Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WDR1_HUMAN

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed, PubMed, PubMed). Enhances cofilin-mediated actin severing . Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance . Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension . Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.
Position Amino acid Mutation Disease Overlap with binding region
293 Leu Phe Periodicfever,immunodeficiency,andthrombocytopeniasyndrome(PFITS) -
572 Asp Val Periodicfever,immunodeficiency,andthrombocytopeniasyndrome(PFITS) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in WDR1_HUMAN
GO:0003779 actin binding 32.8947 4 yes
GO:0017076 purine nucleotide binding 28.9474 4 no
GO:0032555 purine ribonucleotide binding 27.6316 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.6316 4 no
GO:0045296 cadherin binding 27.6316 4 no
GO:0019900 kinase binding 21.0526 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in WDR1_HUMAN
GO:0048522 positive regulation of cellular process 56.5789 4 yes
GO:0051128 regulation of cellular component organization 52.6316 4 yes
GO:0048523 negative regulation of cellular process 51.3158 4 no
GO:0060255 regulation of macromolecule metabolic process 47.3684 4 no
GO:0006996 organelle organization 42.1053 4 yes
GO:0009893 positive regulation of metabolic process 40.7895 4 no
GO:0031323 regulation of cellular metabolic process 40.7895 4 no
GO:0080090 regulation of primary metabolic process 40.7895 4 no
GO:0010468 regulation of gene expression 40.7895 5 no
GO:0008104 protein localization 38.1579 4 no
GO:0051171 regulation of nitrogen compound metabolic process 38.1579 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.8421 5 no
GO:0007010 cytoskeleton organization 34.2105 5 yes
GO:0033043 regulation of organelle organization 34.2105 5 yes
GO:0022607 cellular component assembly 31.5789 4 yes
GO:0010646 regulation of cell communication 30.2632 4 no
GO:0009892 negative regulation of metabolic process 30.2632 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.9474 5 no
GO:0051246 regulation of protein metabolic process 28.9474 5 no
GO:0009966 regulation of signal transduction 27.6316 4 no
GO:0051493 regulation of cytoskeleton organization 26.3158 6 yes
GO:0044087 regulation of cellular component biogenesis 26.3158 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 yes
GO:0051049 regulation of transport 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 23.6842 4 yes
GO:0097435 supramolecular fiber organization 23.6842 4 yes
GO:0016192 vesicle-mediated transport 23.6842 4 no
GO:0051240 positive regulation of multicellular organismal process 23.6842 4 no
GO:0032970 regulation of actin filament-based process 22.3684 4 yes
GO:1902903 regulation of supramolecular fiber organization 22.3684 5 yes
GO:0071705 nitrogen compound transport 22.3684 4 no
GO:0006796 phosphate-containing compound metabolic process 22.3684 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.3684 5 no
GO:0010941 regulation of cell death 22.3684 4 no
GO:0071310 cellular response to organic substance 22.3684 4 no
GO:0007015 actin filament organization 21.0526 5 yes
GO:0032956 regulation of actin cytoskeleton organization 21.0526 5 yes
GO:0015031 protein transport 21.0526 4 no
GO:0060341 regulation of cellular localization 21.0526 4 no
GO:0120036 plasma membrane bounded cell projection organization 21.0526 5 no
GO:0010628 positive regulation of gene expression 21.0526 6 no
GO:0009889 regulation of biosynthetic process 21.0526 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.0526 5 no
GO:0031326 regulation of cellular biosynthetic process 21.0526 5 no
GO:0110053 regulation of actin filament organization 19.7368 6 yes
GO:0010638 positive regulation of organelle organization 18.4211 6 yes
GO:0043933 protein-containing complex organization 18.4211 4 yes
GO:0045595 regulation of cell differentiation 18.4211 4 yes
GO:0032535 regulation of cellular component size 17.1053 4 yes
GO:0022604 regulation of cell morphogenesis 15.7895 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 14.4737 6 yes
GO:0030832 regulation of actin filament length 14.4737 5 yes
GO:0034330 cell junction organization 14.4737 4 yes
GO:0051495 positive regulation of cytoskeleton organization 13.1579 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 13.1579 6 yes
GO:0034329 cell junction assembly 11.8421 5 yes
GO:0031032 actomyosin structure organization 10.5263 4 yes
GO:0045216 cell-cell junction organization 10.5263 5 yes
GO:0007043 cell-cell junction assembly 9.2105 6 yes
GO:0008154 actin polymerization or depolymerization 9.2105 6 yes
GO:0030834 regulation of actin filament depolymerization 9.2105 7 yes
GO:0043244 regulation of protein-containing complex disassembly 9.2105 5 yes
GO:1901879 regulation of protein depolymerization 9.2105 6 yes
GO:0022411 cellular component disassembly 7.8947 4 yes
GO:0032984 protein-containing complex disassembly 7.8947 5 yes
GO:0008360 regulation of cell shape 6.5789 6 yes
GO:0030042 actin filament depolymerization 6.5789 7 yes
GO:0051261 protein depolymerization 6.5789 6 yes
GO:0030043 actin filament fragmentation 5.2632 8 yes
GO:0030836 positive regulation of actin filament depolymerization 5.2632 7 yes
GO:0030865 cortical cytoskeleton organization 5.2632 6 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 5.2632 4 yes
GO:0043243 positive regulation of protein-containing complex disassembly 5.2632 6 yes
GO:0045214 sarcomere organization 5.2632 5 yes
GO:1901881 positive regulation of protein depolymerization 5.2632 7 yes
GO:0030099 myeloid cell differentiation 3.9474 4 yes
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 3.9474 5 yes
GO:0099623 regulation of cardiac muscle cell membrane repolarization 3.9474 4 yes
GO:0043297 apical junction assembly 2.6316 7 yes
GO:0045685 regulation of glial cell differentiation 2.6316 5 yes
GO:0048713 regulation of oligodendrocyte differentiation 2.6316 6 yes
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 2.6316 5 yes
GO:0097530 granulocyte migration 2.6316 4 yes
GO:1990266 neutrophil migration 2.6316 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in WDR1_HUMAN
DOID:114 heart disease 3.9474 3 no
DOID:612 primary immunodeficiency disease 2.6316 3 no
DOID:0050700 cardiomyopathy 2.6316 4 no
DOID:0060036 intrinsic cardiomyopathy 2.6316 5 no
DOID:12930 dilated cardiomyopathy 2.6316 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
M3K7_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP7_HUMAN [view interactions] Low throughput no yes
SYVN1_HUMAN [view interactions] Low throughput no yes
KEAP1_HUMAN [view interactions] Low throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view interactions] High throughput no yes
CATL1_HUMAN [view interactions] High throughput no yes
CATB_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
CATS_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
IFM3_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no
DDB1_HUMAN [view interactions] High throughput no yes
RHOD_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHBT2_HUMAN [view interactions] High throughput no no
PLK4_HUMAN [view interactions] High throughput no yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1B_HUMAN [view interactions] High throughput no yes
ATG10_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
ITA2B_HUMAN [view interactions] High throughput no no
TXD17_HUMAN [view interactions] High throughput no yes
UBE2K_HUMAN [view interactions] High throughput no yes
TYSY_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
RRP44_HUMAN [view interactions] High throughput no yes
UB2D1_HUMAN [view interactions] High throughput no yes
IF5A1_HUMAN [view interactions] High throughput no yes
CH10_HUMAN [view interactions] High throughput no yes
RBBP7_HUMAN [view interactions] High throughput no yes
CBX3_HUMAN [view interactions] High throughput no yes
MK14_HUMAN [view interactions] High throughput no yes
MVD1_HUMAN [view interactions] High throughput no yes
NAGK_HUMAN [view interactions] High throughput no no
NDKA_HUMAN [view entry] [view interactions] High throughput yes yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
PTMS_HUMAN [view interactions] High throughput no yes
SMAP_HUMAN [view interactions] High throughput no yes
TALDO_HUMAN [view entry] [view interactions] High throughput yes no
THOP1_HUMAN [view interactions] High throughput no yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view interactions] High throughput no yes
COF1_HUMAN [view entry] [view interactions] High throughput yes no
COF2_HUMAN [view entry] [view interactions] High throughput yes yes
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
GILT_HUMAN [view interactions] High throughput no no
ITPA_HUMAN [view interactions] High throughput no yes
LACB2_HUMAN [view interactions] High throughput no yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
LDH6A_HUMAN [view interactions] High throughput no no
LDH6B_HUMAN [view interactions] High throughput no no
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
LDHC_HUMAN [view interactions] High throughput no no
MSI2H_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
PABP4_HUMAN [view entry] [view interactions] High throughput yes yes
PHS_HUMAN [view interactions] High throughput no yes
PPIH_HUMAN [view interactions] High throughput no yes
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
PSMG4_HUMAN [view interactions] High throughput no yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
CK054_HUMAN [view interactions] High throughput no no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CGL_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
GALE_HUMAN [view interactions] High throughput no no
GGCT_HUMAN [view interactions] High throughput no yes
GMPPB_HUMAN [view interactions] High throughput no yes
GSTO2_HUMAN [view interactions] High throughput no no
MOES_HUMAN [view entry] [view interactions] High throughput yes no
RGN_HUMAN [view interactions] High throughput no no
SCLY_HUMAN [view interactions] High throughput no yes
UAP1_HUMAN [view interactions] High throughput no yes
UAP1L_HUMAN [view interactions] High throughput no yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
SYJ2B_HUMAN [view entry] [view interactions] High throughput yes no
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
SCFD1_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
SKIV2_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB2_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
BIRC2_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
NU107_HUMAN [view interactions] High throughput no no
POTEE_HUMAN [view interactions] High throughput no no
SH3L1_HUMAN [view interactions] High throughput no yes
ZBT18_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
MB212_HUMAN [view interactions] High throughput no no
VMP1_HUMAN [view interactions] High throughput no yes
ACADS_HUMAN [view interactions] High throughput no yes
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
PIM3_HUMAN [view interactions] High throughput no no
TBCK_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
TR10D_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
CAV3_HUMAN [view interactions] High throughput no no
TX101_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
SRPK1_HUMAN [view interactions] High throughput no yes
RB33B_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB21_HUMAN [view entry] [view interactions] High throughput yes yes
RAB19_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4B_HUMAN [view entry] [view interactions] High throughput yes no
RB27B_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
FOS_HUMAN [view interactions] High throughput no yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
WDR61_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
LEO1_HUMAN [view interactions] High throughput no yes
SF3B4_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
AMRA1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
PPME1_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
ATRX_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
PURA2_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
DUS28_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
MAGA3_HUMAN [view interactions] High throughput no no
VAV_HUMAN [view interactions] High throughput no no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
VINC_HUMAN [view entry] [view interactions] Computational yes no
BRPF3_HUMAN [view interactions] Computational no yes
STXB2_HUMAN [view interactions] Computational no no
HABP4_HUMAN [view interactions] Computational no yes
TAGL2_HUMAN [view entry] [view interactions] Computational yes no
MANF_HUMAN [view interactions] Computational no yes
ENDD1_HUMAN [view interactions] Computational no yes
TBA4A_HUMAN [view entry] [view interactions] Computational yes yes
TLN1_HUMAN [view entry] [view interactions] Computational yes no
ANXA5_HUMAN [view entry] [view interactions] Computational yes no
ARP2_HUMAN [view entry] [view interactions] Computational yes yes
PLEK_HUMAN [view entry] [view interactions] Computational yes no
SODC_HUMAN [view interactions] Computational no yes