AUXI_HUMAN
Evidence for PS localization
Functions
Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons . [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 37%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Close ✖
AUXI_HUMAN has binary interactions with 29 proteins
Isoforms
Interacting regions
Canonical [AUXI_HUMAN]
Isoform [O75061-2] alignment
Isoform [O75061-3] alignment
Isoform [O75061-4] alignment
Isoform [S4R305] alignment
LOADING 37%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AUXI_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 23.3333 | 4 | no |
| GO:0017124 | SH3 domain binding | 13.3333 | 4 | yes |
| GO:0016791 | phosphatase activity | 6.6667 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 6.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AUXI_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 53.3333 | 4 | yes |
| GO:0008104 | protein localization | 53.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0098657 | import into cell | 46.6667 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.6667 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 46.6667 | 4 | no |
| GO:0071702 | organic substance transport | 43.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 43.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 43.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0015031 | protein transport | 36.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.6667 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.6667 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.6667 | 5 | no |
| GO:0006898 | receptor-mediated endocytosis | 36.6667 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 36.6667 | 4 | yes |
| GO:0051049 | regulation of transport | 33.3333 | 4 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 33.3333 | 5 | yes |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0006886 | intracellular protein transport | 30.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 30.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABRX2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBX1_HUMAN | [view interactions] | High throughput | no | no |
| GCP5_HUMAN | [view interactions] | High throughput | no | yes |