SYT1_HUMAN
Calcium sensor that participates in triggering neurotransmitter release at the synapse . May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse . It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
368 | Ile | Thr | Baker-Gordonsyndrome(BAGOS) | - |
303 | Met | Lys | Baker-Gordonsyndrome(BAGOS) | - |
304 | Asp | Gly | Baker-Gordonsyndrome(BAGOS) | - |
366 | Asp | Glu | Baker-Gordonsyndrome(BAGOS) | - |
371 | Asn | Lys | Baker-Gordonsyndrome(BAGOS) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SYT1_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 29.0323 | 4 | yes |
GO:0046872 | metal ion binding | 29.0323 | 5 | yes |
GO:0019900 | kinase binding | 25.8065 | 4 | no |
GO:0019905 | syntaxin binding | 17.7419 | 4 | yes |
GO:0005509 | calcium ion binding | 16.1290 | 6 | yes |
GO:0043168 | anion binding | 16.1290 | 4 | yes |
GO:0005544 | calcium-dependent phospholipid binding | 9.6774 | 4 | yes |
GO:0017075 | syntaxin-1 binding | 9.6774 | 5 | yes |
GO:0035091 | phosphatidylinositol binding | 6.4516 | 4 | yes |
GO:0046982 | protein heterodimerization activity | 6.4516 | 4 | yes |
GO:1901981 | phosphatidylinositol phosphate binding | 6.4516 | 5 | yes |
GO:1902936 | phosphatidylinositol bisphosphate binding | 6.4516 | 6 | yes |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 4.8387 | 5 | yes |
GO:0030348 | syntaxin-3 binding | 3.2258 | 5 | yes |
GO:0050750 | low-density lipoprotein particle receptor binding | 3.2258 | 5 | yes |
GO:0070325 | lipoprotein particle receptor binding | 3.2258 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SYT1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 59.6774 | 4 | yes |
GO:0010646 | regulation of cell communication | 56.4516 | 4 | yes |
GO:0051049 | regulation of transport | 53.2258 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 45.1613 | 4 | yes |
GO:0022607 | cellular component assembly | 41.9355 | 4 | yes |
GO:0006996 | organelle organization | 40.3226 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 38.7097 | 4 | no |
GO:0048523 | negative regulation of cellular process | 38.7097 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 37.0968 | 4 | no |
GO:0008104 | protein localization | 37.0968 | 4 | no |
GO:0009966 | regulation of signal transduction | 35.4839 | 4 | no |
GO:0023056 | positive regulation of signaling | 35.4839 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 35.4839 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 35.4839 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 30.6452 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 30.6452 | 4 | no |
GO:0010647 | positive regulation of cell communication | 30.6452 | 5 | yes |
GO:0098657 | import into cell | 30.6452 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 29.0323 | 5 | no |
GO:0051046 | regulation of secretion | 29.0323 | 5 | yes |
GO:0051050 | positive regulation of transport | 29.0323 | 4 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 29.0323 | 4 | yes |
GO:0071702 | organic substance transport | 29.0323 | 4 | no |
GO:0071705 | nitrogen compound transport | 29.0323 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 27.4194 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 27.4194 | 5 | no |
GO:0034762 | regulation of transmembrane transport | 27.4194 | 4 | no |
GO:0060341 | regulation of cellular localization | 27.4194 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 25.8065 | 5 | no |
GO:0043933 | protein-containing complex organization | 25.8065 | 4 | yes |
GO:0046903 | secretion | 25.8065 | 4 | yes |
GO:1903530 | regulation of secretion by cell | 25.8065 | 4 | yes |
GO:0015031 | protein transport | 25.8065 | 4 | no |
GO:0032880 | regulation of protein localization | 25.8065 | 5 | no |
GO:0031399 | regulation of protein modification process | 24.1935 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 24.1935 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 24.1935 | 5 | yes |
GO:0030030 | cell projection organization | 22.5806 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 22.5806 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 22.5806 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 22.5806 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 22.5806 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 22.5806 | 5 | no |
GO:0010468 | regulation of gene expression | 22.5806 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 22.5806 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 22.5806 | 5 | no |
GO:0017157 | regulation of exocytosis | 22.5806 | 5 | yes |
GO:0051094 | positive regulation of developmental process | 22.5806 | 4 | yes |
GO:0034765 | regulation of monoatomic ion transmembrane transport | 22.5806 | 5 | no |
GO:0043269 | regulation of monoatomic ion transport | 22.5806 | 5 | no |
GO:0071310 | cellular response to organic substance | 22.5806 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 20.9677 | 4 | no |
GO:0042325 | regulation of phosphorylation | 20.9677 | 7 | no |
GO:0010038 | response to metal ion | 20.9677 | 4 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 20.9677 | 4 | yes |
GO:0050806 | positive regulation of synaptic transmission | 20.9677 | 5 | yes |
GO:0010959 | regulation of metal ion transport | 20.9677 | 6 | no |
GO:0022898 | regulation of transmembrane transporter activity | 20.9677 | 4 | no |
GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 20.9677 | 5 | no |
GO:1904062 | regulation of monoatomic cation transmembrane transport | 20.9677 | 6 | no |
GO:0045055 | regulated exocytosis | 19.3548 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 19.3548 | 5 | yes |
GO:1903305 | regulation of regulated secretory pathway | 19.3548 | 6 | yes |
GO:0007268 | chemical synaptic transmission | 17.7419 | 7 | yes |
GO:0033043 | regulation of organelle organization | 17.7419 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 17.7419 | 6 | yes |
GO:0099536 | synaptic signaling | 17.7419 | 4 | yes |
GO:0099537 | trans-synaptic signaling | 17.7419 | 5 | yes |
GO:0016079 | synaptic vesicle exocytosis | 16.1290 | 4 | yes |
GO:0017156 | calcium-ion regulated exocytosis | 16.1290 | 5 | yes |
GO:0023061 | signal release | 16.1290 | 4 | yes |
GO:0051592 | response to calcium ion | 16.1290 | 5 | yes |
GO:0099643 | signal release from synapse | 16.1290 | 5 | yes |
GO:0048488 | synaptic vesicle endocytosis | 14.5161 | 5 | yes |
GO:0051952 | regulation of amine transport | 14.5161 | 5 | yes |
GO:0140238 | presynaptic endocytosis | 14.5161 | 4 | yes |
GO:0046928 | regulation of neurotransmitter secretion | 12.9032 | 5 | yes |
GO:0051588 | regulation of neurotransmitter transport | 12.9032 | 5 | yes |
GO:0071241 | cellular response to inorganic substance | 12.9032 | 4 | yes |
GO:0071248 | cellular response to metal ion | 12.9032 | 5 | yes |
GO:0001558 | regulation of cell growth | 11.2903 | 4 | yes |
GO:0017158 | regulation of calcium ion-dependent exocytosis | 11.2903 | 7 | yes |
GO:0048278 | vesicle docking | 11.2903 | 4 | yes |
GO:0048638 | regulation of developmental growth | 11.2903 | 4 | yes |
GO:0050433 | regulation of catecholamine secretion | 11.2903 | 5 | yes |
GO:0051047 | positive regulation of secretion | 11.2903 | 5 | yes |
GO:1903532 | positive regulation of secretion by cell | 11.2903 | 5 | yes |
GO:0010638 | positive regulation of organelle organization | 9.6774 | 6 | yes |
GO:0014059 | regulation of dopamine secretion | 9.6774 | 6 | yes |
GO:0022604 | regulation of cell morphogenesis | 9.6774 | 5 | yes |
GO:0030307 | positive regulation of cell growth | 9.6774 | 5 | yes |
GO:0045921 | positive regulation of exocytosis | 9.6774 | 6 | yes |
GO:0045927 | positive regulation of growth | 9.6774 | 4 | yes |
GO:0048639 | positive regulation of developmental growth | 9.6774 | 5 | yes |
GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 9.6774 | 5 | yes |
GO:0071277 | cellular response to calcium ion | 9.6774 | 6 | yes |
GO:1903307 | positive regulation of regulated secretory pathway | 9.6774 | 7 | yes |
GO:2000300 | regulation of synaptic vesicle exocytosis | 9.6774 | 6 | yes |
GO:0005513 | detection of calcium ion | 8.0645 | 4 | yes |
GO:0031338 | regulation of vesicle fusion | 8.0645 | 5 | yes |
GO:0051259 | protein complex oligomerization | 8.0645 | 6 | yes |
GO:0051954 | positive regulation of amine transport | 8.0645 | 5 | yes |
GO:1903859 | regulation of dendrite extension | 8.0645 | 5 | yes |
GO:1903861 | positive regulation of dendrite extension | 8.0645 | 6 | yes |
GO:0006836 | neurotransmitter transport | 6.4516 | 4 | yes |
GO:0031630 | regulation of synaptic vesicle fusion to presynaptic active zone membrane | 6.4516 | 6 | yes |
GO:0045956 | positive regulation of calcium ion-dependent exocytosis | 6.4516 | 8 | yes |
GO:0051966 | regulation of synaptic transmission, glutamatergic | 6.4516 | 6 | yes |
GO:1901632 | regulation of synaptic vesicle membrane organization | 6.4516 | 5 | yes |
GO:0001956 | positive regulation of neurotransmitter secretion | 4.8387 | 6 | yes |
GO:0033605 | positive regulation of catecholamine secretion | 4.8387 | 6 | yes |
GO:0051590 | positive regulation of neurotransmitter transport | 4.8387 | 5 | yes |
GO:0007269 | neurotransmitter secretion | 3.2258 | 4 | yes |
GO:0031340 | positive regulation of vesicle fusion | 3.2258 | 5 | yes |
GO:0031632 | positive regulation of synaptic vesicle fusion to presynaptic active zone membrane | 3.2258 | 6 | yes |
GO:0033603 | positive regulation of dopamine secretion | 3.2258 | 7 | yes |
GO:0051291 | protein heterooligomerization | 3.2258 | 7 | yes |
GO:0061669 | spontaneous neurotransmitter secretion | 3.2258 | 5 | yes |
GO:0071911 | synchronous neurotransmitter secretion | 3.2258 | 5 | yes |
GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter | 3.2258 | 6 | yes |
GO:0099502 | calcium-dependent activation of synaptic vesicle fusion | 3.2258 | 7 | yes |
GO:1901634 | positive regulation of synaptic vesicle membrane organization | 3.2258 | 6 | yes |
GO:1903233 | regulation of calcium ion-dependent exocytosis of neurotransmitter | 3.2258 | 7 | yes |
GO:1903235 | positive regulation of calcium ion-dependent exocytosis of neurotransmitter | 3.2258 | 8 | yes |
GO:2000302 | positive regulation of synaptic vesicle exocytosis | 3.2258 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RB27A_HUMAN | [view interactions] | Low throughput | no | yes |
HNRPQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
STX2_HUMAN | [view interactions] | Low throughput | no | no |
STX3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
STX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
S10AD_HUMAN | [view interactions] | Low throughput | no | yes |
FGF1_HUMAN | [view interactions] | Low throughput | no | no |
RBM14_HUMAN | [view interactions] | Low throughput | no | yes |
SET_HUMAN | [view interactions] | Low throughput | no | yes |
AN32A_HUMAN | [view interactions] | Low throughput | no | yes |
RFA2_HUMAN | [view interactions] | Low throughput | no | yes |
BTBD8_HUMAN | [view interactions] | Low throughput | no | yes |
CPLX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LRRT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
VAMP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
WNK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CACB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SV2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STON2_HUMAN | [view interactions] | Low throughput | no | yes |
SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SYT4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SCN1B_HUMAN | [view interactions] | Low throughput | no | no |
SCN2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SCAM5_HUMAN | [view interactions] | Low throughput | no | yes |
PI51C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MFF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SV2C_HUMAN | [view interactions] | Low throughput | no | no |
ZDH17_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CSN4_HUMAN | [view interactions] | Low throughput | no | yes |
DNJC5_HUMAN | [view interactions] | Low throughput | no | yes |
SIN3A_HUMAN | [view interactions] | Low throughput | no | yes |
SV2B_HUMAN | [view interactions] | Low throughput | no | yes |
CF015_HUMAN | [view interactions] | Low throughput | no | no |
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RB33A_HUMAN | [view interactions] | Low throughput | no | no |
A16L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CMGA_HUMAN | [view interactions] | Low throughput | no | yes |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBM18_HUMAN | [view interactions] | High throughput | no | no |
CD63_HUMAN | [view interactions] | High throughput | no | no |
TR10C_HUMAN | [view interactions] | High throughput | no | no |
BLMH_HUMAN | [view interactions] | High throughput | no | yes |
KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
MCTS1_HUMAN | [view interactions] | High throughput | no | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBP48_HUMAN | [view interactions] | High throughput | no | yes |
SMC5_HUMAN | [view interactions] | High throughput | no | yes |
NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CACB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S4A10_HUMAN | [view interactions] | High throughput | no | yes |
CBPZ_HUMAN | [view interactions] | High throughput | no | no |
KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CSKI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
RRP7A_HUMAN | [view interactions] | High throughput | no | yes |
ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
BOREA_HUMAN | [view interactions] | High throughput | no | yes |
PGK2_HUMAN | [view interactions] | High throughput | no | no |
EI2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRP2_HUMAN | [view interactions] | High throughput | no | no |
EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CWC22_HUMAN | [view interactions] | High throughput | no | yes |
EI2BG_HUMAN | [view interactions] | High throughput | no | yes |
SYT5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TSHR_HUMAN | [view interactions] | High throughput | no | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAC1B_HUMAN | [view interactions] | High throughput | no | yes |
SYT3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UT2_HUMAN | [view interactions] | High throughput | no | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APH1A_HUMAN | [view interactions] | High throughput | no | yes |
PEN2_HUMAN | [view interactions] | High throughput | no | yes |
CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RD3_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHD8_HUMAN | [view interactions] | High throughput | no | no |
GIMA5_HUMAN | [view interactions] | High throughput | no | no |
TM14C_HUMAN | [view interactions] | High throughput | no | no |
HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIP_HUMAN | [view interactions] | High throughput | no | no |
UBIA1_HUMAN | [view interactions] | High throughput | no | no |
BT2A2_HUMAN | [view interactions] | High throughput | no | no |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TM254_HUMAN | [view interactions] | High throughput | no | yes |
BNIP2_HUMAN | [view interactions] | High throughput | no | yes |
TMM60_HUMAN | [view interactions] | High throughput | no | no |
CGAT2_HUMAN | [view interactions] | High throughput | no | yes |
SNAB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SOX4_HUMAN | [view interactions] | High throughput | no | yes |
PEBB_HUMAN | [view interactions] | High throughput | no | no |
TFCP2_HUMAN | [view interactions] | High throughput | no | no |
SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
PHS_HUMAN | [view interactions] | High throughput | no | yes |
CBP_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HAX1_HUMAN | [view interactions] | High throughput | no | no |
DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
KTU_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
VLDLR_HUMAN | [view interactions] | High throughput | no | yes |
EI2BD_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |