AUXI_HUMAN
Evidence for PS localization
Functions
Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AUXI_HUMAN |
|---|---|---|---|---|
| GO:0017124 | SH3 domain binding | 10.4167 | 4 | yes |
| GO:0016791 | phosphatase activity | 4.1667 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 4.1667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AUXI_HUMAN |
|---|---|---|---|---|
| GO:0016192 | vesicle-mediated transport | 60.4167 | 4 | yes |
| GO:0008104 | protein localization | 60.4167 | 4 | no |
| GO:0071702 | organic substance transport | 56.2500 | 4 | no |
| GO:0071705 | nitrogen compound transport | 56.2500 | 4 | no |
| GO:0015031 | protein transport | 52.0833 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0006897 | endocytosis | 45.8333 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 45.8333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.7500 | 4 | yes |
| GO:0006886 | intracellular protein transport | 43.7500 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.7500 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 41.6667 | 4 | no |
| GO:0043933 | protein-containing complex organization | 39.5833 | 4 | yes |
| GO:0022607 | cellular component assembly | 39.5833 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 37.5000 | 6 | yes |
| GO:0051049 | regulation of transport | 37.5000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 31.2500 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.2500 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.2500 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.2500 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.2500 | 5 | no |
| GO:0010468 | regulation of gene expression | 31.2500 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 29.1667 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.0833 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.0833 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.0833 | 5 | no |
| GO:0072583 | clathrin-dependent endocytosis | 25.0000 | 7 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 22.9167 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 22.9167 | 4 | no |
| GO:0051050 | positive regulation of transport | 22.9167 | 4 | no |
| GO:0061024 | membrane organization | 22.9167 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.9167 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.8333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.8333 | 5 | no |
| GO:0010941 | regulation of cell death | 20.8333 | 4 | no |
| GO:0023056 | positive regulation of signaling | 20.8333 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.8333 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.8333 | 5 | no |
| GO:0030100 | regulation of endocytosis | 16.6667 | 5 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 14.5833 | 6 | yes |
| GO:0022411 | cellular component disassembly | 10.4167 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 10.4167 | 5 | yes |
| GO:0051261 | protein depolymerization | 8.3333 | 6 | yes |
| GO:2000369 | regulation of clathrin-dependent endocytosis | 8.3333 | 7 | yes |
| GO:0016191 | synaptic vesicle uncoating | 6.2500 | 9 | yes |
| GO:0072318 | clathrin coat disassembly | 6.2500 | 8 | yes |
| GO:0072319 | vesicle uncoating | 6.2500 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| GCP5_HUMAN | [view interactions] | High throughput | no | yes |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| GNAT1_HUMAN | [view interactions] | High throughput | no | no |
| ILRL2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTR1_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX2_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| GBX1_HUMAN | [view interactions] | High throughput | no | no |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXK3_HUMAN | [view interactions] | High throughput | no | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| MYH13_HUMAN | [view interactions] | High throughput | no | no |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GULP1_HUMAN | [view interactions] | High throughput | no | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABRX2_HUMAN | [view interactions] | High throughput | no | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| WDR11_HUMAN | [view interactions] | High throughput | no | yes |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1S3_HUMAN | [view interactions] | Computational | no | yes |
| TPD52_HUMAN | [view interactions] | Computational | no | yes |
| ALMS1_HUMAN | [view interactions] | Computational | no | no |
| AP4E1_HUMAN | [view interactions] | Computational | no | no |
| TXND5_HUMAN | [view interactions] | Computational | no | yes |
| SNX5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBC8B_HUMAN | [view interactions] | Computational | no | yes |
| AP1S1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CATZ_HUMAN | [view interactions] | Computational | no | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LZTS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SORT_HUMAN | [view interactions] | Computational | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ABCA3_HUMAN | [view interactions] | Computational | no | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| YIPF6_HUMAN | [view interactions] | Computational | no | yes |
| DNS2A_HUMAN | [view interactions] | Computational | no | yes |
| TMPS6_HUMAN | [view interactions] | Computational | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ZN384_HUMAN | [view interactions] | Computational | no | yes |
| S38A7_HUMAN | [view interactions] | Computational | no | yes |
| CLHC1_HUMAN | [view interactions] | Computational | no | no |
| AP3S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SNX9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TPD53_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP4B1_HUMAN | [view interactions] | Computational | no | yes |
| AP180_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNX2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SNAPN_HUMAN | [view interactions] | Computational | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP1M2_HUMAN | [view interactions] | Computational | no | no |
| ACHA6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNS_HUMAN | [view interactions] | Computational | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 4ET_HUMAN | [view interactions] | Computational | no | yes |
| CBPD_HUMAN | [view interactions] | Computational | no | yes |