.2766 5 no
GO:0051050 positive regulation of transport 21.2766 4 no
GO:0006886 intracellular protein transport 21.2766 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.2766 6 no
GO:0032101 regulation of response to external stimulus 21.2766 4 no
GO:0036211 protein modification process 21.2766 4 no
GO:0043412 macromolecule modification 21.2766 4 no
GO:0045597 positive regulation of cell differentiation 21.2766 5 no
GO:0045937 positive regulation of phosphate metabolic process 21.2766 7 no
GO:0050776 regulation of immune response 21.2766 4 no
GO:0060284 regulation of cell development 21.2766 5 no
GO:0007015 actin filament organization 19.1489 5 yes
GO:0007417 central nervous system development 6.3830 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LOXL2_HUMAN [view interactions] Low throughput no yes
DCTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
GPSM1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
PAX6_HUMAN [view interactions] High throughput no no
SPHK1_HUMAN [view interactions] High throughput no yes
NMT2_HUMAN [view interactions] High throughput no yes
RET4_HUMAN [view interactions] High throughput no no
SNX21_HUMAN [view interactions] High throughput no yes
P4R3A_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
SCRN2_HUMAN [view interactions] High throughput no yes
RMI1_HUMAN [view interactions] High throughput no no
PP4R2_HUMAN [view interactions] High throughput no yes
VPP2_HUMAN [view interactions] High throughput no yes
VATD_HUMAN [view entry] [view interactions] High throughput yes yes
SH2D3_HUMAN [view interactions] High throughput no no
SOAT1_HUMAN [view interactions] High throughput no no
SODC_HUMAN [view interactions] High throughput no yes
M3K7_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
MYLK4_HUMAN [view interactions] High throughput no no
HASP_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
MK14_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
TIF1A_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
EPHA1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
PAN2_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
STB5L_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
BCCIP_HUMAN [view interactions] High throughput no no
NMT1_HUMAN [view interactions] High throughput no yes
TOP3A_HUMAN [view interactions] High throughput no yes
AT11C_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP2_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
UBQL2_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
ZBTB2_HUMAN [view interactions] High throughput no yes
EPS8_HUMAN [view entry] [view interactions] High throughput yes yes
CSCL2_HUMAN [view interactions] High throughput no yes
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
CACO2_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOU_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
CCAR1_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
RM16_HUMAN [view interactions] High throughput no yes
RALB_HUMAN [view interactions] High throughput no no
ZBT43_HUMAN [view interactions] High throughput no yes
NDUB5_HUMAN [view interactions] High throughput no yes
RM46_HUMAN [view interactions] High throughput no yes
RALA_HUMAN [view entry] [view interactions] High throughput yes yes
MRM3_HUMAN [view interactions] High throughput no yes
RM30_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
PCDH7_HUMAN [view entry] [view interactions] High throughput yes no
RM22_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CNBP_HUMAN [view interactions] High throughput no no
PTMA_HUMAN [view interactions] High throughput no yes
TAF6_HUMAN [view interactions] High throughput no no
SET_HUMAN [view interactions] High throughput no yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A2_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
DNJ5B_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
SEC63_HUMAN [view interactions] High throughput no yes
DJB14_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CAV1_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
STING_HUMAN [view interactions] High throughput no yes
ARL4C_HUMAN [view interactions] High throughput no yes
ARL5A_HUMAN [view interactions] High throughput no yes
ARL14_HUMAN [view interactions] High throughput no no
ARL15_HUMAN [view interactions] High throughput no yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes