Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WDR1_HUMAN

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed, PubMed, PubMed). Enhances cofilin-mediated actin severing . Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance . Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension . Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.
Position Amino acid Mutation Disease Overlap with binding region
293 Leu Phe Periodicfever,immunodeficiency,andthrombocytopeniasyndrome(PFITS) -
572 Asp Val Periodicfever,immunodeficiency,andthrombocytopeniasyndrome(PFITS) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in WDR1_HUMAN
GO:0043168 anion binding 36.2500 4 no
GO:0000166 nucleotide binding 35.0000 4 no
GO:0017076 purine nucleotide binding 35.0000 5 no
GO:0032555 purine ribonucleotide binding 32.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.2500 4 no
GO:0003779 actin binding 27.5000 4 yes
GO:0030554 adenyl nucleotide binding 26.2500 6 no
GO:0003723 RNA binding 26.2500 4 no
GO:0045296 cadherin binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 23.7500 5 no
GO:0019900 kinase binding 23.7500 4 no
GO:0005524 ATP binding 22.5000 5 no
GO:0043169 cation binding 21.2500 4 no
GO:0046872 metal ion binding 21.2500 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in WDR1_HUMAN
GO:0048522 positive regulation of cellular process 62.5000 4 yes
GO:0051128 regulation of cellular component organization 55.0000 4 yes
GO:0031323 regulation of cellular metabolic process 55.0000 4 no
GO:0048523 negative regulation of cellular process 52.5000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0009889 regulation of biosynthetic process 46.2500 4 no
GO:0010468 regulation of gene expression 45.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 45.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 45.0000 5 no
GO:0009893 positive regulation of metabolic process 41.2500 4 no
GO:0080090 regulation of primary metabolic process 41.2500 4 no
GO:0008104 protein localization 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.7500 5 no
GO:0031325 positive regulation of cellular metabolic process 38.7500 5 no
GO:0006996 organelle organization 37.5000 4 yes
GO:0033043 regulation of organelle organization 36.2500 5 yes
GO:0010646 regulation of cell communication 35.0000 4 no
GO:0022607 cellular component assembly 33.7500 4 yes
GO:0009966 regulation of signal transduction 33.7500 4 no
GO:0051130 positive regulation of cellular component organization 32.5000 5 yes
GO:0009891 positive regulation of biosynthetic process 32.5000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.2500 6 no
GO:0031328 positive regulation of cellular biosynthetic process 31.2500 6 no
GO:0044087 regulation of cellular component biogenesis 31.2500 4 no
GO:0051246 regulation of protein metabolic process 31.2500 5 no
GO:0051240 positive regulation of multicellular organismal process 30.0000 4 no
GO:0007010 cytoskeleton organization 28.7500 5 yes
GO:0006796 phosphate-containing compound metabolic process 28.7500 4 no
GO:0043933 protein-containing complex organization 27.5000 4 yes
GO:0009892 negative regulation of metabolic process 27.5000 4 no
GO:0010628 positive regulation of gene expression 26.2500 7 no
GO:0042981 regulation of apoptotic process 26.2500 5 no
GO:0043067 regulation of programmed cell death 26.2500 4 no
GO:0031324 negative regulation of cellular metabolic process 26.2500 5 no
GO:0071310 cellular response to organic substance 26.2500 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.2500 5 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 yes
GO:0051049 regulation of transport 25.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0097435 supramolecular fiber organization 23.7500 4 yes
GO:1902903 regulation of supramolecular fiber organization 23.7500 5 yes
GO:0009894 regulation of catabolic process 23.7500 4 no
GO:0032880 regulation of protein localization 23.7500 5 no
GO:0042127 regulation of cell population proliferation 23.7500 4 no
GO:1902531 regulation of intracellular signal transduction 23.7500 5 no
GO:0009890 negative regulation of biosynthetic process 22.5000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.5000 6 no
GO:0031327 negative regulation of cellular biosynthetic process 22.5000 6 no
GO:0006355 regulation of DNA-templated transcription 22.5000 7 no
GO:0051094 positive regulation of developmental process 22.5000 4 no
GO:2001141 regulation of RNA biosynthetic process 22.5000 6 no
GO:0071702 organic substance transport 22.5000 4 no
GO:0071705 nitrogen compound transport 22.5000 4 no
GO:0051247 positive regulation of protein metabolic process 22.5000 6 no
GO:0010638 positive regulation of organelle organization 21.2500 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 21.2500 4 yes
GO:0014070 response to organic cyclic compound 21.2500 4 no
GO:0009967 positive regulation of signal transduction 21.2500 5 no
GO:0010647 positive regulation of cell communication 21.2500 5 no
GO:0023056 positive regulation of signaling 21.2500 4 no
GO:0007015 actin filament organization 20.0000 5 yes
GO:0032970 regulation of actin filament-based process 18.7500 4 yes
GO:0032956 regulation of actin cytoskeleton organization 17.5000 5 yes
GO:0045595 regulation of cell differentiation 17.5000 4 yes
GO:0110053 regulation of actin filament organization 17.5000 6 yes
GO:0051495 positive regulation of cytoskeleton organization 15.0000 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 15.0000 6 yes
GO:0022604 regulation of cell morphogenesis 13.7500 5 yes
GO:0032535 regulation of cellular component size 13.7500 4 yes
GO:0008064 regulation of actin polymerization or depolymerization 11.2500 6 yes
GO:0022411 cellular component disassembly 11.2500 4 yes
GO:0030832 regulation of actin filament length 11.2500 5 yes
GO:0034330 cell junction organization 11.2500 4 yes
GO:0032984 protein-containing complex disassembly 10.0000 5 yes
GO:0030834 regulation of actin filament depolymerization 8.7500 7 yes
GO:0031032 actomyosin structure organization 8.7500 4 yes
GO:0034329 cell junction assembly 8.7500 5 yes
GO:0043244 regulation of protein-containing complex disassembly 8.7500 5 yes
GO:1901879 regulation of protein depolymerization 8.7500 6 yes
GO:0008154 actin polymerization or depolymerization 7.5000 6 yes
GO:0045216 cell-cell junction organization 7.5000 5 yes
GO:0051261 protein depolymerization 7.5000 6 yes
GO:0007043 cell-cell junction assembly 6.2500 6 yes
GO:0030042 actin filament depolymerization 6.2500 7 yes
GO:0030043 actin filament fragmentation 5.0000 8 yes
GO:0030099 myeloid cell differentiation 5.0000 4 yes
GO:0045214 sarcomere organization 5.0000 5 yes
GO:0030836 positive regulation of actin filament depolymerization 3.7500 7 yes
GO:0030865 cortical cytoskeleton organization 3.7500 6 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 3.7500 4 yes
GO:0043243 positive regulation of protein-containing complex disassembly 3.7500 6 yes
GO:0099623 regulation of cardiac muscle cell membrane repolarization 3.7500 4 yes
GO:1901881 positive regulation of protein depolymerization 3.7500 7 yes
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 2.5000 5 yes
GO:0045685 regulation of glial cell differentiation 2.5000 5 yes
GO:0048713 regulation of oligodendrocyte differentiation 2.5000 6 yes
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 2.5000 5 yes
GO:0097530 granulocyte migration 2.5000 4 yes
GO:1990266 neutrophil migration 2.5000 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBP7_HUMAN [view interactions] Low throughput no yes
SYVN1_HUMAN [view interactions] Low throughput no yes
KEAP1_HUMAN [view interactions] Low throughput no yes
M3K7_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SKI2_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB2_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
BIRC2_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
NU107_HUMAN [view interactions] High throughput no no
POTEE_HUMAN [view interactions] High throughput no no
SH3L1_HUMAN [view interactions] High throughput no yes
ZBT18_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
MB212_HUMAN [view interactions] High throughput no no
VMP1_HUMAN [view interactions] High throughput no yes
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
ACADS_HUMAN [view interactions] High throughput no yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
PIM3_HUMAN [view interactions] High throughput no no
TBCK_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
TR10D_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
CAV3_HUMAN [view interactions] High throughput no no
TX101_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
SRPK1_HUMAN [view interactions] High throughput no yes
RB33B_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB21_HUMAN [view entry] [view interactions] High throughput yes yes
RAB19_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4B_HUMAN [view entry] [view interactions] High throughput yes no
RB27B_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
FOS_HUMAN [view interactions] High throughput no yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
SKI8_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
LEO1_HUMAN [view interactions] High throughput no yes
SF3B4_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
ISG15_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
AMRA1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
PPME1_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
ATRX_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
PURA2_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
DUS28_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
MAGA3_HUMAN [view interactions] High throughput no no
VAV_HUMAN [view interactions] High throughput no no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
CATL1_HUMAN [view interactions] High throughput no yes
CATB_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
CATS_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
IFM3_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no
DDB1_HUMAN [view interactions] High throughput no yes
RHOD_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHBT2_HUMAN [view interactions] High throughput no no
PLK4_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1B_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
FOXC1_HUMAN [view interactions] High throughput no no
TLS1_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
DX39B_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
RHG24_HUMAN [view interactions] High throughput no yes
CFAH_HUMAN [view interactions] High throughput no no
EZH2_HUMAN [view interactions] High throughput no no
SPOP_HUMAN [view interactions] High throughput no no
RN207_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
ATG10_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
ITA2B_HUMAN [view interactions] High throughput no no
TXD17_HUMAN [view interactions] High throughput no yes
UBE2K_HUMAN [view interactions] High throughput no yes
TYSY_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
RRP44_HUMAN [view interactions] High throughput no yes
UB2D1_HUMAN [view interactions] High throughput no yes
IF5A1_HUMAN [view interactions] High throughput no yes
CH10_HUMAN [view interactions] High throughput no yes
RBBP7_HUMAN [view interactions] High throughput no yes
CBX3_HUMAN [view interactions] High throughput no yes
MK14_HUMAN [view interactions] High throughput no yes
MVD1_HUMAN [view interactions] High throughput no yes
NAGK_HUMAN [view interactions] High throughput no no
NDKA_HUMAN [view entry] [view interactions] High throughput yes yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
PTMS_HUMAN [view interactions] High throughput no yes
SMAP_HUMAN [view interactions] High throughput no yes
TALDO_HUMAN [view entry] [view interactions] High throughput yes no
THOP1_HUMAN [view interactions] High throughput no yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view entry] [view interactions] High throughput yes yes
COF1_HUMAN [view entry] [view interactions] High throughput yes no
COF2_HUMAN [view entry] [view interactions] High throughput yes yes
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
GILT_HUMAN [view interactions] High throughput no no
ITPA_HUMAN [view interactions] High throughput no yes
LACB2_HUMAN [view interactions] High throughput no yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
LDH6A_HUMAN [view interactions] High throughput no no
LDH6B_HUMAN [view interactions] High throughput no no
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
LDHC_HUMAN [view interactions] High throughput no no
MSI2H_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
PABP4_HUMAN [view entry] [view interactions] High throughput yes yes
PHS_HUMAN [view interactions] High throughput no yes
PPIH_HUMAN [view interactions] High throughput no yes
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
PSMG4_HUMAN [view interactions] High throughput no yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
CK054_HUMAN [view interactions] High throughput no no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CGL_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
GALE_HUMAN [view interactions] High throughput no no
GGCT_HUMAN [view interactions] High throughput no yes
GMPPB_HUMAN [view interactions] High throughput no yes
GSTO2_HUMAN [view interactions] High throughput no no
MOES_HUMAN [view entry] [view interactions] High throughput yes no
RGN_HUMAN [view interactions] High throughput no no
SCLY_HUMAN [view interactions] High throughput no yes
UAP1_HUMAN [view interactions] High throughput no yes
UAP1L_HUMAN [view interactions] High throughput no yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
SYJ2B_HUMAN [view interactions] High throughput no no
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
SCFD1_HUMAN [view entry] [view interactions] High throughput yes yes
ARBK1_HUMAN [view entry] [view interactions] High throughput yes yes
MIPEP_HUMAN [view interactions] High throughput no yes
UBQL1_HUMAN [view interactions] High throughput no yes
SYFA_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
PHOCN_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes