Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SYT1_HUMAN

GO
G2C
SynGO

Calcium sensor that participates in triggering neurotransmitter release at the synapse . May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse . It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
368 Ile Thr Baker-Gordonsyndrome(BAGOS) -
303 Met Lys Baker-Gordonsyndrome(BAGOS) -
304 Asp Gly Baker-Gordonsyndrome(BAGOS) -
366 Asp Glu Baker-Gordonsyndrome(BAGOS) -
371 Asn Lys Baker-Gordonsyndrome(BAGOS) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SYT1_HUMAN
GO:0046872 metal ion binding 30.1370 4 yes
GO:0019900 kinase binding 23.2877 4 no
GO:0005509 calcium ion binding 19.1781 5 yes
GO:0019905 syntaxin binding 17.8082 4 yes
GO:0017075 syntaxin-1 binding 10.9589 5 yes
GO:0005544 calcium-dependent phospholipid binding 9.5890 4 yes
GO:0046982 protein heterodimerization activity 8.2192 4 yes
GO:0035091 phosphatidylinositol binding 5.4795 4 yes
GO:1901981 phosphatidylinositol phosphate binding 5.4795 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 5.4795 6 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4.1096 4 yes
GO:0050750 low-density lipoprotein particle receptor binding 4.1096 5 yes
GO:0070325 lipoprotein particle receptor binding 4.1096 4 yes
GO:0030348 syntaxin-3 binding 2.7397 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SYT1_HUMAN
GO:0048522 positive regulation of cellular process 61.6438 4 yes
GO:0010646 regulation of cell communication 56.1644 4 yes
GO:0051049 regulation of transport 56.1644 4 yes
GO:0051128 regulation of cellular component organization 49.3151 4 yes
GO:0016192 vesicle-mediated transport 46.5753 4 yes
GO:0008104 protein localization 43.8356 4 no
GO:0050804 modulation of chemical synaptic transmission 42.4658 5 yes
GO:0099177 regulation of trans-synaptic signaling 42.4658 4 yes
GO:0006996 organelle organization 41.0959 4 no
GO:0022607 cellular component assembly 38.3562 4 yes
GO:0046903 secretion 38.3562 4 yes
GO:0048523 negative regulation of cellular process 38.3562 4 no
GO:0043269 regulation of ion transport 36.9863 5 yes
GO:0071702 organic substance transport 35.6164 4 no
GO:0071705 nitrogen compound transport 35.6164 4 no
GO:0009966 regulation of signal transduction 34.2466 4 no
GO:0006887 exocytosis 32.8767 4 yes
GO:0023056 positive regulation of signaling 32.8767 4 yes
GO:0051046 regulation of secretion 32.8767 5 yes
GO:0051050 positive regulation of transport 32.8767 4 yes
GO:0060627 regulation of vesicle-mediated transport 32.8767 4 yes
GO:0015031 protein transport 32.8767 4 no
GO:0060255 regulation of macromolecule metabolic process 32.8767 4 no
GO:0010647 positive regulation of cell communication 31.5068 5 yes
GO:0023061 signal release 31.5068 4 yes
GO:0099643 signal release from synapse 31.5068 5 yes
GO:0043933 protein-containing complex organization 30.1370 4 yes
GO:1903530 regulation of secretion by cell 30.1370 4 yes
GO:0031323 regulation of cellular metabolic process 28.7671 4 no
GO:0048584 positive regulation of response to stimulus 27.3973 4 no
GO:0017157 regulation of exocytosis 26.0274 5 yes
GO:0045055 regulated exocytosis 26.0274 5 yes
GO:0061024 membrane organization 26.0274 4 no
GO:0051171 regulation of nitrogen compound metabolic process 26.0274 4 no
GO:0080090 regulation of primary metabolic process 26.0274 4 no
GO:0099537 trans-synaptic signaling 24.6575 4 yes
GO:0016050 vesicle organization 24.6575 5 no
GO:0009893 positive regulation of metabolic process 24.6575 4 no
GO:0006836 neurotransmitter transport 23.2877 4 yes
GO:0007268 chemical synaptic transmission 23.2877 6 yes
GO:0050806 positive regulation of synaptic transmission 23.2877 5 yes
GO:0051094 positive regulation of developmental process 23.2877 4 yes
GO:0065003 protein-containing complex assembly 23.2877 5 yes
GO:0098916 anterograde trans-synaptic signaling 23.2877 5 yes
GO:0044087 regulation of cellular component biogenesis 23.2877 4 no
GO:0060341 regulation of cellular localization 23.2877 4 no
GO:0051246 regulation of protein metabolic process 23.2877 5 no
GO:0017156 calcium-ion regulated exocytosis 21.9178 6 yes
GO:0051130 positive regulation of cellular component organization 21.9178 5 yes
GO:1903305 regulation of regulated secretory pathway 21.9178 6 yes
GO:0034762 regulation of transmembrane transport 21.9178 4 no
GO:0034765 regulation of ion transmembrane transport 21.9178 5 no
GO:0032880 regulation of protein localization 21.9178 5 no
GO:0050890 cognition 21.9178 4 no
GO:0009892 negative regulation of metabolic process 21.9178 4 no
GO:0010468 regulation of gene expression 21.9178 5 no
GO:0010604 positive regulation of macromolecule metabolic process 21.9178 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.9178 5 no
GO:0034330 cell junction organization 21.9178 4 no
GO:0007269 neurotransmitter secretion 20.5479 4 yes
GO:0010038 response to metal ion 20.5479 4 yes
GO:0033043 regulation of organelle organization 20.5479 5 yes
GO:0099003 vesicle-mediated transport in synapse 20.5479 5 yes
GO:0030030 cell projection organization 20.5479 4 no
GO:0031324 negative regulation of cellular metabolic process 20.5479 5 no
GO:0031325 positive regulation of cellular metabolic process 20.5479 5 no
GO:0050808 synapse organization 20.5479 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 20.5479 5 no
GO:0006897 endocytosis 19.1781 5 yes
GO:0016079 synaptic vesicle exocytosis 19.1781 4 yes
GO:0046928 regulation of neurotransmitter secretion 19.1781 4 yes
GO:0051588 regulation of neurotransmitter transport 19.1781 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 17.8082 4 yes
GO:0043270 positive regulation of ion transport 17.8082 5 yes
GO:0051952 regulation of amine transport 16.4384 5 yes
GO:0048278 vesicle docking 15.0685 4 yes
GO:0051592 response to calcium ion 15.0685 5 yes
GO:0071241 cellular response to inorganic substance 15.0685 4 yes
GO:0071248 cellular response to metal ion 13.6986 5 yes
GO:0001558 regulation of cell growth 12.3288 4 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 12.3288 7 yes
GO:0048638 regulation of developmental growth 12.3288 4 yes
GO:0050433 regulation of catecholamine secretion 12.3288 5 yes
GO:0051047 positive regulation of secretion 12.3288 5 yes
GO:1903532 positive regulation of secretion by cell 12.3288 5 yes
GO:0014059 regulation of dopamine secretion 10.9589 6 yes
GO:0022604 regulation of cell morphogenesis 10.9589 5 yes
GO:0030307 positive regulation of cell growth 10.9589 5 yes
GO:0045921 positive regulation of exocytosis 10.9589 6 yes
GO:0045927 positive regulation of growth 10.9589 4 yes
GO:0048488 synaptic vesicle endocytosis 10.9589 5 yes
GO:0048639 positive regulation of developmental growth 10.9589 5 yes
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 10.9589 5 yes
GO:0140238 presynaptic endocytosis 10.9589 4 yes
GO:1903307 positive regulation of regulated secretory pathway 10.9589 7 yes
GO:2000300 regulation of synaptic vesicle exocytosis 10.9589 5 yes
GO:0010638 positive regulation of organelle organization 9.5890 6 yes
GO:0031338 regulation of vesicle fusion 9.5890 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 9.5890 6 yes
GO:0071277 cellular response to calcium ion 9.5890 6 yes
GO:1903859 regulation of dendrite extension 9.5890 5 yes
GO:1903861 positive regulation of dendrite extension 9.5890 6 yes
GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane 8.2192 6 yes
GO:0051954 positive regulation of amine transport 8.2192 5 yes
GO:1901632 regulation of synaptic vesicle membrane organization 8.2192 5 yes
GO:0001956 positive regulation of neurotransmitter secretion 6.8493 5 yes
GO:0005513 detection of calcium ion 6.8493 4 yes
GO:0045956 positive regulation of calcium ion-dependent exocytosis 6.8493 8 yes
GO:0051259 protein complex oligomerization 6.8493 6 yes
GO:0051590 positive regulation of neurotransmitter transport 6.8493 5 yes
GO:0007420 brain development 4.1096 4 yes
GO:0031340 positive regulation of vesicle fusion 4.1096 5 yes
GO:0031632 positive regulation of synaptic vesicle fusion to presynaptic active zone membrane 4.1096 6 yes
GO:0033605 positive regulation of catecholamine secretion 4.1096 6 yes
GO:0061669 spontaneous neurotransmitter secretion 4.1096 5 yes
GO:0099502 calcium-dependent activation of synaptic vesicle fusion 4.1096 7 yes
GO:1901634 positive regulation of synaptic vesicle membrane organization 4.1096 6 yes
GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter 4.1096 6 yes
GO:0033603 positive regulation of dopamine secretion 2.7397 6 yes
GO:0051291 protein heterooligomerization 2.7397 7 yes
GO:0071911 synchronous neurotransmitter secretion 2.7397 5 yes
GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter 2.7397 6 yes
GO:1903235 positive regulation of calcium ion-dependent exocytosis of neurotransmitter 2.7397 7 yes
GO:2000302 positive regulation of synaptic vesicle exocytosis 2.7397 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in SYT1_HUMAN
DOID:1826 epilepsy 5.4795 5 no
DOID:331 central nervous system disease 5.4795 3 no
DOID:936 brain disease 5.4795 4 no
DOID:0050701 electroclinical syndrome 4.1096 6 no
DOID:0050700 cardiomyopathy 2.7397 4 no
DOID:0060036 intrinsic cardiomyopathy 2.7397 5 no
DOID:114 heart disease 2.7397 3 no
DOID:2843 long QT syndrome 2.7397 6 no
DOID:0050703 infancy electroclinical syndrome 2.7397 7 no
DOID:0060169 benign familial infantile epilepsy 2.7397 8 no
DOID:0112202 developmental and epileptic encephalopathy 2.7397 7 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
WNK1_HUMAN [view entry] [view interactions] Low throughput yes no
CACB3_HUMAN [view entry] [view interactions] Low throughput yes no
NEMO_HUMAN [view interactions] Low throughput no yes
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] Low throughput yes no
SV2A_HUMAN [view entry] [view interactions] Low throughput yes yes
STON2_HUMAN [view interactions] Low throughput no yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
SYT4_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
SCN1B_HUMAN [view interactions] Low throughput no no
SCN2A_HUMAN [view entry] [view interactions] Low throughput yes yes
SCAM5_HUMAN [view interactions] Low throughput no yes
PI51C_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
MFF_HUMAN [view entry] [view interactions] Low throughput yes yes
ZDH17_HUMAN [view interactions] Low throughput no yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
AP1G1_HUMAN [view entry] [view interactions] Low throughput yes yes
CSN4_HUMAN [view interactions] Low throughput no yes
DNJC5_HUMAN [view interactions] Low throughput no yes
SIN3A_HUMAN [view interactions] Low throughput no yes
SV2B_HUMAN [view interactions] Low throughput no yes
CF015_HUMAN [view interactions] Low throughput no no
SV2C_HUMAN [view interactions] Low throughput no no
TERA_HUMAN [view entry] [view interactions] Low throughput yes yes
RB33A_HUMAN [view interactions] Low throughput no no
A16L1_HUMAN [view entry] [view interactions] Low throughput yes yes
CMGA_HUMAN [view interactions] Low throughput no yes
RB27A_HUMAN [view interactions] Low throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1A_HUMAN [view interactions] Low throughput no no
STX2_HUMAN [view interactions] Low throughput no no
STX3_HUMAN [view entry] [view interactions] Low throughput yes no
STX4_HUMAN [view entry] [view interactions] Low throughput yes no
S10AD_HUMAN [view interactions] Low throughput no yes
FGF1_HUMAN [view interactions] Low throughput no no
RBM14_HUMAN [view interactions] Low throughput no yes
SET_HUMAN [view interactions] Low throughput no yes
AN32A_HUMAN [view interactions] Low throughput no yes
RFA2_HUMAN [view interactions] Low throughput no yes
K1107_HUMAN [view interactions] Low throughput no yes
CPLX1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRT2_HUMAN [view entry] [view interactions] Low throughput yes no
VAMP3_HUMAN [view entry] [view interactions] Low throughput yes no
CSKI1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
NUFP1_HUMAN [view interactions] High throughput no yes
RRP7A_HUMAN [view interactions] High throughput no yes
ARMC1_HUMAN [view interactions] High throughput no yes
BOREA_HUMAN [view interactions] High throughput no yes
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
EI2BG_HUMAN [view interactions] High throughput no yes
CWC22_HUMAN [view interactions] High throughput no yes
EI2BE_HUMAN [view interactions] High throughput no yes
LRP2_HUMAN [view interactions] High throughput no no
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
PGK2_HUMAN [view interactions] High throughput no no
SYT5_HUMAN [view entry] [view interactions] High throughput yes no
TSHR_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
CAC1B_HUMAN [view interactions] High throughput no yes
SYT3_HUMAN [view entry] [view interactions] High throughput yes no
UT2_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
APH1A_HUMAN [view interactions] High throughput no yes
PEN2_HUMAN [view interactions] High throughput no yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
RD3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
GIMA5_HUMAN [view interactions] High throughput no no
TM14C_HUMAN [view interactions] High throughput no no
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
MIP_HUMAN [view interactions] High throughput no no
UBIA1_HUMAN [view interactions] High throughput no no
BT2A2_HUMAN [view interactions] High throughput no no
ZFPL1_HUMAN [view interactions] High throughput no yes
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
TM254_HUMAN [view interactions] High throughput no yes
BNIP2_HUMAN [view interactions] High throughput no yes
TMM60_HUMAN [view interactions] High throughput no no
CGAT2_HUMAN [view interactions] High throughput no yes
SNAB_HUMAN [view entry] [view interactions] High throughput yes yes
GOLM1_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PEBB_HUMAN [view interactions] High throughput no no
TFCP2_HUMAN [view interactions] High throughput no no
SMAD2_HUMAN [view interactions] High throughput no yes
PHS_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
VLDLR_HUMAN [view interactions] High throughput no yes
EI2BD_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
SDC2_HUMAN [view interactions] High throughput no yes
RBM18_HUMAN [view interactions] High throughput no no
CD63_HUMAN [view interactions] High throughput no no
TR10C_HUMAN [view interactions] High throughput no no
BLMH_HUMAN [view interactions] High throughput no yes
KCNE3_HUMAN [view interactions] High throughput no yes
MCTS1_HUMAN [view interactions] High throughput no no
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CACB4_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
S4A10_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
HSP7C_HUMAN [view entry] [view interactions] Computational yes yes
STX1B_HUMAN [view entry] [view interactions] Computational yes yes
NRX2A_HUMAN [view entry] [view interactions] Computational yes no
SYT11_HUMAN [view entry] [view interactions] Computational yes yes
NRX3A_HUMAN [view entry] [view interactions] Computational yes yes
LIN7B_HUMAN [view entry] [view interactions] Computational yes no
VACHT_HUMAN [view interactions] Computational no no
UN13B_HUMAN [view interactions] Computational no no
DCE2_HUMAN [view interactions] Computational no yes
RAB3A_HUMAN [view entry] [view interactions] Computational yes yes
SYN2_HUMAN [view entry] [view interactions] Computational yes no
LIN7A_HUMAN [view entry] [view interactions] Computational yes yes
VGLU1_HUMAN [view entry] [view interactions] Computational yes no
SYN1_HUMAN [view entry] [view interactions] Computational yes no
VIAAT_HUMAN [view interactions] Computational no yes
PRRT2_HUMAN [view entry] [view interactions] Computational yes no
VAMP1_HUMAN [view interactions] Computational no no
LIN7C_HUMAN [view entry] [view interactions] Computational yes yes
VAPA_HUMAN [view entry] [view interactions] Computational yes yes
SCG1_HUMAN [view interactions] Computational no no
STON1_HUMAN [view interactions] Computational no yes
STXB1_HUMAN [view entry] [view interactions] Computational yes yes
FEZ1_HUMAN [view interactions] Computational no no
RIMS1_HUMAN [view entry] [view interactions] Computational yes yes
NRX1A_HUMAN [view entry] [view interactions] Computational yes no
UN13A_HUMAN [view entry] [view interactions] Computational yes no
APBA1_HUMAN [view interactions] Computational no no
SYN3_HUMAN [view entry] [view interactions] Computational yes yes