Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RBP1_HUMAN

Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RBP1_HUMAN
GO:0017076 purine nucleotide binding 29.2683 4 yes
GO:0032555 purine ribonucleotide binding 29.2683 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 29.2683 4 yes
GO:0019900 kinase binding 23.1707 4 no
GO:0019901 protein kinase binding 21.9512 5 no
GO:0016462 pyrophosphatase activity 20.7317 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 20.7317 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 20.7317 6 no
GO:0030695 GTPase regulator activity 13.4146 4 yes
GO:0005524 ATP binding 10.9756 5 yes
GO:0030554 adenyl nucleotide binding 10.9756 5 yes
GO:0032559 adenyl ribonucleotide binding 10.9756 5 yes
GO:0005096 GTPase activator activity 9.7561 4 yes
GO:0051020 GTPase binding 9.7561 4 yes
GO:0031267 small GTPase binding 6.0976 5 yes
GO:0008559 ABC-type xenobiotic transporter activity 2.4390 4 yes
GO:0015399 primary active transmembrane transporter activity 2.4390 4 yes
GO:0015431 ABC-type glutathione S-conjugate transporter activity 2.4390 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RBP1_HUMAN
GO:0048522 positive regulation of cellular process 53.6585 4 yes
GO:0051128 regulation of cellular component organization 45.1220 4 yes
GO:0048523 negative regulation of cellular process 45.1220 4 no
GO:0006996 organelle organization 45.1220 4 no
GO:0010646 regulation of cell communication 42.6829 4 yes
GO:0008104 protein localization 42.6829 4 no
GO:0022607 cellular component assembly 41.4634 4 no
GO:0009966 regulation of signal transduction 40.2439 4 yes
GO:0016192 vesicle-mediated transport 39.0244 4 yes
GO:0060255 regulation of macromolecule metabolic process 36.5854 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 34.1463 4 yes
GO:0080090 regulation of primary metabolic process 34.1463 4 yes
GO:0031323 regulation of cellular metabolic process 32.9268 4 yes
GO:0051049 regulation of transport 32.9268 4 no
GO:0009893 positive regulation of metabolic process 30.4878 4 yes
GO:0071702 organic substance transport 29.2683 4 yes
GO:0071705 nitrogen compound transport 29.2683 4 yes
GO:0007010 cytoskeleton organization 29.2683 5 no
GO:0006897 endocytosis 28.0488 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 28.0488 4 yes
GO:1902531 regulation of intracellular signal transduction 28.0488 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 26.8293 5 yes
GO:0031325 positive regulation of cellular metabolic process 26.8293 5 yes
GO:0015031 protein transport 26.8293 4 no
GO:0030030 cell projection organization 26.8293 4 no
GO:0010941 regulation of cell death 26.8293 4 no
GO:0051130 positive regulation of cellular component organization 25.6098 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 25.6098 5 yes
GO:0033043 regulation of organelle organization 24.3902 5 yes
GO:0060627 regulation of vesicle-mediated transport 24.3902 4 no
GO:0010468 regulation of gene expression 24.3902 5 no
GO:0043067 regulation of programmed cell death 24.3902 5 no
GO:0051246 regulation of protein metabolic process 23.1707 5 yes
GO:0032880 regulation of protein localization 23.1707 5 no
GO:0060341 regulation of cellular localization 23.1707 4 no
GO:0042981 regulation of apoptotic process 23.1707 6 no
GO:0044087 regulation of cellular component biogenesis 23.1707 4 no
GO:0006886 intracellular protein transport 21.9512 4 no
GO:0042127 regulation of cell population proliferation 21.9512 4 no
GO:0048584 positive regulation of response to stimulus 21.9512 4 no
GO:0051247 positive regulation of protein metabolic process 20.7317 6 yes
GO:0043933 protein-containing complex organization 20.7317 4 no
GO:0023056 positive regulation of signaling 20.7317 4 no
GO:0061024 membrane organization 20.7317 4 no
GO:0120036 plasma membrane bounded cell projection organization 20.7317 5 no
GO:0007264 small GTPase mediated signal transduction 19.5122 4 yes
GO:0043085 positive regulation of catalytic activity 18.2927 4 yes
GO:0010638 positive regulation of organelle organization 17.0732 6 yes
GO:0031399 regulation of protein modification process 17.0732 6 yes
GO:0031401 positive regulation of protein modification process 17.0732 7 yes
GO:0051094 positive regulation of developmental process 17.0732 4 yes
GO:0051336 regulation of hydrolase activity 17.0732 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 15.8537 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 14.6341 6 yes
GO:0019220 regulation of phosphate metabolic process 14.6341 6 yes
GO:0042325 regulation of phosphorylation 14.6341 7 yes
GO:0042327 positive regulation of phosphorylation 14.6341 8 yes
GO:0045937 positive regulation of phosphate metabolic process 14.6341 7 yes
GO:0051174 regulation of phosphorus metabolic process 14.6341 5 yes
GO:0001932 regulation of protein phosphorylation 13.4146 7 yes
GO:0001934 positive regulation of protein phosphorylation 13.4146 8 yes
GO:0051345 positive regulation of hydrolase activity 12.1951 5 yes
GO:0043087 regulation of GTPase activity 10.9756 5 yes
GO:0046578 regulation of Ras protein signal transduction 10.9756 7 yes
GO:0043547 positive regulation of GTPase activity 7.3171 6 yes
GO:0010821 regulation of mitochondrion organization 6.0976 6 yes
GO:0035023 regulation of Rho protein signal transduction 6.0976 8 yes
GO:0010822 positive regulation of mitochondrion organization 4.8780 7 yes
GO:0006811 ion transport 3.6585 4 yes
GO:0006812 cation transport 3.6585 5 yes
GO:0090140 regulation of mitochondrial fission 3.6585 5 yes
GO:0090141 positive regulation of mitochondrial fission 3.6585 5 yes
GO:0015695 organic cation transport 2.4390 5 yes
GO:0015850 organic hydroxy compound transport 2.4390 5 yes
GO:0032489 regulation of Cdc42 protein signal transduction 2.4390 9 yes
GO:0042908 xenobiotic transport 2.4390 4 yes
GO:1900753 doxorubicin transport 2.4390 5 yes
GO:1901264 carbohydrate derivative transport 2.4390 5 yes
GO:1901656 glycoside transport 2.4390 6 yes
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane 2.4390 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in RBP1_HUMAN
DOID:10595 Charcot-Marie-Tooth disease 2.4390 6 no
DOID:440 neuromuscular disease 2.4390 5 no
DOID:574 peripheral nervous system disease 2.4390 3 no
DOID:870 neuropathy 2.4390 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RALA_HUMAN [view entry] [view interactions] Low throughput yes yes
REPS1_HUMAN [view interactions] Low throughput no yes
AP2A1_HUMAN [view entry] [view interactions] Low throughput yes yes
RALB_HUMAN [view interactions] Low throughput no no
CCND1_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF11_HUMAN [view interactions] Low throughput no yes
ITCH_HUMAN [view interactions] Low throughput no yes
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
RS27A_HUMAN [view entry] [view interactions] Low throughput yes yes
RL40_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
CCNB1_HUMAN [view interactions] Low throughput no no
HSF1_HUMAN [view interactions] Low throughput no yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
AP1M2_HUMAN [view interactions] Low throughput no no
TF3A_HUMAN [view interactions] Low throughput no yes
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN2_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN3_HUMAN [view interactions] Low throughput no no
SYJ2B_HUMAN [view entry] [view interactions] Low throughput yes no
REPS2_HUMAN [view entry] [view interactions] Low throughput yes no
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
CCL20_HUMAN [view interactions] Low throughput no no
TAXB1_HUMAN [view interactions] Low throughput no yes
NUMB_HUMAN [view entry] [view interactions] Low throughput yes yes
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF7_HUMAN [view interactions] High throughput no yes
CCDC6_HUMAN [view interactions] High throughput no yes
GPS2_HUMAN [view interactions] High throughput no yes
JUND_HUMAN [view interactions] High throughput no yes
SKI_HUMAN [view interactions] High throughput no yes
TFPT_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
ALBU_HUMAN [view interactions] High throughput no no
PEPL_HUMAN [view interactions] High throughput no yes
BAF_HUMAN [view entry] [view interactions] High throughput yes yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
H10_HUMAN [view interactions] High throughput no yes
HCK_HUMAN [view entry] [view interactions] High throughput yes no
HMGB1_HUMAN [view interactions] High throughput no yes
HGB1A_HUMAN [view interactions] High throughput no no
H14_HUMAN [view interactions] High throughput no yes
TOP1_HUMAN [view interactions] High throughput no yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
HMGA1_HUMAN [view interactions] High throughput no yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
LAP2A_HUMAN [view interactions] High throughput no yes
NEST_HUMAN [view interactions] High throughput no no
EMD_HUMAN [view interactions] High throughput no yes
PP4C_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
H31T_HUMAN [view interactions] High throughput no yes
H32_HUMAN [view interactions] High throughput no yes
H3C_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
DSG1_HUMAN [view entry] [view interactions] High throughput yes no
SEPT7_HUMAN [view entry] [view interactions] High throughput yes yes
F263_HUMAN [view interactions] High throughput no yes
MPP7_HUMAN [view entry] [view interactions] High throughput yes no
GRAM4_HUMAN [view interactions] High throughput no no
PP4R1_HUMAN [view interactions] High throughput no yes
H2A1C_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
H2A3_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC6_HUMAN [view entry] [view interactions] High throughput yes yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
SEP10_HUMAN [view interactions] High throughput no yes
SEPT9_HUMAN [view interactions] High throughput no no
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
TBB8_HUMAN [view interactions] High throughput no no
MRCKG_HUMAN [view interactions] High throughput no no
CAVN1_HUMAN [view interactions] High throughput no no
SEPT2_HUMAN [view interactions] High throughput no no
WNK3_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
PLCG2_HUMAN [view interactions] High throughput no yes
GSE1_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
CA216_HUMAN [view interactions] High throughput no yes
SMCE1_HUMAN [view interactions] High throughput no yes
ZN707_HUMAN [view interactions] High throughput no yes
DRC4_HUMAN [view interactions] High throughput no yes
LDOC1_HUMAN [view interactions] High throughput no no
KANK2_HUMAN [view entry] [view interactions] High throughput yes yes
ASPP1_HUMAN [view interactions] High throughput no yes
CC88B_HUMAN [view interactions] High throughput no no
CCD13_HUMAN [view interactions] High throughput no no
AMOL2_HUMAN [view interactions] High throughput no no
EFTS_HUMAN [view interactions] High throughput no no
SYCE1_HUMAN [view interactions] High throughput no no
TCP1L_HUMAN [view interactions] High throughput no no
FGFR3_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
NEMO_HUMAN [view interactions] High throughput no yes
TRAF2_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
LMTK1_HUMAN [view interactions] High throughput no yes
TBRG1_HUMAN [view interactions] High throughput no no
ZBT38_HUMAN [view interactions] High throughput no no
PCM1_HUMAN [view interactions] High throughput no yes
CC136_HUMAN [view interactions] High throughput no yes
ASPP2_HUMAN [view interactions] High throughput no yes
CCHCR_HUMAN [view interactions] High throughput no no
TNFA_HUMAN [view interactions] High throughput no no
CASP8_HUMAN [view interactions] High throughput no yes
GPSM1_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA4_HUMAN [view interactions] High throughput no yes
CACO1_HUMAN [view entry] [view interactions] High throughput yes yes
RUN3A_HUMAN [view interactions] High throughput no yes
ANR26_HUMAN [view interactions] High throughput no yes
EPN4_HUMAN [view interactions] High throughput no yes
CP250_HUMAN [view interactions] High throughput no no
CE164_HUMAN [view interactions] High throughput no yes
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
RUFY1_HUMAN [view interactions] High throughput no yes
CK5P2_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
HMGN1_HUMAN [view interactions] High throughput no yes
TPC2L_HUMAN [view interactions] High throughput no yes
RNPS1_HUMAN [view interactions] High throughput no yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
AUXI_HUMAN [view entry] [view interactions] High throughput yes yes
RBM47_HUMAN [view interactions] High throughput no yes
IFT43_HUMAN [view interactions] High throughput no yes
CRBG2_HUMAN [view interactions] High throughput no no
ZN784_HUMAN [view interactions] High throughput no no
BIRC8_HUMAN [view interactions] High throughput no no
PAAT_HUMAN [view interactions] High throughput no yes
RRAGB_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
CCD82_HUMAN [view interactions] High throughput no yes
AP2A2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOU_HUMAN [view interactions] High throughput no no
CPSF2_HUMAN [view entry] [view interactions] High throughput yes yes
RPB1_HUMAN [view interactions] High throughput no no
RHG15_HUMAN [view interactions] High throughput no no
RHG19_HUMAN [view interactions] High throughput no yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
RHG35_HUMAN [view interactions] High throughput no yes
CHIO_HUMAN [view interactions] High throughput no yes
DNMBP_HUMAN [view interactions] High throughput no no
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
LPXN_HUMAN [view interactions] High throughput no yes
OPHN1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
AVR2A_HUMAN [view interactions] High throughput no yes
RHG40_HUMAN [view interactions] High throughput no no
RHG42_HUMAN [view interactions] High throughput no yes
PRIC1_HUMAN [view interactions] High throughput no yes
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TIM44_HUMAN [view interactions] High throughput no yes
VINEX_HUMAN [view interactions] High throughput no no
SRGP1_HUMAN [view interactions] High throughput no no
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
STA13_HUMAN [view interactions] High throughput no yes
SYNE2_HUMAN [view interactions] High throughput no no
TOM70_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP57_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
GTSE1_HUMAN [view interactions] High throughput no no
MYH11_HUMAN [view entry] [view interactions] High throughput yes no
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
HDAC1_HUMAN [view interactions] High throughput no no
S2541_HUMAN [view interactions] High throughput no no
PRS8_HUMAN [view interactions] High throughput no yes
HIP1R_HUMAN [view entry] [view interactions] High throughput yes yes
STABP_HUMAN [view interactions] High throughput no yes
AP2S1_HUMAN [view entry] [view interactions] High throughput yes no
LSR_HUMAN [view interactions] High throughput no yes
MSD4_HUMAN [view interactions] High throughput no yes
CBY1_HUMAN [view interactions] High throughput no no
BMP2K_HUMAN [view interactions] High throughput no yes
ZHANG_HUMAN [view interactions] High throughput no yes
KIFC1_HUMAN [view interactions] High throughput no yes
GCC1_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
SAPC2_HUMAN [view interactions] High throughput no no
PHLB3_HUMAN [view interactions] High throughput no yes
CROCC_HUMAN [view interactions] High throughput no no
RRAS2_HUMAN [view interactions] Computational no yes
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
RAC2_HUMAN [view entry] [view interactions] Computational yes yes
ERD23_HUMAN [view interactions] Computational no yes
COPA_HUMAN [view entry] [view interactions] Computational yes yes
RASN_HUMAN [view entry] [view interactions] Computational yes no
ARF6_HUMAN [view entry] [view interactions] Computational yes yes
ERD22_HUMAN [view interactions] Computational no yes
CYH2_HUMAN [view entry] [view interactions] Computational yes yes
RASM_HUMAN [view entry] [view interactions] Computational yes yes
CLCB_HUMAN [view entry] [view interactions] Computational yes yes
ERD21_HUMAN [view interactions] Computational no yes
CLCA_HUMAN [view entry] [view interactions] Computational yes no
ARF1_HUMAN [view entry] [view interactions] Computational yes yes
RRAS_HUMAN [view interactions] Computational no yes
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
RAC3_HUMAN [view entry] [view interactions] Computational yes no