RBP1_HUMAN
Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RBP1_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 29.3333 | 4 | yes |
GO:0000166 | nucleotide binding | 25.3333 | 4 | yes |
GO:0017076 | purine nucleotide binding | 25.3333 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 25.3333 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 24.0000 | 4 | yes |
GO:0043169 | cation binding | 24.0000 | 4 | no |
GO:0046872 | metal ion binding | 24.0000 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 16.0000 | 6 | yes |
GO:0030695 | GTPase regulator activity | 16.0000 | 4 | yes |
GO:0032559 | adenyl ribonucleotide binding | 16.0000 | 5 | yes |
GO:0005524 | ATP binding | 14.6667 | 5 | yes |
GO:0005096 | GTPase activator activity | 12.0000 | 4 | yes |
GO:0051020 | GTPase binding | 12.0000 | 4 | yes |
GO:0031267 | small GTPase binding | 9.3333 | 5 | yes |
GO:0008559 | ABC-type xenobiotic transporter activity | 2.6667 | 4 | yes |
GO:0015399 | primary active transmembrane transporter activity | 2.6667 | 4 | yes |
GO:0015431 | ABC-type glutathione S-conjugate transporter activity | 2.6667 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RBP1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 54.6667 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 46.6667 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 46.6667 | 4 | no |
GO:0010646 | regulation of cell communication | 44.0000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 42.6667 | 4 | yes |
GO:0008104 | protein localization | 42.6667 | 4 | no |
GO:0022607 | cellular component assembly | 41.3333 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | yes |
GO:0006996 | organelle organization | 40.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 37.3333 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 30.6667 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 30.6667 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 30.6667 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 29.3333 | 5 | yes |
GO:0071702 | organic substance transport | 29.3333 | 4 | yes |
GO:0071705 | nitrogen compound transport | 29.3333 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 29.3333 | 5 | yes |
GO:0051049 | regulation of transport | 29.3333 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 28.0000 | 5 | yes |
GO:0098657 | import into cell | 26.6667 | 4 | yes |
GO:0010468 | regulation of gene expression | 26.6667 | 6 | no |
GO:0015031 | protein transport | 26.6667 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 25.3333 | 5 | yes |
GO:0043067 | regulation of programmed cell death | 25.3333 | 4 | no |
GO:0043933 | protein-containing complex organization | 25.3333 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 24.0000 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 24.0000 | 5 | yes |
GO:0042981 | regulation of apoptotic process | 24.0000 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 24.0000 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 24.0000 | 4 | no |
GO:0007010 | cytoskeleton organization | 24.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 22.6667 | 4 | no |
GO:0030030 | cell projection organization | 22.6667 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 21.3333 | 6 | yes |
GO:0009967 | positive regulation of signal transduction | 21.3333 | 5 | no |
GO:0010647 | positive regulation of cell communication | 21.3333 | 5 | no |
GO:0065003 | protein-containing complex assembly | 21.3333 | 5 | no |
GO:0033043 | regulation of organelle organization | 20.0000 | 5 | yes |
GO:0031399 | regulation of protein modification process | 18.6667 | 6 | yes |
GO:0031401 | positive regulation of protein modification process | 17.3333 | 7 | yes |
GO:0051056 | regulation of small GTPase mediated signal transduction | 17.3333 | 6 | yes |
GO:0051336 | regulation of hydrolase activity | 17.3333 | 4 | yes |
GO:0043085 | positive regulation of catalytic activity | 16.0000 | 4 | yes |
GO:0141124 | intracellular signaling cassette | 16.0000 | 4 | yes |
GO:0010638 | positive regulation of organelle organization | 14.6667 | 6 | yes |
GO:0051094 | positive regulation of developmental process | 14.6667 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 13.3333 | 7 | yes |
GO:0019220 | regulation of phosphate metabolic process | 13.3333 | 6 | yes |
GO:0042325 | regulation of phosphorylation | 13.3333 | 7 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 13.3333 | 5 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 12.0000 | 8 | yes |
GO:0007264 | small GTPase-mediated signal transduction | 12.0000 | 5 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 12.0000 | 6 | yes |
GO:0042327 | positive regulation of phosphorylation | 12.0000 | 8 | yes |
GO:0043087 | regulation of GTPase activity | 12.0000 | 5 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 12.0000 | 7 | yes |
GO:0051345 | positive regulation of hydrolase activity | 12.0000 | 5 | yes |
GO:0035023 | regulation of Rho protein signal transduction | 8.0000 | 7 | yes |
GO:0043547 | positive regulation of GTPase activity | 8.0000 | 6 | yes |
GO:0010821 | regulation of mitochondrion organization | 6.6667 | 6 | yes |
GO:0090140 | regulation of mitochondrial fission | 4.0000 | 5 | yes |
GO:0090141 | positive regulation of mitochondrial fission | 4.0000 | 5 | yes |
GO:0015695 | organic cation transport | 2.6667 | 5 | yes |
GO:0015850 | organic hydroxy compound transport | 2.6667 | 5 | yes |
GO:0032489 | regulation of Cdc42 protein signal transduction | 2.6667 | 8 | yes |
GO:0042908 | xenobiotic transport | 2.6667 | 4 | yes |
GO:1900753 | doxorubicin transport | 2.6667 | 5 | yes |
GO:1901264 | carbohydrate derivative transport | 2.6667 | 5 | yes |
GO:1901656 | glycoside transport | 2.6667 | 6 | yes |
GO:1990961 | xenobiotic detoxification by transmembrane export across the plasma membrane | 2.6667 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CCNB1_HUMAN | [view interactions] | Low throughput | no | no |
HSF1_HUMAN | [view interactions] | Low throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
AP1M2_HUMAN | [view interactions] | Low throughput | no | no |
TF3A_HUMAN | [view interactions] | Low throughput | no | yes |
EPN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPN3_HUMAN | [view interactions] | Low throughput | no | no |
SYJ2B_HUMAN | [view interactions] | Low throughput | no | no |
REPS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CCL20_HUMAN | [view interactions] | Low throughput | no | no |
TAXB1_HUMAN | [view interactions] | Low throughput | no | yes |
NUMB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
REPS1_HUMAN | [view interactions] | Low throughput | no | yes |
RALA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RALB_HUMAN | [view interactions] | Low throughput | no | no |
CCND1_HUMAN | [view interactions] | Low throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RNF11_HUMAN | [view interactions] | Low throughput | no | yes |
ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RS27A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RL40_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP13_HUMAN | [view interactions] | High throughput | no | yes |
ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEMO_HUMAN | [view interactions] | High throughput | no | yes |
TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
TBRG1_HUMAN | [view interactions] | High throughput | no | no |
ZBT38_HUMAN | [view interactions] | High throughput | no | no |
PCM1_HUMAN | [view interactions] | High throughput | no | yes |
CC136_HUMAN | [view interactions] | High throughput | no | yes |
ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
CCHCR_HUMAN | [view interactions] | High throughput | no | no |
TNFA_HUMAN | [view interactions] | High throughput | no | no |
CASP8_HUMAN | [view interactions] | High throughput | no | yes |
GPSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
CACO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
ANR26_HUMAN | [view interactions] | High throughput | no | yes |
EPN4_HUMAN | [view interactions] | High throughput | no | yes |
CP250_HUMAN | [view interactions] | High throughput | no | no |
CE164_HUMAN | [view interactions] | High throughput | no | yes |
PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMGN1_HUMAN | [view interactions] | High throughput | no | yes |
TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBM47_HUMAN | [view interactions] | High throughput | no | yes |
IFT43_HUMAN | [view interactions] | High throughput | no | yes |
CRBG2_HUMAN | [view interactions] | High throughput | no | no |
ZN784_HUMAN | [view interactions] | High throughput | no | no |
BIRC8_HUMAN | [view interactions] | High throughput | no | no |
PAAT_HUMAN | [view interactions] | High throughput | no | yes |
RRAGB_HUMAN | [view interactions] | High throughput | no | yes |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCD82_HUMAN | [view interactions] | High throughput | no | yes |
AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
CPSF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPB1_HUMAN | [view interactions] | High throughput | no | no |
RHG15_HUMAN | [view interactions] | High throughput | no | no |
RHG19_HUMAN | [view interactions] | High throughput | no | yes |
RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG35_HUMAN | [view interactions] | High throughput | no | yes |
CHIO_HUMAN | [view interactions] | High throughput | no | yes |
DNMBP_HUMAN | [view interactions] | High throughput | no | no |
DOCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LPXN_HUMAN | [view interactions] | High throughput | no | yes |
OPHN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AVR2A_HUMAN | [view interactions] | High throughput | no | yes |
RHG40_HUMAN | [view interactions] | High throughput | no | no |
RHG42_HUMAN | [view interactions] | High throughput | no | yes |
PRIC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIM44_HUMAN | [view interactions] | High throughput | no | yes |
VINEX_HUMAN | [view interactions] | High throughput | no | no |
SRGP1_HUMAN | [view interactions] | High throughput | no | no |
SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STA13_HUMAN | [view interactions] | High throughput | no | yes |
SYNE2_HUMAN | [view interactions] | High throughput | no | no |
TOM70_HUMAN | [view interactions] | High throughput | no | yes |
RBM25_HUMAN | [view interactions] | High throughput | no | yes |
RBGPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIG1_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CEP57_HUMAN | [view interactions] | High throughput | no | yes |
CUL1_HUMAN | [view interactions] | High throughput | no | yes |
KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GTSE1_HUMAN | [view interactions] | High throughput | no | no |
MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HDAC1_HUMAN | [view interactions] | High throughput | no | no |
S2541_HUMAN | [view interactions] | High throughput | no | no |
PRS8_HUMAN | [view interactions] | High throughput | no | yes |
HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STABP_HUMAN | [view interactions] | High throughput | no | yes |
AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LSR_HUMAN | [view interactions] | High throughput | no | yes |
ALBU_HUMAN | [view interactions] | High throughput | no | no |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
TFPT_HUMAN | [view interactions] | High throughput | no | yes |
SKI_HUMAN | [view interactions] | High throughput | no | yes |
JUND_HUMAN | [view interactions] | High throughput | no | yes |
GPS2_HUMAN | [view interactions] | High throughput | no | yes |
CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
KIF7_HUMAN | [view interactions] | High throughput | no | yes |
AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CROCC_HUMAN | [view interactions] | High throughput | no | no |
PHLB3_HUMAN | [view interactions] | High throughput | no | yes |
SAPC2_HUMAN | [view interactions] | High throughput | no | no |
HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MSD4_HUMAN | [view interactions] | High throughput | no | yes |
GCC1_HUMAN | [view interactions] | High throughput | no | yes |
KIFC1_HUMAN | [view interactions] | High throughput | no | yes |
ZHANG_HUMAN | [view interactions] | High throughput | no | yes |
BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
CBY1_HUMAN | [view interactions] | High throughput | no | no |
SEPT9_HUMAN | [view interactions] | High throughput | no | no |
SEP10_HUMAN | [view interactions] | High throughput | no | yes |
LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
H2A3_HUMAN | [view interactions] | High throughput | no | yes |
H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
H2A1C_HUMAN | [view interactions] | High throughput | no | yes |
PP4R1_HUMAN | [view interactions] | High throughput | no | yes |
GRAM4_HUMAN | [view interactions] | High throughput | no | no |
MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
F263_HUMAN | [view interactions] | High throughput | no | yes |
SEPT7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H3C_HUMAN | [view interactions] | High throughput | no | yes |
H32_HUMAN | [view interactions] | High throughput | no | yes |
H31T_HUMAN | [view interactions] | High throughput | no | yes |
H33_HUMAN | [view interactions] | High throughput | no | yes |
H31_HUMAN | [view interactions] | High throughput | no | yes |
PP4C_HUMAN | [view interactions] | High throughput | no | yes |
EMD_HUMAN | [view interactions] | High throughput | no | yes |
NEST_HUMAN | [view interactions] | High throughput | no | no |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOP1_HUMAN | [view interactions] | High throughput | no | yes |
H14_HUMAN | [view interactions] | High throughput | no | yes |
HGB1A_HUMAN | [view interactions] | High throughput | no | no |
HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
HCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
H10_HUMAN | [view interactions] | High throughput | no | yes |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PEPL_HUMAN | [view interactions] | High throughput | no | yes |
CAVN1_HUMAN | [view interactions] | High throughput | no | no |
MRCKG_HUMAN | [view interactions] | High throughput | no | no |
TBB8_HUMAN | [view interactions] | High throughput | no | no |
CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H4_HUMAN | [view interactions] | High throughput | no | yes |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SEPT2_HUMAN | [view interactions] | High throughput | no | no |
WNK3_HUMAN | [view interactions] | High throughput | no | no |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
PLCG2_HUMAN | [view interactions] | High throughput | no | yes |
GSE1_HUMAN | [view interactions] | High throughput | no | yes |
TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
CA216_HUMAN | [view interactions] | High throughput | no | yes |
SMCE1_HUMAN | [view interactions] | High throughput | no | yes |
ZN707_HUMAN | [view interactions] | High throughput | no | yes |
DRC4_HUMAN | [view interactions] | High throughput | no | yes |
LDOC1_HUMAN | [view interactions] | High throughput | no | no |
KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASPP1_HUMAN | [view interactions] | High throughput | no | yes |
CC88B_HUMAN | [view interactions] | High throughput | no | no |
CCD13_HUMAN | [view interactions] | High throughput | no | no |
AMOL2_HUMAN | [view interactions] | High throughput | no | no |
EFTS_HUMAN | [view interactions] | High throughput | no | no |
SYCE1_HUMAN | [view interactions] | High throughput | no | no |
TCP1L_HUMAN | [view interactions] | High throughput | no | no |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |