ENOG_HUMAN
Evidence for PS localization
Functions
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ENOG_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 30.7692 | 4 | no |
| GO:0043169 | cation binding | 27.6923 | 4 | yes |
| GO:0046872 | metal ion binding | 27.6923 | 5 | yes |
| GO:0043168 | anion binding | 21.5385 | 4 | no |
| GO:0000287 | magnesium ion binding | 9.2308 | 6 | yes |
| GO:0004634 | phosphopyruvate hydratase activity | 6.1538 | 5 | yes |
| GO:0016836 | hydro-lyase activity | 6.1538 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ENOG_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 41.5385 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 41.5385 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.5385 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.5385 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 35.3846 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.3846 | 5 | no |
| GO:0022607 | cellular component assembly | 35.3846 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.8462 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.8462 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 33.8462 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.8462 | 4 | no |
| GO:0006996 | organelle organization | 32.3077 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.3077 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.3077 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 32.3077 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.7692 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.2308 | 5 | no |
| GO:0009966 | regulation of signal transduction | 27.6923 | 4 | no |
| GO:0043412 | macromolecule modification | 26.1538 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.6154 | 4 | no |
| GO:0036211 | protein modification process | 24.6154 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.0769 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.0769 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.0769 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.0769 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 21.5385 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 21.5385 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 21.5385 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 21.5385 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.5385 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.5385 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.5385 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.5385 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.5385 | 6 | no |
| GO:0019693 | ribose phosphate metabolic process | 20.0000 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 20.0000 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 20.0000 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 20.0000 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 20.0000 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 18.4615 | 6 | yes |
| GO:0006006 | glucose metabolic process | 18.4615 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 18.4615 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 18.4615 | 5 | yes |
| GO:0019318 | hexose metabolic process | 18.4615 | 4 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 16.9231 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 16.9231 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 16.9231 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 16.9231 | 7 | yes |
| GO:0046034 | ATP metabolic process | 15.3846 | 7 | yes |
| GO:0046496 | nicotinamide nucleotide metabolic process | 15.3846 | 6 | yes |
| GO:0072524 | pyridine-containing compound metabolic process | 15.3846 | 4 | yes |
| GO:0019362 | pyridine nucleotide metabolic process | 15.3846 | 5 | yes |
| GO:0019364 | pyridine nucleotide catabolic process | 13.8462 | 6 | yes |
| GO:0034655 | nucleobase-containing compound catabolic process | 13.8462 | 4 | yes |
| GO:0046031 | ADP metabolic process | 13.8462 | 7 | yes |
| GO:0046032 | ADP catabolic process | 13.8462 | 7 | yes |
| GO:0046434 | organophosphate catabolic process | 13.8462 | 4 | yes |
| GO:0072523 | purine-containing compound catabolic process | 13.8462 | 5 | yes |
| GO:0072526 | pyridine-containing compound catabolic process | 13.8462 | 5 | yes |
| GO:1901136 | carbohydrate derivative catabolic process | 13.8462 | 4 | yes |
| GO:1901292 | nucleoside phosphate catabolic process | 13.8462 | 5 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 13.8462 | 4 | yes |
| GO:0006090 | pyruvate metabolic process | 13.8462 | 7 | yes |
| GO:0006096 | glycolytic process | 13.8462 | 4 | yes |
| GO:0006195 | purine nucleotide catabolic process | 13.8462 | 6 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 13.8462 | 5 | yes |
| GO:0009134 | nucleoside diphosphate catabolic process | 13.8462 | 6 | yes |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 13.8462 | 6 | yes |
| GO:0009137 | purine nucleoside diphosphate catabolic process | 13.8462 | 7 | yes |
| GO:0009154 | purine ribonucleotide catabolic process | 13.8462 | 6 | yes |
| GO:0009166 | nucleotide catabolic process | 13.8462 | 6 | yes |
| GO:0009179 | purine ribonucleoside diphosphate metabolic process | 13.8462 | 7 | yes |
| GO:0009181 | purine ribonucleoside diphosphate catabolic process | 13.8462 | 8 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 13.8462 | 6 | yes |
| GO:0009191 | ribonucleoside diphosphate catabolic process | 13.8462 | 7 | yes |
| GO:0009261 | ribonucleotide catabolic process | 13.8462 | 5 | yes |
| GO:0016051 | carbohydrate biosynthetic process | 13.8462 | 4 | yes |
| GO:0016052 | carbohydrate catabolic process | 13.8462 | 4 | yes |
| GO:0019674 | NAD metabolic process | 12.3077 | 6 | yes |
| GO:0019677 | NAD catabolic process | 12.3077 | 7 | yes |
| GO:0046364 | monosaccharide biosynthetic process | 12.3077 | 4 | yes |
| GO:0046365 | monosaccharide catabolic process | 12.3077 | 4 | yes |
| GO:0061615 | glycolytic process through fructose-6-phosphate | 12.3077 | 5 | yes |
| GO:0061620 | glycolytic process through glucose-6-phosphate | 12.3077 | 6 | yes |
| GO:0061621 | canonical glycolysis | 12.3077 | 7 | yes |
| GO:0061718 | glucose catabolic process to pyruvate | 12.3077 | 7 | yes |
| GO:0006007 | glucose catabolic process | 12.3077 | 6 | yes |
| GO:0006094 | gluconeogenesis | 12.3077 | 6 | yes |
| GO:0006734 | NADH metabolic process | 12.3077 | 7 | yes |
| GO:0006735 | NADH regeneration | 12.3077 | 8 | yes |
| GO:0019319 | hexose biosynthetic process | 12.3077 | 5 | yes |
| GO:0019320 | hexose catabolic process | 12.3077 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KPYM_HUMAN | [view interactions] | Low throughput | no | yes |
| ENOG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| ALX3_HUMAN | [view interactions] | High throughput | no | no |
| PCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COASY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GUAA_HUMAN | [view interactions] | High throughput | no | no |
| PNPH_HUMAN | [view interactions] | High throughput | no | no |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| AK1BF_HUMAN | [view interactions] | High throughput | no | no |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUT_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CGL_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPD52_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| FKB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP7_HUMAN | [view interactions] | High throughput | no | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUS7_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AADAT_HUMAN | [view interactions] | High throughput | no | no |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAT3_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRXR2_HUMAN | [view interactions] | High throughput | no | yes |
| GSHR_HUMAN | [view interactions] | High throughput | no | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| OAT_HUMAN | [view interactions] | High throughput | no | yes |
| TRFE_HUMAN | [view interactions] | High throughput | no | no |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| PIM1_HUMAN | [view interactions] | High throughput | no | yes |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKC_HUMAN | [view interactions] | High throughput | no | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAT9_HUMAN | [view interactions] | High throughput | no | no |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENSA_HUMAN | [view interactions] | High throughput | no | yes |
| HABP4_HUMAN | [view interactions] | High throughput | no | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPN1_HUMAN | [view interactions] | High throughput | no | yes |
| MERB1_HUMAN | [view interactions] | High throughput | no | yes |
| CF047_HUMAN | [view interactions] | High throughput | no | no |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| IL17B_HUMAN | [view interactions] | High throughput | no | no |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIA4B_HUMAN | [view interactions] | High throughput | no | yes |
| SIGIR_HUMAN | [view interactions] | High throughput | no | no |
| UBE2C_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| ACD_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| POC1A_HUMAN | [view interactions] | High throughput | no | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ASB5_HUMAN | [view interactions] | High throughput | no | no |
| ASB9_HUMAN | [view interactions] | High throughput | no | no |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NGB_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |