SYT1_HUMAN
Calcium sensor that participates in triggering neurotransmitter release at the synapse . May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse . It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 368 | Ile | Thr | Baker-Gordonsyndrome(BAGOS) | - |
| 303 | Met | Lys | Baker-Gordonsyndrome(BAGOS) | - |
| 304 | Asp | Gly | Baker-Gordonsyndrome(BAGOS) | - |
| 366 | Asp | Glu | Baker-Gordonsyndrome(BAGOS) | - |
| 371 | Asn | Lys | Baker-Gordonsyndrome(BAGOS) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYT1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 29.0323 | 4 | yes |
| GO:0046872 | metal ion binding | 29.0323 | 5 | yes |
| GO:0019900 | kinase binding | 25.8065 | 4 | no |
| GO:0019905 | syntaxin binding | 17.7419 | 4 | yes |
| GO:0005509 | calcium ion binding | 16.1290 | 6 | yes |
| GO:0043168 | anion binding | 16.1290 | 4 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 9.6774 | 4 | yes |
| GO:0017075 | syntaxin-1 binding | 9.6774 | 5 | yes |
| GO:0035091 | phosphatidylinositol binding | 6.4516 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 6.4516 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 6.4516 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 6.4516 | 6 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 4.8387 | 5 | yes |
| GO:0030348 | syntaxin-3 binding | 3.2258 | 5 | yes |
| GO:0050750 | low-density lipoprotein particle receptor binding | 3.2258 | 5 | yes |
| GO:0070325 | lipoprotein particle receptor binding | 3.2258 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYT1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.6774 | 4 | yes |
| GO:0010646 | regulation of cell communication | 56.4516 | 4 | yes |
| GO:0051049 | regulation of transport | 53.2258 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.1613 | 4 | yes |
| GO:0022607 | cellular component assembly | 41.9355 | 4 | yes |
| GO:0006996 | organelle organization | 40.3226 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.7097 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 38.7097 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.0968 | 4 | no |
| GO:0008104 | protein localization | 37.0968 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.4839 | 4 | no |
| GO:0023056 | positive regulation of signaling | 35.4839 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 35.4839 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 35.4839 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 30.6452 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.6452 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 30.6452 | 5 | yes |
| GO:0098657 | import into cell | 30.6452 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 29.0323 | 5 | no |
| GO:0051046 | regulation of secretion | 29.0323 | 5 | yes |
| GO:0051050 | positive regulation of transport | 29.0323 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 29.0323 | 4 | yes |
| GO:0071702 | organic substance transport | 29.0323 | 4 | no |
| GO:0071705 | nitrogen compound transport | 29.0323 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.4194 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.4194 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 27.4194 | 4 | no |
| GO:0060341 | regulation of cellular localization | 27.4194 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.8065 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.8065 | 4 | yes |
| GO:0046903 | secretion | 25.8065 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 25.8065 | 4 | yes |
| GO:0015031 | protein transport | 25.8065 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.8065 | 5 | no |
| GO:0031399 | regulation of protein modification process | 24.1935 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 24.1935 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.1935 | 5 | yes |
| GO:0030030 | cell projection organization | 22.5806 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.5806 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.5806 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.5806 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.5806 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.5806 | 5 | no |
| GO:0010468 | regulation of gene expression | 22.5806 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.5806 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.5806 | 5 | no |
| GO:0017157 | regulation of exocytosis | 22.5806 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 22.5806 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 22.5806 | 5 | no |
| GO:0043269 | regulation of monoatomic ion transport | 22.5806 | 5 | no |
| GO:0071310 | cellular response to organic substance | 22.5806 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.9677 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 20.9677 | 7 | no |
| GO:0010038 | response to metal ion | 20.9677 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.9677 | 4 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 20.9677 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 20.9677 | 6 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 20.9677 | 4 | no |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 20.9677 | 5 | no |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 20.9677 | 6 | no |
| GO:0045055 | regulated exocytosis | 19.3548 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 19.3548 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 19.3548 | 6 | yes |
| GO:0007268 | chemical synaptic transmission | 17.7419 | 7 | yes |
| GO:0033043 | regulation of organelle organization | 17.7419 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 17.7419 | 6 | yes |
| GO:0099536 | synaptic signaling | 17.7419 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 17.7419 | 5 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 16.1290 | 4 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 16.1290 | 5 | yes |
| GO:0023061 | signal release | 16.1290 | 4 | yes |
| GO:0051592 | response to calcium ion | 16.1290 | 5 | yes |
| GO:0099643 | signal release from synapse | 16.1290 | 5 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 14.5161 | 5 | yes |
| GO:0051952 | regulation of amine transport | 14.5161 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 14.5161 | 4 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 12.9032 | 5 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 12.9032 | 5 | yes |
| GO:0071241 | cellular response to inorganic substance | 12.9032 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 12.9032 | 5 | yes |
| GO:0001558 | regulation of cell growth | 11.2903 | 4 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 11.2903 | 7 | yes |
| GO:0048278 | vesicle docking | 11.2903 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 11.2903 | 4 | yes |
| GO:0050433 | regulation of catecholamine secretion | 11.2903 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 11.2903 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 11.2903 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 9.6774 | 6 | yes |
| GO:0014059 | regulation of dopamine secretion | 9.6774 | 6 | yes |
| GO:0022604 | regulation of cell morphogenesis | 9.6774 | 5 | yes |
| GO:0030307 | positive regulation of cell growth | 9.6774 | 5 | yes |
| GO:0045921 | positive regulation of exocytosis | 9.6774 | 6 | yes |
| GO:0045927 | positive regulation of growth | 9.6774 | 4 | yes |
| GO:0048639 | positive regulation of developmental growth | 9.6774 | 5 | yes |
| GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 9.6774 | 5 | yes |
| GO:0071277 | cellular response to calcium ion | 9.6774 | 6 | yes |
| GO:1903307 | positive regulation of regulated secretory pathway | 9.6774 | 7 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 9.6774 | 6 | yes |
| GO:0005513 | detection of calcium ion | 8.0645 | 4 | yes |
| GO:0031338 | regulation of vesicle fusion | 8.0645 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 8.0645 | 6 | yes |
| GO:0051954 | positive regulation of amine transport | 8.0645 | 5 | yes |
| GO:1903859 | regulation of dendrite extension | 8.0645 | 5 | yes |
| GO:1903861 | positive regulation of dendrite extension | 8.0645 | 6 | yes |
| GO:0006836 | neurotransmitter transport | 6.4516 | 4 | yes |
| GO:0031630 | regulation of synaptic vesicle fusion to presynaptic active zone membrane | 6.4516 | 6 | yes |
| GO:0045956 | positive regulation of calcium ion-dependent exocytosis | 6.4516 | 8 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 6.4516 | 6 | yes |
| GO:1901632 | regulation of synaptic vesicle membrane organization | 6.4516 | 5 | yes |
| GO:0001956 | positive regulation of neurotransmitter secretion | 4.8387 | 6 | yes |
| GO:0033605 | positive regulation of catecholamine secretion | 4.8387 | 6 | yes |
| GO:0051590 | positive regulation of neurotransmitter transport | 4.8387 | 5 | yes |
| GO:0007269 | neurotransmitter secretion | 3.2258 | 4 | yes |
| GO:0031340 | positive regulation of vesicle fusion | 3.2258 | 5 | yes |
| GO:0031632 | positive regulation of synaptic vesicle fusion to presynaptic active zone membrane | 3.2258 | 6 | yes |
| GO:0033603 | positive regulation of dopamine secretion | 3.2258 | 7 | yes |
| GO:0051291 | protein heterooligomerization | 3.2258 | 7 | yes |
| GO:0061669 | spontaneous neurotransmitter secretion | 3.2258 | 5 | yes |
| GO:0071911 | synchronous neurotransmitter secretion | 3.2258 | 5 | yes |
| GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter | 3.2258 | 6 | yes |
| GO:0099502 | calcium-dependent activation of synaptic vesicle fusion | 3.2258 | 7 | yes |
| GO:1901634 | positive regulation of synaptic vesicle membrane organization | 3.2258 | 6 | yes |
| GO:1903233 | regulation of calcium ion-dependent exocytosis of neurotransmitter | 3.2258 | 7 | yes |
| GO:1903235 | positive regulation of calcium ion-dependent exocytosis of neurotransmitter | 3.2258 | 8 | yes |
| GO:2000302 | positive regulation of synaptic vesicle exocytosis | 3.2258 | 7 | yes |
Disease
No data found.
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RB27A_HUMAN | [view interactions] | Low throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX2_HUMAN | [view interactions] | Low throughput | no | no |
| STX3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| S10AD_HUMAN | [view interactions] | Low throughput | no | yes |
| FGF1_HUMAN | [view interactions] | Low throughput | no | no |
| RBM14_HUMAN | [view interactions] | Low throughput | no | yes |
| SET_HUMAN | [view interactions] | Low throughput | no | yes |
| AN32A_HUMAN | [view interactions] | Low throughput | no | yes |
| RFA2_HUMAN | [view interactions] | Low throughput | no | yes |
| BTBD8_HUMAN | [view interactions] | Low throughput | no | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VAMP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WNK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CACB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SV2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STON2_HUMAN | [view interactions] | Low throughput | no | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYT4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCN1B_HUMAN | [view interactions] | Low throughput | no | no |
| SCN2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCAM5_HUMAN | [view interactions] | Low throughput | no | yes |
| PI51C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MFF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SV2C_HUMAN | [view interactions] | Low throughput | no | no |
| ZDH17_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSN4_HUMAN | [view interactions] | Low throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | Low throughput | no | yes |
| SIN3A_HUMAN | [view interactions] | Low throughput | no | yes |
| SV2B_HUMAN | [view interactions] | Low throughput | no | yes |
| CF015_HUMAN | [view interactions] | Low throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB33A_HUMAN | [view interactions] | Low throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CMGA_HUMAN | [view interactions] | Low throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM18_HUMAN | [view interactions] | High throughput | no | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| BLMH_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| MCTS1_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S4A10_HUMAN | [view interactions] | High throughput | no | yes |
| CBPZ_HUMAN | [view interactions] | High throughput | no | no |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSKI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| RRP7A_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| PGK2_HUMAN | [view interactions] | High throughput | no | no |
| EI2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP2_HUMAN | [view interactions] | High throughput | no | no |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CWC22_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BG_HUMAN | [view interactions] | High throughput | no | yes |
| SYT5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSHR_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAC1B_HUMAN | [view interactions] | High throughput | no | yes |
| SYT3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UT2_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APH1A_HUMAN | [view interactions] | High throughput | no | yes |
| PEN2_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RD3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD8_HUMAN | [view interactions] | High throughput | no | no |
| GIMA5_HUMAN | [view interactions] | High throughput | no | no |
| TM14C_HUMAN | [view interactions] | High throughput | no | no |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIP_HUMAN | [view interactions] | High throughput | no | no |
| UBIA1_HUMAN | [view interactions] | High throughput | no | no |
| BT2A2_HUMAN | [view interactions] | High throughput | no | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM254_HUMAN | [view interactions] | High throughput | no | yes |
| BNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| TMM60_HUMAN | [view interactions] | High throughput | no | no |
| CGAT2_HUMAN | [view interactions] | High throughput | no | yes |
| SNAB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| PEBB_HUMAN | [view interactions] | High throughput | no | no |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| PHS_HUMAN | [view interactions] | High throughput | no | yes |
| CBP_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| VLDLR_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BD_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |