GPSM1_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GPSM1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 27.7778 | 4 | no |
| GO:0046872 | metal ion binding | 27.7778 | 5 | no |
| GO:0001664 | G protein-coupled receptor binding | 22.2222 | 4 | no |
| GO:0000166 | nucleotide binding | 22.2222 | 4 | no |
| GO:0043168 | anion binding | 22.2222 | 4 | no |
| GO:0030695 | GTPase regulator activity | 16.6667 | 4 | yes |
| GO:0005092 | GDP-dissociation inhibitor activity | 11.1111 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GPSM1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 72.2222 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 66.6667 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 55.5556 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 55.5556 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0006996 | organelle organization | 44.4444 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 44.4444 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 44.4444 | 5 | yes |
| GO:0010646 | regulation of cell communication | 44.4444 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 44.4444 | 5 | no |
| GO:0009966 | regulation of signal transduction | 38.8889 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.8889 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 38.8889 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 33.3333 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0009896 | positive regulation of catabolic process | 27.7778 | 5 | yes |
| GO:0043086 | negative regulation of catalytic activity | 27.7778 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 27.7778 | 7 | no |
| GO:0008104 | protein localization | 27.7778 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 27.7778 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 27.7778 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 27.7778 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.7778 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.7778 | 6 | no |
| GO:0023056 | positive regulation of signaling | 27.7778 | 4 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 27.7778 | 6 | no |
| GO:0033043 | regulation of organelle organization | 27.7778 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 27.7778 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.7778 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.7778 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.7778 | 5 | no |
| GO:0007010 | cytoskeleton organization | 22.2222 | 5 | yes |
| GO:0010506 | regulation of autophagy | 22.2222 | 6 | yes |
| GO:0010508 | positive regulation of autophagy | 22.2222 | 7 | yes |
| GO:0031329 | regulation of cellular catabolic process | 22.2222 | 5 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 22.2222 | 6 | yes |
| GO:0051099 | positive regulation of binding | 22.2222 | 4 | yes |
| GO:0016567 | protein ubiquitination | 22.2222 | 8 | no |
| GO:0032446 | protein modification by small protein conjugation | 22.2222 | 7 | no |
| GO:0036211 | protein modification process | 22.2222 | 4 | no |
| GO:0043412 | macromolecule modification | 22.2222 | 4 | no |
| GO:0043687 | post-translational protein modification | 22.2222 | 5 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 22.2222 | 6 | no |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 22.2222 | 9 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.2222 | 7 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 22.2222 | 8 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
| GO:0022607 | cellular component assembly | 22.2222 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.2222 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.2222 | 4 | no |
| GO:0045892 | negative regulation of DNA-templated transcription | 22.2222 | 8 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 22.2222 | 6 | no |
| GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
| GO:0071702 | organic substance transport | 22.2222 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.2222 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 22.2222 | 4 | no |
| GO:1902679 | negative regulation of RNA biosynthetic process | 22.2222 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.2222 | 6 | no |
| GO:0010564 | regulation of cell cycle process | 22.2222 | 5 | no |
| GO:0051726 | regulation of cell cycle | 22.2222 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 22.2222 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.2222 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.2222 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.2222 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
| GO:0007399 | nervous system development | 16.6667 | 4 | yes |
| GO:0016239 | positive regulation of macroautophagy | 16.6667 | 8 | yes |
| GO:0016241 | regulation of macroautophagy | 16.6667 | 7 | yes |
| GO:0043087 | regulation of GTPase activity | 16.6667 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 16.6667 | 4 | yes |
| GO:0000132 | establishment of mitotic spindle orientation | 11.1111 | 6 | yes |
| GO:0034260 | negative regulation of GTPase activity | 11.1111 | 4 | yes |
| GO:0040001 | establishment of mitotic spindle localization | 11.1111 | 5 | yes |
| GO:0051293 | establishment of spindle localization | 11.1111 | 4 | yes |
| GO:0051294 | establishment of spindle orientation | 11.1111 | 5 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 11.1111 | 5 | yes |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 11.1111 | 4 | yes |
| GO:1904424 | regulation of GTP binding | 11.1111 | 4 | yes |
| GO:1905097 | regulation of guanyl-nucleotide exchange factor activity | 11.1111 | 5 | yes |
| GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity | 11.1111 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ROBO1_HUMAN | [view interactions] | Low throughput | no | yes |
| MRP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STK11_HUMAN | [view interactions] | Low throughput | no | yes |
| USP9X_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OSTM1_HUMAN | [view interactions] | Low throughput | no | yes |
| CD158_HUMAN | [view interactions] | High throughput | no | no |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| ZBED1_HUMAN | [view interactions] | High throughput | no | yes |
| DAZP2_HUMAN | [view interactions] | High throughput | no | no |
| CTDS1_HUMAN | [view interactions] | High throughput | no | no |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMRT3_HUMAN | [view interactions] | High throughput | no | no |
| DCA11_HUMAN | [view interactions] | High throughput | no | yes |
| TASO2_HUMAN | [view interactions] | High throughput | no | yes |
| GCM2_HUMAN | [view interactions] | High throughput | no | no |
| GLIS2_HUMAN | [view interactions] | High throughput | no | no |
| BHE40_HUMAN | [view interactions] | High throughput | no | yes |
| VEZF1_HUMAN | [view interactions] | High throughput | no | yes |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| FA83A_HUMAN | [view interactions] | High throughput | no | no |
| F161B_HUMAN | [view interactions] | High throughput | no | yes |
| RIBC1_HUMAN | [view interactions] | High throughput | no | no |
| TEKT4_HUMAN | [view interactions] | High throughput | no | no |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| SEPT1_HUMAN | [view interactions] | High throughput | no | no |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| WDR83_HUMAN | [view interactions] | High throughput | no | yes |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| UGPA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| SAPC2_HUMAN | [view interactions] | High throughput | no | no |
| KLH18_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRS10_HUMAN | [view interactions] | High throughput | no | yes |
| OTU1_HUMAN | [view interactions] | High throughput | no | yes |
| SP14L_HUMAN | [view interactions] | High throughput | no | no |
| OARD1_HUMAN | [view interactions] | High throughput | no | yes |
| DACH1_HUMAN | [view interactions] | High throughput | no | no |
| PTPC1_HUMAN | [view interactions] | High throughput | no | yes |
| TENS2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| INSC_HUMAN | [view interactions] | High throughput | no | yes |
| CHAP1_HUMAN | [view interactions] | High throughput | no | yes |
| POGZ_HUMAN | [view interactions] | High throughput | no | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| RM03_HUMAN | [view interactions] | High throughput | no | yes |
| COQ7_HUMAN | [view interactions] | High throughput | no | yes |
| MIC13_HUMAN | [view interactions] | High throughput | no | yes |
| LTMD1_HUMAN | [view interactions] | High throughput | no | no |
| TF3B_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |