AUXI_HUMAN
Evidence for PS localization
Functions
Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AUXI_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 23.3333 | 4 | no |
| GO:0017124 | SH3 domain binding | 13.3333 | 4 | yes |
| GO:0016791 | phosphatase activity | 6.6667 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 6.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AUXI_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 53.3333 | 4 | yes |
| GO:0008104 | protein localization | 53.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0098657 | import into cell | 46.6667 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.6667 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 46.6667 | 4 | no |
| GO:0071702 | organic substance transport | 43.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 43.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 43.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0015031 | protein transport | 36.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.6667 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.6667 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.6667 | 5 | no |
| GO:0006898 | receptor-mediated endocytosis | 36.6667 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 36.6667 | 4 | yes |
| GO:0051049 | regulation of transport | 33.3333 | 4 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 33.3333 | 5 | yes |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0006886 | intracellular protein transport | 30.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 30.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.6667 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 26.6667 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.6667 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0031623 | receptor internalization | 23.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.3333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.3333 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.0000 | 4 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 16.6667 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 16.6667 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 16.6667 | 5 | yes |
| GO:0051261 | protein depolymerization | 10.0000 | 6 | yes |
| GO:0022411 | cellular component disassembly | 10.0000 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 10.0000 | 5 | yes |
| GO:0072318 | clathrin coat disassembly | 6.6667 | 8 | yes |
| GO:0072319 | vesicle uncoating | 6.6667 | 7 | yes |
| GO:0016191 | synaptic vesicle uncoating | 6.6667 | 9 | yes |
| GO:0016311 | dephosphorylation | 6.6667 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX2_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| GBX1_HUMAN | [view interactions] | High throughput | no | no |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXK3_HUMAN | [view interactions] | High throughput | no | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| MYH13_HUMAN | [view interactions] | High throughput | no | no |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GULP1_HUMAN | [view interactions] | High throughput | no | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABRX2_HUMAN | [view interactions] | High throughput | no | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| WDR11_HUMAN | [view interactions] | High throughput | no | yes |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| GCP5_HUMAN | [view interactions] | High throughput | no | yes |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| GNAT1_HUMAN | [view interactions] | High throughput | no | no |
| ILRL2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTR1_HUMAN | [view interactions] | High throughput | no | no |