ENOG_HUMAN
Evidence for PS localization
Functions
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ENOG_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 26.8657 | 4 | no |
| GO:0046872 | metal ion binding | 23.8806 | 4 | yes |
| GO:0000287 | magnesium ion binding | 8.9552 | 5 | yes |
| GO:0004634 | phosphopyruvate hydratase activity | 5.9701 | 5 | yes |
| GO:0016836 | hydro-lyase activity | 5.9701 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ENOG_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 37.3134 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.8209 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 34.3284 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 34.3284 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 32.8358 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.8358 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 31.3433 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 29.8507 | 4 | no |
| GO:0010646 | regulation of cell communication | 29.8507 | 4 | no |
| GO:0006996 | organelle organization | 28.3582 | 4 | no |
| GO:0022607 | cellular component assembly | 28.3582 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.8657 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.3731 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 23.8806 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 23.8806 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 23.8806 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 23.8806 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 23.8806 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 23.8806 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.8806 | 4 | no |
| GO:0016310 | phosphorylation | 22.3881 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.3881 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.3881 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.3881 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 22.3881 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 20.8955 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 20.8955 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 20.8955 | 5 | yes |
| GO:0010941 | regulation of cell death | 20.8955 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 20.8955 | 6 | yes |
| GO:0072521 | purine-containing compound metabolic process | 20.8955 | 4 | yes |
| GO:0043412 | macromolecule modification | 20.8955 | 4 | no |
| GO:0051049 | regulation of transport | 20.8955 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.8955 | 5 | no |
| GO:0006165 | nucleoside diphosphate phosphorylation | 19.4030 | 6 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 19.4030 | 5 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 19.4030 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 19.4030 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 19.4030 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 19.4030 | 7 | yes |
| GO:0046939 | nucleotide phosphorylation | 19.4030 | 6 | yes |
| GO:0006090 | pyruvate metabolic process | 17.9104 | 7 | yes |
| GO:0006096 | glycolytic process | 17.9104 | 5 | yes |
| GO:0006757 | ATP generation from ADP | 17.9104 | 4 | yes |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 17.9104 | 6 | yes |
| GO:0009179 | purine ribonucleoside diphosphate metabolic process | 17.9104 | 7 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 17.9104 | 6 | yes |
| GO:0014070 | response to organic cyclic compound | 17.9104 | 4 | yes |
| GO:0016052 | carbohydrate catabolic process | 17.9104 | 4 | yes |
| GO:0019318 | hexose metabolic process | 17.9104 | 4 | yes |
| GO:0046031 | ADP metabolic process | 17.9104 | 7 | yes |
| GO:0046034 | ATP metabolic process | 17.9104 | 7 | yes |
| GO:0006006 | glucose metabolic process | 16.4179 | 5 | yes |
| GO:0060548 | negative regulation of cell death | 16.4179 | 5 | yes |
| GO:0016051 | carbohydrate biosynthetic process | 11.9403 | 4 | yes |
| GO:0033993 | response to lipid | 11.9403 | 4 | yes |
| GO:0046364 | monosaccharide biosynthetic process | 8.9552 | 4 | yes |
| GO:0006094 | gluconeogenesis | 7.4627 | 6 | yes |
| GO:0019319 | hexose biosynthetic process | 7.4627 | 5 | yes |
| GO:1901214 | regulation of neuron death | 7.4627 | 5 | yes |
| GO:0006007 | glucose catabolic process | 5.9701 | 6 | yes |
| GO:0019320 | hexose catabolic process | 5.9701 | 5 | yes |
| GO:0032355 | response to estradiol | 5.9701 | 4 | yes |
| GO:0046365 | monosaccharide catabolic process | 5.9701 | 4 | yes |
| GO:0061615 | glycolytic process through fructose-6-phosphate | 5.9701 | 6 | yes |
| GO:0061620 | glycolytic process through glucose-6-phosphate | 5.9701 | 7 | yes |
| GO:0061621 | canonical glycolysis | 5.9701 | 4 | yes |
| GO:0061718 | glucose catabolic process to pyruvate | 5.9701 | 7 | yes |
| GO:1901215 | negative regulation of neuron death | 4.4776 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ENOG_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 2.9851 | 3 | no |
| DOID:6457 | Cowden syndrome | 2.9851 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ENOG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| PIM1_HUMAN | [view interactions] | High throughput | no | yes |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKC_HUMAN | [view interactions] | High throughput | no | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAT9_HUMAN | [view interactions] | High throughput | no | no |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENSA_HUMAN | [view interactions] | High throughput | no | yes |
| HABP4_HUMAN | [view interactions] | High throughput | no | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPN1_HUMAN | [view interactions] | High throughput | no | yes |
| MERB1_HUMAN | [view interactions] | High throughput | no | yes |
| CF047_HUMAN | [view interactions] | High throughput | no | no |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| IL17B_HUMAN | [view interactions] | High throughput | no | no |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIA4B_HUMAN | [view interactions] | High throughput | no | yes |
| SIGIR_HUMAN | [view interactions] | High throughput | no | no |
| UBE2C_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| ACD_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| POC1A_HUMAN | [view interactions] | High throughput | no | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ASB5_HUMAN | [view interactions] | High throughput | no | no |
| ASB9_HUMAN | [view interactions] | High throughput | no | no |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NGB_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| ALX3_HUMAN | [view interactions] | High throughput | no | no |
| PCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| COASY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GUAA_HUMAN | [view interactions] | High throughput | no | no |
| PNPH_HUMAN | [view interactions] | High throughput | no | no |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| AK1BF_HUMAN | [view interactions] | High throughput | no | no |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| DUT_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CGL_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPD52_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| FKB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP7_HUMAN | [view interactions] | High throughput | no | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUS7_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AADAT_HUMAN | [view interactions] | High throughput | no | no |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAT3_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRXR2_HUMAN | [view interactions] | High throughput | no | yes |
| GSHR_HUMAN | [view interactions] | High throughput | no | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| OAT_HUMAN | [view interactions] | High throughput | no | yes |
| TRFE_HUMAN | [view interactions] | High throughput | no | no |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYR_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PMGE_HUMAN | [view interactions] | Computational | no | no |
| PCKGM_HUMAN | [view interactions] | Computational | no | no |
| MINP1_HUMAN | [view interactions] | Computational | no | yes |
| CMGA_HUMAN | [view interactions] | Computational | no | yes |
| PCKGC_HUMAN | [view interactions] | Computational | no | no |
| CEAM5_HUMAN | [view interactions] | Computational | no | no |
| G6PD_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GLCTK_HUMAN | [view interactions] | Computational | no | yes |
| KPYM_HUMAN | [view interactions] | Computational | no | yes |
| PGAM2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DEOC_HUMAN | [view interactions] | Computational | no | no |
| A0A2U3TZM8_HUMAN | [view interactions] | Computational | no | no |
| PGAM4_HUMAN | [view interactions] | Computational | no | no |
| TALDO_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| G3PT_HUMAN | [view interactions] | Computational | no | no |
| SYPH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| S100B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| G6PE_HUMAN | [view interactions] | Computational | no | yes |
| PGK2_HUMAN | [view interactions] | Computational | no | no |
| PGM1_HUMAN | [view interactions] | Computational | no | no |
| GRP_HUMAN | [view interactions] | Computational | no | no |
| ALDOC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |