Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SYT1_HUMAN

Calcium sensor that participates in triggering neurotransmitter release at the synapse . May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse . It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.
Position Amino acid Mutation Disease Overlap with binding region
368 Ile Thr Baker-Gordonsyndrome(BAGOS) -
303 Met Lys Baker-Gordonsyndrome(BAGOS) -
304 Asp Gly Baker-Gordonsyndrome(BAGOS) -
366 Asp Glu Baker-Gordonsyndrome(BAGOS) -
371 Asn Lys Baker-Gordonsyndrome(BAGOS) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SYT1_HUMAN
GO:0043169 cation binding 29.0323 4 yes
GO:0046872 metal ion binding 29.0323 5 yes
GO:0019900 kinase binding 25.8065 4 no
GO:0019905 syntaxin binding 17.7419 4 yes
GO:0005509 calcium ion binding 16.1290 6 yes
GO:0043168 anion binding 16.1290 4 yes
GO:0005544 calcium-dependent phospholipid binding 9.6774 4 yes
GO:0017075 syntaxin-1 binding 9.6774 5 yes
GO:0035091 phosphatidylinositol binding 6.4516 4 yes
GO:0046982 protein heterodimerization activity 6.4516 4 yes
GO:1901981 phosphatidylinositol phosphate binding 6.4516 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 6.4516 6 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4.8387 5 yes
GO:0030348 syntaxin-3 binding 3.2258 5 yes
GO:0050750 low-density lipoprotein particle receptor binding 3.2258 5 yes
GO:0070325 lipoprotein particle receptor binding 3.2258 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SYT1_HUMAN
GO:0048522 positive regulation of cellular process 59.6774 4 yes
GO:0010646 regulation of cell communication 56.4516 4 yes
GO:0051049 regulation of transport 53.2258 4 yes
GO:0051128 regulation of cellular component organization 45.1613 4 yes
GO:0022607 cellular component assembly 41.9355 4 yes
GO:0006996 organelle organization 40.3226 4 no
GO:0060255 regulation of macromolecule metabolic process 38.7097 4 no
GO:0048523 negative regulation of cellular process 38.7097 4 no
GO:0031323 regulation of cellular metabolic process 37.0968 4 no
GO:0008104 protein localization 37.0968 4 no
GO:0009966 regulation of signal transduction 35.4839 4 no
GO:0023056 positive regulation of signaling 35.4839 4 yes
GO:0050804 modulation of chemical synaptic transmission 35.4839 5 yes
GO:0099177 regulation of trans-synaptic signaling 35.4839 4 yes
GO:0080090 regulation of primary metabolic process 30.6452 4 no
GO:0009893 positive regulation of metabolic process 30.6452 4 no
GO:0010647 positive regulation of cell communication 30.6452 5 yes
GO:0098657 import into cell 30.6452 4 yes
GO:0051246 regulation of protein metabolic process 29.0323 5 no
GO:0051046 regulation of secretion 29.0323 5 yes
GO:0051050 positive regulation of transport 29.0323 4 yes
GO:0060627 regulation of vesicle-mediated transport 29.0323 4 yes
GO:0071702 organic substance transport 29.0323 4 no
GO:0071705 nitrogen compound transport 29.0323 4 no
GO:0048584 positive regulation of response to stimulus 27.4194 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.4194 5 no
GO:0034762 regulation of transmembrane transport 27.4194 4 no
GO:0060341 regulation of cellular localization 27.4194 4 no
GO:0031325 positive regulation of cellular metabolic process 25.8065 5 no
GO:0043933 protein-containing complex organization 25.8065 4 yes
GO:0046903 secretion 25.8065 4 yes
GO:1903530 regulation of secretion by cell 25.8065 4 yes
GO:0015031 protein transport 25.8065 4 no
GO:0032880 regulation of protein localization 25.8065 5 no
GO:0031399 regulation of protein modification process 24.1935 6 no
GO:0009889 regulation of biosynthetic process 24.1935 4 no
GO:0051130 positive regulation of cellular component organization 24.1935 5 yes
GO:0030030 cell projection organization 22.5806 4 no
GO:0009892 negative regulation of metabolic process 22.5806 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.5806 5 no
GO:0019220 regulation of phosphate metabolic process 22.5806 6 no
GO:0031324 negative regulation of cellular metabolic process 22.5806 5 no
GO:0051174 regulation of phosphorus metabolic process 22.5806 5 no
GO:0010468 regulation of gene expression 22.5806 6 no
GO:0010556 regulation of macromolecule biosynthetic process 22.5806 5 no
GO:0031326 regulation of cellular biosynthetic process 22.5806 5 no
GO:0017157 regulation of exocytosis 22.5806 5 yes
GO:0051094 positive regulation of developmental process 22.5806 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 22.5806 5 no
GO:0043269 regulation of monoatomic ion transport 22.5806 5 no
GO:0071310 cellular response to organic substance 22.5806 4 no
GO:0044087 regulation of cellular component biogenesis 20.9677 4 no
GO:0042325 regulation of phosphorylation 20.9677 7 no
GO:0010038 response to metal ion 20.9677 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 20.9677 4 yes
GO:0050806 positive regulation of synaptic transmission 20.9677 5 yes
GO:0010959 regulation of metal ion transport 20.9677 6 no
GO:0022898 regulation of transmembrane transporter activity 20.9677 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 20.9677 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 20.9677 6 no
GO:0045055 regulated exocytosis 19.3548 4 yes
GO:0065003 protein-containing complex assembly 19.3548 5 yes
GO:1903305 regulation of regulated secretory pathway 19.3548 6 yes
GO:0007268 chemical synaptic transmission 17.7419 7 yes
GO:0033043 regulation of organelle organization 17.7419 5 yes
GO:0098916 anterograde trans-synaptic signaling 17.7419 6 yes
GO:0099536 synaptic signaling 17.7419 4 yes
GO:0099537 trans-synaptic signaling 17.7419 5 yes
GO:0016079 synaptic vesicle exocytosis 16.1290 4 yes
GO:0017156 calcium-ion regulated exocytosis 16.1290 5 yes
GO:0023061 signal release 16.1290 4 yes
GO:0051592 response to calcium ion 16.1290 5 yes
GO:0099643 signal release from synapse 16.1290 5 yes
GO:0048488 synaptic vesicle endocytosis 14.5161 5 yes
GO:0051952 regulation of amine transport 14.5161 5 yes
GO:0140238 presynaptic endocytosis 14.5161 4 yes
GO:0046928 regulation of neurotransmitter secretion 12.9032 5 yes
GO:0051588 regulation of neurotransmitter transport 12.9032 5 yes
GO:0071241 cellular response to inorganic substance 12.9032 4 yes
GO:0071248 cellular response to metal ion 12.9032 5 yes
GO:0001558 regulation of cell growth 11.2903 4 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 11.2903 7 yes
GO:0048278 vesicle docking 11.2903 4 yes
GO:0048638 regulation of developmental growth 11.2903 4 yes
GO:0050433 regulation of catecholamine secretion 11.2903 5 yes
GO:0051047 positive regulation of secretion 11.2903 5 yes
GO:1903532 positive regulation of secretion by cell 11.2903 5 yes
GO:0010638 positive regulation of organelle organization 9.6774 6 yes
GO:0014059 regulation of dopamine secretion 9.6774 6 yes
GO:0022604 regulation of cell morphogenesis 9.6774 5 yes
GO:0030307 positive regulation of cell growth 9.6774 5 yes
GO:0045921 positive regulation of exocytosis 9.6774 6 yes
GO:0045927 positive regulation of growth 9.6774 4 yes
GO:0048639 positive regulation of developmental growth 9.6774 5 yes
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 9.6774 5 yes
GO:0071277 cellular response to calcium ion 9.6774 6 yes
GO:1903307 positive regulation of regulated secretory pathway 9.6774 7 yes
GO:2000300 regulation of synaptic vesicle exocytosis 9.6774 6 yes
GO:0005513 detection of calcium ion 8.0645 4 yes
GO:0031338 regulation of vesicle fusion 8.0645 5 yes
GO:0051259 protein complex oligomerization 8.0645 6 yes
GO:0051954 positive regulation of amine transport 8.0645 5 yes
GO:1903859 regulation of dendrite extension 8.0645 5 yes
GO:1903861 positive regulation of dendrite extension 8.0645 6 yes
GO:0006836 neurotransmitter transport 6.4516 4 yes
GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane 6.4516 6 yes
GO:0045956 positive regulation of calcium ion-dependent exocytosis 6.4516 8 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 6.4516 6 yes
GO:1901632 regulation of synaptic vesicle membrane organization 6.4516 5 yes
GO:0001956 positive regulation of neurotransmitter secretion 4.8387 6 yes
GO:0033605 positive regulation of catecholamine secretion 4.8387 6 yes
GO:0051590 positive regulation of neurotransmitter transport 4.8387 5 yes
GO:0007269 neurotransmitter secretion 3.2258 4 yes
GO:0031340 positive regulation of vesicle fusion 3.2258 5 yes
GO:0031632 positive regulation of synaptic vesicle fusion to presynaptic active zone membrane 3.2258 6 yes
GO:0033603 positive regulation of dopamine secretion 3.2258 7 yes
GO:0051291 protein heterooligomerization 3.2258 7 yes
GO:0061669 spontaneous neurotransmitter secretion 3.2258 5 yes
GO:0071911 synchronous neurotransmitter secretion 3.2258 5 yes
GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter 3.2258 6 yes
GO:0099502 calcium-dependent activation of synaptic vesicle fusion 3.2258 7 yes
GO:1901634 positive regulation of synaptic vesicle membrane organization 3.2258 6 yes
GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter 3.2258 7 yes
GO:1903235 positive regulation of calcium ion-dependent exocytosis of neurotransmitter 3.2258 8 yes
GO:2000302 positive regulation of synaptic vesicle exocytosis 3.2258 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RB27A_HUMAN [view interactions] Low throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1A_HUMAN [view entry] [view interactions] Low throughput yes no
STX2_HUMAN [view interactions] Low throughput no no
STX3_HUMAN [view entry] [view interactions] Low throughput yes no
STX4_HUMAN [view entry] [view interactions] Low throughput yes no
S10AD_HUMAN [view interactions] Low throughput no yes
FGF1_HUMAN [view interactions] Low throughput no no
RBM14_HUMAN [view interactions] Low throughput no yes
SET_HUMAN [view interactions] Low throughput no yes
AN32A_HUMAN [view interactions] Low throughput no yes
RFA2_HUMAN [view interactions] Low throughput no yes
BTBD8_HUMAN [view interactions] Low throughput no yes
CPLX1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRT2_HUMAN [view entry] [view interactions] Low throughput yes no
VAMP3_HUMAN [view entry] [view interactions] Low throughput yes no
WNK1_HUMAN [view entry] [view interactions] Low throughput yes no
CACB3_HUMAN [view entry] [view interactions] Low throughput yes no
NEMO_HUMAN [view interactions] Low throughput no yes
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] Low throughput yes no
SV2A_HUMAN [view entry] [view interactions] Low throughput yes yes
STON2_HUMAN [view interactions] Low throughput no yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
SYT4_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
SCN1B_HUMAN [view interactions] Low throughput no no
SCN2A_HUMAN [view entry] [view interactions] Low throughput yes yes
SCAM5_HUMAN [view interactions] Low throughput no yes
PI51C_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
MFF_HUMAN [view entry] [view interactions] Low throughput yes yes
SV2C_HUMAN [view interactions] Low throughput no no
ZDH17_HUMAN [view entry] [view interactions] Low throughput yes yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
AP1G1_HUMAN [view entry] [view interactions] Low throughput yes yes
CSN4_HUMAN [view interactions] Low throughput no yes
DNJC5_HUMAN [view interactions] Low throughput no yes
SIN3A_HUMAN [view interactions] Low throughput no yes
SV2B_HUMAN [view interactions] Low throughput no yes
CF015_HUMAN [view interactions] Low throughput no no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
TERA_HUMAN [view entry] [view interactions] Low throughput yes yes
RB33A_HUMAN [view interactions] Low throughput no no
A16L1_HUMAN [view entry] [view interactions] Low throughput yes yes
CMGA_HUMAN [view interactions] Low throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
SDC2_HUMAN [view entry] [view interactions] High throughput yes yes
RBM18_HUMAN [view interactions] High throughput no no
CD63_HUMAN [view interactions] High throughput no no
TR10C_HUMAN [view interactions] High throughput no no
BLMH_HUMAN [view interactions] High throughput no yes
KCNE3_HUMAN [view interactions] High throughput no yes
MCTS1_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
UBP48_HUMAN [view interactions] High throughput no yes
SMC5_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CACB4_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
S4A10_HUMAN [view interactions] High throughput no yes
CBPZ_HUMAN [view interactions] High throughput no no
KCNQ2_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
CSKI1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
NUFP1_HUMAN [view interactions] High throughput no yes
RRP7A_HUMAN [view interactions] High throughput no yes
ARMC1_HUMAN [view interactions] High throughput no yes
BOREA_HUMAN [view interactions] High throughput no yes
PGK2_HUMAN [view interactions] High throughput no no
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
LRP2_HUMAN [view interactions] High throughput no no
EI2BE_HUMAN [view interactions] High throughput no yes
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
CWC22_HUMAN [view interactions] High throughput no yes
EI2BG_HUMAN [view interactions] High throughput no yes
SYT5_HUMAN [view entry] [view interactions] High throughput yes no
TSHR_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
CAC1B_HUMAN [view interactions] High throughput no yes
SYT3_HUMAN [view entry] [view interactions] High throughput yes no
UT2_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
APH1A_HUMAN [view interactions] High throughput no yes
PEN2_HUMAN [view interactions] High throughput no yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
RD3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
CHD8_HUMAN [view interactions] High throughput no no
GIMA5_HUMAN [view interactions] High throughput no no
TM14C_HUMAN [view interactions] High throughput no no
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
MIP_HUMAN [view interactions] High throughput no no
UBIA1_HUMAN [view interactions] High throughput no no
BT2A2_HUMAN [view interactions] High throughput no no
ZFPL1_HUMAN [view interactions] High throughput no yes
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
TM254_HUMAN [view interactions] High throughput no yes
BNIP2_HUMAN [view interactions] High throughput no yes
TMM60_HUMAN [view interactions] High throughput no no
CGAT2_HUMAN [view interactions] High throughput no yes
SNAB_HUMAN [view entry] [view interactions] High throughput yes yes
GOLM1_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SOX4_HUMAN [view interactions] High throughput no yes
PEBB_HUMAN [view interactions] High throughput no no
TFCP2_HUMAN [view interactions] High throughput no no
SMAD2_HUMAN [view interactions] High throughput no yes
PHS_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
VLDLR_HUMAN [view interactions] High throughput no yes
EI2BD_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes