AP2A2_HUMAN
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in AP2A2_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 25.7426 | 4 | yes |
GO:0019901 | protein kinase binding | 23.7624 | 5 | yes |
GO:0017076 | purine nucleotide binding | 22.7723 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 22.7723 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 22.7723 | 4 | no |
GO:0046872 | metal ion binding | 20.7921 | 4 | no |
GO:0035615 | clathrin adaptor activity | 7.9208 | 4 | yes |
GO:0097718 | disordered domain specific binding | 3.9604 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in AP2A2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 57.4257 | 4 | no |
GO:0016192 | vesicle-mediated transport | 56.4356 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 54.4554 | 4 | no |
GO:0006897 | endocytosis | 43.5644 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 42.5743 | 4 | no |
GO:0010646 | regulation of cell communication | 41.5842 | 4 | no |
GO:0008104 | protein localization | 40.5941 | 4 | yes |
GO:0022607 | cellular component assembly | 37.6238 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 36.6337 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 36.6337 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 35.6436 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 34.6535 | 4 | no |
GO:0006996 | organelle organization | 33.6634 | 4 | no |
GO:0051049 | regulation of transport | 33.6634 | 4 | no |
GO:0009966 | regulation of signal transduction | 33.6634 | 4 | no |
GO:0071702 | organic substance transport | 32.6733 | 4 | yes |
GO:0071705 | nitrogen compound transport | 31.6832 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 30.6931 | 4 | no |
GO:0015031 | protein transport | 29.7030 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 29.7030 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 28.7129 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 27.7228 | 5 | no |
GO:0006898 | receptor-mediated endocytosis | 26.7327 | 6 | yes |
GO:0033043 | regulation of organelle organization | 26.7327 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.7327 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 25.7426 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.7426 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 24.7525 | 4 | no |
GO:0010647 | positive regulation of cell communication | 24.7525 | 5 | no |
GO:0023056 | positive regulation of signaling | 24.7525 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 24.7525 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 23.7624 | 4 | no |
GO:0006886 | intracellular protein transport | 22.7723 | 4 | yes |
GO:0043933 | protein-containing complex organization | 22.7723 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 22.7723 | 4 | no |
GO:0051094 | positive regulation of developmental process | 22.7723 | 4 | no |
GO:0010941 | regulation of cell death | 22.7723 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 21.7822 | 4 | no |
GO:0010468 | regulation of gene expression | 21.7822 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.7822 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 21.7822 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 21.7822 | 6 | no |
GO:0031399 | regulation of protein modification process | 21.7822 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 21.7822 | 5 | no |
GO:0030100 | regulation of endocytosis | 20.7921 | 5 | no |
GO:0042325 | regulation of phosphorylation | 20.7921 | 7 | no |
GO:0036211 | protein modification process | 20.7921 | 4 | no |
GO:0043412 | macromolecule modification | 20.7921 | 4 | no |
GO:0072583 | clathrin-dependent endocytosis | 16.8317 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in AP2A2_HUMAN |
---|---|---|---|---|
DOID:0060038 | specific developmental disorder | 1.9802 | 3 | no |
DOID:1059 | intellectual disability | 1.9802 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
AAGAB_HUMAN | [view interactions] | Low throughput | no | yes |
FCHO2_HUMAN | [view interactions] | Low throughput | no | yes |
TGON2_HUMAN | [view interactions] | Low throughput | no | yes |
SPTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RN111_HUMAN | [view interactions] | Low throughput | no | yes |
GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PI51C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AT1A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
TXNIP_HUMAN | [view interactions] | Low throughput | no | no |
NECP2_HUMAN | [view interactions] | Low throughput | no | yes |
GTR8_HUMAN | [view interactions] | Low throughput | no | yes |
NMD3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CD4_HUMAN | [view interactions] | Low throughput | no | no |
AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
OCRL_HUMAN | [view interactions] | Low throughput | no | yes |
SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP180_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STON2_HUMAN | [view interactions] | Low throughput | no | yes |
SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
AFTIN_HUMAN | [view interactions] | Low throughput | no | yes |
KCJ11_HUMAN | [view interactions] | Low throughput | no | no |
NECP1_HUMAN | [view interactions] | Low throughput | no | no |
DAB2_HUMAN | [view interactions] | Low throughput | no | yes |
ATAT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP2S1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EGFR_HUMAN | [view interactions] | Low throughput | no | no |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV3_HUMAN | [view interactions] | High throughput | no | no |
LITD1_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
HOIL1_HUMAN | [view interactions] | High throughput | no | no |
NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TERF2_HUMAN | [view interactions] | High throughput | no | yes |
SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRK5_HUMAN | [view interactions] | High throughput | no | yes |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RARA_HUMAN | [view interactions] | High throughput | no | no |
PAN2_HUMAN | [view interactions] | High throughput | no | no |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
LRFN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZBT46_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF11_HUMAN | [view interactions] | High throughput | no | yes |
IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FAN1_HUMAN | [view interactions] | High throughput | no | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GTSE1_HUMAN | [view interactions] | High throughput | no | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
MCM2_HUMAN | [view interactions] | High throughput | no | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
RN126_HUMAN | [view interactions] | High throughput | no | yes |
MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
UTP25_HUMAN | [view interactions] | High throughput | no | yes |
MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MTMR4_HUMAN | [view interactions] | High throughput | no | no |
RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
ARFG1_HUMAN | [view interactions] | High throughput | no | no |
SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
GP156_HUMAN | [view interactions] | High throughput | no | no |
EPN4_HUMAN | [view interactions] | High throughput | no | yes |
FCHO1_HUMAN | [view interactions] | High throughput | no | yes |
REPS1_HUMAN | [view interactions] | High throughput | no | yes |
LSR_HUMAN | [view interactions] | High throughput | no | yes |
CPS4L_HUMAN | [view interactions] | High throughput | no | no |
INT4_HUMAN | [view interactions] | High throughput | no | yes |
PPIE_HUMAN | [view interactions] | High throughput | no | yes |
RNF6_HUMAN | [view interactions] | High throughput | no | no |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCD15_HUMAN | [view interactions] | High throughput | no | no |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRD7_HUMAN | [view interactions] | High throughput | no | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
FBXW8_HUMAN | [view interactions] | High throughput | no | yes |
DVL2_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
IF16_HUMAN | [view interactions] | High throughput | no | no |
FZR1_HUMAN | [view interactions] | High throughput | no | no |
ISG15_HUMAN | [view interactions] | High throughput | no | no |
TULP3_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCD32_HUMAN | [view interactions] | High throughput | no | yes |
COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SGIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAAT_HUMAN | [view interactions] | High throughput | no | yes |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
TFR1_HUMAN | [view interactions] | High throughput | no | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANR28_HUMAN | [view interactions] | High throughput | no | no |
RHG18_HUMAN | [view interactions] | High throughput | no | yes |
CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTF2_HUMAN | [view interactions] | High throughput | no | yes |
EI2BA_HUMAN | [view interactions] | High throughput | no | yes |
AP1S1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
FURIN_HUMAN | [view interactions] | High throughput | no | yes |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SMAD1_HUMAN | [view interactions] | High throughput | no | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAXI_HUMAN | [view interactions] | High throughput | no | yes |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FNBP1_HUMAN | [view interactions] | High throughput | no | yes |
CIP4_HUMAN | [view interactions] | High throughput | no | no |
MB212_HUMAN | [view interactions] | High throughput | no | no |
M3K9_HUMAN | [view interactions] | High throughput | no | yes |
WNK3_HUMAN | [view interactions] | High throughput | no | no |
VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP4M1_HUMAN | [view interactions] | Computational | no | yes |
GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GRIA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRIP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HIP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DYN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EPN3_HUMAN | [view interactions] | Computational | no | no |
ROR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KPCG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AP3S2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SYNRG_HUMAN | [view interactions] | Computational | no | yes |
AP4E1_HUMAN | [view interactions] | Computational | no | no |
UBQL2_HUMAN | [view interactions] | Computational | no | yes |
KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FZD2_HUMAN | [view interactions] | Computational | no | no |
ROR1_HUMAN | [view interactions] | Computational | no | no |
AP5M1_HUMAN | [view interactions] | Computational | no | no |
CLH2_HUMAN | [view interactions] | Computational | no | no |
AP5B1_HUMAN | [view interactions] | Computational | no | yes |
AP3M2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ITSN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AP3S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KCNQ5_HUMAN | [view interactions] | Computational | no | yes |
AP1G1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EHD2_HUMAN | [view interactions] | Computational | no | no |
AP5S1_HUMAN | [view interactions] | Computational | no | yes |
NCALD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PICK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FZD5_HUMAN | [view interactions] | Computational | no | yes |
DNAL4_HUMAN | [view interactions] | Computational | no | yes |
AP4B1_HUMAN | [view interactions] | Computational | no | yes |